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Breast Cancer Res. 1; 14\u201317.","DOI":"10.1186\/bcr6"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Ponder BA, Antoniou A, Dunning A, Easton DF, Pharoah PD (2005) Polygenic inherited predisposition to breast cancer. Cold Spring Harb Symp Quant Biol 70; 35\u201341.","DOI":"10.1101\/sqb.2005.70.029"},{"key":"ref3","unstructured":"Szabo CI, King MC (1997) Population genetics of BRCA1 and BRCA2. Am J Hum Genet 60; 1013\u20131020."},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Antoniou A, Pharoah PD, Narod S, Risch HA, Eyfjord JE, <etal>et al<\/etal>. (2003) Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet 72; 1117\u20131130.","DOI":"10.1086\/375033"},{"key":"ref5","unstructured":"Serova OM, Mazoyer S, Puget N, Dubois V, Tonin P, <etal>et al<\/etal>. (1997) Mutations in BRCA1 and BRCA2 in breast cancer families: are there more breast cancer-susceptibility genes? Am J Hum Genet 60; 486\u2013495."},{"key":"ref6","unstructured":"Schubert EL, Lee MK, Mefford HC, Argonza RH, Morrow JE, <etal>et al<\/etal>. (1997) BRCA2 in American families with four or more cases of breast or ovarian cancer: recurrent and novel mutations, variableexpression, penetrance, and the possibility of families whose cancer is not attributable to BRCA1 or BRCA2. Am J Hum Genet 60; 1031\u20131040."},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Peto J, Collins N, Barfoot R, Seal S, Warren W, <etal>et al<\/etal>. (1999) Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer. J Natl Cancer Inst 91; 943\u2013949.","DOI":"10.1093\/jnci\/91.11.943"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Seal S, Thompson D, Renwick A, Elliott A, Kelly P, <etal>et al<\/etal>. (2006) Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles. Nat Genet 38; 1239\u20131241.","DOI":"10.1038\/ng1902"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Byrnes GB, Southey MC, Hopper JL (2008) Are the so-called low penetrance breast cancer genes, ATM, BRIP1, PALB2 and CHEK2, high risk for women with strong family histories? Breast Cancer Res 10; 208.","DOI":"10.1186\/bcr2099"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Cantor SB, Bell DW, Ganesan S, Kass EM, Drapkin R, <etal>et al<\/etal>. (2001) BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell 105; 149\u2013160.","DOI":"10.1016\/S0092-8674(01)00304-X"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Yu X, Chini CC, He M, Mer G, Chen J (2003) The BRCT domain is a phospho-protein binding domain. Science 302; 639\u2013642.","DOI":"10.1126\/science.1088753"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Cantor S, Drapkin R, Zhang F, Lin Y, Han J, <etal>et al<\/etal>. (2004) The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations. Proc Natl Acad Sci U S A 101; 2357\u20132362.","DOI":"10.1073\/pnas.0308717101"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Peng M, Litman R, Jin Z, Fong G, Cantor SB (2006) BACH1 is a DNA repair protein supporting BRCA1 damage response. Oncogene 25; 2245\u20132253.","DOI":"10.1038\/sj.onc.1209257"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Tu Z, Aird KM, Bitler BG, Nicodemus JP, Beeharry N, <etal>et al<\/etal>. (2011) Oncogenic Ras Regulates BRIP1 Expression to Induce Dissociation of BRCA1 from Chromatin, Inhibit DNA Repair, and Promote Senescence. Dev Cell 21; 1077\u20131091.","DOI":"10.1016\/j.devcel.2011.10.010"},{"key":"ref15","unstructured":"Phelan CM, Borg A, Cuny M, Crichton DN, Baldersson T, <etal>et al<\/etal>. (1998) Consortium study on 1280 breast carcinomas: allelic loss on chromosome 17 targets subregions associated with family history and clinical parameters. Cancer Res 58; 1004\u20131012."},{"key":"ref16","unstructured":"Callahan R (1998) Somatic mutations that contribute to breast cancer. Biochem Soc Symp 63; 211\u2013221."},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Cantor SB, Guillemette S (2011) Hereditary breast cancer and the BRCA1-associated FANCJ\/BACH1\/BRIP1. Future Oncol 7; 253\u2013261.","DOI":"10.2217\/fon.10.191"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"De Nicolo A, Tancredi M, Lombardi G, Flemma CC, Barbuti S, <etal>et al<\/etal>. (2008) A novel breast cancer-associated BRIP1 (FANCJ\/BACH1) germ-line mutation impairs protein stability and function. Clin Cancer Res 14; 4672\u20134680.","DOI":"10.1158\/1078-0432.CCR-08-0087"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Deng CX, Wang RH (2003) Roles of BRCA1 in DNA damage repair: a link between development and cancer. Hum Mol Genet 12; R113\u2013123.","DOI":"10.1093\/hmg\/ddg082"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Phillips ER, McKinnon PJ (2007) DNA double-strand break repair and development. Oncogene 26; 7799\u20137808.","DOI":"10.1038\/sj.onc.1210877"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Xu X, Wagner KU, Larson D, Weaver Z, Li C, <etal>et al<\/etal>. (1999) Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Nat Genet 22; 37\u201343.","DOI":"10.1038\/8743"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Furuta S, Jiang X, Gu B, Cheng E, Chen PL, <etal>et al<\/etal>. (2005) Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells. Proc Natl Acad Sci U S A 102; 9176\u20139181.","DOI":"10.1073\/pnas.0503793102"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Debnath J, Muthuswamy SK, Brugge JS (2003) Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 30; 256\u2013268.","DOI":"10.1016\/S1046-2023(03)00032-X"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Ishida Y, Takabatake T, Kakinuma S, Doi K, Yamauchi K, <etal>et al<\/etal>. (2010) Genomic and gene expression signatures of radiation in medulloblastomas after low-dose irradiation in Ptch1 