{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:26:59Z","timestamp":1791066419308,"version":"4.1.0"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2013,8,21]],"date-time":"2013-08-21T00:00:00Z","timestamp":1377043200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0072302","type":"journal-article","created":{"date-parts":[[2013,8,21]],"date-time":"2013-08-21T16:59:42Z","timestamp":1377104382000},"page":"e72302","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":101,"title":["Effect of Maternal Methionine Supplementation on the Transcriptome of Bovine Preimplantation Embryos"],"prefix":"10.1371","volume":"8","author":[{"given":"Francisco","family":"Pe\u00f1agaricano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex H.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo D.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley M.","family":"Driver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocio","family":"Gambra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Kropp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine S.","family":"Hackbart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Luchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy D.","family":"Shaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milo C.","family":"Wiltbank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Khatib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,8,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1753-4887.2009.00265.x","article-title":"Fetal programming: link between early nutrition, DNA methylation, and complex diseases","volume":"68","author":"A Chmurzynska","year":"2010","journal-title":"Nutrition Reviews"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1146\/annurev.nutr.012809.104751","article-title":"Nutrition, Epigenetics, and Developmental Plasticity: Implications for Understanding Human Disease","volume":"30","author":"GC Burdge","year":"2010","journal-title":"Annual Review of Nutrition, Vol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1093\/jn\/134.9.2169","article-title":"Maternal nutrition and fetal development","volume":"134","author":"GY Wu","year":"2004","journal-title":"Journal of Nutrition"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1098\/rstb.2009.0184","article-title":"Nutritional effects on oocyte and embryo development in mammals: implications for reproductive efficiency and environmental sustainability","volume":"364","author":"CJ Ashworth","year":"2009","journal-title":"Philosophical Transactions of the Royal Society B-Biological Sciences"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.anireprosci.2012.01.015","article-title":"Nutrition of females during the peri-conceptional period and effects on foetal programming and health of offspring","volume":"130","author":"TP Fleming","year":"2012","journal-title":"Animal Reproduction Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1210\/en.2007-1273","article-title":"One-cell zygote transfer from diabetic to nondiabetic mouse results in congenital malformations and growth retardation in offspring","volume":"149","author":"A Wyman","year":"2008","journal-title":"Endocrinology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1242\/dev.127.19.4195","article-title":"Maternal undernutrition during the preimplantation period of rat development causes blastocyst abnormalities and programming of postnatal hypertension","volume":"127","author":"WY Kwong","year":"2000","journal-title":"Development"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/mrd.20606","article-title":"Maternal low protein diet restricted to the preimplantation period induces a gender-specific change on hepatic gene expression in rat fetuses","volume":"74","author":"WY Kwong","year":"2007","journal-title":"Molecular Reproduction and Development"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1095\/biolreprod.107.064220","article-title":"Adaptive responses by mouse early embryos to maternal diet protect fetal growth but predispose to adult onset disease","volume":"78","author":"AJ Watkins","year":"2008","journal-title":"Biology of Reproduction"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1017\/S0007114509993783","article-title":"Maternal low-protein diet during mouse pre-implantation development induces vascular dysfunction and altered renin-angiotensin-system homeostasis in the offspring","volume":"103","author":"AJ Watkins","year":"2010","journal-title":"British Journal of Nutrition"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Igosheva N, Abramov AY, Poston L, Eckert JJ, Fleming TP, et al. (2010) Maternal Diet-Induced Obesity Alters Mitochondrial Activity and Redox Status in Mouse Oocytes and Zygotes. Plos One 5.","DOI":"10.1371\/journal.pone.0010074"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1017\/S0007114507682920","article-title":"Epigenetic regulation of transcription: a mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life","volume":"97","author":"GC Burdge","year":"2007","journal-title":"British Journal of Nutrition"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev.nutr.22.010402.102932","article-title":"Genetic effects of methylation diets","volume":"22","author":"IB Van den Veyver","year":"2002","journal-title":"Annual Review of Nutrition"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0168-9525(02)02709-9","article-title":"Metastable epialleles in mammals","volume":"18","author":"VK Rakyan","year":"2002","journal-title":"Trends in Genetics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2393S","DOI":"10.1093\/jn\/132.8.2393S","article-title":"Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring","volume":"132","author":"CA Cooney","year":"2002","journal-title":"Journal of Nutrition"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/dvg.20230","article-title":"Maternal methyl supplements increase offspring DNA methylation at axin fused","volume":"44","author":"RA Waterland","year":"2006","journal-title":"Genesis"},{"key":"ref17","first-page":"49","article-title":"Maternal diet during pregnancy induces gene expression and DNA methylation changes in fetal tissues in sheep","volume":"4","author":"X Lan","year":"2013","journal-title":"Frontiers in Genetics"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"E259","DOI":"10.1111\/j.1439-0396.2009.00966.x","article-title":"Effect of rumen-protected choline and methionine on physiological and metabolic disorders and reproductive indices of dairy cows","volume":"94","author":"M Ardalan","year":"2010","journal-title":"Journal of Animal Physiology and Animal Nutrition"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"19351","DOI":"10.1073\/pnas.0707258104","article-title":"DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status","volume":"104","author":"KD Sinclair","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref20","unstructured":"NRC (2001) Nutrient Requirements of Dairy Cattle: Seventh Revised Edition: National Research Council, National Academy Press, Washington, DC, USA."