{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:07:45Z","timestamp":1780344465261,"version":"3.54.1"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T00:00:00Z","timestamp":1377216000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0073409","type":"journal-article","created":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T17:08:16Z","timestamp":1377277696000},"page":"e73409","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["NF-kappaB Mediated Transcriptional Repression of Acid Modifying Hormone Gastrin"],"prefix":"10.1371","volume":"8","author":[{"given":"Dipanjana","family":"Datta De","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arindam","family":"Datta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumana","family":"Bhattacharjya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanta","family":"Roychoudhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,8,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1056\/NEJM199110173251603","article-title":"Helicobacter pylori infection and the risk of gastric carcinoma","volume":"325","author":"J Parsonnet","year":"1991","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1053\/gast.1997.v112.agast970670a","article-title":"Role of the host in Helicobacter disease","volume":"112","author":"JG Nedrud","year":"1997","journal-title":"Gastroenterology"},{"key":"ref3","article-title":"Clinical Tests of Gastric Secretion","author":"JH Baron","year":"1998"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1136\/gut.38.5.663","article-title":"Eradication of Helicobacter pylori in patients with duodenal ulcer lowers basal and peak acid outputs to gastrin releasing peptide and pentagastrin","volume":"38","author":"AW Harris","year":"1996","journal-title":"Gut"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1023\/A:1005452307860","article-title":"Effect of pro-inflammatory cytokines on acid secretion","volume":"45","author":"IL Beales","year":"2000","journal-title":"Dig Dis Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.biocel.2008.12.017","article-title":"IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin","volume":"41","author":"M Chakravorty","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e14775","DOI":"10.1371\/journal.pone.0014775","article-title":"IL1B Induced Smad 7 Negatively Regulates Gastrin Expression","volume":"6","author":"D Datta De","year":"2011","journal-title":"PLOS ONE"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1084\/jem.189.11.1839","article-title":"The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappa B activation and prevention of apoptosis","volume":"189","author":"ZW Li","year":"1999","journal-title":"J Exp Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1101\/gad.9.22.2723","article-title":"Rel\/NF-kappa B\/I kappa B family: intimate tales of association and dissociation","volume":"9","author":"IM Verma","year":"1995","journal-title":"Genes Dev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"41028","DOI":"10.1074\/jbc.M006179200","article-title":"Dynamic shuttling of nuclear factor kappa B between the nucleus and cytoplasm as a consequence of inhibitor dissociation","volume":"275","author":"F Carlotti","year":"2000","journal-title":"J Biol Chem"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"7065","DOI":"10.1128\/MCB.21.20.7065-7077.2001","article-title":"The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression","volume":"21","author":"BP Ashburner","year":"2001","journal-title":"Mol Cell Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1161\/01.RES.0000251744.06138.50","article-title":"Transcriptional silencing of the death gene BNIP3 by cooperative action of NF-kappaB and histone deacetylase 1 in ventricular myocytes","volume":"99","author":"J Shaw","year":"2006","journal-title":"Circ Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1161\/CIRCULATIONAHA.105.573899","article-title":"Nuclear factor-kappaB-mediated cell survival involves transcriptional silencing of the mitochondrial death gene BNIP3 in ventricular myocytes","volume":"112","author":"D Baetz","year":"2005","journal-title":"Circulation"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"10057","DOI":"10.1073\/pnas.94.19.10057","article-title":"Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control","volume":"94","author":"ZL Chu","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1126\/science.281.5383.1680","article-title":"NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation","volume":"281","author":"CY Wang","year":"1998","journal-title":"Science"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nrm1368","article-title":"Shaping the nuclear action of NF-kappaB","volume":"5","author":"LF Chen","year":"2004","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0168-9525(00)89045-9","article-title":"A role for phosphorylation and degradation in the control of NF-kappa B activity","volume":"11","author":"A Isra\u00ebl","year":"1995","journal-title":"Trends Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1002\/cbic.200400144","article-title":"NF-kappaB: a multifaceted transcription factor regulated at several levels","volume":"5","author":"ML Schmitz","year":"2004","journal-title":"Chembiochem"},{"key":"ref19","first-page":"a000067","article-title":"Specification of DNA binding activity of NF-kappaB proteins","volume":"1","author":"F Wan","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1046-2023(03)00081-1","article-title":"Histone modifications","volume":"31","author":"E Seto","year":"2003","journal-title":"Methods"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1126\/science.278.5343.1612","article-title":"IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling","volume":"278","author":"M