{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:09:36Z","timestamp":1789729776270,"version":"4.0.1"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T00:00:00Z","timestamp":1379548800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0073909","type":"journal-article","created":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T01:25:58Z","timestamp":1379640358000},"page":"e73909","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Pathological Role of Interleukin-17 in Poly I:C-Induced Hepatitis"],"prefix":"10.1371","volume":"8","author":[{"given":"Jianqin","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanjing","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiping","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanjuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,9,19]]},"reference":[{"key":"ref1","unstructured":"Hanafiah KM, Groeger J, Flaxman AD, Wiersma ST (2012) Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to hepatitis C virus seroprevalence. Hepatology."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/j.vaccine.2011.12.116","article-title":"Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity","volume":"30","author":"JJ Ott","year":"2012","journal-title":"Vaccine"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nri1573","article-title":"Immunology of hepatitis B virus and hepatitis C virus infection","volume":"5","author":"B Rehermann","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.iy.13.040195.000333","article-title":"Hepatitis B virus immunopathogenesis","volume":"13","author":"FV Chisari","year":"1995","journal-title":"Annu Rev Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.3748\/wjg.v18.i20.2443","article-title":"T cell immunopathogenesis and immunotherapeutic strategies for chronic hepatitis B virus infection","volume":"18","author":"Y Shimizu","year":"2012","journal-title":"World J Gastroenterol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/hep.22034","article-title":"Liver: An organ with predominant innate immunity","volume":"47","author":"B Gao","year":"2008","journal-title":"Hepatology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1002\/hep.21060","article-title":"The liver as an immunological organ","volume":"43","author":"V Racanelli","year":"2006","journal-title":"Hepatology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1365-2893.2005.00543.x","article-title":"Activation and function of hepatic NK cells in hepatitis B infection: an underinvestigated innate immune response","volume":"12","author":"Y Chen","year":"2005","journal-title":"J Viral Hepat"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"466","DOI":"10.4049\/jimmunol.0900687","article-title":"Increased killing of liver NK cells by Fas\/Fas ligand and NKG2D\/NKG2D ligand contributes to hepatocyte necrosis in virus-induced liver failure","volume":"184","author":"Y Zou","year":"2010","journal-title":"J Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.4049\/jimmunol.164.12.6480","article-title":"NK cells cause liver injury and facilitate the induction of T cell-mediated immunity to a viral liver infection","volume":"164","author":"ZX Liu","year":"2000","journal-title":"J Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1084\/jem.20061287","article-title":"Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage","volume":"204","author":"C Dunn","year":"2007","journal-title":"J Exp Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.23977","article-title":"Hypercytolytic activity of hepatic natural killer cells correlates with liver injury in chronic hepatitis B patients","volume":"53","author":"Z Zhang","year":"2011","journal-title":"Hepatology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.jhep.2004.08.021","article-title":"Involvement of natural killer cells in PolyI:C-induced liver injury","volume":"41","author":"Z Dong","year":"2004","journal-title":"J Hepatol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jhep.2007.02.020","article-title":"Liver-specific HBsAg transgenic mice are over-sensitive to Poly(I:C)-induced liver injury in NK cell- and IFN-gamma-dependent manner","volume":"47","author":"Y Chen","year":"2007","journal-title":"J Hepatol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1074\/jbc.M207577200","article-title":"Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17","volume":"278","author":"S Aggarwal","year":"2003","journal-title":"J Biol Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.immuni.2004.08.018","article-title":"Interleukin-17 family members and inflammation","volume":"21","author":"JK Kolls","year":"2004","journal-title":"Immunity"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"199","DOI":"10.2217\/1750743X.1.2.199","article-title":"Th17 cells in autoimmune disease: changing the verdict","volume":"1","author":"S Haak","year":"2009","journal-title":"Immunotherapy"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","article-title":"IL-17 and Th17 Cells","volume":"27","author":"T Korn","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ajpath.2012.03.044","article-title":"Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies","volume":"181","author":"MS Maddur","year":"2012","journal-title":"Am J Pathol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00011-011-0419-1","article-title":"Th17 cell cytokine secretion profile in host defense and autoimmunity","volume":"61","author":"KE Graeber","year":"2012","journal-title":"Inflamm Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.4049\/jimmunol.181.5.3456","article-title":"IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver","volume":"181","author":"S Hamada","year":"2008","journal-title":"J Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"5879","DOI":"10.4049\/jimmunol.1001763","article-title":"IL-17A-producing gammadeltaT cells promote CTL responses against Listeria monocytogenes infection by enhancing dendritic cell cross-presentation","volume":"185","author":"S Xu","year":"2010","journal-title":"J Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.immuni.2007.07.023","article-title":"Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation","volume":"27","author":"LA Zenewicz","year":"2007","journal-title":"Immunity"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.4049\/jimmunol.1101315","article-title":"Vgamma4 gammadelta T cell-derived IL-17A negatively regulates NKT cell function in Con A-induced fulminant hepatitis","volume":"187","author":"N Zhao","year":"2011","journal-title":"J Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"7473","DOI":"10.4049\/jimmunol.181.11.7473","article-title":"Requirement of IL-17RA in Con A induced hepatitis and negative regulation of IL-17 production in mouse T cells","volume":"181","author":"T Nagata","year":"2008","journal-title":"J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Lafdil F, Wang