{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:32:46Z","timestamp":1790008366011,"version":"4.0.1"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T00:00:00Z","timestamp":1377820800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0072856","type":"journal-article","created":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T21:24:39Z","timestamp":1377897879000},"page":"e72856","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":82,"title":["Dependence of Brain Intravoxel Incoherent Motion Perfusion Parameters on the Cardiac Cycle"],"prefix":"10.1371","volume":"8","author":[{"given":"Christian","family":"Federau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patric","family":"Hagmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Maeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Meuli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Stuber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kieran","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,8,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1103\/PhysRev.80.580","article-title":"Spin Echoes","volume":"80","author":"EL Hahn","year":"1950","journal-title":"Phys Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1103\/PhysRev.94.630","article-title":"Effects of diffusion on free precession in nuclear magnetic resonance experiments","volume":"94","author":"HY Carr","year":"1954","journal-title":"Phys Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1063\/1.1695690","article-title":"Spin Diffusion Measurements: Spin Echoes in the Presence of a Time-Dependent Field Gradient","volume":"42","author":"EO Stejskal","year":"1965","journal-title":"J Chem Phys"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Callaghan PT (1991) Principles of Nuclear Magnetic Resonance Microscopy. Oxford: Oxford University Press.","DOI":"10.1093\/oso\/9780198539445.001.0001"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1126\/science.4059917","article-title":"Projective imaging of pulsatile flow with magnetic resonance","volume":"230","author":"VJ Wedeen","year":"1985","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1148\/radiology.161.2.3763909","article-title":"MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders","volume":"161","author":"D Le Bihan","year":"1986","journal-title":"Radiology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1148\/radiology.177.2.2217777","article-title":"Echo-planar imaging of intravoxel incoherent motion","volume":"177","author":"R Turner","year":"1990","journal-title":"Radiology"},{"key":"ref8","first-page":"1131","article-title":"Diffusion, confusion and functional MRI","volume":"62(2)","author":"D Le Bihan","year":"2011","journal-title":"Neuroimage"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1148\/radiology.168.2.3393671","article-title":"Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging","volume":"168","author":"D Le Bihan","year":"1988","journal-title":"Radiology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1118\/1.596093","article-title":"The effects of random directional distributed flow in nuclear magnetic resonance imaging","volume":"14","author":"CB Ahn","year":"1987","journal-title":"Med Phys"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/mrm.1910320407","article-title":"A quantitative interpretation of IVIM measurements of vascular perfusion in the rat brain","volume":"32","author":"RM Henkelman","year":"1994","journal-title":"Magn Reson Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1118\/1.597170","article-title":"A general model of microcirculatory blood flow effects in gradient sensitized MRI","volume":"21","author":"RP Kennan","year":"1994","journal-title":"Med Phys"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/nbm.1940080706","article-title":"Diffusion MRI: precision, accuracy and flow effects","volume":"8","author":"TE Conturo","year":"1995","journal-title":"NMR Biomed"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/mrm.1910270116","article-title":"The capillary network: a link between IVIM and classical perfusion","volume":"27","author":"D Le Bihan","year":"1992","journal-title":"Magn Reson Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.2214\/AJR.10.5515","article-title":"Intravoxel incoherent motion in body diffusion-weighted MRI: reality and challenges","volume":"196","author":"DM Koh","year":"2011","journal-title":"AJR Am J Roentgenol"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Federau C, O'Brien K, Meuli R, Hagmann P, Maeder P (2013) Measuring Brain Perfusion with Intravoxel Incoherent Motion (IVIM): Initial Clinical Experience. J Magn Reson Imag. In press.","DOI":"10.1002\/jmri.24195"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1002\/mrm.22565","article-title":"An in vivo verification of the intravoxel incoherent motion effect in diffusion-weighted imaging of the abdomen","volume":"64","author":"A Lemke","year":"2010","journal-title":"Magn Reson Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/RLI.0b013e3182396410","article-title":"Temporally resolved electrocardiogram-triggered diffusion-weighted imaging of the human kidney: correlation between intravoxel incoherent motion parameters and renal blood flow at different time points of the cardiac cycle","volume":"47","author":"HJ Wittsack","year":"2012","journal-title":"Invest Radiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1148\/radiol.12120584","article-title":"Quantitative measurement of brain perfusion with intravoxel incoherent motion MR imaging","volume":"265","author":"C Federau","year":"2012","journal-title":"Radiology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/mrm.1910100305","article-title":"Effects