Muzio","year":"1997","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1093\/hmg\/ddi405","article-title":"TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd","volume":"14","author":"A Morlon","year":"2005","journal-title":"Hum Mol Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1042\/bst0310643","article-title":"The role of MyD88-like adapters in Toll-like receptor signal transduction","volume":"31","author":"LA O\u2019Neill","year":"2003","journal-title":"Biochem Soc Trans"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1126\/science.272.5265.1179","article-title":"TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction","volume":"272","author":"H Shibuya","year":"1996","journal-title":"Science"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"a000034","DOI":"10.1101\/cshperspect.a000034","article-title":"The NF-kappaB family of transcription factors and its regulation","volume":"1","author":"A Oeckinghaus","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1042\/bj20021321","article-title":"Histone deacetylases (HDACs): characterization of the classical HDAC family","volume":"370","author":"AJ de Ruijter","year":"2003","journal-title":"Biochem J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/387043a0","article-title":"A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression","volume":"387","author":"T Heinzel","year":"1997","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1046\/j.1365-2036.2000.014s1101.x","article-title":"Induction of signal transduction pathways in rat gastric epithelial cells stimulated with interleukin-1beta","volume":"14","author":"K Tominaga","year":"2000","journal-title":"Aliment Pharmacol Ther"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1126\/science.274.5288.782","article-title":"An essential role for NF-kappaB in preventing TNF-alpha-induced cell death","volume":"274","author":"AA Beg","year":"1996","journal-title":"Science"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S1097-2765(02)00477-X","article-title":"The phosphorylation status of nuclear NF-kappa B determines its association with CBP\/p300 or HDAC-1","volume":"9","author":"H Zhong","year":"2002","journal-title":"Mol Cell"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"55633","DOI":"10.1074\/jbc.M409825200","article-title":"Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription","volume":"279","author":"H Buss","year":"2004","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1074\/jbc.M208696200","article-title":"The NF-kappa B activation in lymphotoxin beta receptor signaling depends on the phosphorylation of p65 at serine 536","volume":"278","author":"X Jiang","year":"2003","journal-title":"J Biol Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"18137","DOI":"10.1074\/jbc.M401397200","article-title":"Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA\/p65","volume":"279","author":"AM O\u2019Mahony","year":"2004","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"30353","DOI":"10.1074\/jbc.274.43.30353","article-title":"IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain","volume":"274","author":"H Sakurai","year":"1999","journal-title":"J Biol Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/jcb.20179","article-title":"Regulation of histone deacetylase activities","volume":"93","author":"N Sengupta","year":"2004","journal-title":"J Cell Biochem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1083\/jcb.200209065","article-title":"Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response","volume":"160","author":"GD Kao","year":"2003","journal-title":"J Cell Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0959-437X(00)00224-0","article-title":"Control of muscle development by dueling HATs and HDACs","volume":"11","author":"TA McKinsey","year":"2001","journal-title":"Curr Opin Genet Dev"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1128\/MCB.21.4.1249-1259.2001","article-title":"Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state","volume":"21","author":"KD McCullough","year":"2001","journal-title":"Mol Cell Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1038\/sj.onc.1204292","article-title":"Repression of GADD153\/CHOP by NF-kappaB: a possible cellular defense against endoplasmic reticulum stress-induced cell death","volume":"20","author":"S Nozaki","year":"2001","journal-title":"Oncogene"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/384641a0","article-title":"The CBP co-activator is a histone acetyltransferase","volume":"384","author":"AJ Bannister","year":"1996","journal-title":"Nature"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0092-8674(00)82001-2","article-title":"The transcriptional coactivators p300 and CBP are histone acetyltransferases","volume":"87","author":"VV Ogryzko","year":"1996","journal-title":"Cell"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/38304","article-title":"Steroid receptor coactivator-1 is a histone acetyltransferase","volume":"389","author":"TE Spencer","year":"1997","journal-title":"Nature"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/382319a0","article-title":"A p300\/CBP-associated factor that competes with the adenoviral oncoprotein E1A","volume":"382","author":"XJ Yang","year":"1996","journal-title":"Nature"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0073409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T15:19:54Z","timestamp":1540307994000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0073409"}},"subtitle":[],"editor":[{"given":"Holger","family":"Bruggemann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,8,23]]},"references-count":43,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,8,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0073409","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,23]]}}}