H, Park O, Zhang W, Moritoki Y, <etal>et al<\/etal>.. (2009) Myeloid STAT3 inhibits T cell-mediated hepatitis by regulating T helper 1 cytokine and interleukin-17 production. Gastroenterology 137: 2125\u20132135 e2121-2122.","DOI":"10.1053\/j.gastro.2009.08.004"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1093\/toxsci\/kfp165","article-title":"Halothane-induced liver injury is mediated by interleukin-17 in mice","volume":"111","author":"E Kobayashi","year":"2009","journal-title":"Toxicol Sci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/hep.22680","article-title":"The interleukin-17 pathway is involved in human alcoholic liver disease","volume":"49","author":"A Lemmers","year":"2009","journal-title":"Hepatology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1872-034X.2007.00040.x","article-title":"Interleukin-17 as a new marker of severity of acute hepatic injury","volume":"37","author":"Y Yasumi","year":"2007","journal-title":"Hepatol Res"},{"key":"ref30","first-page":"81","article-title":"Interleukin-17-producing CD4(+) T cells increase with severity of liver damage in patients with chronic hepatitis B. Hepatology","volume":"51","author":"JY Zhang","year":"2010"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.immunol.021908.132629","article-title":"The liver as a lymphoid organ","volume":"27","author":"IN Crispe","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"345803","DOI":"10.1155\/2011\/345803","article-title":"Role of IL-17 and Th17 cells in liver diseases","volume":"2011","author":"L Hammerich","year":"2011","journal-title":"Clin Dev Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.clim.2008.08.008","article-title":"NK and NKT cells in liver injury and fibrosis","volume":"130","author":"G Notas","year":"2009","journal-title":"Clin Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.jhep.2008.12.033","article-title":"Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients","volume":"50","author":"JP Zhang","year":"2009","journal-title":"J Hepatol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature04808","article-title":"IL-23 promotes tumour incidence and growth","volume":"442","author":"JL Langowski","year":"2006","journal-title":"Nature"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/hep.23291","article-title":"Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cells","volume":"51","author":"DM Kuang","year":"2010","journal-title":"Hepatology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1084\/jem.20082835","article-title":"Inhibition of NK cell activity by IL-17 allows vaccinia virus to induce severe skin lesions in a mouse model of eczema vaccinatum","volume":"206","author":"Y Kawakami","year":"2009","journal-title":"J Exp Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4049\/jimmunol.172.1.138","article-title":"APC-independent activation of NK cells by the Toll-like receptor 3 agonist double-stranded RNA","volume":"172","author":"KN Schmidt","year":"2004","journal-title":"J Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1084\/jem.20072195","article-title":"TLR-dependent cross talk between human Kupffer cells and NK cells","volume":"205","author":"Z Tu","year":"2008","journal-title":"J Exp Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"10116","DOI":"10.1073\/pnas.0403744101","article-title":"CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells","volume":"101","author":"S Sivori","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1084\/jem.20091181","article-title":"Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells","volume":"206","author":"S McCartney","year":"2009","journal-title":"J Exp Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"14954","DOI":"10.1073\/pnas.0904021106","article-title":"Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response","volume":"106","author":"MK Oyoshi","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1084\/jem.20082030","article-title":"Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection","volume":"206","author":"W Hou","year":"2009","journal-title":"J Exp Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.coi.2008.03.006","article-title":"gammadelta T cells: an important source of IL-17","volume":"20","author":"CL Roark","year":"2008","journal-title":"Curr Opin Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.immuni.2008.04.022","article-title":"Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma","volume":"29","author":"KD Jensen","year":"2008","journal-title":"Immunity"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.immuni.2009.08.001","article-title":"Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity","volume":"31","author":"CE Sutton","year":"2009","journal-title":"Immunity"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/hep.25982","article-title":"High-mobility group box 1 (HMGB1)-Toll-like receptor (TLR)4-interleukin (IL)-23-IL-17A axis in drug-induced damage-associated lethal hepatitis: Interaction of gammadelta T cells with macrophages","volume":"57","author":"X Wang","year":"2013","journal-title":"Hepatology"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.4049\/jimmunol.0901843","article-title":"IL-6 promotes NK cell production of IL-17 during toxoplasmosis","volume":"184","author":"ST Passos","year":"2010","journal-title":"J Immunol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1128\/IAI.73.1.617-621.2005","article-title":"Interleukin-17\/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection","volume":"73","author":"MN Kelly","year":"2005","journal-title":"Infect Immun"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.chom.2009.09.011","article-title":"Aging promotes neutrophil-induced mortality by augmenting IL-17 production during viral infection","volume":"6","author":"HW Stout-Delgado","year":"2009","journal-title":"Cell Host Microbe"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"865","DOI":"10.4049\/jimmunol.0804080","article-title":"IL-17A controls IL-17F production and maintains blood neutrophil counts in mice","volume":"183","author":"S von Vietinghoff","year":"2009","journal-title":"J Immunol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/hep.20184","article-title":"Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation","volume":"39","author":"S Radaeva","year":"2004","journal-title":"Hepatology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0073909","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T11:50:02Z","timestamp":1540036202000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0073909"}},"subtitle":[],"editor":[{"given":"Bernhard","family":"Ryffel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,9,19]]},"references-count":52,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,9,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0073909","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,19]]}}}