{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:13:18Z","timestamp":1790363598689,"version":"4.1.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T00:00:00Z","timestamp":1378252800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0073244","type":"journal-article","created":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T21:14:29Z","timestamp":1378329269000},"page":"e73244","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":95,"title":["Factors Secreted by Endothelial Progenitor Cells Enhance Neurorepair Responses after Cerebral Ischemia in Mice"],"prefix":"10.1371","volume":"8","author":[{"given":"Anna","family":"Rosell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Morancho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Navarro-Sobrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Mart\u00ednez-Saez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Hern\u00e1ndez-Guillamon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Lope-Piedrafita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Barcel\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Borr\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Penalba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Garc\u00eda-Bonilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Montaner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,9,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Molina CA (2011) Reperfusion therapies for acute ischemic stroke: current pharmacological and mechanical approaches. Stroke 42(1 Suppl): S16\u201319.","DOI":"10.1161\/STROKEAHA.110.598763"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1161\/STROKEAHA.107.499962","article-title":"Themes and strategies for studying the biology of stroke recovery in the poststroke epoch","volume":"39","author":"ST Carmichael","year":"2008","journal-title":"Stroke"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1126\/science.1095505","article-title":"Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells","volume":"304","author":"Q Shen","year":"2004","journal-title":"Science"},{"key":"ref4","first-page":"13007","article-title":"A neurovascular niche for neurogenesis after stroke. J Neurosci","volume":"26","author":"JJ Ohab","year":"2006"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1161\/01.ATV.17.4.605","article-title":"Manipulating angiogenesis. From basic science to the bedside","volume":"17","author":"MS Pepper","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1126\/science.275.5302.964","article-title":"Isolation of putative progenitor endothelial cells for angiogenesis","volume":"275","author":"T Asahara","year":"1997","journal-title":"Science"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1172\/JCI200420622","article-title":"Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model","volume":"114","author":"A Taguchi","year":"2004","journal-title":"J Clin Invest"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1227\/01.NEU.0000229058.08706.88","article-title":"Administration of ex vivo-expanded bone marrow-derived endothelial progenitor cells attenuates focal cerebral ischemia reperfusion injury in rats","volume":"59","author":"T Ohta","year":"2006","journal-title":"Neurosurgery"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s12015-010-9157-y","article-title":"Transplanted Late Outgrowth Endothelial Progenitor Cells as Cell Therapy Product for Stroke","volume":"7","author":"C Moubarik","year":"2011","journal-title":"Stem Cell Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/ana.21919","article-title":"Endothelial progenitor cell transplantation improves long-term stroke outcome in mice","volume":"67","author":"Y Fan","year":"2010","journal-title":"Ann Neurol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1756-9966-30-9","article-title":"Stem cells in clinical practice: applications and warnings","volume":"30","author":"D Lodi","year":"2011","journal-title":"J Exp Clin Cancer Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1161\/STROKEAHA.109.563015","article-title":"The postischemic environment differentially impacts teratoma or tumor formation after transplantation of human embryonic stem cell-derived neural progenitors","volume":"41","author":"C Seminatore","year":"2010","journal-title":"Stroke"},{"key":"ref13","first-page":"w13130","article-title":"Current developments in the use of stem cell for therapeutic neovascularisation: is the future therapy \u201ccell-free\u201d?","volume":"140","author":"Z Yang","year":"2010","journal-title":"Swiss Med Wkly"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/jcbfm.2009.17","article-title":"Interleukin-1beta augments angiogenic responses of murine endothelial progenitor cells in vitro","volume":"29","author":"A Rosell","year":"2009","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1365-2990.2012.01252.x","article-title":"A new method for focal transient cerebral ischemia by distal compression of the middle cerebral artery","volume":"38","author":"A Morancho","year":"2012","journal-title":"Neuropathol Appl Neurobiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/jmri.1076","article-title":"Diffusion tensor imaging: concepts and applications","volume":"13","author":"D Le Bihan","year":"2001","journal-title":"J Magn Reson Imaging"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.neuroimage.2006.05.025","article-title":"MRI detects white matter reorganization after neural progenitor cell treatment of stroke","volume":"32","author":"Q