{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:34:25Z","timestamp":1791174865862,"version":"4.1.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T00:00:00Z","timestamp":1378684800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0073404","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T18:42:48Z","timestamp":1378752168000},"page":"e73404","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":56,"title":["Effects of Indoleamine 2,3-Dioxygenase Deficiency on High-Fat Diet-Induced Hepatic Inflammation"],"prefix":"10.1371","volume":"8","author":[{"given":"Junji","family":"Nagano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Shirakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Ohtaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyasu","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Tsurumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniaki","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Seishima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisataka","family":"Moriwaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,9,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMra011775","article-title":"Nonalcoholic fatty liver disease","volume":"346","author":"P Angulo","year":"2002","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.1002\/hep.20973","article-title":"Nonalcoholic fatty liver disease: from steatosis to cirrhosis","volume":"43","author":"GC Farrell","year":"2006","journal-title":"Hepatology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1053\/j.gastro.2012.02.003","article-title":"Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications","volume":"142","author":"K Cusi","year":"2012","journal-title":"Gastroenterology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"4652","DOI":"10.3748\/wjg.v16.i37.4652","article-title":"Roles of liver innate immune cells in nonalcoholic fatty liver disease","volume":"16","author":"YT Zhan","year":"2010","journal-title":"World J Gastroenterol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1007\/s00125-012-2607-0","article-title":"Lymphocytes in obesity-related adipose tissue inflammation","volume":"55","author":"A Chatzigeorgiou","year":"2012","journal-title":"Diabetologia"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1172\/JCI200319246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","author":"SP Weisberg","year":"2003","journal-title":"J Clin Invest"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00535-012-0527-x","article-title":"Inflammation and fibrogenesis in steatohepatitis","volume":"47","author":"H Fujii","year":"2012","journal-title":"J Gastroenterol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1002\/eji.201242572","article-title":"Indoleamine 2,3-dioxygenase: from catalyst to signaling function","volume":"42","author":"F Fallarino","year":"2012","journal-title":"Eur J Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1084\/jem.20020121","article-title":"Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase","volume":"196","author":"G Frumento","year":"2002","journal-title":"J Exp Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nri1457","article-title":"IDO expression by dendritic cells: tolerance and tryptophan catabolism","volume":"4","author":"AL Mellor","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.2174\/092986711795656045","article-title":"Indoleamine 2,3-dioxygenase, Tregs and cancer","volume":"18","author":"DH Munn","year":"2011","journal-title":"Curr Med Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000282065","article-title":"Pathology of immune-mediated liver injury","volume":"28","author":"HP Dienes","year":"2010","journal-title":"Dig Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.cca.2005.06.013","article-title":"Monitoring tryptophan metabolism in chronic immune activation","volume":"364","author":"K Schr\u00f6cksnadel","year":"2006","journal-title":"Clin Chim Acta"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1128\/JVI.02248-06","article-title":"Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection","volume":"81","author":"E Larrea","year":"2007","journal-title":"J Virol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/s00535-012-0667-z","article-title":"Association of enhanced activity of indoleamine 2,3-dioxygenase in dendritic cells with the induction of regulatory T cells in chronic hepatitis C infection","volume":"48","author":"K Higashitani","year":"2012","journal-title":"J Gastroenterol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"R135","DOI":"10.1152\/ajpregu.00373.2011","article-title":"Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone","volume":"303","author":"I Wolowczuk","year":"2012","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1478-3231.2008.01748.x","article-title":"Upregulation of indoleamine 2,3-dioxygenase in hepatocyte during acute hepatitis caused by hepatitis B virus-specific cytotoxic T lymphocytes in vivo","volume":"29","author":"N Iwamoto","year":"2009","journal-title":"Liver Int"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4554","DOI":"10.4049\/jimmunol.0904173","article-title":"Ability of IDO to attenuate liver injury in alpha-galactosylceramide-induced hepatitis model","volume":"185","author":"H Ito","year":"2010","journal-title":"J Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/cbf.2803","article-title":"Effects of indoleamine 2,3-dioxygenases in carbon tetrachloride-induced hepatitis model of rats","volume":"30","author":"D Li","year":"2012","journal-title":"Cell Biochem Funct"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"DE Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1093\/carcin\/bgs303","article-title":"Preventive effects of branched-chain amino acid supplementation on the spontaneous development of hepatic preneoplastic lesions in C57BL\/KsJ-db\/db obese mice","volume":"33","author":"D Terakura","year":"2012","journal-title":"Carcinogenesis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cbi.2009.07.015","article-title":"(-)-Epigallocatechin gallate prevents carbon tetrachloride-induced rat hepatic fibrosis by inhibiting the expression of the PDGFRbeta and IGF-1R","volume":"182","author":"Y Yasuda","year":"2009","journal-title":"Chem Biol Interact"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/j.1349-7006.2012.02237.x","article-title":"Suppression of azoxymethane-induced colonic preneoplastic lesions in rats by 1-methyltryptophan, an inhibitor of indoleamine 2,3-dioxygenase","volume":"103","author":"K Ogawa","year":"2012","journal-title":"Cancer Sci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1586\/egh.11.16","article-title":"Cell death and nonalcoholic steatohepatitis: where is ballooning relevant?","volume":"5","author":"MV Machado","year":"2011","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00441-011-1246-y","article-title":"TGF-beta in progression of liver disease","volume":"347","author":"S Dooley","year":"2012","journal-title":"Cell Tissue Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/hep.20678","article-title":"Regulatory T cells and the liver: a new piece of the puzzle","volume":"41","author":"KM Chang","year":"2005","journal-title":"Hepatology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1002\/hep.21823","article-title":"A high-fat diet and regulatory T cells influence susceptibility to endotoxin-induced liver injury","volume":"46","author":"X Ma","year":"2007","journal-title":"Hepatology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1381\/096089206776945066","article-title":"Bariatric surgery cannot prevent tryptophan depletion due to chronic immune activation in morbidly obese patients","volume":"16","author":"G Brandacher","year":"2006","journal-title":"Obes Surg"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"34800","DOI":"10.1074\/jbc.M111.235473","article-title":"L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin","volume":"286","author":"Y Osawa","year":"2011","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1572-0241.2006.00478.x","article-title":"Cryptogenic cirrhosis and NAFLD: are they related?","volume":"101","author":"A Maheshwari","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S1665-2681(19)31748-X","article-title":"NASH and cryptogenic cirrhosis: a histological analysis","volume":"8","author":"SH Caldwell","year":"2009","journal-title":"Ann Hepatol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1053\/j.gastro.2011.12.044","article-title":"Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues","volume":"142","author":"V Hern\u00e1ndez-Gea","year":"2012","journal-title":"Gastroenterology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0073404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T16:09:26Z","timestamp":1563898166000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0073404"}},"subtitle":[],"editor":[{"given":"Rafael","family":"Aldabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,9,9]]},"references-count":32,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,9,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0073404","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,9]]}}}