{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T05:49:15Z","timestamp":1789364955188,"version":"build-2803163510"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T00:00:00Z","timestamp":1378252800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0072591","type":"journal-article","created":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T17:09:43Z","timestamp":1378314583000},"page":"e72591","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":80,"title":["Comparative Gene Expression Profiling Identifies Common Molecular Signatures of NF-\u03baB Activation in Canine and Human Diffuse Large B Cell Lymphoma (DLBCL)"],"prefix":"10.1371","volume":"8","author":[{"given":"Manikhandan A. V.","family":"Mudaliar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross D.","family":"Haggart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gino","family":"Miele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Sellar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A. L.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Goodlad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elspeth","family":"Milne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Vail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilene","family":"Kurzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Crowther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Argyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,9,4]]},"reference":[{"key":"ref1","first-page":"e1000161","article-title":"The Comparative Oncology Trials Consortium: using spontaneously occurring cancers in dogs to inform the cancer drug development pathway. PLoS Med","volume":"6(10)","author":"I Gordon","year":"2009"},{"key":"ref2","first-page":"512","article-title":"Methods and mortality results of a health survey of purebred dogs in the UK. J Small Anim Pract","volume":"51(10)","author":"VJ Adams","year":"2010"},{"key":"ref3","first-page":"27","article-title":"Leading the way: canine models of genomics and disease. Disease models &amp; mechanisms","volume":"3(1\u20132)","author":"AL Shearin","year":"2010"},{"key":"ref4","first-page":"147","article-title":"Translation of new cancer treatments from pet dogs to humans. Nat Rev Cancer","volume":"8(2)","author":"M Paoloni","year":"2008"},{"key":"ref5","first-page":"135","article-title":"Comparative expression pathway analysis of human and canine mammary tumors. BMC Genomics","volume":"10","author":"P Uva","year":"2009"},{"key":"ref6","unstructured":"Cancer statistics registrations (2010) Available at: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ons.gov.uk\/ons\/rel\/vsob1\/cancer-registrations-in-england\/2010\/2010-cancer-registrations-in-england-statistical-bulletin-2.html\" xlink:type=\"simple\">http:\/\/www.ons.gov.uk\/ons\/rel\/vsob1\/cancer-registrations-in-england\/2010\/2010-cancer-registrations-in-england-statistical-bulletin-2.html<\/ext-link> (Accessed August 2013)."},{"key":"ref7","unstructured":"Cancer Incidence in Wales 2003\u20132007 (2009) Available at: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.wales.nhs.uk\/sites3\/Documents\/242\/Cancer%20Incidence%20in%20Wales%202003-2007.pdf\" xlink:type=\"simple\">http:\/\/www.wales.nhs.uk\/sites3\/Documents\/242\/Cancer%20Incidence%20in%20Wales%202003-2007.pdf<\/ext-link> (Accessed August 2013)."},{"key":"ref8","unstructured":"Cancer incidence in Scotland (2013) Available at: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.isdscotland.org\/Health-Topics\/Cancer\/\" xlink:type=\"simple\">http:\/\/www.isdscotland.org\/Health-Topics\/Cancer\/<\/ext-link> (Accessed August 2013)."},{"key":"ref9","unstructured":"Vail DM, Young KM (2007) Canine Lymphoma and Lymphoid Leukemia. In:. Withrow and MacEwen&apos;s small animal clinical oncology, Withrow SJ, Vail DM, (ed) 4ed. London\/GB: Elsevier Health Sciences; 2007. p. 699\u2013700."