{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:50:49Z","timestamp":1780606249668,"version":"3.54.1"},"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T00:00:00Z","timestamp":1377648000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0074070","type":"journal-article","created":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T21:14:14Z","timestamp":1377724454000},"page":"e74070","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Structural Interactions within the Default Mode Network Identified by Bayesian Network Analysis in Alzheimer\u2019s Disease"],"prefix":"10.1371","volume":"8","author":[{"given":"Yan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,8,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/nimg.2001.0786","article-title":"A voxel-based morphometric study of ageing in 465 normal adult human brains","volume":"14","author":"CD Good","year":"2001","journal-title":"Neuroimage"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Fjell AM, Westlye LT, Grydeland H, Amlien I, Espeseth T, <etal>et al<\/etal>.. (2013) Critical ages in the life course of the adult brain: nonlinear subcortical aging. Neurobiol Aging.","DOI":"10.1016\/j.neurobiolaging.2013.04.006"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1212\/WNL.55.4.484","article-title":"Rates of hippocampal atrophy correlate with change in clinical status in aging and AD","volume":"55","author":"CJ Jack","year":"2000","journal-title":"Neurology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S1053-8119(03)00041-7","article-title":"A comprehensive study of gray matter loss in patients with Alzheimer&apos;s disease using optimized voxel-based morphometry","volume":"18","author":"GB Karas","year":"2003","journal-title":"Neuroimage"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3233\/JAD-2006-9304","article-title":"Relationship of cognitive measures and gray and white matter in Alzheimer&apos;s disease","volume":"9","author":"LC Baxter","year":"2006","journal-title":"J Alzheimers Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1006\/nimg.2002.1202","article-title":"Automatic differentiation of anatomical patterns in the human brain: validation with studies of degenerative dementias","volume":"17","author":"CD Good","year":"2002","journal-title":"Neuroimage"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"4703","DOI":"10.1073\/pnas.052587399","article-title":"Mapping the evolution of regional atrophy in Alzheimer&apos;s disease: unbiased analysis of fluid-registered serial MRI","volume":"99","author":"RI Scahill","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.pscychresns.2006.04.003","article-title":"Volumetric reduction of the corpus callosum in Alzheimer&apos;s disease in vivo as assessed with voxel-based morphometry","volume":"154","author":"TM Chaim","year":"2007","journal-title":"Psychiatry Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.neuroimage.2008.10.030","article-title":"Regional white matter volume differences in nondemented aging and Alzheimer&apos;s disease","volume":"44","author":"DH Salat","year":"2009","journal-title":"Neuroimage"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"10041","DOI":"10.1073\/pnas.0603414103","article-title":"Hippocampal disconnection contributes to memory dysfunction in individuals at risk for Alzheimer&apos;s disease","volume":"103","author":"TR Stoub","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1001\/archneur.59.2.243","article-title":"Progression of corpus callosum atrophy in Alzheimer disease","volume":"59","author":"SJ Teipel","year":"2002","journal-title":"Arch Neurol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"18191","DOI":"10.1073\/pnas.1003109107","article-title":"Network-level structural covariance in the developing brain","volume":"107","author":"BA Zielinski","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.neurobiolaging.2005.12.016","article-title":"Structural MRI covariance patterns associated with normal aging and neuropsychological functioning","volume":"28","author":"AM Brickman","year":"2007","journal-title":"Neurobiol Aging"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/hbm.20865","article-title":"Source-based morphometry of gray matter volume in men with first-episode schizophrenia","volume":"31","author":"T Kasparek","year":"2010","journal-title":"Hum Brain Mapp"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1016\/j.neurobiolaging.2012.01.014","article-title":"Gray matter network associated with risk for Alzheimer&apos;s disease in young to middle-aged adults","volume":"33","author":"GE Alexander","year":"2012","journal-title":"Neurobiology of Aging"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.neuroimage.2006.07.047","article-title":"Multivariate network analysis of fiber tract integrity in Alzheimer&apos;s disease","volume":"34","author":"SJ Teipel","year":"2007","journal-title":"Neuroimage"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neulet.2012.10.038","article-title":"Mapping joint grey and white matter reductions in Alzheimer&apos;s disease using joint independent component analysis","volume":"531","author":"X Guo","year":"2012","journal-title":"Neuroscience Letters"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4756","DOI":"10.1523\/JNEUROSCI.0141-08.2008","article-title":"Structural insights into aberrant topological patterns of large-scale cortical networks in Alzheimer&apos;s disease","volume":"28","author":"Y