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Toranzo","year":"1994","journal-title":"Anat Embryol (Berl)"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/ar.1092290204","article-title":"Heterogeneity in granulosa cells of developing rat follicles","volume":"229","author":"IM Rao","year":"1991","journal-title":"The Anatomical record"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1210\/endo-100-5-1341","article-title":"Androgen production by theca and granulosa isolated from proestrous rat follicles","volume":"100","author":"JE Fortune","year":"1977","journal-title":"Endocrinology"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1210\/endo-102-1-227","article-title":"Hormonal control of 17 beta-estradiol biosynthesis in proestrous rat follicles: estradiol production by isolated theca versus granulosa","volume":"102","author":"JE 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