{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T12:31:23Z","timestamp":1789216283608,"version":"build-2803163510"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T00:00:00Z","timestamp":1377648000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0072543","type":"journal-article","created":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T20:55:24Z","timestamp":1377723324000},"page":"e72543","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Clioquinol Synergistically Augments Rescue by Zinc Supplementation in a Mouse Model of Acrodermatitis Enteropathica"],"prefix":"10.1371","volume":"8","author":[{"given":"Jim","family":"Geiser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"De Lisle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Finkelstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Adlard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley I.","family":"Bush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen K.","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,8,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jtemb.2012.04.004","article-title":"Discovery of human zinc deficiency: 50 years later","volume":"26","author":"AS Prasad","year":"2012","journal-title":"J Trace Elem Med Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1093\/ajcn\/51.4.678","article-title":"A positive association between maternal serum zinc concentration and birth weight","volume":"51","author":"YH Neggers","year":"1990","journal-title":"Am J Clin Nutr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/ajcn\/71.1.109","article-title":"Maternal plasma zinc concentrations and pregnancy outcome","volume":"71","author":"T Tamura","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1542\/peds.112.6.1419","article-title":"Zinc, low birth weight, and breastfeeding","volume":"112","author":"KM Hambidge","year":"2003","journal-title":"Pediatrics"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/S0002-9378(96)80062-7","article-title":"Zinc deficiency and abnormal fetal development: Assessment of maternal or fetal zinc status","volume":"175","author":"DL Bloxam","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/0140-6736(92)93186-Q","article-title":"Diabetes and schizophrenia: Genes or zinc deficiency","volume":"340","author":"RCR Andrews","year":"1992","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/68.2.464S","article-title":"Zinc deficiency and child development","volume":"68","author":"MM Black","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1385\/BTER:99:1-3:049","article-title":"Zinc deficiency and growth - Current concepts in relationship to two important points: Intellectual and sexual development","volume":"99","author":"MJ Salgueiro","year":"2004","journal-title":"Biol Trace Elem Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1093\/jn\/137.5.1345","article-title":"Zinc: mechanisms of host defense","volume":"137","author":"AS Prasad","year":"2007","journal-title":"J Nutr"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1485S","DOI":"10.1093\/jn\/133.5.1485S","article-title":"Zinc deficiency, infectious disease and mortality in the developing world","volume":"133","author":"RE Black","year":"2003","journal-title":"J Nutr"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.1021\/bi00476a001","article-title":"Zinc coordination, function, and structure of zinc enzymes and other proteins","volume":"29","author":"BL Vallee","year":"1990","journal-title":"Biochemistry"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.271.5252.1081","article-title":"The galvanization of biology: A growing appreciation for the roles of zinc","volume":"271","author":"JM Berg","year":"1996","journal-title":"Science"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1093\/nar\/gkg161","article-title":"Structural classification of zinc fingers","volume":"31","author":"SS Krishna","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/jn\/136.5.1185","article-title":"Zinc Supplementation Reduces Iron Absorption through Age-Dependent Changes in Small Intestine Iron Transporter Expression in Suckling Rat Pups","volume":"136","author":"SL Kelleher","year":"2006","journal-title":"J Nutr"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/sj.bdj.2011.428","article-title":"Zinc-containing denture adhesive: a potential source of excess zinc resulting in copper deficiency myelopathy","volume":"210","author":"K Doherty","year":"2011","journal-title":"Br Dent J"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/MAJ.0b013e3181e3648c","article-title":"Fatal copper deficiency from excessive use of zinc-based denture adhesive","volume":"340","author":"LB Afrin","year":"2010","journal-title":"Am J Med Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e55384","DOI":"10.1371\/journal.pone.0055384","article-title":"High