{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:33:14Z","timestamp":1790713994838,"version":"4.1.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T00:00:00Z","timestamp":1381190400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0075709","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T21:34:46Z","timestamp":1381268086000},"page":"e75709","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Androgen Receptor CAG Repeats Length Polymorphism and the Risk of Polycystic Ovarian Syndrome (PCOS)"],"prefix":"10.1371","volume":"8","author":[{"given":"Singh","family":"Rajender","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silas Justin","family":"Carlus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep Kumar","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahendra Pratap Singh","family":"Negi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmala","family":"Sadasivam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthusamy Narayanan","family":"Sadasivam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumarasamy","family":"Thangaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,10,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","year":"2004","journal-title":"Fertil Steril"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/GRF.0b013e31802f351b","article-title":"Diagnosis of polycystic ovary syndrome","volume":"50","author":"B Trivax","year":"2007","journal-title":"Clin Obstet Gynecol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1210\/jc.2006-0178","article-title":"Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline","volume":"91","author":"R Azziz","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1093\/nar\/22.15.3181","article-title":"The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function","volume":"22","author":"NL Chamberlain","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1745-7262.2007.00250.x","article-title":"Phenotypic heterogeneity of mutations in androgen receptor gene","volume":"9","author":"S Rajender","year":"2007","journal-title":"Asian J Androl"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1210\/jc.2002-021791","article-title":"Androgen receptor gene CAG repeat polymorphism in the development of ovarian hyperandrogenism","volume":"88","author":"L Ib\u00e1\u00f1ez","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1210\/jcem.85.9.6832","article-title":"Androgen receptor gene CAG trinucleotide repeats in anovulatory infertility and polycystic ovaries","volume":"85","author":"A Mifsud","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1210\/jcem.87.1.8137","article-title":"The androgen receptor CAG repeat polymorphism and X-chromosome inactivation in Australian Caucasian women with infertility related to polycystic ovary syndrome","volume":"87","author":"T Hickey","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1210\/jc.2008-0038","article-title":"Association of androgen receptor CAG repeat polymorphism and polycystic ovary syndrome","volume":"93","author":"NA Shah","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/humrep\/dem382","article-title":"The role of sex hormone-binding globulin and androgen receptor gene variants in the development of polycystic ovary syndrome","volume":"23","author":"N Xita","year":"2008","journal-title":"Hum Reprod"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/BF03346648","article-title":"The relationship between CAG repeat length polymorphism and infertility in Southern Chinese Han women","volume":"33","author":"D Tong","year":"2010","journal-title":"J Endocrinol Invest"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.fertnstert.2004.11.080","article-title":"Androgen receptor gene CAG length polymorphism in women with polycystic ovary syndrome","volume":"83","author":"J J\u00e4\u00e4skel\u00e4inen","year":"2005","journal-title":"Fertil Steril"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.fertnstert.2007.07.1291","article-title":"Androgen receptor gene (CAG)n polymorphism in patients with polycystic ovary syndrome","volume":"90","author":"P Ferk","year":"2008","journal-title":"Fertil Steril"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1016\/j.fertnstert.2007.10.030","article-title":"Androgen receptor gene CAG repeat polymorphism in women with polycystic ovary syndrome","volume":"90","author":"JJ Kim","year":"2008","journal-title":"Fertil Steril"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s12020-008-9069-7","article-title":"Androgen receptor gene CAG(n) trinucleotide repeats polymorphism in Chinese women with polycystic ovary syndrome","volume":"33","author":"Q Liu","year":"2008","journal-title":"Endocrine"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e12401","DOI":"10.1371\/journal.pone.0012401","article-title":"Androgen receptor CAG repeat polymorphism and epigenetic influence among the south Indian women with Polycystic Ovary Syndrome","volume":"5","author":"S Dasgupta","year":"2010","journal-title":"PLoS