Jiang","year":"2006","journal-title":"Neuroimage"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.neuroimage.2011.02.049","article-title":"Post-treatment with amphetamine enhances reinnervation of the ipsilateral side cortex in stroke rats","volume":"56","author":"HS Liu","year":"2011","journal-title":"Neuroimage"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0006-8993(96)00122-9","article-title":"Mild postischemic hypothermia limits cerebral injury following transient focal ischemia in rat neocortex","volume":"718","author":"H Yanamoto","year":"1996","journal-title":"Brain Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.brainres.2009.04.055","article-title":"Effects of gemfibrozil on outcome after permanent middle cerebral artery occlusion in mice","volume":"1279","author":"Q Guo","year":"2009","journal-title":"Brain Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s12975-012-0234-1","article-title":"Distal occlusion of the middle cerebral artery in mice: Are we ready to assess long-term functional outcome?","volume":"4","author":"A Rosell","year":"2013","journal-title":"Transl Stroke Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3171\/jns.2005.103.1.0038","article-title":"Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trial","volume":"103","author":"D Kondziolka","year":"2005","journal-title":"J Neurosurg"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/ana.20501","article-title":"Autologous mesenchymal stem cell transplantation in stroke patients","volume":"57","author":"OY Bang","year":"2005","journal-title":"Ann Neurol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1161\/STROKEAHA.112.659409","article-title":"Intra-arterial bone marrow mononuclear cells in ischemic stroke: a pilot clinical trial","volume":"43","author":"F Moniche","year":"2012","journal-title":"Stroke"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2217\/rme.10.97","article-title":"Safety of autologous bone marrow mononuclear cell transplantation in patients with nonacute ischemic stroke","volume":"6","author":"V Battistella","year":"2001","journal-title":"Regen Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"7505","DOI":"10.1073\/pnas.1121146109","article-title":"Astrocytic high-mobility group box 1 promotes endothelial progenitor cell-mediated neurovascular remodeling during stroke recovery","volume":"109","author":"K Hayakawa","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1152\/japplphysiol.00909.2006","article-title":"Cerebral angiogenic factors, angiogenesis, and physiological response to chronic hypoxia differ among four commonly used mouse strains","volume":"102","author":"NL Ward","year":"2007","journal-title":"J Appl Physiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1172\/JCI9369","article-title":"VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain","volume":"106","author":"ZG Zhang","year":"2000","journal-title":"J Clin Invest"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1161\/01.CIR.0000109496.82683.49","article-title":"Novel therapeutic strategy to treat brain ischemia: overexpression of hepatocyte growth factor gene reduced ischemic injury without cerebral edema in rat model","volume":"10","author":"M Shimamura","year":"2004","journal-title":"Circulation"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e5643","DOI":"10.1371\/journal.pone.0005643","article-title":"Novel cell-free strategy for therapeutic angiogenesis: in vitro generated conditioned medium can replace progenitor cell transplantation","volume":"4","author":"S Di Santo","year":"2009","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.3727\/096368910X516637","article-title":"Human cord blood-derived endothelial progenitor cells and their conditioned media exhibit therapeutic equivalence for diabetic wound healing","volume":"19","author":"JY Kim","year":"2010","journal-title":"Cell Transplant"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.mvr.2010.05.008","article-title":"Mobilization, endothelial differentiation and functional capacity of endothelial progenitor cells after ischemic stroke","volume":"80","author":"M Navarro-Sobrino","year":"2010","journal-title":"Microvasc Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1177\/1073858407309545","article-title":"Poststroke neurogenesis: emerging principles of migration and localization of immature neurons","volume":"14","author":"JJ Ohab","year":"2008","journal-title":"Neuroscientist"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1093\/brain\/awr094","article-title":"Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain","volume":"134","author":"RH Andres","year":"2011","journal-title":"Brain"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/stem.584","article-title":"Transplanted stem cell-secreted vascular endothelial growth factor effects poststroke recovery, inflammation, and vascular repair","volume":"29","author":"N Horie","year":"2011","journal-title":"Stem Cells"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0073244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T22:32:42Z","timestamp":1540247562000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0073244"}},"subtitle":[],"editor":[{"given":"Vardan","family":"Karamyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,9,4]]},"references-count":35,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,9,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0073244","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,4]]}}}