{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T05:52:08Z","timestamp":1783662728004,"version":"3.55.0"},"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T00:00:00Z","timestamp":1379635200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0075312","type":"journal-article","created":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T20:51:44Z","timestamp":1379710304000},"page":"e75312","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":51,"title":["4-Ethylphenyl-Cobalamin Impairs Tissue Uptake of Vitamin B12 and Causes Vitamin B12 Deficiency in Mice"],"prefix":"10.1371","volume":"8","author":[{"given":"Elena","family":"Mutti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Ruetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Birn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Kr\u00e4utler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebba","family":"Nexo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,9,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1074-5521(97)90286-6","article-title":"The Yin-Yang of cobalamin biochemistry","volume":"4","author":"R Banerjee","year":"1997","journal-title":"Chem Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1039\/c1cs15118e","article-title":"Vitamin B<sub>12<\/sub>-derivates \u2013 enzyme cofactors and ligands of proteins and nucleic acids","volume":"40","author":"K Gruber","year":"2011","journal-title":"Chem Soc Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/jnen\/60.2.109","article-title":"Subacute combined degeneration one century later. The neurotrophic action of cobalamin (vitamin B<sub>12<\/sub>) revisited","volume":"60","author":"G Scalabrino","year":"2001","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1002\/anie.201209651","article-title":"Access to Organometallic Arylcobaltcorrins through Radical Synthesis: 4-Ethylphenylcobalamin, a Potential &quot;Antivitamin B<sub>12<\/sub>&quot;","volume":"52","author":"M Ruetz","year":"2013","journal-title":"Angew Chem Int Ed Engl"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e20638","DOI":"10.1371\/journal.pone.0020638","article-title":"Mouse transcobalamin has features resembling both human transcobalamin and haptocorrin","volume":"6","author":"K Hygum","year":"2011","journal-title":"PLOS ONE"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1432-1033.1991.tb16124.x","article-title":"Effect of the cobalt-N coordination on the cobamide recognition by the human vitamin B12 binding proteins intrinsic factor, transcobalamin and haptocorrin","volume":"199","author":"E Stupperich","year":"1991","journal-title":"Eur J Biochem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e46657","DOI":"10.1371\/journal.pone.0046657","article-title":"Changes in Vitamin B12 related parameters in mice treated for four weeks with high dose vitamin B12 or cobinamide","volume":"7","author":"DL Lildballe","year":"2012","journal-title":"PLOS ONE"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1373\/clinchem.2007.101253","article-title":"Quantification of methylmalonic acid in human plasma with hydrophilic interaction liquid chromatography separation and mass spectrometric detection","volume":"54","author":"HA Lakso","year":"2008","journal-title":"Clin Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1056\/NEJM197810122991501","article-title":"Cobalamin analogues are present in human plasma and can mask cobalamin deficiency because current radioisotope dilution assays are not specific for true cobalamin","volume":"299","author":"JF Kolhouse","year":"1978","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1373\/clinchem.2008.114132","article-title":"A new principle for measurement of cobalamin and corrinoids, used for studies of cobalamin analogs on serum haptocorrin","volume":"55","author":"TF Hardlei","year":"2009","journal-title":"Clin Chem"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1093\/ndt\/gfg089","article-title":"Diversity in rat tissue accumulation of vitamin B<sub>12<\/sub> supports a distinct role for the kidney in vitamin B12 homeostasis","volume":"18","author":"H Birn","year":"2003","journal-title":"Nephrol Dial Transplant"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2013.01.050","article-title":"Vitamin B<sub>12<\/sub> dependent changes in mouse spinal cord expression of vitamin B12 related proteins and the epidermal growth factor system","volume":"1503","author":"E Mutti","year":"2013","journal-title":"Brain Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1158\/0008-5472.CAN-07-6771","article-title":"New derivatives of vitamin B12 show preferential targeting of tumors","volume":"68","author":"R Waibel","year":"2008","journal-title":"Cancer Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jconrel.2007.05.019","article-title":"Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles","volume":"122","author":"KB Chalasani","year":"2007","journal-title":"J Control Release"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"F22","DOI":"10.1152\/ajprenal.00385.2005","article-title":"The kidney in vitamin B12 and folate homeostasis: characterization of receptors for tubular uptake of vitamins and carrier proteins","volume":"291","author":"H Birn","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.biochi.2012.11.004","article-title":"Vitamin B12 absorption: Mammalian physiology and acquired and inherited disorders","volume":"95","author":"R Kozyraki","year":"2013","journal-title":"Biochimie"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1006\/exnr.1996.6376","article-title":"Enhanced levels of biochemical markers for cobalamin deficiency in totally gastrectomized rats: uncoupling of the enhancement from the severity of spongy vacuolation in spinal cord","volume":"144","author":"G Scalabrino","year":"1997","journal-title":"Exp Neurol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.brainres.2007.04.055","article-title":"Cobalamin deficiency-induced down-regulation of p75-immunoreactive cell levels in rat central nervous system","volume":"1157","author":"E Mutti","year":"2007","journal-title":"Brain Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e40609","DOI":"10.1371\/journal.pone.0040609","article-title":"Mouse models for methylmalonic aciduria","volume":"7","author":"HL Peters","year":"2012","journal-title":"PLOS ONE"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0075312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T07:01:44Z","timestamp":1540278104000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0075312"}},"subtitle":[],"editor":[{"given":"Joseph\u00a0Alan","family":"Bauer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Victoria","family":"Lawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,9,20]]},"references-count":19,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,9,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0075312","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,20]]}}}