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Metabolic and Molecular Bases of Inherited Disease (OMMBID Mark II) New York: McGraw-Hill Companies, Inc."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jbspin.2007.06.006","article-title":"Gaucher disease","volume":"75","author":"P Guggenbuhl","year":"2008","journal-title":"Joint Bone Spine"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1182\/blood.V82.2.408.408","article-title":"Enzyme therapy in Gaucher disease type 1: dosage efficacy and adverse effects in 33 patients treated for 6 to 24 months","volume":"82","author":"GM Pastores","year":"1993","journal-title":"Blood"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.7326\/0003-4819-122-1-199501010-00005","article-title":"Enzyme therapy in type 1 Gaucher disease: comparative efficacy of mannose-terminated glucocerebrosidase from natural and recombinant sources","volume":"122","author":"GA Grabowski","year":"1995","journal-title":"Ann Intern Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1001\/archinte.160.18.2835","article-title":"The Gaucher registry: demographics and disease characteristics of 1698 patients with Gaucher disease","volume":"160","author":"J Charrow","year":"2000","journal-title":"Arch Intern Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0002-9343(02)01150-6","article-title":"Effectiveness of enzyme replacement therapy in 1028 patients with type 1 Gaucher disease after 2 to 5 years of treatment: a report from the Gaucher Registry","volume":"113","author":"NJ Weinreb","year":"2002","journal-title":"Am J Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e10750","DOI":"10.1371\/journal.pone.0010750","article-title":"Comparative therapeutic effects of velaglucerase alfa and imiglucerase in a Gaucher disease mouse model","volume":"5","author":"YH Xu","year":"2010","journal-title":"PLoS 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Brumshtein","year":"2010","journal-title":"Glycobiology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/sj.embor.embor873","article-title":"X-ray structure of human acid-beta-glucosidase, the defective enzyme in Gaucher disease","volume":"4","author":"H Dvir","year":"2003","journal-title":"EMBO Rep"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1101\/gr.079558.108","article-title":"RNA-seq: an assessment of technical reproducibility and comparison with gene expression arrays","volume":"18","author":"JC Marioni","year":"2008","journal-title":"Genome Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1074\/jbc.M310872200","article-title":"Activated eIF4E-binding protein slows G1 progression and blocks transformation by c-myc without inhibiting cell growth","volume":"279","author":"M Lynch","year":"2004","journal-title":"J Biol 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Pevny","year":"1995","journal-title":"Development"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1182\/blood.V91.9.3447","article-title":"Mechanisms of transcription in eosinophils: GATA-1, but not GATA-2, transactivates the promoter of the eosinophil granule major basic protein gene","volume":"91","author":"Y Yamaguchi","year":"1998","journal-title":"Blood"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1196\/annals.1329.064","article-title":"GATA-1: friends, brothers, and coworkers","volume":"1030","author":"F Morceau","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1038\/sj.onc.1205326","article-title":"Transcriptional regulation of erythropoiesis: an affair involving multiple partners","volume":"21","author":"AB 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RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors","volume":"103","author":"E van den Akker","year":"2004","journal-title":"Blood"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"5205","DOI":"10.1128\/MCB.25.12.5205-5214.2005","article-title":"The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability","volume":"25","author":"R Drissen","year":"2005","journal-title":"Mol Cell Biol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/qjmed\/90.1.19","article-title":"Pro-inflammatory cytokines and the pathogenesis of Gaucher's disease: increased release of interleukin-6 and interleukin-10","volume":"90","author":"MJ Allen","year":"1997","journal-title":"QJM"},{"key":"ref72","first-page":"205","article-title":"Cytokines in Gaucher's disease","volume":"10","author":"V Barak","year":"1999","journal-title":"Eur Cytokine Netw"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1006\/bcmd.1997.0137","article-title":"Elevated levels of M-CSF, sCD14 and IL8 in type 1 Gaucher disease","volume":"23","author":"CE Hollak","year":"1997","journal-title":"Blood Cells Mol Dis"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0925-4439(96)00056-7","article-title":"Plasma tumor necrosis factor-a (TNF-a) levels in Gaucher disease","volume":"1317","author":"H Michelakakis","year":"1996","journal-title":"Biochim Biophys Acta"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.stem.2007.07.004","article-title":"Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages","volume":"1","author":"Y Arinobu","year":"2007","journal-title":"Cell Stem 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RNA-Seq","volume":"25","author":"C Trapnell","year":"2009","journal-title":"Bioinformatics"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1093\/bioinformatics\/btr355","article-title":"Identification of novel transcripts in annotated genomes using RNA-Seq","volume":"27","author":"A Roberts","year":"2011","journal-title":"Bioinformatics"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0166-4328(01)00297-2","article-title":"Controlling the false discovery rate in behavior genetics research","volume":"125","author":"Y Benjamini","year":"2001","journal-title":"Behav Brain Res"},{"key":"ref82","doi-asserted-by":"crossref","unstructured":"Cameron AC, Trivedi PK (1998) Regression analysis of count data. Cambridge, UK; New YorkNYUSA: Cambridge University Press. xvii, 411 p.","DOI":"10.1017\/CBO9780511814365"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"W Huang da","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"W Huang da","year":"2009","journal-title":"Nat Protoc"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0074912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T22:34:01Z","timestamp":1646692441000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0074912"}},"subtitle":[],"editor":[{"given":"Israel","family":"Silman","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,10,4]]},"references-count":84,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0074912","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,4]]}}}