He","year":"2008","journal-title":"J Neurosci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1177\/1073858409334423","article-title":"Neuronal Networks in Alzheimer&apos;s Disease","volume":"15","author":"Y He","year":"2009","journal-title":"The Neuroscientist"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1016\/j.neuroimage.2011.09.023","article-title":"Dynamic Bayesian network modeling for longitudinal brain morphometry","volume":"59","author":"R Chen","year":"2012","journal-title":"Neuroimage"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.neuroimage.2005.08.020","article-title":"Network analysis of mild cognitive impairment","volume":"29","author":"R Chen","year":"2006","journal-title":"Neuroimage"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.neuroimage.2006.01.031","article-title":"Learning functional structure from fMR images","volume":"31","author":"X Zheng","year":"2006","journal-title":"Neuroimage"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1002\/hbm.21153","article-title":"Altered default mode network connectivity in Alzheimer&apos;s disease\u2014a resting functional MRI and Bayesian network study","volume":"32","author":"X Wu","year":"2011","journal-title":"Hum Brain Mapp"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/cercor\/bhn059","article-title":"Resting-state functional connectivity reflects structural connectivity in the default mode network","volume":"19","author":"MD Greicius","year":"2009","journal-title":"Cereb Cortex"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00429-009-0208-6","article-title":"Greater than the sum of its parts: a review of studies combining structural connectivity and resting-state functional connectivity","volume":"213","author":"JS Damoiseaux","year":"2009","journal-title":"Brain Struct Funct"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1073\/pnas.0308627101","article-title":"Default-mode network activity distinguishes Alzheimer&apos;s disease from healthy aging: evidence from functional MRI","volume":"101","author":"MD Greicius","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neuron.2009.03.024","article-title":"Neurodegenerative diseases target large-scale human brain networks","volume":"62","author":"WW Seeley","year":"2009","journal-title":"Neuron"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1212\/01.wnl.0000250326.77323.01","article-title":"Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease","volume":"68","author":"Y Zhang","year":"2007","journal-title":"Neurology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1089\/brain.2011.0026","article-title":"Constrained source-based morphometry identifies structural networks associated with default mode network","volume":"2","author":"L Luo","year":"2012","journal-title":"Brain Connect"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.neuroimage.2010.04.009","article-title":"Development of functional and structural connectivity within the default mode network in young children","volume":"52","author":"K Supekar","year":"2010","journal-title":"Neuroimage"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"&quot;Mini-mental state&quot;","volume":"12","author":"MF Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): current version and scoring rules","volume":"43","author":"JC Morris","year":"1993","journal-title":"Neurology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer&apos;s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer&apos;s Disease","volume":"34","author":"G McKhann","year":"1984","journal-title":"Neurology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/jmri.21049","article-title":"The Alzheimer&apos;s disease neuroimaging initiative (ADNI): MRI methods","volume":"27","author":"CR Jack","year":"2008","journal-title":"Journal of Magnetic Resonance Imaging"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1109\/42.563663","article-title":"Statistical approach to segmentation of single-channel cerebral MR images","volume":"16","author":"JC Rajapakse","year":"1997","journal-title":"IEEE Trans Med Imaging"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neuroimage.2004.05.007","article-title":"Fast and robust parameter estimation for statistical partial volume models in brain MRI","volume":"23","author":"J Tohka","year":"2004","journal-title":"Neuroimage"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/jmri.22003","article-title":"Adaptive non-local means denoising of MR images with spatially varying noise levels","volume":"31","author":"JV Manjon","year":"2010","journal-title":"J Magn Reson Imaging"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuroimage.2007.07.007","article-title":"A fast diffeomorphic image registration algorithm","volume":"38","author":"J Ashburner","year":"2007","journal-title":"Neuroimage"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"9673","DOI":"10.1073\/pnas.0504136102","article-title":"The human brain is intrinsically organized into dynamic, anticorrelated functional networks","volume":"102","author":"MD Fox","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1073\/pnas.0800376105","article-title":"The maturing architecture of the brain&apos;s default network","volume":"105","author":"DA Fair","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8","article-title":"Automated Talairach atlas labels for functional brain mapping","volume":"10","author":"JL Lancaster","year":"2000","journal-title":"Hum Brain