heterozygous mice. Carcinogenesis 31; 1694\u20131701.","DOI":"10.1093\/carcin\/bgq145"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, <etal>et al<\/etal>. (2003) PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34; 267\u2013273.","DOI":"10.1038\/ng1180"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, <etal>et al<\/etal>. (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102; 15545\u201315550.","DOI":"10.1073\/pnas.0506580102"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Han HJ, Russo J, Kohwi Y, Kohwi-Shigematsu T (2008) SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis. Nature 452; 187\u2013193.","DOI":"10.1038\/nature06781"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Contos JJ, Ishii I, Chun J (2000) Lysophosphatidic acid receptors. Mol Pharmacol 58; 1188\u20131196.","DOI":"10.1124\/mol.58.6.1188"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Moolenaar WH, van Meeteren LA, Giepmans BN (2004) The ins and outs of lysophosphatidic acid signaling. Bioessays 26; 870\u2013881.","DOI":"10.1002\/bies.20081"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Kitayama J, Shida D, Sako A, Ishikawa M, Hama K, <etal>et al<\/etal>. (2004) Over-expression of lysophosphatidic acid receptor-2 in human invasive ductal carcinoma. Breast Cancer Res 6; R640\u2013646.","DOI":"10.1186\/bcr935"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Liu S, Umezu-Goto M, Murph M, Lu Y, Liu W, <etal>et al<\/etal>. (2009) Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases. Cancer Cell 15; 539\u2013550.","DOI":"10.1016\/j.ccr.2009.03.027"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Chen Y, Olopade OI (2008) MYC in breast tumor progression. Expert Rev Anticancer Ther 8; 1689\u20131698.","DOI":"10.1586\/14737140.8.10.1689"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Xu J, Chen Y, Olopade OI (2010) MYC and Breast Cancer. Genes Cancer 1; 629\u2013640.","DOI":"10.1177\/1947601910378691"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Boras-Granic K, Wysolmerski JJ (2008) Wnt signaling in breast organogenesis. Organogenesis 4; 116\u2013122.","DOI":"10.4161\/org.4.2.5858"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Roy R, Chun J, Powell SN (2012) BRCA1 and BRCA2: different roles in a common pathway of genome protection. 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Science 319; 1352\u20131355.","DOI":"10.1126\/science.1140735"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Cully M, You H, Levine AJ, Mak TW (2006) Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 6; 184\u2013192.","DOI":"10.1038\/nrc1819"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Fournier MV, Fata JE, Martin KJ, Yaswen P, Bissell MJ (2009) Interaction of E-cadherin and PTEN regulates morphogenesis and growth arrest in human mammary epithelial cells. Cancer Res 69; 4545\u20134552.","DOI":"10.1158\/0008-5472.CAN-08-1694"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Liu H, Radisky DC, Wang F, Bissell MJ (2004) Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells. J Cell Biol 164; 603\u2013612.","DOI":"10.1083\/jcb.200306090"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Isakoff SJ, Engelman JA, Irie HY, Luo J, Brachmann SM, <etal>et al<\/etal>. (2005) Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res 65; 10992\u201311000.","DOI":"10.1158\/0008-5472.CAN-05-2612"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Patani N, Jiang W, Mansel R, Newbold R, Mokbel K (2009) The mRNA expression of SATB1 and SATB2 in human breast cancer. Cancer Cell Int 9; 18.","DOI":"10.1186\/1475-2867-9-18"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Ordinario E, Han HJ, Furuta S, Heiser LM, Jakkula LR, <etal>et al<\/etal>. (2012) ATM Suppresses SATB1-Induced Malignant Progression in Breast Epithelial Cells. PLoS One 7; e51786.","DOI":"10.1371\/journal.pone.0051786"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Rollason R, Korolchuk V, Hamilton C, Jepson M, Banting G (2009) A CD317\/tetherin-RICH2 complex plays a critical role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. J Cell Biol 184; 721\u2013736.","DOI":"10.1083\/jcb.200804154"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Heng S, Cervero A, Simon C, Stephens AN, Li Y, <etal>et al<\/etal>. (2011) Proprotein convertase 5\/6 is critical for embryo implantation in women: regulating receptivity by cleaving EBP50, modulating ezrin binding, and membrane-cytoskeletal interactions. Endocrinology 152; 5041\u20135052.","DOI":"10.1210\/en.2011-1273"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Neve R, Chang CH, Scott GK, Wong A, Friis RR, <etal>et al<\/etal>. (1998) The epithelium-specific ets transcription factor ESX is associated with mammary gland development and involution. FASEB J 12; 1541\u20131550.","DOI":"10.1096\/fasebj.12.14.1541"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Chang CH, Scott GK, Kuo WL, Xiong X, Suzdaltseva Y, <etal>et al<\/etal>. (1997) ESX: a structurally unique Ets overexpressed early during human breast tumorigenesis. Oncogene 14; 1617\u20131622.","DOI":"10.1038\/sj.onc.1200978"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Cechowska-Pasko M, Palka J, Wojtukiewicz MZ (2006) Enhanced prolidase activity and decreased collagen content in breast cancer tissue. Int J Exp Pathol 87; 289\u2013296.","DOI":"10.1111\/j.1365-2613.2006.00486.x"},{"key":"ref50","unstructured":"Shih LM, Hsu MY, Palazzo JP, Herlyn M (1997) The cell-cell adhesion receptor Mel-CAM acts as a tumor suppressor in breast carcinoma. Am J Pathol 151; 745\u2013751."},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Kurisu S, Takenawa T (2009) The WASP and WAVE family proteins. 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