{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:49:11Z","timestamp":1791942551117,"version":"4.3.4"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2013,9,23]],"date-time":"2013-09-23T00:00:00Z","timestamp":1379894400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0075188","type":"journal-article","created":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T01:20:01Z","timestamp":1379985601000},"page":"e75188","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":67,"title":["Heat Shock Protein 70 Is Associated with Replicase Complex of Japanese Encephalitis Virus and Positively Regulates Viral Genome Replication"],"prefix":"10.1371","volume":"8","author":[{"given":"Jing","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Zohaib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanchun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengbo","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,9,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/jnnp.68.4.405","article-title":"Japanese encephalitis","volume":"68","author":"T Solomon","year":"2000","journal-title":"J Neurol Neurosurg, Psychiatry"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.pneurobio.2010.01.008","article-title":"Overview: Japanese encephalitis","volume":"91","author":"UK Misra","year":"2010","journal-title":"Prog Neurobiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0042-6822(87)90144-9","article-title":"Complete nucleotide sequence of the Japanese encephalitis virus genome RNA","volume":"161","author":"H Sumiyoshi","year":"1987","journal-title":"Virology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.antiviral.2009.11.009","article-title":"Structure and functionality in flavivirus NS-proteins: perspectives for drug design","volume":"87","author":"M Bollati","year":"2010","journal-title":"Antiviral Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0065-3527(09)74002-3","article-title":"New insights into flavivirus nonstructural protein 5","volume":"74","author":"AD Davidson","year":"2009","journal-title":"Adv Virus Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1128\/JVI.01982-05","article-title":"Nuclear localization of flavivirus RNA synthesis in infected cells","volume":"80","author":"PD Uchil","year":"2006","journal-title":"J Virol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"9285","DOI":"10.1128\/JVI.78.17.9285-9294.2004","article-title":"Blocking of the alpha interferon-induced Jak-Stat signaling pathway by Japanese encephalitis virus infection","volume":"78","author":"RJ Lin","year":"2004","journal-title":"J Virol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5908","DOI":"10.1128\/JVI.02714-05","article-title":"Blocking of interferon-induced Jak-Stat signaling by Japanese encephalitis virus NS5 through a protein tyrosine phosphatase-mediated mechanism","volume":"80","author":"RJ Lin","year":"2006","journal-title":"J Virol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.antiviral.2010.04.014","article-title":"Role of host cell factors in flavivirus infection: Implications for pathogenesis and development of antiviral drugs","volume":"87","author":"B Pastorino","year":"2010","journal-title":"Antiviral Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"36757","DOI":"10.1074\/jbc.274.51.36757","article-title":"Heat shock protein (Hsp) 40 mutants inhibit Hsp70 in mammalian cells","volume":"274","author":"AA Michels","year":"1999","journal-title":"J Biol Chem"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0092-8674(00)80830-2","article-title":"Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine","volume":"101","author":"C Scheufler","year":"2000","journal-title":"Cell"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/s00018-004-4464-6","article-title":"Hsp70 chaperones: cellular functions and molecular mechanism","volume":"62","author":"MP Mayer","year":"2005","journal-title":"Cell Mol Life Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.tibs.2003.08.009","article-title":"More than folding: localized functions of cytosolic chaperones","volume":"28","author":"JC Young","year":"2003","journal-title":"Trends Biochem Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1177\/153537020322800201","article-title":"Regulation of signaling protein function and trafficking by the hsp90\/hsp70-based chaperone machinery","volume":"228","author":"WB Pratt","year":"2003","journal-title":"Exp Biol Med (Maywood)"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"9697","DOI":"10.1128\/JVI.78.18.9697-9704.2004","article-title":"Heat shock protein 70 protects cells from cell cycle arrest and apoptosis induced by human immunodeficiency virus type 1 viral protein R","volume":"78","author":"S Iordanskiy","year":"2004","journal-title":"J Virol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"11031","DOI":"10.1128\/JVI.01438-06","article-title":"hsp72, a host determinant of measles virus neurovirulence","volume":"80","author":"T Carsillo","year":"2006","journal-title":"J Virol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"19956","DOI":"10.1073\/pnas.0810851105","article-title":"In vitro assembly of the Tomato bushy stunt virus replicase requires the host Heat shock protein 70","volume":"105","author":"J Pogany","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1128\/JVI.01336-06","article-title":"Hsp70 negatively controls rotavirus protein bioavailability in caco-2 cells infected by the rotavirus RF strain","volume":"81","author":"AH Broquet","year":"2007","journal-title":"J Virol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1128\/JVI.78.3.1263-1270.2004","article-title":"Heat shock protein 70 is related to thermal inhibition of nuclear export of the influenza virus ribonucleoprotein complex","volume":"78","author":"E Hirayama","year":"2004","journal-title":"J Virol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e16546","DOI":"10.1371\/journal.pone.0016546","article-title":"Heat shock protein 70 inhibits the activity of Influenza A virus ribonucleoprotein and blocks the replication of virus in vitro and in vivo","volume":"6","author":"G Li","year":"2011","journal-title":"PLOS ONE"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1128\/JVI.79.8.4557-4567.2005","article-title":"Heat shock protein 90 and heat shock protein 70 are components of dengue virus receptor complex in human cells","volume":"79","author":"J Reyes-Del Valle","year":"2005","journal-title":"J Virol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10254-004-0025-5","article-title":"Recruitment of Hsp70 chaperones: a crucial part of viral survival strategies","volume":"153","author":"MP Mayer","year":"2005","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.virol.2008.10.025","article-title":"Heat shock