of intravoxel incoherent motions (IVIM) in steady-state free precession (SSFP) imaging: application to molecular diffusion imaging","volume":"10","author":"D Le Bihan","year":"1989","journal-title":"Magn Reson Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.mvr.2010.05.001","article-title":"Blood velocity pulse quantification in the human conjunctival pre-capillary arterioles","volume":"80","author":"AG Koutsiaris","year":"2010","journal-title":"Microvasc Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1111\/1523-1747.ep12348955","article-title":"Synchronous measurements of blood pressure and red blood cell velocity in capillaries of human skin","volume":"106","author":"M Hahn","year":"1996","journal-title":"J Invest Dermatol"},{"key":"ref23","first-page":"H811","article-title":"Flow pulsation and network structure in mesenteric microvasculature of rats","volume":"266","author":"J Seki","year":"1994","journal-title":"Am J Physiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/0026-2862(86)90051-8","article-title":"Pressure pulse transmission into vascular beds","volume":"32","author":"AG Salotto","year":"1986","journal-title":"Microvasc Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0026-2862(70)90003-8","article-title":"Erythrocyte flow velocities in mesenteric microvessels of the cat","volume":"2","author":"P Gaehtgens","year":"1970","journal-title":"Microvasc Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1152\/ajplegacy.1974.226.5.1117","article-title":"Network model of pulsatile hemodynamics in the microcirculation of the rabbit omentum","volume":"226","author":"JF Gross","year":"1974","journal-title":"Am J Physiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1152\/ajplegacy.1964.207.1.173","article-title":"Pulsatile Pressures in the Microcirculation of Frog's Mesentery","volume":"207","author":"CA Wiederhielm","year":"1964","journal-title":"Am J Physiol"},{"key":"ref28","first-page":"233","article-title":"Velocity profiles in the rat cerebral microvessels measured by optical coherence tomography","volume":"34","author":"J Seki","year":"2006","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1161\/01.RES.24.6.887","article-title":"Erythrocyte velocity and a velocity pulse in minute blood vessels on the surface of the mouse brain","volume":"24","author":"WI Rosenblum","year":"1969","journal-title":"Circ Res"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"McAllister J, Wagshul ME, Rashid S, Li J (2009) Measurement of capillary pulsations in the rat neocortex with two-photon laser scanning confocal microscopy. Cerebrospinal Fluid Research (Suppl 2): S10.","DOI":"10.1186\/1743-8454-6-S2-S10"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"H1367","DOI":"10.1152\/ajpheart.00417.2011","article-title":"In vivo two-photon excited fluorescence microscopy reveals cardiac- and respiration-dependent pulsatile blood flow in cortical blood vessels in mice","volume":"302","author":"TP Santisakultarm","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref32","unstructured":"Harris CRS (1973) The Heart and Vascular System in Ancient Greek Medicine From Alcmaeon to Galen. Oxford: Oxford University Press."},{"key":"ref33","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0003-4975(10)63539-4","article-title":"To pulse or not to pulse","volume":"25","author":"C Mavroudis","year":"1978","journal-title":"Ann Thorac Surg"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1213\/ane.0b013e3181875e2e","article-title":"Optimal perfusion during cardiopulmonary bypass: an evidence-based approach","volume":"108","author":"GS Murphy","year":"2009","journal-title":"Anesthesia and analgesia"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1001\/archsurg.1966.01330050034005","article-title":"Energy equivalent pressure","volume":"93","author":"RB Shepard","year":"1966","journal-title":"Arch Surg"},{"key":"ref36","first-page":"II47","article-title":"Pulsatility improves hemodynamics during fetal bypass. Experimental comparative study of pulsatile versus steady flow","volume":"90","author":"G Champsaur","year":"1994","journal-title":"Circulation"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1098\/rstl.1883.0029","article-title":"An experimental investigation of the circumstances which determine whether the motion of water in parallel channels shall be direct or sinuous and of the law of resistance in parallel channels","volume":"174","author":"O Reynolds","year":"1883","journal-title":"Philos Trans R Soc"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1098\/rsta.1895.0004","article-title":"On the dynamical theory of incompressible viscous fluids and the determination of the criterion","volume":"186","author":"O Reynolds","year":"1895","journal-title":"Philos Trans R Soc"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.fluid.29.1.399","article-title":"Blood flow in arteries","volume":"29","author":"DN Ku","year":"1997","journal-title":"Annual Review of Fluid Mechanics"},{"key":"ref40","unstructured":"Fung YC (1996) Biomechanics Circulation. Berlin: Springer Verlag. p. 571."}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0072856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T14:12:23Z","timestamp":1715955143000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0072856"}},"subtitle":[],"editor":[{"given":"Jeroen","family":"Hendrikse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,8,30]]},"references-count":40,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,8,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0072856","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,30]]}}}