{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:08:24Z","timestamp":1791925704723,"version":"4.3.4"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T00:00:00Z","timestamp":1378080000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0073589","type":"journal-article","created":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T20:54:23Z","timestamp":1378155263000},"page":"e73589","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":77,"title":["miR-206 Represses Hypertrophy of Myogenic Cells but Not Muscle Fibers via Inhibition of HDAC4"],"prefix":"10.1371","volume":"8","author":[{"given":"Catherine E.","family":"Winbanks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Beyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Hagg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricio V.","family":"Sepulveda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Gregorevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,9,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/ncb0309-228","article-title":"Many roads to maturity: microRNA biogenesis pathways and their regulation","volume":"11","author":"J Winter","year":"2009","journal-title":"Nat Cell Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1083\/jcb.200603039","article-title":"MyoD inhibits Fstl1 and Utrn expression by inducing transcription of miR-206","volume":"175","author":"MI Rosenberg","year":"2006","journal-title":"J Cell Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/ng1725","article-title":"The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation","volume":"38","author":"JF Chen","year":"2006","journal-title":"Nat Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nm1582","article-title":"MicroRNA-133 controls cardiac hypertrophy","volume":"13","author":"A Car\u00e8","year":"2007","journal-title":"Nat Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1172\/JCI36154","article-title":"MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice","volume":"119","author":"TE Callis","year":"2009","journal-title":"J Clin Invest"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"11903","DOI":"10.1074\/jbc.M109.098004","article-title":"miR-9 and NFATc3 regulate myocardin in cardiac hypertrophy","volume":"285","author":"K Wang","year":"2010","journal-title":"J Biol Chem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"12103","DOI":"10.1073\/pnas.0811371106","article-title":"miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy","volume":"106","author":"Z Lin","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5863","DOI":"10.1093\/nar\/gkl743","article-title":"MIR-206 regulates connexin 43 expression during skeletal muscle development","volume":"34","author":"C Anderson","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1083\/jcb.200603008","article-title":"Muscle-specific microRNA miR-206 promotes muscle differentiation","volume":"174","author":"HK Kim","year":"2006","journal-title":"J Cell Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1111\/j.1582-4934.2009.00898.x","article-title":"Acceleration of muscle regeneration by local injection of muscle-specific microRNAs in rat skeletal muscle injury model","volume":"14","author":"T Nakasa","year":"2009","journal-title":"J Cell Mol Med"},{"key":"ref11","first-page":"2366","article-title":"The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation","volume":"119","author":"R Taulli","year":"2009","journal-title":"J Clin Invest"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1126\/science.1181046","article-title":"MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice","volume":"326","author":"AH Williams","year":"2009","journal-title":"Science"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1172\/JCI62656","article-title":"microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice","volume":"122","author":"N Liu","year":"2012","journal-title":"J Clin Invest"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1096\/fj.08-128579","article-title":"Common micro-RNA signature in skeletal muscle damage and regeneration induced by Duchenne muscular dystrophy and acute ischemia","volume":"23","author":"S Greco","year":"2009","journal-title":"FASEB J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1247\/csf.08022","article-title":"MicroRNA-206 is highly expressed in newly formed muscle fibers: implications regarding potential for muscle regeneration and maturation in muscular dystrophy","volume":"33","author":"K Yuasa","year":"2008","journal-title":"Cell Struct Funct"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/ng1810","article-title":"A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep","volume":"38","author":"A Clop","year":"2006","journal-title":"Nat Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrg2485","article-title":"The many roles of histone deacetylases in development and physiology: implications for disease and therapy","volume":"10","author":"M Haberland","year":"2009","journal-title":"Nat Rev Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4868","DOI":"10.1073\/pnas.96.9.4868","article-title":"Three proteins define a class of human histone deacetylases related to yeast Hda1p","volume":"96","author":"CM Grozinger","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1093\/emboj\/18.18.5099","article-title":"HDAC4 deacetylase associates with and represses the MEF2 transcription factor","volume":"18","author":"EA Miska","year":"1999","journal-title":"EMBO J"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"28930","DOI":"10.1074\/jbc.M303113200","article-title":"Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors","volume":"278","author":"CL