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Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/j.1460-2075.1991.tb07921.x","article-title":"Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid","volume":"10","author":"P Leroy","year":"1991","journal-title":"EMBO J"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"10138","DOI":"10.1073\/pnas.88.22.10138","article-title":"Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response element","volume":"88","author":"P Leroy","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.1073\/pnas.87.14.5392","article-title":"Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene","volume":"87","author":"HM Sucov","year":"1990","journal-title":"Proc Natl Acad Sci U S 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Baynash","year":"1994","journal-title":"Cell"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1242\/dev.121.11.3787","article-title":"Intercellular signals downstream of endothelin receptor-B mediate colonization of the large intestine by enteric neuroblasts","volume":"121","author":"RP Kapur","year":"1995","journal-title":"Development"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"9645","DOI":"10.1073\/pnas.93.18.9645","article-title":"Endothelin-B receptor is expressed by neural crest cells in the avian embryo","volume":"93","author":"V Nataf","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1172\/JCI65963","article-title":"Transplanted progenitors generate functional enteric neurons in the postnatal colon","volume":"123","author":"R Hotta","year":"2013","journal-title":"J Clin Invest"},{"key":"ref61","article-title":"The endothelin axis influences enteric glia 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Shoba","year":"2002","journal-title":"Neurosci Lett"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00441-005-0047-6","article-title":"Phenotypes of neural-crest-derived cells in vagal and sacral pathways","volume":"323","author":"RB Anderson","year":"2006","journal-title":"Cell Tissue Res"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.1002\/dvdy.21801","article-title":"Retinoid regulation of the zebrafish cyp26a1 promoter","volume":"237","author":"P Hu","year":"2008","journal-title":"Dev Dyn"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.bcp.2005.02.024","article-title":"Regulation of CYP26A1 expression by selective RAR and RXR agonists in human NB4 promyelocytic leukemia cells","volume":"69","author":"N Idres","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1389200033336900","article-title":"Retinoic acid metabolism and mechanism of action: a review","volume":"4","author":"J Marill","year":"2003","journal-title":"Curr Drug Metab"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/00001574-200103000-00015","article-title":"Vitamin A: recent advances in the biotransformation, transport, and metabolism of retinoids","volume":"17","author":"AC Ross","year":"2001","journal-title":"Curr Opin Gastroenterol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ydbio.2006.01.032","article-title":"Endothelin-3 regulates neural crest cell proliferation and differentiation in the hindgut enteric nervous system","volume":"293","author":"N Nagy","year":"2006","journal-title":"Dev Biol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.mod.2004.02.008","article-title":"Feedback mechanisms regulate retinoic acid production and degradation in the zebrafish embryo","volume":"121","author":"B Dobbs-McAuliffe","year":"2004","journal-title":"Mech Dev"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1053\/j.gastro.2011.04.010","article-title":"MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of dendritic cells","volume":"141","author":"EJ Villablanca","year":"2011","journal-title":"Gastroenterology"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jtbi.2011.07.013","article-title":"On the role of differential adhesion in gangliogenesis in the enteric nervous system","volume":"287","author":"EJ Hackett-Jones","year":"2011","journal-title":"J Theor Biol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/dvdy.20943","article-title":"Gangliogenesis in the enteric nervous system: roles of the polysialylation of the neural cell adhesion molecule and its regulation by bone morphogenetic protein-4","volume":"236","author":"C 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