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(2006) \u2018Sometimes similar, sometimes different\u2019: a systematic review of meta-analyses of random and non-randomized policy intervention studies. 14th Cochrane Colloquium; 23-26 October; Dublin, Ireland."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/01.sla.0000225356.04304.bc","article-title":"Comparison of effects in randomized controlled trials with observational studies in digestive surgery","volume":"244","author":"S Shikata","year":"2006","journal-title":"Ann Surg"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta14160","article-title":"Randomised controlled trials for policy interventions: a review of reviews and meta-regression","volume":"14","author":"S Oliver","year":"2010","journal-title":"Health Technol Assess"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jclinepi.2012.09.013","article-title":"Some improvements are apparent in identifying adverse effects in systematic reviews from 1994 to 2011","volume":"66","author":"S Golder","year":"2013","journal-title":"J Clin Epidemiol"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Higgins JPT, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. 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Cardiovascular ischaemia with anti-inflammatory drugs. University of York: York, UK."},{"key":"ref47","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1136\/heart.89.7.767","article-title":"Adverse events in coronary artery bypass graft (CABG) trials: a systematic review and analysis","volume":"89","author":"L Nalysnyk","year":"2003","journal-title":"Heart"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1503\/cmaj.050873","article-title":"Comparison of evidence on harms of medical interventions in randomized and nonrandomized studies","volume":"174","author":"PN Papanikolaou","year":"2006","journal-title":"CMAJ"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1002\/j.1875-9114.1998.tb03150.x","article-title":"Safety of GM-CSF in patients with AIDS: A review of the literature","volume":"18","author":"SD Ross","year":"1998","journal-title":"Pharmacotherapy"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.cgh.2009.01.004","article-title":"Risk of lymphoma associated with combination anti-tumor necrosis factor and immunomodulator therapy for the treatment of Crohn&apos;s disease: a meta-analysis","volume":"7","author":"CA Siegel","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.2337\/dc07-0141","article-title":"Thiazolidinediones and heart failure: A teleo-analysis","volume":"30","author":"S Singh","year":"2007","journal-title":"Diabetes Care"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/uog.6328","article-title":"Safety of ultrasonography in pregnancy: WHO systematic review of the literature and meta-analysis","volume":"33","author":"MR Torloni","year":"2009","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/bja\/78.6.642","article-title":"Propofol and bradycardia: causation, frequency and severity","volume":"78","author":"MR Tramer","year":"1997","journal-title":"Br J Anaesth"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0304-3959(99)00267-5","article-title":"Quantitative estimation of rare adverse events which follow a biological progression: a new model applied to chronic NSAID use","volume":"85","author":"MR Tramer","year":"2000","journal-title":"Pain"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"e275","DOI":"10.1542\/peds.2006-1392","article-title":"Adverse events associated with pediatric spinal manipulation: a systematic review","volume":"119","author":"S Vohra","year":"2007","journal-title":"Pediatrics"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1503\/cmaj.071178","article-title":"Adverse effects of medical cannabinoids: a systematic review","volume":"178","author":"T Wang","year":"2008","journal-title":"CMAJ"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1467-842X.1999.tb01202.x","article-title":"Water fluoridation, bone mass and fracture: a quantitative overview of the literature","volume":"23","author":"G Jones","year":"1999","journal-title":"Aust N Z J Public Health"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1001\/archinte.1992.00400180139023","article-title":"The impact of research quality and study design on epidemiologic estimates of the effect of nonsteroidal anti-inflammatory drugs on upper gastrointestinal tract disease","volume":"152","author":"P Bollini","year":"1992","journal-title":"Arch Intern Med"},{"key":"ref59","unstructured":"Agency for Healthcare Research and Quality (2002) Hormone Replacement Therapy and Risk of Venous Thromboembolism. Rockville, MD: Agency for Healthcare Research and Quality."},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1111\/j.1365-2036.2007.03495.x","article-title":"Meta-analysis: the use of non-steroidal anti-inflammatory drugs and pancreatic cancer risk for different exposure categories","volume":"26","author":"G Capurso","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1001\/archinte.164.7.741","article-title":"Risk of stroke in women exposed to low-dose oral contraceptives: a critical evaluation of the evidence","volume":"164","author":"WS Chan","year":"2004","journal-title":"Arch Intern Med"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1136\/bmj.317.7162.839","article-title":"Benzodiazepine use in pregnancy and major malformations or oral cleft: meta-analysis of cohort and case-control studies","volume":"317","author":"LR Dolovich","year":"1998","journal-title":"BMJ"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1001\/archinte.1997.00440350022002","article-title":"A reevaluation of the risk for venous thromboembolism with the use of oral contraceptives and hormone replacement therapy","volume":"157","author":"JD Douketis","year":"1997","journal-title":"Arch Intern Med"},{"key":"ref64","first-page":"472","article-title":"Hormone replacement therapy and the risk of epithelial ovarian carcinoma: a meta-analysis","volume":"92","author":"PP Garg","year":"1998","journal-title":"Obstet Gynecol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1001\/jama.284.1.72","article-title":"Ischemic stroke risk with oral contraceptives: a meta-analysis","volume":"284","author":"LA Gillum","year":"2000","journal-title":"JAMA"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/0029-7844(94)00383-O","article-title":"Hormone replacement therapy and endometial cancer risk: a meta-analysis","volume":"85","author":"D Grady","year":"1995","journal-title":"Obstet Gynecol"},{"key":"ref67","unstructured":"Henry D, McGettigan P (2003) Epidemiology overview of gastrointestinal and renal toxicity of NSAIDs. Int J Clin Pract Suppl 135: 43\u201349."},{"key":"ref68","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1212\/WNL.51.2.411","article-title":"Oral contraceptives and the risk of subarachnoid hemorrhage","volume":"51","author":"SC Johnston","year":"1998","journal-title":"Neurology"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1365-2796.1995.tb00896.x","article-title":"Oral contraceptives and venous thromboembolism: a quantitative discussion of the uncertainties","volume":"238","author":"T Koster","year":"1995","journal-title":"J Intern Med"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1532-5415.1999.tb01898.x","article-title":"Drugs and falls in older people: a systematic review and meta-analysis: I. 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