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resistance induced by immunization with M2 encoded by a recombinant vaccinia virus","volume":"69","author":"AB Kulkarni","year":"1995","journal-title":"J Virol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jim.2007.07.011","article-title":"Detection and quantitation of eosinophils in the murine respiratory tract by flow cytometry","volume":"327","author":"WW Stevens","year":"2007","journal-title":"J Immunol Methods"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/viro.2002.1382","article-title":"RSV-induced immunopathology: dynamic interplay between the virus and host immune response","volume":"295","author":"SM Varga","year":"2002","journal-title":"Virology"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"6487","DOI":"10.4049\/jimmunol.165.11.6487","article-title":"The attachment (G) glycoprotein of respiratory syncytial virus contains a single immunodominant epitope that elicits both Th1 and Th2 CD4+ T 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I. Virus recovery and other observations during 1960 outbreak of bronchiolitis, pneumonia, and minor respiratory diseases in children","volume":"176","author":"RM Chanock","year":"1961","journal-title":"JAMA"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1128\/CMR.11.3.430","article-title":"Respiratory syncytial virus vaccines","volume":"11","author":"RA Dudas","year":"1998","journal-title":"Clin Microbiol Rev"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/00006454-199405000-00037","article-title":"Passive protection against respiratory syncytial virus disease in infants: the role of maternal antibody","volume":"13","author":"JA Englund","year":"1994","journal-title":"Pediatr Infect Dis J"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1089\/vim.2004.17.370","article-title":"Respiratory syncytial virus-induced immunoprotection and immunopathology","volume":"17","author":"JE 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