dose zinc supplementation induces hippocampal zinc deficiency and memory impairment with inhibition of BDNF signaling","volume":"8","author":"Y Yang","year":"2013","journal-title":"PLoS One"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Seok SH, Cho WS, Park JS, Na Y, Jang A, <etal>et al<\/etal>.. (2013) Rat pancreatitis produced by 13-week administration of zinc oxide nanoparticles: biopersistence of nanoparticles and possible solutions. J Appl Toxicol e-pub; In Press.","DOI":"10.1002\/jat.2862"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1136\/vr.100376","article-title":"Haemolytic anaemia and acute pancreatitis associated with zinc toxicosis in a dog","volume":"172","author":"R Blundell","year":"2013","journal-title":"Vet Rec"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jemermed.2007.11.023","article-title":"Massive penny ingestion: the loot with local and systemic effects","volume":"35","author":"SS Dhawan","year":"2008","journal-title":"J Emerg Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1378S","DOI":"10.1093\/jn\/130.5.1378S","article-title":"Dietary factors influencing zinc absorption","volume":"130","author":"B Lonnerdal","year":"2000","journal-title":"J Nutr"},{"key":"ref22","first-page":"2829","article-title":"Discovery and importance of zinc in human nutrition","volume":"43","author":"AS Prasad","year":"1984","journal-title":"Fed Proc"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"39699","DOI":"10.1074\/jbc.M605821200","article-title":"Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency","volume":"281","author":"W Chowanadisai","year":"2006","journal-title":"J Biol Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e3642","DOI":"10.1371\/journal.pone.0003642","article-title":"The zinc transporter SLC39A13\/ZIP13 is required for connective tissue development; its involvement in BMP\/TGF-beta signaling pathways","volume":"3","author":"T Fukada","year":"2008","journal-title":"PLoS ONE"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1042\/cs0560505","article-title":"A defect in zinc uptake by jejunal biopsies in acrodermatitis enteropathica","volume":"56","author":"DJ Atherton","year":"1979","journal-title":"Clin Sci (Lond)"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e1002766","DOI":"10.1371\/journal.pgen.1002766","article-title":"A Mouse Model of Acrodermatitis Enteropathica: Loss of Intestine Zinc Transporter ZIP4 (Slc39a4) Disrupts the Stem Cell Niche and Intestine Integrity","volume":"8","author":"J Geiser","year":"2012","journal-title":"PLoS Genet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0140-6736(74)91772-3","article-title":"Letter: Acrodermatitis enteropathica: a lethal inherited human zinc- deficiency disorder","volume":"2","author":"EJ Moynahan","year":"1974","journal-title":"Lancet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/8904_2011_38","article-title":"A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene","volume":"2","author":"M Kilic","year":"2012","journal-title":"JIMD Rep"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fpsyt.2012.00015","article-title":"Metal chaperones: a holistic approach to the treatment of Alzheimer&apos;s disease","volume":"3","author":"PA Adlard","year":"2012","journal-title":"Front Psychiatry"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1755-5949.2010.00231.x","article-title":"Clioquinol: review of its mechanisms of action and clinical uses in neurodegenerative disorders","volume":"18","author":"SR Bareggi","year":"2012","journal-title":"CNS Neurosci Ther"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1001\/archderm.1974.01630110009001","article-title":"Acrodermatitis enteropathica. A clinical and biochemical survey","volume":"110","author":"KH Neldner","year":"1974","journal-title":"Arch Dermatol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/jid.1955.29","article-title":"Acrodermatitis enteropathica successfully treated with diodoquin","volume":"24","author":"D Bloom","year":"1955","journal-title":"J Invest Dermatol"},{"key":"ref33","first-page":"486","article-title":"Enteropathic acrodermatitis (Danbolt-Closs) and diodoquin treatment","volume":"3","author":"A Sundal","year":"1957","journal-title":"Ann Paediatr Fenn"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1542\/peds.65.3.610","article-title":"Zinc deficiency, acrodermatitis enteropathica, optic atrophy, subacute myelo-optic neuropathy, and 5,7-dihalo-8-quinolinols","volume":"65","author":"FM Sturtevant","year":"1980","journal-title":"Pediatrics"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/0006-291X(79)91825-4","article-title":"The possible role of diodoquin as a zinc ionophore in the treatment of acrodermatitis enteropathica","volume":"87","author":"PJ Aggett","year":"1979","journal-title":"Biochem Biophys Res Commun"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1136\/jcp.30.3.284","article-title":"Zinc and di-iodohydroxyquinoline therapy in acrodermatitis enteropathica","volume":"30","author":"MJ Jackson","year":"1977","journal-title":"J Clin Pathol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00109-006-0140-7","article-title":"Copper and clioquinol treatment in young APP transgenic and wild-type mice: effects on life expectancy, body weight, and metal-ion levels","volume":"85","author":"S Schafer","year":"2007","journal-title":"J Mol Med (Berl)"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1074\/jbc.M111.308668","article-title":"Different 8-hydroxyquinolines protect models of TDP-43 protein, alpha-synuclein, and polyglutamine proteotoxicity through distinct mechanisms","volume":"287","author":"DF Tardiff","year":"2012","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/jcp.21628","article-title":"Zinc chloride stimulates DNA synthesis of mouse embryonic stem cells: involvement of PI3K\/Akt, MAPKs, and mTOR","volume":"218","author":"JM Ryu","year":"2009","journal-title":"J Cell Physiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.brainres.2008.08.040","article-title":"Zinc deficiency impairs neuronal precursor cell proliferation and induces apoptosis via p53-mediated mechanisms","volume":"1237","author":"RS Corniola","year":"2008","journal-title":"Brain Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"e13158","DOI":"10.1371\/journal.pone.0013158","article-title":"Zip4 (Slc39a4) expression is activated in hepatocellular carcinomas and functions to repress apoptosis, enhance cell cycle and increase migration","volume":"5","author":"BP Weaver","year":"2010","journal-title":"PLoS ONE"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"18636","DOI":"10.1073\/pnas.0709307104","article-title":"Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression","volume":"104","author":"M Li","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1158\/1078-0432.CCR-09-2405","article-title":"ZIP4 regulates pancreatic cancer cell growth by activating IL-6\/STAT3 pathway through zinc finger transcription factor CREB","volume":"16","author":"Y Zhang","year":"2010","journal-title":"Clin Cancer Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bone.2005.08.010","article-title":"Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells","volume":"38","author":"Z Tang","year":"2006","journal-title":"Bone"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1083\/jcb.200702081","article-title":"Zinc is a novel intracellular second messenger","volume":"177","author":"S Yamasaki","year":"2007","journal-title":"J Cell Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00775-011-0797-4","article-title":"Zinc homeostasis and signaling in health and diseases: Zinc signaling","volume":"16","author":"T Fukada","year":"2011","journal-title":"J Biol Inorg Chem"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"26097","DOI":"10.1074\/jbc.M110.107490","article-title":"Zinc released from injured cells is acting via the Zn2+-sensing receptor, ZnR, to trigger signaling leading to epithelial repair","volume":"285","author":"H Sharir","year":"2010","journal-title":"J Biol Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1053\/j.gastro.2012.02.046","article-title":"The zinc transporter Zip14 influences c-Met phosphorylation and hepatocyte proliferation during liver regeneration in mice","volume":"142","author":"TB Aydemir","year":"2012","journal-title":"Gastroenterology"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0014-4827(03)00406-3","article-title":"Intracellular zinc fluctuations modulate protein tyrosine phosphatase activity in insulin\/insulin-like growth factor-1 signaling","volume":"291","author":"H Haase","year":"2003","journal-title":"Exp Cell Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.molmed.2009.01.004","article-title":"Zinc transporters and cancer: a potential role for ZIP7 as a hub for tyrosine kinase activation","volume":"15","author":"C Hogstrand","year":"2009","journal-title":"Trends Mol Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuron.2008.06.018","article-title":"Rapid restoration of cognition in Alzheimer&apos;s transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta","volume":"59","author":"PA Adlard","year":"2008","journal-title":"Neuron"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S1474-4422(08)70167-4","article-title":"Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer&apos;s disease: a phase IIa, double-blind, randomised, placebo-controlled trial","volume":"7","author":"L Lannfelt","year":"2008","journal-title":"Lancet Neurol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3233\/JAD-2010-1390","article-title":"PBT2 