{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T18:36:35Z","timestamp":1718908595676},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T00:00:00Z","timestamp":1379635200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0075166","type":"journal-article","created":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T20:51:24Z","timestamp":1379710284000},"page":"e75166","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["T Cell and Dendritic Cell Abnormalities Synergize to Expand Pro-Inflammatory T Cell Subsets Leading to Fatal Autoimmunity in B6.NZBc1 Lupus-Prone Mice"],"prefix":"10.1371","volume":"8","author":[{"given":"Nafiseh","family":"Talaei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yui-Ho","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Landolt-Marticorena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babak","family":"Noamani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan E.","family":"Wither","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,9,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1097\/BOR.0b013e328349a255","article-title":"Effector T-cell subsets in systemic lupus erythematosus: update focusing on Th17 cells","volume":"23","author":"MS Shin","year":"2004","journal-title":"Curr Opin Rheumatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nri1714","article-title":"Follicular B helper T cells in antibody responses and autoimmunity","volume":"5","author":"CG Vinuesa","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/342929a0","article-title":"Mechanism of antigen-driven selection in germinal centres","volume":"342","author":"YJ Liu","year":"1989","journal-title":"Nature"},{"key":"ref4","first-page":"207","article-title":"T follicular helper cells during immunity and tolerance. Prog Mol Biol","volume":"92","author":"MA Linterman","year":"2010","journal-title":"Transl Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","article-title":"IL-17 and Th17 Cells","volume":"27","author":"T Korn","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"R59","DOI":"10.1186\/ar2682","article-title":"Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells","volume":"11","author":"HK Kang","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.4049\/jimmunol.0802948","article-title":"Accelerated pathological and clinical nephritis in systemic lupus erythematosus-prone New Zealand Mixed 2328 mice doubly deficient in TNF receptor 1 and TNF receptor 2 via a Th17-associated pathway","volume":"182","author":"N Jacob","year":"2009","journal-title":"J Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/ni1552","article-title":"Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice","volume":"9","author":"HC Hsu","year":"2008","journal-title":"Nat Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/gene.2010.71","article-title":"The lupus phenotype in B6.NZBc1 congenic mice reflects interactions between multiple susceptibility loci and a suppressor locus","volume":"12","author":"YH Cheung","year":"2011","journal-title":"Genes Immun"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"8154","DOI":"10.4049\/jimmunol.175.12.8154","article-title":"Functional interplay between intrinsic B and T cell defects leads to amplification of autoimmune disease in New Zealand black chromosome 1 congenic mice","volume":"175","author":"YH Cheung","year":"2005","journal-title":"J Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1084\/jem.20081886","article-title":"Follicular helper T cells are required for systemic autoimmunity","volume":"206","author":"MA Linterman","year":"2009","journal-title":"J Exp Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.clim.2011.02.005","article-title":"Abrogation of pathogenic IgG autoantibody production in CD40L gene-deleted lupus-prone New Zealand Black mice","volume":"139","author":"E Pau","year":"2011","journal-title":"Clin Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s002510000252","article-title":"Ly108: a new member of the mouse CD2 family of cell surface proteins","volume":"52","author":"SR Peck","year":"2000","journal-title":"Immunogenetics"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1126\/science.1125893","article-title":"Regulation of B cell tolerance by the lupus susceptibility gene Ly108","volume":"312","author":"KR Kumar","year":"2006","journal-title":"Science"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1084\/jem.194.3.235","article-title":"NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease","volume":"194","author":"C Bottino","year":"2001","journal-title":"J Exp Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1084\/jem.20101653","article-title":"A novel isoform of the Ly108 gene ameliorates murine lupus","volume":"208","author":"M Keszei","year":"2011","journal-title":"J Exp Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"18662","DOI":"10.1074\/jbc.M312313200","article-title":"NTB-A, a new activating receptor in T cells that regulates autoimmune disease","volume":"279","author":"PA Valdez","year":"2004","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1096\/fj.12-226951","article-title":"Expansion of an osteopontin-expressing T follicular helper cell subset correlates with autoimmunity in B6.Sle1b mice and is suppressed by the H1-isoform of the Slamf6 receptor","volume":"27","author":"M Keszei","year":"2013","journal-title":"FASEB J"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1002\/eji.200535366","article-title":"An essential role for Rxr alpha in the development of Th2 responses","volume":"35","author":"X Du","year":"2005","journal-title":"Eur J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1002\/eji.200535588","article-title":"Twisting the Th1\/Th2 immune response via the retinoid X receptor: lessons from a genetic approach","volume":"35","author":"CG Spilianakis","year":"2005","journal-title":"Eur J Immunol"},{"key":"ref21","first-page":"416910","article-title":"Regulation of FoxP3 regulatory T cells and Th17 cells by retinoids","author":"CH Kim","year":"2008"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"604","DOI":"10.4049\/jimmunol.1002362","article-title":"Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans","volume":"188","author":"CM Cuda","year":"2012","journal-title":"J Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.4049\/jimmunol.154.10.5071","article-title":"Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells","volume":"154","author":"SE Macatonia","year":"1995","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/icb.2009.64","article-title":"Early commitment of naive human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12","volume":"87","author":"CS Ma","year":"2009","journal-title":"Immunol Cell Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/eji.1830260323","article-title":"Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells","volume":"26","author":"C Heufler","year":"1996","journal-title":"Eur J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.immuni.2008.05.009","article-title":"Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2. Or 17 cell lineages","volume":"29","author":"RI Nurieva","year":"2008","journal-title":"Immunity"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e17739","DOI":"10.1371\/journal.pone.0017739","article-title":"IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation","volume":"6","author":"D Eto","year":"2011","journal-title":"PLOS ONE"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/intimm\/dxm045","article-title":"IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state","volume":"19","author":"M Nishihara","year":"2007","journal-title":"Int Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/ni1488","article-title":"IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways","volume":"8","author":"L Zhou","year":"2007","journal-title":"Nat Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature05969","article-title":"Essential autocrine regulation by IL-21 in the generation of inflammatory T cells","volume":"448","author":"R Nurieva","year":"2007","journal-title":"Nature"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nature05970","article-title":"IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells","volume":"448","author":"T Korn","year":"2007","journal-title":"Nature"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.smim.2007.10.015","article-title":"Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation","volume":"19","author":"Z Chen","year":"2007","journal-title":"Semin Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e36761","DOI":"10.1371\/journal.pone.0036761","article-title":"TLR tolerance reduces IFN-alpha production despite plasmacytoid dendritic cell expansion and anti-nuclear antibodies in NZB bicongenic mice","volume":"7","author":"E Pau","year":"2012","journal-title":"PLOS ONE"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.4049\/jimmunol.1003426","article-title":"Epistatic suppression of fatal autoimmunity in New Zealand black bicongenic mice","volume":"186","author":"C Loh","year":"2011","journal-title":"J Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1172\/JCI5827","article-title":"Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies","volume":"103","author":"C Mohan","year":"1999","journal-title":"J Clin Invest"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1073\/pnas.97.12.6670","article-title":"Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains","volume":"97","author":"L Morel","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1084\/jem.20072057","article-title":"Development and characterization of IL-21-producing CD4+ T cells","volume":"205","author":"A Suto","year":"2008","journal-title":"J Exp Med"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0075166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T18:39:02Z","timestamp":1688495942000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0075166"}},"subtitle":[],"editor":[{"given":"Ciriaco\u00a0A.","family":"Piccirillo","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,9,20]]},"references-count":37,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,9,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0075166","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,20]]}}}