{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:49:05Z","timestamp":1779104945694,"version":"3.51.4"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T00:00:00Z","timestamp":1378944000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0073120","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T21:09:52Z","timestamp":1379020192000},"page":"e73120","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Striatal Infusion of Glial Conditioned Medium Diminishes Huntingtin Pathology in R6\/1 Mice"],"prefix":"10.1371","volume":"8","author":[{"given":"Juan","family":"Perucho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jos\u00e9","family":"Casarejos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Ru\u00edz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria \u00c1ngeles","family":"Fern\u00e1ndez-Estevez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Paz","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justo Garc\u00eda","family":"de Y\u00e9benes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria \u00c1ngeles","family":"Mena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,9,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/WCO.0b013e328304b692","article-title":"Pathophysiology of Huntington&apos;s disease: from huntingtin functions to potential treatments","volume":"21","author":"E Roze","year":"2008","journal-title":"Curr Opin Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00005072-199805000-00001","article-title":"Huntington disease","volume":"57","author":"JP Vonsattel","year":"1998","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref3","first-page":"615","article-title":"Homozygote for Huntington disease","volume":"45","author":"RH Myers","year":"1989","journal-title":"Am J Hum Genet"},{"key":"ref4","first-page":"481","article-title":"Factors related to onset age of Huntington disease","volume":"34","author":"RH Myers","year":"1982","journal-title":"Am J Hum Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/jnen\/60.2.161","article-title":"Early and progressive accumulation of reactive microglia in the Huntington disease brain","volume":"60","author":"E Sapp","year":"2001","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/2510","article-title":"Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA","volume":"20","author":"PH Reddy","year":"1998","journal-title":"Nat Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1523\/JNEUROSCI.23-06-02193.2003","article-title":"Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington&apos;s disease","volume":"23","author":"ZX Yu","year":"2003","journal-title":"J Neurosci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"10653","DOI":"10.1074\/jbc.M109.083287","article-title":"Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice","volume":"285","author":"J Bradford","year":"2010","journal-title":"J Biol Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1083\/jcb.200508072","article-title":"Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity","volume":"171","author":"JY Shin","year":"2005","journal-title":"J Cell Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"13285","DOI":"10.1523\/JNEUROSCI.4393-08.2008","article-title":"Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons","volume":"28","author":"S Tydlacka","year":"2008","journal-title":"J Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"L Mangiarini","year":"1996","journal-title":"Cell"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.brainres.2004.01.021","article-title":"Early exploratory behavior abnormalities in R6\/1 Huntington&apos;s disease transgenic mice","volume":"1005","author":"VJ Bolivar","year":"2004","journal-title":"Brain Res"},{"key":"ref13","unstructured":"Folstein S (1989) Huntington&apos;s disease: A disorder of families. Baltimore, MD, US: MD, US: Johns Hopkins University Press. (1989). \u00d7251."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0092-8674(00)80513-9","article-title":"Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation","volume":"90","author":"SW Davies","year":"1997","journal-title":"Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.neuroscience.2003.08.053","article-title":"Molecular and behavioral analysis of the R6\/1 Huntington&apos;s disease transgenic mouse","volume":"122","author":"B Naver","year":"2003","journal-title":"Neuroscience"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"8093","DOI":"10.1073\/pnas.110078997","article-title":"Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington&apos;s disease","volume":"97","author":"M Turmaine","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1098\/rstb.1999.0449","article-title":"Altered neurotransmitter receptor expression in transgenic mouse models of Huntington&apos;s disease","volume":"354","author":"JH Cha","year":"1999","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1097\/00001756-200011270-00032","article-title":"N-Acetylaspartate and DARPP-32 levels decrease in the corpus striatum of Huntington&apos;s disease mice","volume":"11","author":"A van Dellen","year":"2000","journal-title":"Neuroreport"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/jnr.10704","article-title":"Glia-conditioned medium induces de novo synthesis of tyrosine hydroxylase and increases dopamine cell survival by differential signaling pathways","volume":"73","author":"S de Bernardo","year":"2003","journal-title":"J Neurosci Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/BF01277654","article-title":"Glia protect fetal midbrain dopamine neurons in culture from L-DOPA toxicity through multiple mechanisms","volume":"104","author":"MA Mena","year":"1997","journal-title":"J Neural Transm"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1385\/MN:25:3:245","article-title":"The role of astroglia on the survival of dopamine neurons","volume":"25","author":"MA Mena","year":"2002","journal-title":"Mol Neurobiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1177\/1073858408322839","article-title":"Glial cells as players in parkinsonism: the \u201cgood,\u201d the \u201cbad,\u201d and the \u201cmysterious\u201d glia","volume":"14","author":"MA Mena","year":"2008","journal-title":"Neuroscientist"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e4fbca54a2028b","DOI":"10.1371\/4fbca54a2028b","article-title":"Protection by glia-conditioned