{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:02:23Z","timestamp":1790193743815,"version":"4.1.0"},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T00:00:00Z","timestamp":1378166400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0073154","type":"journal-article","created":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T21:30:40Z","timestamp":1378243840000},"page":"e73154","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":37,"title":["Mechanisms of the Incretin Effect in Subjects with Normal Glucose Tolerance and Patients with Type 2 Diabetes"],"prefix":"10.1371","volume":"8","author":[{"given":"Andrea","family":"Mari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonatan I.","family":"Bagger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ele","family":"Ferrannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens J.","family":"Holst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip K.","family":"Knop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Vilsb\u00f8ll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,9,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/BF02427280","article-title":"Reduced incretin effect in type 2 (non-insulin-dependent) diabetes","volume":"29","author":"M Nauck","year":"1986","journal-title":"Diabetologia"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.2337\/db07-1315","article-title":"Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients","volume":"57","author":"E Muscelli","year":"2008","journal-title":"Diabetes"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1463-1326.2011.01549.x","article-title":"Impaired incretin effect and fasting hyperglucagonaemia characterizing type 2 diabetic subjects are early signs of dysmetabolism in obesity","volume":"14","author":"FK Knop","year":"2012","journal-title":"Diabetes, obesity & metabolism"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1210\/jcem-63-2-492","article-title":"Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses","volume":"63","author":"MA Nauck","year":"1986","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1210\/jc.2010-2435","article-title":"Impaired regulation of the incretin effect in patients with type 2 diabetes","volume":"96","author":"JI Bagger","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"E1144","DOI":"10.1152\/ajpendo.00571.2005","article-title":"Impact of incretin hormones on beta-cell function in subjects with normal or impaired glucose tolerance","volume":"291","author":"E Muscelli","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.2337\/diacare.26.10.2860","article-title":"Characterization of GLP-1 Effects on beta-Cell Function After Meal Ingestion in Humans","volume":"26","author":"B Ahr\u00e9n","year":"2003","journal-title":"Diabetes Care"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"380","DOI":"10.2337\/diabetes.52.2.380","article-title":"The Influence of GLP-1 on Glucose-Stimulated Insulin Secretion: Effects on beta-Cell Sensitivity in Type 2 and Nondiabetic Subjects","volume":"52","author":"LL Kjems","year":"2003","journal-title":"Diabetes"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"S221","DOI":"10.2337\/diabetes.51.2007.S221","article-title":"Assessing insulin secretion by modeling in multiple-meal tests: role of potentiation","volume":"51","author":"A Mari","year":"2002","journal-title":"Diabetes"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"E1159","DOI":"10.1152\/ajpendo.00093.2002","article-title":"Meal and oral glucose tests for the assessment of \u03b2-cell function: modeling analysis in normal subjects","volume":"283","author":"A Mari","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"470","DOI":"10.2337\/diabetes.52.2.470","article-title":"Altered homeostatic adaptation of first- and second-phase beta-cell secretion in the offspring of patients with type 2 diabetes: studies with a minimal model to assess beta-cell function","volume":"52","author":"RC Bonadonna","year":"2003","journal-title":"Diabetes"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"4679","DOI":"10.1210\/jc.2009-0921","article-title":"Preserved inhibitory potency of GLP-1 on glucagon secretion in type 2 diabetes mellitus","volume":"94","author":"KJ Hare","year":"2009","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0167-0115(84)90005-3","article-title":"The heterogeneity of gastric inhibitory polypeptide in porcine and human gastrointestinal mucosa evaluated with five different antisera","volume":"9","author":"T Krarup","year":"1984","journal-title":"Regulatory peptides"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"535","DOI":"10.2337\/diab.43.4.535","article-title":"Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans","volume":"43","author":"C Orskov","year":"1994","journal-title":"Diabetes"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1463-1326.2008.00946.x","article-title":"Beta-cell function assessment from modelling of oral tests: an effective approach","volume":"10","author":"A Mari","year":"2008","journal-title":"Diabetes Obes Metab"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2337\/diacare.24.3.539","article-title":"A model-based method for assessing insulin sensitivity from the oral glucose tolerance test","volume":"24","author":"A Mari","year":"2001","journal-title":"Diabetes Care"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.2337\/db09-1899","article-title":"Is the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired beta-cell function?","volume":"59","author":"JJ Meier","year":"2010","journal-title":"Diabetes"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.2337\/diabetes.48.10.1979","article-title":"Altered cAMP and Ca2+ signaling in mouse pancreatic islets with glucagon-like peptide-1 receptor null phenotype","volume":"48","author":"D Flamez","year":"1999","journal-title":"Diabetes"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"E532","DOI":"10.1152\/ajpendo.00127.2009","article-title":"Improved tolerance to sequential glucose loading (Staub-Traugott effect): size and mechanisms","volume":"297","author":"S Bonuccelli","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00125-009-1647-6","article-title":"Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance","volume":"53","author":"A Mari","year":"2010","journal-title":"Diabetologia"},{"key":"ref21","first-page":"E214","article-title":"Glucose clamp technique: a method for quantifying insulin secretion and resistance","volume":"237","author":"RA DeFronzo","year":"1979","journal-title":"Am J Physiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1210\/jc.2004-1133","article-title":"beta-cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis","volume":"90","author":"E Ferrannini","year":"2005","journal-title":"J Clin Endocrinol Metab"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0073154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T14:26:56Z","timestamp":1540218416000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0073154"}},"subtitle":[],"editor":[{"given":"Jose A. L.","family":"Calbet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,9,3]]},"references-count":22,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,9,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0073154","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,3]]}}}