One"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/j.1939-4640.2002.tb02338.x","article-title":"CAG repeat expansion in the androgen receptor gene is not associated with male infertility in Indian populations","volume":"23","author":"K Thangaraj","year":"2002","journal-title":"J Androl"},{"key":"ref18","first-page":"498","article-title":"CAG repeat alleles of the androgen receptor are associated with polycystic ovary syndrome (PCOS) in the Romanian population","volume":"22","author":"S Radian","year":"2010","journal-title":"Endocrine Abstracts"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"JP Higgins","year":"2002","journal-title":"Stat Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"R DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1002\/sim.1091","article-title":"Approaches to heterogeneity in meta-analysis","volume":"20","author":"DB Petitti","year":"2001","journal-title":"Stat Med"},{"key":"ref22","first-page":"1330","article-title":"Polymorphic CAG repeat in the androgen receptor gene in polycystic ovary syndrome patients","volume":"5","author":"Y Xia","year":"2012","journal-title":"Mol Med Report"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1530\/eje.1.02195","article-title":"The androgen receptor CAG repeat modifies the impact of testosterone on insulin resistance in women with polycystic ovary syndrome","volume":"155","author":"M M\u00f6hlig","year":"2006","journal-title":"Eur J Endocrinol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.3109\/00016349.2010.526182","article-title":"Androgen receptor epigenetic variations influence early follicular phase gonadotropin levels","volume":"89","author":"T Laisk","year":"2010","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1055\/s-0031-1291343","article-title":"Role of the CAG repeat polymorphism of the androgen receptor gene in polycystic ovary syndrome (PCOS)","volume":"120","author":"AN Sch\u00fcring","year":"2012","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1080\/09513590802342841","article-title":"Shorter CAG repeats in the androgen receptor gene may enhance hyperandrogenicity in polycystic ovary syndrome","volume":"24","author":"F Van Nieuwerburgh","year":"2008","journal-title":"Gynecol Endocrinol"},{"key":"ref27","first-page":"459","article-title":"CAG repeat polymorphism in women with PCOS and healthy controls","volume":"22","author":"R Robeva","year":"2010","journal-title":"Endocrine Abstracts"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jsbmb.2011.11.006","article-title":"CAG repeat polymorphism in androgen receptor gene is not directly associated with polycystic ovary syndrome but influences serum testosterone levels","volume":"128","author":"L Skrgatic","year":"2012","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"317241","DOI":"10.1155\/2012\/317241","article-title":"Obesity differentially affects phenotypes of polycystic ovary syndrome","volume":"2012","author":"C Moran","year":"2012","journal-title":"Int J Endocrinol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/molehr\/gap097","article-title":"CAG repeat number is not inversely associated with androgen receptor activity in vitro","volume":"16","author":"H Nenonen","year":"2010","journal-title":"Mol Hum Reprod"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1365-2605.2010.01084.x","article-title":"Non-linear association between androgen receptor CAG repeat length and risk of male subfertility\u2013a meta-analysis","volume":"34","author":"HA Nenonen","year":"2011","journal-title":"Int J Androl"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1093\/molehr\/gas024","article-title":"Negative association between androgen receptor gene CAG repeat polymorphism and polycystic ovary syndrome? A systematic review and meta-analysis","volume":"18","author":"R Wang","year":"2012","journal-title":"Mol Hum Reprod"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.gene.2013.04.040","article-title":"Association of the CAG repeat polymorphisms in androgen receptor gene with polycystic ovary syndrome: a systemic review and meta-analysis","volume":"524","author":"T Zhang","year":"2013","journal-title":"Gene"}],"updated-by":[{"DOI":"10.1371\/annotation\/39f987f3-76a0-44c6-82bf-fcba435414e0","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T00:00:00Z","timestamp":1387411200000}},{"DOI":"10.1371\/annotation\/61e2a995-4084-465a-9e4e-0b71d02f8f31","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T00:00:00Z","timestamp":1384473600000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0075709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T15:01:07Z","timestamp":1716044467000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0075709"}},"subtitle":[],"editor":[{"given":"Wei","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,10,8]]},"references-count":33,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0075709","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,8]]}}}