Antos","year":"2003","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cell.2010.09.004","article-title":"Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases","volume":"143","author":"V Moresi","year":"2010","journal-title":"Cell"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"13805","DOI":"10.1074\/jbc.M110.192625","article-title":"TGF-beta regulates miR-206 and miR-29 to control myogenic differentiation through regulation of HDAC4","volume":"286","author":"CE Winbanks","year":"2011","journal-title":"J Biol Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.ymthe.2004.07.016","article-title":"Efficient transduction of skeletal muscle using vectors based on adeno-associated virus serotype 6","volume":"10","author":"MJ Blankinship","year":"2004","journal-title":"Mol Ther"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1083\/jcb.201109091","article-title":"Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin","volume":"197","author":"CE Winbanks","year":"2012","journal-title":"J Cell Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1083\/jcb.134.1.93","article-title":"Forced expression of dystrophin deletion constructs reveals structure-function correlations","volume":"134","author":"JA Rafael","year":"1996","journal-title":"J Cell Biol"},{"key":"ref26","first-page":"TAK-1","article-title":"Muscle 2: 3","author":"AU Trendelenburg","year":"2012"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.yexcr.2004.05.023","article-title":"IGF-1 induces human myotube hypertrophy by increasing cell recruitment","volume":"299","author":"V Jacquemin","year":"2004","journal-title":"Exp Cell Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0303-7207(95)03476-N","article-title":"Effects of dexamethasone on protein degradation and protease gene expression in rat L8 myotube cultures","volume":"108","author":"DH Hong","year":"1995","journal-title":"Mol Cell Endocrinol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1093\/emboj\/20.24.6969","article-title":"Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells","volume":"20","author":"M G\u00f6ttlicher","year":"2001","journal-title":"EMBO J"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1016\/S0021-9258(17)34804-4","article-title":"Suppression of histone deacetylation in vivo and in vitro by sodium butyrate","volume":"253","author":"LC Boffa","year":"1978","journal-title":"J Biol Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e789","DOI":"10.1371\/journal.pone.0000789","article-title":"Quadrupling muscle mass in mice by targeting TGF-beta signaling pathways","volume":"2","author":"SJ Lee","year":"2007","journal-title":"PLOS ONE"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.bbagrm.2008.07.011","article-title":"Differential expression of microRNA species in organs of hibernating ground squirrels: a role in translational suppression during torpor","volume":"1779","author":"P Morin Jr.","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e8760","DOI":"10.1371\/journal.pone.0008760","article-title":"Genomic profiling of messenger RNAs and microRNAs reveals potential mechanisms of TWEAK-induced skeletal muscle wasting in mice","volume":"5","author":"SK Panguluri","year":"2010","journal-title":"PLOS ONE"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/1756-0500-3-297","article-title":"Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle","volume":"3","author":"S Rachagani","year":"2010","journal-title":"BMC Res Notes"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0092-8674(02)00861-9","article-title":"Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy","volume":"110","author":"CL Zhang","year":"2002","journal-title":"Cell"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1161\/CIRCULATIONAHA.106.625467","article-title":"Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy","volume":"113","author":"Y Kong","year":"2006","journal-title":"Circulation"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nmeth1079","article-title":"MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells","volume":"4","author":"MS Ebert","year":"2007","journal-title":"Nat Methods"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1126\/science.1139089","article-title":"Control of stress-dependent cardiac growth and gene expression by a microRNA","volume":"316","author":"E van Rooij","year":"2007","journal-title":"Science"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"38456","DOI":"10.1074\/jbc.M111.271270","article-title":"Translational suppression of atrophic regulators by microRNA-23a integrates resistance to skeletal muscle atrophy","volume":"286","author":"S Wada","year":"2011","journal-title":"J Biol Chem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/2044-5040-2-7","article-title":"miR-206 integrates multiple components of differentiation pathways to control the transition from growth to differentiation in rhabdomyosarcoma cells","volume":"2","author":"KL Macquarrie","year":"2012","journal-title":"Skelet Muscle"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0073589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T11:23:21Z","timestamp":1646479401000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0073589"}},"subtitle":[],"editor":[{"given":"James\u00a0M.","family":"Ervasti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,9,2]]},"references-count":40,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,9,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0073589","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,2]]}}}