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.theriogenology.2008.03.014","article-title":"A new presynchronization system (Double-Ovsynch) increases fertility at first postpartum timed AI in lactating dairy cows","volume":"70","author":"AH Souza","year":"2008","journal-title":"Theriogenology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0093-691X(95)00279-H","article-title":"Synchronization of ovulation in dairy cows using PGF2alpha and GnRH","volume":"44","author":"JR Pursley","year":"1995","journal-title":"Theriogenology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","article-title":"TopHat: discovering splice junctions with RNA-Seq","volume":"25","author":"C Trapnell","year":"2009","journal-title":"Bioinformatics"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"C Trapnell","year":"2010","journal-title":"Nature Biotechnology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"MD Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate - a practical and powerfull approach to multiple testing","volume":"57","author":"Y Benjamini","year":"1995","journal-title":"Journal of the Royal Statistical Society Series B-Methodological"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2<sup>\u2212DDCT<\/sup> method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/10343","article-title":"Systematic determination of genetic network architecture","volume":"22","author":"S Tavazoie","year":"1999","journal-title":"Nature Genetics"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/bioinformatics\/btg455","article-title":"FatiGO: a web tool for finding significant associations of Gene Ontology terms with groups of genes","volume":"20","author":"F Al-Shahrour","year":"2004","journal-title":"Bioinformatics"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"W210","DOI":"10.1093\/nar\/gkq388","article-title":"Babelomics: an integrative platform for the analysis of transcriptomics, proteomics and genomic data with advanced functional profiling","volume":"38","author":"I Medina","year":"2010","journal-title":"Nucleic Acids Research"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1471-2164-13-118","article-title":"RNA-Seq analysis uncovers transcriptomic variations between morphologically similar in vivo- and in vitro-derived bovine blastocysts","volume":"13","author":"AM Driver","year":"2012","journal-title":"Bmc Genomics"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1128\/MCB.01124-12","article-title":"Developmentally Programmed 3\u2032 CpG Island Methylation Confers Tissue- and Cell-Type-Specific Transcriptional Activation","volume":"33","author":"DH Yu","year":"2013","journal-title":"Molecular and Cellular Biology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1111\/j.1753-4887.2008.00056.x","article-title":"The agouti mouse model: an epigenetic biosensor for nutritional and environmental alterations on the fetal epigenome","volume":"66","author":"DC Dolinoy","year":"2008","journal-title":"Nutrition Reviews"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1530\/rep.0.1250607","article-title":"Immunohistochemical and ultrastructural characterization of the initial post-hatching development of bovine embryos","volume":"125","author":"P Maddox-Hyttel","year":"2003","journal-title":"Reproduction"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1095\/biolreprod.110.090019","article-title":"Conceptus-Induced Changes in the Endometrial Transcriptome: How Soon Does the Cow Know She Is Pregnant","volume":"85","author":"N Forde","year":"2011","journal-title":"Biology of Reproduction"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1530\/REP-10-0504","article-title":"Involvement of BCL2 family members in the regulation of human oocyte and early embryo survival and death: gene expression and beyond","volume":"141","author":"I Boumela","year":"2011","journal-title":"Reproduction"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Naiche LA, Harrelson Z, Kelly RG, Papaioannou VE (2005) T-box genes in vertebrate development. Annual Review of Genetics. 219\u2013239.","DOI":"10.1146\/annurev.genet.39.073003.105925"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1046\/j.1439-0264.2001.00341.x","article-title":"Immunocytochemical analysis of vimentin expression patterns in porcine embryos suggests mesodermal differentiation from day 9 after conception","volume":"30","author":"K Prelle","year":"2001","journal-title":"Anatomia Histologia Embryologia-Journal of Veterinary Medicine Series C"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1056\/NEJM199212243272602","article-title":"Prevention of the first occurrence of neural tube defects by periconceptional vitamin supplementation","volume":"327","author":"AE Czeizel","year":"1992","journal-title":"New England Journal of Medicine"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1017\/S0029665101000088","article-title":"Genes, folate and homocysteine in embryonic development","volume":"60","author":"TH Rosenquist","year":"2001","journal-title":"Proceedings of the Nutrition Society"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/biof.170","article-title":"Human neural tube defects: Genetic causes and prevention","volume":"37","author":"P De Marco","year":"2011","journal-title":"Biofactors"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/0198-8859(93)90006-M","article-title":"Characterization of a novel gene (NKG7) on human chromosome 19 that is expressed in natural killer cells and T cells","volume":"36","author":"MA Turman","year":"1993","journal-title":"Human Immunology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/eji.200425932","article-title":"KARAP\/DAP12\/TYROBP: three names and a multiplicity of biological functions","volume":"35","author":"E Tomasello","year":"2005","journal-title":"European Journal of Immunology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.molimm.2012.12.017","article-title":"YY1 and a unique DNA repeat element regulates the transcription of mouse CS1 (CD319, SLAMF7) gene","volume":"54","author":"P Dongre","year":"2013","journal-title":"Molecular Immunology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"6357","DOI":"10.4049\/jimmunol.1103242","article-title":"L-Plastin Regulates Polarization and Migration in Chemokine-Stimulated Human T Lymphocytes","volume":"188","author":"M Freeley","year":"2012","journal-title":"Journal of Immunology"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1744-313X.2007.00654.x","article-title":"Identification of genetic variations of exon 2 of BoLA-DQB gene in five Chinese yellow cattle breeds","volume":"34","author":"K Wang","year":"2007","journal-title":"International Journal of Immunogenetics"},{"key":"ref47","first-page":"3462","article-title":"In utero supplementation with methyl donors enhances allergic airway disease in mice","volume":"118","author":"JW Hollingsworth","year":"2008","journal-title":"Journal of Clinical Investigation"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0072302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T19:41:49Z","timestamp":1715888509000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0072302"}},"subtitle":[],"editor":[{"given":"Jason Glenn","family":"Knott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,8,21]]},"references-count":47,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,8,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0072302","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,21]]}}}