medium in a cell model of Huntington disease","volume":"4","author":"C Ruiz","year":"2012","journal-title":"PLoS Curr"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/00001756-199304000-00025","article-title":"Levodopa toxicity in foetal rat midbrain neurones in culture: modulation by ascorbic acid","volume":"4","author":"MA Mena","year":"1993","journal-title":"Neuroreport"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1385-299X(96)00020-7","article-title":"Neuronal-enriched cultures from embryonic rat ventral mesencephalon for pharmacological studies of dopamine neurons","volume":"1","author":"B Pardo","year":"1997","journal-title":"Brain Res Brain Res Protoc"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/j.1471-4159.2005.03249.x","article-title":"Differential effects of l-DOPA on monoamine metabolism, cell survival and glutathione production in midbrain neuronal-enriched cultures from parkin knockout and wild-type mice","volume":"94","author":"MJ Casarejos","year":"2005","journal-title":"J Neurochem"},{"key":"ref27","first-page":"286","article-title":"Integration of autophagy, proteasomal degradation, unfolded protein response and apoptosis","volume":"34","author":"DM Benbrook","year":"2012","journal-title":"Exp Oncol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/ana.20207","article-title":"Generalized brain and skin proteasome inhibition in Huntington&apos;s disease","volume":"56","author":"H Seo","year":"2004","journal-title":"Ann Neurol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1038\/nn1988","article-title":"Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease","volume":"10","author":"CS Lobsiger","year":"2007","journal-title":"Nat Neurosci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/ncpneuro0355","article-title":"Mechanisms of Disease: astrocytes in neurodegenerative disease","volume":"2","author":"NJ Maragakis","year":"2006","journal-title":"Nat Clin Pract Neurol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrneurol.2010.17","article-title":"Microglia in neurodegenerative disease","volume":"6","author":"VH Perry","year":"2010","journal-title":"Nat Rev Neurol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/j.1471-4159.2005.03047.x","article-title":"Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington&apos;s disease","volume":"93","author":"JR Pineda","year":"2005","journal-title":"J Neurochem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1093\/brain\/awf180","article-title":"Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation","volume":"125","author":"PF Behrens","year":"2002","journal-title":"Brain"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/hbm.21008","article-title":"Microglial activation in regions related to cognitive function predicts disease onset in Huntington&apos;s disease: a multimodal imaging study","volume":"32","author":"M Politis","year":"2011","journal-title":"Hum Brain Mapp"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"6112","DOI":"10.1523\/JNEUROSCI.4630-12.2013","article-title":"BDNF Regulates Rab11-Mediated Recycling Endosome Dynamics to Induce Dendritic Branching","volume":"33","author":"OM Lazo","year":"2013","journal-title":"J Neurosci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"6298","DOI":"10.1523\/JNEUROSCI.2033-12.2013","article-title":"Mutant Huntingtin Alters Retrograde Transport of TrkB Receptors in Striatal Dendrites","volume":"33","author":"G Liot","year":"2013","journal-title":"J Neurosci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"7366","DOI":"10.1523\/JNEUROSCI.1739-04.2004","article-title":"BDNF regulates the translation of a select group of mRNAs by a mammalian target of rapamycin-phosphatidylinositol 3-kinase-dependent pathway during neuronal development","volume":"24","author":"GM Schratt","year":"2004","journal-title":"J Neurosci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"4498","DOI":"10.1523\/JNEUROSCI.5744-03.2004","article-title":"The p75 neurotrophin receptor can induce autophagy and death of cerebellar Purkinje neurons","volume":"24","author":"ML Florez-McClure","year":"2004","journal-title":"J Neurosci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.7150\/ijbs.7.1114","article-title":"FRS2alpha is essential for the fibroblast growth factor to regulate the mTOR pathway and autophagy in mouse embryonic fibroblasts","volume":"7","author":"X Lin","year":"2011","journal-title":"Int J Biol Sci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/jnr.490300212","article-title":"Conditioned media derived from glial cell lines promote survival and differentiation of dopaminergic neurons <italic>in vitro<\/italic>: role of mesencephalic glia","volume":"30","author":"J Engele","year":"1991","journal-title":"J Neurosci Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0304-3940(94)90218-6","article-title":"Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons <italic>in vivo<\/italic>","volume":"182","author":"BJ Hoffer","year":"1994","journal-title":"Neurosci Lett"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1126\/science.8493557","article-title":"GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons","volume":"260","author":"LF Lin","year":"1993","journal-title":"Science"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1006\/mcne.2000.0906","article-title":"Survival and differentiation of dopaminergic mesencephalic neurons are promoted by dopamine-mediated induction of FGF-2 in striatal astroglial cells","volume":"16","author":"B Reuss","year":"2000","journal-title":"Mol Cell Neurosci"},{"key":"ref44","first-page":"1112","article-title":"[Glia conditioned medium offers protection against the toxicity induced by 6-OH-dopamine in vivo]","volume":"34","author":"A Rojo","year":"2002","journal-title":"Rev Neurol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0073120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T01:40:06Z","timestamp":1563932406000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0073120"}},"subtitle":[],"editor":[{"given":"David R.","family":"Borchelt","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,9,12]]},"references-count":44,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,9,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0073120","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,12]]}}}