protein 70 on Neuro2a cells is a putative receptor for Japanese encephalitis virus","volume":"385","author":"S Das","year":"2009","journal-title":"Virology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1099\/vir.0.034637-0","article-title":"Association of heat-shock protein 70 with lipid rafts is required for Japanese encephalitis virus infection in Huh7 cells","volume":"93","author":"YZ Zhu","year":"2012","journal-title":"J Gen Virol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1089\/hyb.2011.0107","article-title":"Monoclonal antibodies against NS3 and NS5 proteins of Japanese encephalitis virus","volume":"31","author":"Z Chen","year":"2012","journal-title":"Hybridoma (Larchmt)"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"10976","DOI":"10.1128\/JVI.00846-11","article-title":"Heterogeneous nuclear ribonucleoprotein A2 participates in the replication of Japanese encephalitis virus through an interaction with viral proteins and RNA","volume":"85","author":"H Katoh","year":"2011","journal-title":"J Virol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1186\/1743-422X-8-471","article-title":"DnaJ homolog Hdj2 facilitates Japanese encephalitis virus replication","volume":"8","author":"RY Wang","year":"2011","journal-title":"Virol J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.copbio.2008.06.002","article-title":"Mapping multiprotein complexes by affinity purification and mass spectrometry","volume":"19","author":"MO Collins","year":"2008","journal-title":"Curr Opin Biotechnol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(03)01357-7","article-title":"Recent developments in the analysis of protein complexes","volume":"556","author":"A Dziembowski","year":"2004","journal-title":"FEBS Lett"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"6433","DOI":"10.1128\/JVI.71.9.6433-6444.1997","article-title":"Translation elongation factor-1 alpha interacts with the 3' stem-loop region of West Nile virus genomic RNA","volume":"71","author":"JL Blackwell","year":"1997","journal-title":"J Virol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"10172","DOI":"10.1128\/JVI.00531-07","article-title":"Interaction between the cellular protein eEF1A and the 3'-terminal stem-loop of West Nile virus genomic RNA facilitates viral minus-strand RNA synthesis","volume":"81","author":"WG Davis","year":"2007","journal-title":"J Virol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"27004","DOI":"10.1016\/S0021-9258(18)47118-9","article-title":"Interaction of poliovirus polypeptide 3CDpro with the 5' and 3' termini of the poliovirus genome. Identification of viral and cellular cofactors needed for efficient binding","volume":"269","author":"KS Harris","year":"1994","journal-title":"J Biol Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.virol.2003.10.028","article-title":"eEF1A binding to aminoacylated viral RNA represses minus strand synthesis by TYMV RNA-dependent RNA polymerase","volume":"321","author":"D Matsuda","year":"2004","journal-title":"Virology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"5952","DOI":"10.1073\/pnas.0401449101","article-title":"Two RNA polymerase complexes from vesicular stomatitis virus-infected cells that carry out transcription and replication of genome RNA","volume":"101","author":"KR Qanungo","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1134\/S0006297907130032","article-title":"Nucleocytoplasmic transport of proteins","volume":"72","author":"AV Sorokin","year":"2007","journal-title":"Biochemistry (Mosc)"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nrm2114","article-title":"Molecular mechanism of the nuclear protein import cycle","volume":"8","author":"M Stewart","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"19100","DOI":"10.1074\/jbc.270.32.19100","article-title":"Association between NS3 and NS5 proteins of dengue virus type 2 in the putative RNA replicase is linked to differential phosphorylation of NS5","volume":"270","author":"M Kapoor","year":"1995","journal-title":"J Biol Chem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1089\/vim.2010.0052","article-title":"Dengue virus infection activates cellular chaperone Hsp70 in THP-1 cells: downregulation of Hsp70 by siRNA revealed decreased viral replication","volume":"23","author":"YS Padwad","year":"2010","journal-title":"Viral Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"28183","DOI":"10.1074\/jbc.M110.118323","article-title":"Heat shock protein 72 is associated with the hepatitis C virus replicase complex and enhances viral RNA replication","volume":"285","author":"YJ Chen","year":"2010","journal-title":"J Biol Chem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1128\/JVI.76.9.4162-4171.2002","article-title":"Japanese encephalitis virus infection initiates endoplasmic reticulum stress and an unfolded protein response","volume":"76","author":"HL Su","year":"2002","journal-title":"J Virol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"10849","DOI":"10.1128\/JVI.01151-07","article-title":"West Nile virus infection activates the unfolded protein response, leading to CHOP induction and apoptosis","volume":"81","author":"GR Medigeshi","year":"2007","journal-title":"J Virol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.virol.2010.10.010","article-title":"Dengue infection of monocytic cells activates ER stress pathways, but apoptosis is induced through both extrinsic and intrinsic pathways","volume":"409","author":"P Klomporn","year":"2011","journal-title":"Virology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1743-422X-8-128","article-title":"Japanese encephalitis virus co-opts the ER-stress response protein GRP78 for viral infectivity","volume":"8","author":"YP Wu","year":"2011","journal-title":"Virol J"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1128\/JVI.06501-11","article-title":"Hsp70 protein positively regulates rabies virus infection","volume":"86","author":"X Lahaye","year":"2012","journal-title":"J Virol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1128\/MCB.19.3.2069","article-title":"In vivo chaperone activity of heat shock protein 70 and thermotolerance","volume":"19","author":"EA Nollen","year":"1999","journal-title":"Mol Cell Biol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0075188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T19:52:00Z","timestamp":1646596320000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0075188"}},"subtitle":[],"editor":[{"given":"A.L.N.","family":"Rao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,9,23]]},"references-count":45,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,9,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0075188","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,23]]}}}