{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:59:33Z","timestamp":1761541173576},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T00:00:00Z","timestamp":1377475200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0071981","type":"journal-article","created":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T21:25:55Z","timestamp":1377552355000},"page":"e71981","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Zebularine Induces Long-Term Survival of Pancreatic Islet Allotransplants in Streptozotocin Treated Diabetic Rats"],"prefix":"10.1371","volume":"8","author":[{"given":"Henrietta","family":"Nittby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ericsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"F\u00f6rnvik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Str\u00f6mblad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Jansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongtian","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Skagerberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengt","family":"Widegren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Olov","family":"Sj\u00f6gren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leif G.","family":"Salford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,8,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1056\/NEJM199209173271202","article-title":"Survival of nationally shared, HLA-matched kidney transplants from cadaveric donors. The UNOS Scientific Renal Transplant Registry","volume":"327","author":"S Takemoto","year":"1992","journal-title":"N Engl J Med"},{"key":"ref2","first-page":"757310","article-title":"Mechanisms and mediators of inflammation: potential models for skin rejection and targeted therapy in vascularized composite allotransplantation","volume":"2012","author":"T Hautz","year":"2012","journal-title":"Clin Devel Immunol"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Tudur\u00ed E, Kieffer TJ (2011) Reprogramming gut and pancreas endocrine cells to treat diabetes. Diabetes Obes Metab Suppl 1: 53\u20139.","DOI":"10.1111\/j.1463-1326.2011.01446.x"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Mudigonda T, Levender MM, O\u2019Neill JL, West CE, Pearce DJ, et al<\/etal>.. (2013) Incidence, risk factors, and preventative management of skin cancers in organ transplant recipients: a review of single- and multicenter retrospective studies from 2006 to 2010. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2319040839<\/ext-link>: 345\u201364.","DOI":"10.1111\/dsu.12028"},{"key":"ref5","first-page":"399","article-title":"Inhibition of DNA methylation and reactivation of silenced genes by zebularine. J Natl Cancer Inst","volume":"95","author":"JC Cheng","year":"2003"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1038\/leu.2008.397","article-title":"The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells","volume":"6","author":"C Flotho","year":"2009","journal-title":"Leukemia"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.molimm.2012.01.006","article-title":"An epigenetic mechanism for high, synergistic expression of indoleamine 2,3-dioxygenase 1 (IDO1) by combined treatment with zebularine and IFN-\u03b3: potential therapeutic use in autoimmune diseases","volume":"51","author":"ZT Xue","year":"2012","journal-title":"Mol Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.canlet.2007.07.013","article-title":"Low dose Zebularine treatment enhances immunogenicity of tumor cells","volume":"257","author":"H Liu","year":"2007","journal-title":"Cancer Letters"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"130","DOI":"10.4049\/jimmunol.177.1.130","article-title":"Kynurenine pathway enzymes in dendritic cells initiate tolerogenesis in the absence of functional IDO","volume":"177","author":"ML Belladonna","year":"2006","journal-title":"J Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/978-1-60761-869-0_19","article-title":"Indoleamine 2,3-dioxygenase and regulatory function: tryptophan starvation and beyond","volume":"677","author":"C Orabona","year":"2011","journal-title":"Methods Mol Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.bcp.2011.06.013","article-title":"Suppression of human CD4+ T cell activation by 3,4-dimethoxycinnamonyl-anthranilic acid (tranilast) is mediated by CXCL9 and CXCL10","volume":"82","author":"A Hertenstein","year":"2011","journal-title":"Biochem Pharmacol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/ni.2077","article-title":"Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells","volume":"12","author":"MT Pallotta","year":"2011","journal-title":"Nat Immunol"},{"key":"ref13","first-page":"176","article-title":"Prolongation of rat major histocompatibility complex-compatible cardiac allograft survival during pregnancy J Heart Lung Transplant","volume":"28","author":"N Funeshima-Fuji","year":"2009"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF01081736","article-title":"The impact of type I diabetes on rat liver gamma-glutamyltranspeptidase","volume":"39","author":"SJ Hemmings","year":"1994","journal-title":"Mol Cell Biochem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0022-4804(81)90091-3","article-title":"Inhibition of tumor size by streptozotocin-induced diabetes mellitus","volume":"30","author":"GM Sloan","year":"1981","journal-title":"J Surg Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1399-3089.2006.00274.x","article-title":"Longterm gene expression and metabolic control exerted by lentivirus transduced pancreatic islets","volume":"13","author":"Z He","year":"2006","journal-title":"Xenotransplantation"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"C1250","DOI":"10.1152\/ajpcell.1995.269.5.C1250","article-title":"Dynamics of pancreatic cell growth and differentiation during diabetes reversion in STZ-treated newborn rats","volume":"269","author":"N Ferrand","year":"1995","journal-title":"Am J Physiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3181\/00379727-151-39209","article-title":"Modification of renal tumorigenic effect of streptozotocin by nicotinamide: spontaneous reversibility of streptozotocin diabetes","volume":"151","author":"N Rakieten","year":"1976","journal-title":"Proc Soc Exp Biol Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1055\/s-2007-1003319","article-title":"Effect of probucol on recovery from streptozotocin diabetes in rats","volume":"24","author":"G Yoshino","year":"1992","journal-title":"Horm Metab Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1111\/j.1600-6143.2010.03190.x","article-title":"Induction of indoleamine 2,3-dioxygenase by gene delivery in allogeneic islets prolongs allograft survival","volume":"10","author":"H Dell\u00ea","year":"2010","journal-title":"Am J Transplant"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"H3415","DOI":"10.1152\/ajpheart.00532.2007","article-title":"Indoleamine 2,3-dioxygenase gene transfer prolongs cardiac allograft survival","volume":"293","author":"J Li","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/art.24229","article-title":"Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models","volume":"60","author":"NR Bianco","year":"2009","journal-title":"Arthritis Rheum"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0071981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T02:53:55Z","timestamp":1563764035000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0071981"}},"subtitle":[],"editor":[{"given":"Paolo","family":"Fiorina","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,8,26]]},"references-count":22,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,8,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0071981","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,26]]}}}