rapidly improves cognition in Alzheimer&apos;s Disease: additional phase II analyses","volume":"20","author":"NG Faux","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1471-4159.2011.07402.x","article-title":"The Alzheimer&apos;s therapeutic PBT2 promotes amyloid-beta degradation and GSK3 phosphorylation via a metal chaperone activity","volume":"119","author":"PJ Crouch","year":"2011","journal-title":"J Neurochem"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1474-9726.2006.00196.x","article-title":"Radioiodinated clioquinol as a biomarker for beta-amyloid: Zn complexes in Alzheimer&apos;s disease","volume":"5","author":"C Opazo","year":"2006","journal-title":"Aging Cell"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0896-6273(01)00317-8","article-title":"Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer&apos;s disease transgenic mice","volume":"30","author":"RA Cherny","year":"2001","journal-title":"Neuron"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuron.2008.06.018","article-title":"Rapid restoration of cognition in Alzheimer&apos;s transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta","volume":"59","author":"PA Adlard","year":"2008","journal-title":"Neuron"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1158\/0008-5472.CAN-04-3577","article-title":"Anticancer activity of the antibiotic clioquinol","volume":"65","author":"WQ Ding","year":"2005","journal-title":"Cancer Res"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/BF03401927","article-title":"Clioquinol-zinc chelate: a candidate causative agent of subacute myelo-optic neuropathy","volume":"4","author":"JL Arbiser","year":"1998","journal-title":"Mol Med"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1042\/BJ20081421","article-title":"Clioquinol targets zinc to lysosomes in human cancer cells","volume":"417","author":"H Yu","year":"2009","journal-title":"Biochem J"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00109-003-0462-7","article-title":"Clioquinol effects on tissue chelatable zinc in mice","volume":"81","author":"YB Nitzan","year":"2003","journal-title":"J Mol Med (Berl)"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/1523-1747.ep12515094","article-title":"Effects of penicillamine and hydroxyquinoline on absorption of orally ingested 65zinc in the rat","volume":"71","author":"K Weismann","year":"1978","journal-title":"J Invest Dermatol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1093\/hmg\/ddm088","article-title":"The mouse acrodermatitis gene Slc39a4 (<italic>ZIP4<\/italic>) is essential for development and heterozygosity causes hypersensitivity to zinc deficiency","volume":"16","author":"J Dufner-Beattie","year":"2007","journal-title":"Hum Mol Genet"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/gene.20042","article-title":"Tissue-specific and inducible Cre-mediated recombination in the gut epithelium","volume":"39","author":"F el Marjou","year":"2004","journal-title":"Genesis"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"49082","DOI":"10.1074\/jbc.M409962200","article-title":"The adaptive response to dietary zinc in mice involves the differential cellular localization and zinc-regulation of the zinc transporters ZIP4 and ZIP5","volume":"279","author":"J Dufner-Beattie","year":"2004","journal-title":"J Biol Chem"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1104\/pp.106.092528","article-title":"Purdue ionomics information management system. An integrated functional genomics platform","volume":"143","author":"I Baxter","year":"2007","journal-title":"Plant Physiol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.neuro.2007.02.004","article-title":"Stoichiometry and conditional stability constants of Cu(II) or Zn(II) clioquinol complexes; implications for Alzheimer&apos;s and Huntington&apos;s disease therapy","volume":"28","author":"E Ferrada","year":"2007","journal-title":"Neurotoxicology"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1021\/ic0494051","article-title":"Clioquinol, a drug for Alzheimer&apos;s disease specifically interfering with brain metal metabolism: structural characterization of its zinc(II) and copper(II) complexes","volume":"43","author":"M Di Vaira","year":"2004","journal-title":"Inorg Chem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0072543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T01:47:20Z","timestamp":1646444840000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0072543"}},"subtitle":[],"editor":[{"given":"Jo\u00e3o","family":"Costa-Rodrigues","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,8,28]]},"references-count":68,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,8,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0072543","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,28]]}}}