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Neurol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.cell.2005.10.030","article-title":"In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets","volume":"123","author":"W Zhai","year":"2005","journal-title":"Cell"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"10458","DOI":"10.1073\/pnas.0401827101","article-title":"Genome-wide analysis of repressor element 1 silencing transcription factor\/neuron-restrictive silencing factor (REST\/NRSF) target genes","volume":"101","author":"AW Bruce","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"24554","DOI":"10.1074\/jbc.M609885200","article-title":"Loss of huntingtin function complemented by small molecules acting as repressor element 1\/neuron restrictive silencer element silencer modulators","volume":"282","author":"D Rigamonti","year":"2007","journal-title":"J Biol Chem"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1097\/00004647-199709000-00003","article-title":"11C-diprenorphine binding in Huntington&apos;s disease: a comparison of region of interest analysis with statistical parametric mapping","volume":"17","author":"RA Weeks","year":"1997","journal-title":"J Cereb Blood Flow Metab"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0075099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T02:17:59Z","timestamp":1646533079000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0075099"}},"subtitle":[],"editor":[{"given":"Philipp 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