},{"key":"ref10","first-page":"219","article-title":"Pathogenesis of diffuse large B cell lymphoma. Int J Hematol","volume":"92(2)","author":"WJ Chan","year":"2010"},{"key":"ref11","first-page":"693","article-title":"Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol","volume":"27","author":"S Vallabhapurapu","year":"2009"},{"key":"ref12","first-page":"503","article-title":"Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature","volume":"403(6769)","author":"AA Alizadeh","year":"2000"},{"key":"ref13","first-page":"1770","article-title":"Comparison of genome profiles for identification of distinct subgroups of diffuse large B-cell lymphoma. Blood","volume":"106(5)","author":"H Tagawa","year":"2005"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"9991","DOI":"10.1073\/pnas.1732008100","article-title":"A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma","volume":"100(17)","author":"G Wright","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","first-page":"1937","article-title":"The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med","volume":"346(25)","author":"A Rosenwald","year":"2002"},{"key":"ref16","first-page":"1417","article-title":"Mechanisms of Disease: Aggressive lymphomas. N Engl J Med","volume":"362(15)","author":"G Lenz","year":"2010"},{"key":"ref17","first-page":"932","article-title":"Establishment and characterization of a novel canine B-cell line derived from a spontaneously occurring diffuse large cell lymphoma. Leuk Res","volume":"34(7)","author":"BC Rutgen","year":"2010"},{"key":"ref18","first-page":"717","article-title":"Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. Nature","volume":"459(7247)","author":"M Compagno","year":"2009"},{"key":"ref19","unstructured":"Gatto L, Yaqcaffy (2010) Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/bioconductor.org\/packages\/release\/bioc\/html\/yaqcaffy.html\" xlink:type=\"simple\">http:\/\/bioconductor.org\/packages\/release\/bioc\/html\/yaqcaffy.html<\/ext-link> (cited and accessed 20 October 2010)."},{"key":"ref20","unstructured":"Parman C, Halling C, Gentleman R, affyQCReport (2010) Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.bioconductor.org\/packages\/release\/bioc\/html\/affyQCReport.html\" xlink:type=\"simple\">http:\/\/www.bioconductor.org\/packages\/release\/bioc\/html\/affyQCReport.html<\/ext-link> (cited and accesses 20 October 2010)."},{"key":"ref21","first-page":"R80","article-title":"Bioconductor: open software development for computational biology and bioinformatics. Genome Biol","volume":"5(10)","author":"RC Gentleman","year":"2004"},{"key":"ref22","unstructured":"The R Project for Statistical Computing (2010) Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.r-project.org\" xlink:type=\"simple\">http:\/\/www.r-project.org<\/ext-link> [cited and accessed 20 October 2010]."},{"key":"ref23","first-page":"249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics","volume":"4(2)","author":"RA Irizarry","year":"2003"},{"key":"ref24","first-page":"e15","article-title":"Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res","volume":"31(4)","author":"RA Irizarry","year":"2003"},{"key":"ref25","unstructured":"NetAffx Analysis Center (2010) Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.affymetrix.com\/analysis\/index.affx\" xlink:type=\"simple\">http:\/\/www.affymetrix.com\/analysis\/index.affx<\/ext-link> [cited 2010 and Accessed August 2010)."},{"key":"ref26","unstructured":"Partek (2010) Partek\u00ae Genomics Suite<sup>TM<\/sup> Revision 6.5 ed. St. Louis: Partek Inc."},{"key":"ref27","first-page":"44","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc","volume":"4(1)","author":"W Huang da","year":"2009"},{"key":"ref28","unstructured":"Bolstad B affy (2009) 1.22.1 ed: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/bioconductor.org\" xlink:type=\"simple\">http:\/\/bioconductor.org<\/ext-link>; (Accessed October 2010)."},{"key":"ref29","first-page":"2366","article-title":"Integration of biological networks and gene expression data using Cytoscape. Nat Protoc","volume":"2(10)","author":"MS Cline","year":"2007"},{"key":"ref30","first-page":"2","article-title":"An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics","volume":"4","author":"GD Bader","year":"2003"},{"key":"ref31","unstructured":"Ingenuity (2010) Ingenuity Pathways Analysis. 8.7 ed. Redwood City, CA Ingenuity Systems Inc."