{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T07:10:35Z","timestamp":1773731435196,"version":"3.50.1"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T00:00:00Z","timestamp":1378166400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0074363","type":"journal-article","created":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T21:12:51Z","timestamp":1378242771000},"page":"e74363","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Pinellia pedatisecta Agglutinin Targets Drug Resistant K562\/ADR Leukemia Cells through Binding with Sarcolemmal Membrane Associated Protein and Enhancing Macrophage Phagocytosis"],"prefix":"10.1371","volume":"8","author":[{"given":"Kan","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meilan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuanghui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gongchu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,9,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nature05630","article-title":"Multiple molecular mechanisms for multidrug resistance transporters","volume":"446","author":"CF Higgins","year":"2007","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1021\/mp200261n","article-title":"The emergence of drug transporter-mediated multidrug resistance to cancer chemotherapy","volume":"8","author":"CP Wu","year":"2011","journal-title":"Mol Pharm"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrc1590","article-title":"Tumour stem cells and drug resistance","volume":"5","author":"M Dean","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10911-009-9109-9","article-title":"ABC transporters, drug resistance, and cancer stem cells","volume":"14","author":"M Dean","year":"2009","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.2174\/092986709788186147","article-title":"Cancer stem cells: a new paradigm for understanding tumor growth and progression and drug resistance","volume":"16","author":"R Gangemi","year":"2009","journal-title":"Curr Med Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"6215","DOI":"10.1182\/blood-2008-05-158311","article-title":"Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML","volume":"113","author":"Z Zeng","year":"2009","journal-title":"Blood"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1038\/leu.2008.125","article-title":"Resistance to FLT3 inhibition in an in vitro model of primary AML cells with a stem cell phenotype in a defined microenvironment","volume":"22","author":"U Mony","year":"2008","journal-title":"Leukemia"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1476-4598-6-32","article-title":"N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma","volume":"6","author":"T Kudo","year":"2007","journal-title":"Mol Cancer"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/308738","article-title":"Cancer biomarker discovery: lectin-based strategies targeting glycoproteins","volume":"33","author":"D Clark","year":"2012","journal-title":"Dis Markers"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1021\/pr8007013","article-title":"Pancreatic cancer serum detection using a lectin\/glyco-antibody array method","volume":"8","author":"C Li","year":"2009","journal-title":"J Proteome Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4149\/neo_2009_01_68","article-title":"Clinical utility of the interaction between lectin and serum prostate specific antigen in prostate cancer","volume":"56","author":"SK Batabyal","year":"2009","journal-title":"Neoplasma"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1093\/glycob\/cwr045","article-title":"Lectin microarray profiling of metastatic breast cancers","volume":"21","author":"SA Fry","year":"2011","journal-title":"Glycobiology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1021\/pr201206w","article-title":"Lectin chromatography\/mass spectrometry discovery workflow identifies putative biomarkers of aggressive breast cancers","volume":"11","author":"PM Drake","year":"2012","journal-title":"J Proteome Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.1021\/pr300330z","article-title":"Identification and confirmation of differentially expressed fucosylated glycoproteins in the serum of ovarian cancer patients using a lectin array and LC-MS\/MS","volume":"11","author":"J Wu","year":"2012","journal-title":"J Proteome Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"5507","DOI":"10.1016\/j.jprot.2012.06.027","article-title":"A lectin-coupled, targeted proteomic mass spectrometry (MRM MS) platform for identification of multiple liver cancer biomarkers in human plasma","volume":"75","author":"YH Ahn","year":"2012","journal-title":"J Proteomics"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1089\/scd.2011.0369","article-title":"Lectins identify glycan biomarkers on glioblastoma-derived cancer stem cells","volume":"21","author":"C Tucker-Burden","year":"2012","journal-title":"Stem Cells Dev"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1021\/pr100012p","article-title":"Identification of cell surface glycoprotein markers for glioblastoma-derived stem-like cells using a lectin microarray and LC-MS\/MS approach","volume":"9","author":"J He","year":"2010","journal-title":"J Proteome Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e41845","DOI":"10.1371\/journal.pone.0041845","article-title":"Plant lectin can target receptors containing sialic acid, exemplified by podoplanin, to inhibit transformed cell growth and migration","volume":"7","author":"JA Ochoa-Alvarez","year":"2012","journal-title":"PLOS ONE"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1423-0127-16-10","article-title":"Lectin of Concanavalin A as an anti-hepatoma therapeutic agent","volume":"16","author":"HY Lei","year":"2009","journal-title":"J Biomed Sci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4161\/auto.5.2.7561","article-title":"Molecular mechanisms of Polygonatum cyrtonema lectin-induced apoptosis and autophagy in cancer cells","volume":"5","author":"B