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Chemically induced alterations in sexual development: The wildlife\/human connection Princeton, NJ: Princeton Scientific Publishing, p.295\u2013309."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.tiv.2013.03.003","article-title":"Effects of triclocarban on the transcription of estrogen, androgen and aryl hydrocarbon receptor responsive genes in human breast cancer cells","volume":"27(5)","author":"P Tarnow","year":"2013","journal-title":"Toxicol In Vitro"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jsbmb.2011.03.002","article-title":"Endocrine disrupting activity in fruits and vegetables evaluated with the <italic>E-screen<\/italic> assay in relation to pesticide residues","volume":"127","author":"T Schilir\u00f3","year":"2011","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s11356-009-0234-1","article-title":"Effect-related monitoring: estrogen-like substances in groundwater","volume":"17","author":"B Kuch","year":"2010","journal-title":"Environ Sci Poll Res Int"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1055\/s-2007-993760","article-title":"Estrogenic activities of isoflavones and flavones and their structure-activity relationships","volume":"74","author":"SY Choi","year":"2008","journal-title":"Planta Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1023\/A:1006422302173","article-title":"Steroid hormone activity of flavonoids and related compounds","volume":"62","author":"RS Zand","year":"2000","journal-title":"Breast Cancer Res Treat"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0027-5107(01)00073-2","article-title":"Role of plant polyphenols in genomic stability","volume":"475","author":"LR Ferguson","year":"2001","journal-title":"Mutat Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1210\/endo.139.10.6216","article-title":"Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta","volume":"139","author":"GG Kuiper","year":"1998","journal-title":"Endocrinol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.phymed.2005.06.003","article-title":"Estrogenic properties of isoflavones derived from <italic>Millettia griffoniana.<\/italic>","volume":"13","author":"GJ Wanda","year":"2006","journal-title":"Phytomed"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1016\/j.scitotenv.2010.06.049","article-title":"Performance of the flow cytometric <italic>E-screen<\/italic> assay in screening estrogenicity of pure compounds and environmental samples","volume":"408","author":"C Vanparys","year":"2010","journal-title":"Sci Total Environ"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.tiv.2009.07.032","article-title":"<italic>In vitro<\/italic> estrogenic and antiestrogenic potential of chlorostyrenes","volume":"23","author":"SM Oh","year":"2009","journal-title":"Toxicol In Vitro"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1124\/mol.112.084228","article-title":"Cooperative activation of gene expression by agonists and antagonists mediated by estrogen receptor heteroligand dimer complexes","volume":"85(5)","author":"S Liu","year":"2013","journal-title":"Mol Pharmacol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1021\/tx000208y","article-title":"Structure-activity relationships for a large diverse set of natural, synthetic, and environmental estrogens","volume":"14","author":"H Fang","year":"2001","journal-title":"Chem Res Toxicol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0039-128X(96)00242-5","article-title":"The estradiol pharmacophore: ligand structure-estrogen receptor binding affinity relationships and a model for the receptor binding site","volume":"62","author":"GM Anstead","year":"1997","journal-title":"Steroids"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.abb.2010.05.018","article-title":"Phytoestrogen consumption and association with breast, prostate and colorectal cancer in EPIC Norfolk","volume":"501","author":"HA Ward","year":"2010","journal-title":"Arch Biochem Bioph"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1089\/ars.2009.2816","article-title":"Flavonoids as protein kinase inhibitors for cancer chemoprevention: direct binding and molecular modeling","volume":"13","author":"DX Hou","year":"2010","journal-title":"Antiox Redox Signal"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0009-2797(99)00139-8","article-title":"Chemical features of flavonols affecting their genotoxicity. 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