},{"key":"ref32","first-page":"440","article-title":"Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res","volume":"70(2)","author":"TC Chou","year":"2010","journal-title":"2010 Jan 15"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1182\/blood-2006-07-025809","article-title":"Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications","volume":"109(7)","author":"PJ Jost","year":"2007","journal-title":"Blood"},{"key":"ref34","first-page":"154","article-title":"The transcription factor nuclear factor-kappa B and cancer. Clin Oncol (R Coll Radiol)","volume":"19(2)","author":"RO Escarcega","year":"2007"},{"key":"ref35","first-page":"431","article-title":"Nuclear factor-kappaB in cancer development and progression. Nature","volume":"441(7092)","author":"M Karin","year":"2006"},{"key":"ref36","first-page":"334","article-title":"The IkappaB kinase \u2013 a bridge between inflammation and cancer. Cell Res","volume":"18(3)","author":"M Karin","year":"2008"},{"key":"ref37","first-page":"348","article-title":"CARMA1, BCL-10 and MALT1 in lymphocyte development and activation. Nat Rev Immunol","volume":"4(5)","author":"M Thome","year":"2004"},{"key":"ref38","first-page":"143","article-title":"Hostile takeovers: viral appropriation of the NF-kappaB pathway. J Clin Invest","volume":"107(2)","author":"J Hiscott","year":"2001"},{"key":"ref39","first-page":"88","article-title":"Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature","volume":"463(7277)","author":"RE Davis","year":"2010"},{"key":"ref40","first-page":"5828","article-title":"Downregulation of Bfl-1 protein expression sensitizes malignant B cells to apoptosis. Oncogene","volume":"26(39)","author":"G Brien","year":"2007"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1158\/0008-5472.CAN-05-2498","article-title":"Constitutive activation of extracellular signal-regulated kinase predisposes diffuse large B-cell lymphoma cell lines to CD40-mediated cell death","volume":"66(7)","author":"CA Hollmann","year":"2006","journal-title":"Cancer Res"},{"key":"ref42","first-page":"772","article-title":"The differential expression of LCK and BAFF-receptor and their role in apoptosis in human lymphomas. Haematologica","volume":"91(6)","author":"JC Paterson","year":"2006"},{"key":"ref43","first-page":"1278","article-title":"NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase. Mol Cell Biol","volume":"20(4)","author":"M Zamanian-Daryoush","year":"2000"},{"key":"ref44","first-page":"115","article-title":"Oncogenically active MYD88 mutations in human lymphoma. Nature","volume":"470(7332)","author":"VN Ngo","year":"2011"},{"key":"ref45","first-page":"4661","article-title":"NEMO-Binding Domain Peptide Inhibits Constitutive NF-kappa B Activity and Reduces Tumor Burden in a Canine Model of Relapsed, Refractory Diffuse Large B-Cell Lymphoma Clinical Cancer Research: 17","volume":"14","author":"A Gaurnier-Hausser","year":"2011"},{"key":"ref46","first-page":"500","article-title":"Elevated dihydrofolate reductase and impaired methotrexate transport as elements in methotrexate resistance in childhood acute lymphoblastic leukemia. Blood","volume":"85(2)","author":"LH Matherly","year":"1995"},{"key":"ref47","first-page":"508","article-title":"Pralatrexate, a dihydrofolate reductase inhibitor for the potential treatment of several malignancies. IDrugs","volume":"11(7)","author":"JR Molina","year":"2008"},{"key":"ref48","first-page":"103","article-title":"Predictive factors for anthracycline-based chemotherapy for human breast cancer. Breast Cancer","volume":"17(2)","author":"Y Miyoshi","year":"2010"},{"key":"ref49","first-page":"3533","article-title":"MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy. Blood","volume":"114(17)","author":"KJ Savage","year":"2009"},{"key":"ref50","first-page":"1107","article-title":"A systematic review and meta-analysis of rituximab-based immunochemotherapy for subtypes of diffuse large B cell lymphoma. Ann Hematol","volume":"89(11)","author":"C Fang","year":"2010"},{"key":"ref51","unstructured":"Frantz AM, Sarver AL, Ito D, Phang TL, Karimpour-Fard A, <etal>et al<\/etal>. (2013) Molecular Profiling Reveals Prognostically Significant Subtypes of Canine Lymphoma <italic>Vet Pathol,<\/italic> vol. 50 no. 4 693\u2013703."}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0072591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T01:44:19Z","timestamp":1596419059000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0072591"}},"subtitle":[],"editor":[{"given":"Jose Angel Martinez","family":"Climent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,9,4]]},"references-count":51,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,9,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0072591","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,4]]}}}