Liu","year":"2009","journal-title":"Autophagy"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.biocel.2011.07.004","article-title":"Plant lectins: targeting programmed cell death pathways as antitumor agents","volume":"43","author":"LL Fu","year":"2011","journal-title":"Int J Biochem Cell Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1038\/oncsis.2012.30","article-title":"Pinellia pedatisecta agglutinin interacts with the methylosome and induces cancer cell death","volume":"1","author":"Q Lu","year":"2012","journal-title":"Oncogenesis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s12185-009-0308-3","article-title":"Mannose-exposing myeloid leukemia cells detected by the sCAR-PPA fusion protein","volume":"89","author":"GC Li","year":"2009","journal-title":"Int J Hematol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.1128\/JVI.02148-09","article-title":"Macrophage receptors for influenza A virus: role of the macrophage galactose-type lectin and mannose receptor in viral entry","volume":"84","author":"JP Upham","year":"2010","journal-title":"J Virol"},{"key":"ref25","first-page":"609","article-title":"Adenovirus targeting to c-erbB-2 oncoprotein by single-chain antibody fused to trimeric form of adenovirus receptor ectodomain","volume":"62","author":"EA Kashentseva","year":"2002","journal-title":"Cancer Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/bcr2577","article-title":"Tumour-associated carbohydrate antigens in breast cancer","volume":"12","author":"A Cazet","year":"2010","journal-title":"Breast Cancer Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2009.05.046","article-title":"CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis","volume":"138","author":"S Jaiswal","year":"2009","journal-title":"Cell"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.cell.2009.05.045","article-title":"CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells","volume":"138","author":"R Majeti","year":"2009","journal-title":"Cell"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"32384","DOI":"10.1074\/jbc.272.51.32384","article-title":"Molecular cloning, expression, and chromosomal assignment of sarcolemmal-associated proteins. A family of acidic amphipathic alpha-helical proteins associated with the membrane","volume":"272","author":"JT Wigle","year":"1997","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"38474","DOI":"10.1074\/jbc.M007682200","article-title":"Alternative splicing, expression, and genomic structure of the 3' region of the gene encoding the sarcolemmal-associated proteins (SLAPs) defines a novel class of coiled-coil tail-anchored membrane proteins","volume":"275","author":"PA Wielowieyski","year":"2000","journal-title":"J Biol Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1242\/jcs.01079","article-title":"A novel isoform of sarcolemmal membrane-associated protein (SLMAP) is a component of the microtubule organizing centre","volume":"117","author":"RM Guzzo","year":"2004","journal-title":"J Cell Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"H1138","DOI":"10.1152\/ajpheart.00872.2011","article-title":"Tail-anchored membrane protein SLMAP is a novel regulator of cardiac function at the sarcoplasmic reticulum","volume":"302","author":"M Nader","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref33","first-page":"2011","article-title":"Increased expression of the tail-anchored membrane protein SLMAP in adipose tissue from type 2 Tally Ho diabetic mice","author":"X Chen","year":"2011","journal-title":"Exp Diabetes Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1161\/CIRCEP.111.969972","article-title":"A Novel Disease Gene for Brugada Syndrome: Sarcolemmal Membrane-Associated Protein Gene Mutations Impair Intracellular Trafficking of hNav1.5","volume":"5","author":"T Ishikawa","year":"2012","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in vivo veritas","volume":"122","author":"A Sica","year":"2012","journal-title":"J Clin Invest"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/ni.1990","article-title":"IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses","volume":"12","author":"T Krausgruber","year":"2011","journal-title":"Nat Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"7565","DOI":"10.4049\/jimmunol.172.12.7565","article-title":"Enhancer-mediated control of macrophage-specific arginase I expression","volume":"172","author":"AL Pauleau","year":"2004","journal-title":"J Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1002\/eji.201040736","article-title":"Convergent pathways of macrophage polarization: The role of B cells","volume":"40","author":"A Sica","year":"2010","journal-title":"Eur J Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1126\/science.1203486","article-title":"Cancer immunoediting: integrating immunity\u2019s roles in cancer suppression and promotion","volume":"331","author":"RD Schreiber","year":"2011","journal-title":"Science"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.ccr.2011.02.006","article-title":"CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3","volume":"19","author":"J Chen","year":"2011","journal-title":"Cancer Cell"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1182\/blood-2012-04-421057","article-title":"Tumor-associated macrophages predict inferior outcomes in classic Hodgkin lymphoma: a correlative study from the E2496 Intergroup trial","volume":"120","author":"KL Tan","year":"2012","journal-title":"Blood"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0074363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:19:37Z","timestamp":1588965577000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0074363"}},"subtitle":[],"editor":[{"given":"Sophia\u00a0N","family":"Karagiannis","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,9,3]]},"references-count":41,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,9,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0074363","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,3]]}}}