Mapp"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S1053-8119(03)00169-1","article-title":"An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets","volume":"19","author":"JA Maldjian","year":"2003","journal-title":"Neuroimage"},{"key":"ref43","unstructured":"Schmidt M, Niculescu-Mizil A, Murphy K (2007) Learning graphical model structure using L1-regularization paths. In Proceedings of the 22ndConference on Artificial Intelligence (AAAI), Vancouver, British Columbia: 1278\u22121283"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hbm.1058","article-title":"Nonparametric permutation tests for functional neuroimaging: a primer with examples","volume":"15","author":"TE Nichols","year":"2002","journal-title":"Hum Brain Mapp"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"8303","DOI":"10.1523\/JNEUROSCI.0357-05.2005","article-title":"Structural covariance in the human cortex","volume":"25","author":"A Mechelli","year":"2005","journal-title":"J Neurosci"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.pscychresns.2008.07.016","article-title":"Principal component analysis in mild and moderate Alzheimer&apos;s disease \u2014 A novel approach to clinical diagnosis","volume":"173","author":"M Pagani","year":"2009","journal-title":"Psychiatry Research: Neuroimaging"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neubiorev.2011.06.009","article-title":"Parietal cortex matters in Alzheimer&apos;s disease: an overview of structural, functional and metabolic findings","volume":"36","author":"HI Jacobs","year":"2012","journal-title":"Neurosci Biobehav Rev"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"12523","DOI":"10.1073\/pnas.0605194103","article-title":"Memory enhancement in healthy older adults using a brain plasticity-based training program: a randomized, controlled study","volume":"103","author":"HW Mahncke","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"16876","DOI":"10.1523\/JNEUROSCI.4136-10.2010","article-title":"Diffusion tensor tractography reveals abnormal topological organization in structural cortical networks in Alzheimer&apos;s disease","volume":"30","author":"CY Lo","year":"2010","journal-title":"J Neurosci"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1093\/cercor\/bhn102","article-title":"Mapping anatomical connectivity patterns of human cerebral cortex using in vivo diffusion tensor imaging tractography","volume":"19","author":"G Gong","year":"2009","journal-title":"Cereb Cortex"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fnagi.2012.00032","article-title":"Is the subcallosal medial prefrontal cortex a common site of atrophy in Alzheimer&apos;s disease and frontotemporal lobar degeneration?","volume":"4","author":"O Lindberg","year":"2012","journal-title":"Front Aging Neurosci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.neuroimage.2008.07.052","article-title":"White matter atrophy and lesion formation explain the loss of structural integrity of white matter in aging","volume":"43","author":"MW Vernooij","year":"2008","journal-title":"Neuroimage"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/alzrt47","article-title":"Role of structural MRI in Alzheimer&apos;s disease","volume":"2","author":"P Vemuri","year":"2010","journal-title":"Alzheimers Res Ther"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.neuroimage.2010.06.013","article-title":"Automatic classification of patients with Alzheimer&apos;s disease from structural MRI: A comparison of ten methods using the ADNI database","volume":"56","author":"R Cuingnet","year":"2011","journal-title":"NeuroImage"},{"key":"ref55","doi-asserted-by":"crossref","DOI":"10.3233\/JAD-2011-111292","article-title":"Magnetic resonance imaging based clinical research in Alzheimer&apos;s disease","volume":"31","author":"N Fayed","year":"2012","journal-title":"J Alzheimers Dis"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nrn2575","article-title":"Complex brain networks: graph theoretical analysis of structural and functional systems","volume":"10","author":"E Bullmore","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1749-6632.2010.05888.x","article-title":"The human connectome: a complex network","volume":"1224","author":"O Sporns","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.tics.2011.03.006","article-title":"Understanding complexity in the human brain","volume":"15","author":"DS Bassett","year":"2011","journal-title":"Trends Cogn Sci"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/WCO.0b013e32835a26b3","article-title":"Neuroimaging insights into network-based neurodegeneration","volume":"25","author":"MD Greicius","year":"2012","journal-title":"Curr Opin Neurol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/S1053-8119(03)00231-3","article-title":"Application of a data-mining method based on Bayesian networks to lesion-deficit analysis","volume":"19","author":"EH Herskovits","year":"2003","journal-title":"Neuroimage"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0074070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T11:26:14Z","timestamp":1715945174000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0074070"}},"subtitle":[],"editor":[{"given":"Stefano L.","family":"Sensi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,8,28]]},"references-count":60,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,8,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0074070","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,28]]}}}