{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:31:51Z","timestamp":1773660711263,"version":"3.50.1"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T00:00:00Z","timestamp":1380067200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0075871","type":"journal-article","created":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T22:37:01Z","timestamp":1380148621000},"page":"e75871","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Broken MLL Gene Is Frequently Located Outside the Inherent Chromosome Territory in Human Lymphoid Cells Treated with DNA Topoisomerase II Poison Etoposide"],"prefix":"10.1371","volume":"8","author":[{"given":"Sergey I.","family":"Glukhov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail A.","family":"Rubtsov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniil A.","family":"Alexeyevsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei V.","family":"Alexeevski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey V.","family":"Razin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga V.","family":"Iarovaia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,9,25]]},"reference":[{"key":"ref1","first-page":"139","article-title":"Chromosomal translocations in cancer","volume":"1786","author":"M Nambiar","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s11684-012-0215-5","article-title":"Mechanisms and impacts of chromosomal translocations in cancers","volume":"6","author":"JH Wang","year":"2012","journal-title":"Front Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00018-002-8429-3","article-title":"Double-strand breaks and translocations in cancer","volume":"59","author":"B Elliott","year":"2002","journal-title":"Cell Mol Life Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.dnarep.2006.05.029","article-title":"DNA double-strand break repair and chromosome translocations","volume":"5","author":"S Agarwal","year":"2006","journal-title":"DNA Repair (Amst)"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/978-90-481-3471-7_14","article-title":"Nonhomologous DNA end joining (NHEJ) and chromosomal translocations in humans","volume":"50","author":"MR Lieber","year":"2010","journal-title":"Subcell Biochem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0079-6603(00)64006-0","article-title":"Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice","volume":"64","author":"JM Fortune","year":"2000","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2174\/1568011054222364","article-title":"Etoposide, topoisomerase II and cancer","volume":"5","author":"EL Baldwin","year":"2005","journal-title":"Curr Med Chem Anti Cancer Agents"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.2174\/092986710793361252","article-title":"Recent advances in the development of dual topoisomerase I and II inhibitors as anticancer drugs","volume":"17","author":"S Salerno","year":"2010","journal-title":"Curr Med Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"758","DOI":"10.2174\/156800910793605785","article-title":"DNA topoisomerase II enzymes as molecular targets for cancer chemotherapy","volume":"10","author":"K Chikamori","year":"2010","journal-title":"Curr Cancer Drug Targets"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nrc2607","article-title":"Targeting DNA topoisomerase II in cancer chemotherapy","volume":"9","author":"JL Nitiss","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2174\/1568026033452519","article-title":"Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes","volume":"3","author":"AM Wilstermann","year":"2003","journal-title":"Curr Top Med Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mrfmmm.2007.06.009","article-title":"DNA topoisomerase II, genotoxicity, and cancer","volume":"623","author":"AK McClendon","year":"2007","journal-title":"Mutat Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/mutage\/gep035","article-title":"Type II topoisomerases--inhibitors, repair mechanisms and mutations","volume":"24","author":"P Heisig","year":"2009","journal-title":"Mutagenesis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e12541","DOI":"10.1371\/journal.pone.0012541","article-title":"Topoisomerase II-mediated DNA damage is differently repaired during the cell cycle by non-homologous end joining and homologous recombination","volume":"5","author":"M de Campos-Nebel","year":"2010","journal-title":"PLOS ONE"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/oxfordjournals.annonc.a058121","article-title":"Therapy-related acute myeloid leukemia secondary to inhibitors of topoisomerase II: from the bedside to the target genes","volume":"3","author":"MJ Ratain","year":"1992","journal-title":"Ann Oncol"},{"key":"ref16","first-page":"535","article-title":"All patients with the T(11; 16)(q23;p13.3) that involves MLL and CBP have treatment-related hematologic disorders","volume":"90","author":"JD Rowley","year":"1997","journal-title":"Blood"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1182\/blood.V82.12.3705.3705","article-title":"Rearrangements of MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA-topoisomeraseII","volume":"82","author":"HJ Super","year":"1993","journal-title":"Blood"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0167-4781(98)00139-0","article-title":"Secondary leukemias induced by topoisomerase-targeted drugs","volume":"1400","author":"CA Felix","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.dnarep.2006.05.031","article-title":"Topoisomerase II and the etiology of chromosomal translocations","volume":"5","author":"CA Felix","year":"2006","journal-title":"DNA Repair (Amst)"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"11014","DOI":"10.1073\/pnas.0704002104","article-title":"Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies","volume":"104","author":"AM Azarova","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s12094-010-0460-5","article-title":"Molecular biology of therapy-related leukaemias","volume":"12","author":"M Joannides","year":"2010","journal-title":"Clin Transl Oncol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/B978-0-12-394280-7.00015-4","article-title":"Molecular logic underlying chromosomal translocations, random or non-random?","volume":"113","author":"C Lin","year":"2012","journal-title":"Adv Cancer Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.4161\/cbt.8.13.8924","article-title":"MLL fusions: pathways to leukemia","volume":"8","author":"H Liu","year":"2009","journal-title":"Cancer Biol Ther"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1615\/CritRevEukaryotGeneExpr.v14.i12.40","article-title":"Breakpoint clusters: reason or consequence?","volume":"14","author":"AA Bystritskiy","year":"2004","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"10024","DOI":"10.1158\/0008-5472.CAN-08-2208","article-title":"Chromosomal rearrangements leading to MLL gene fusions: clinical and biological aspects","volume":"68","author":"DP Harper","year":"2008","journal-title":"Cancer Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/(SICI)1098-2264(199710)20:2<185::AID-GCC9>3.0.CO;2-#","article-title":"Identification of complex genomic breakpoint junctions in the t(9;11) MLL-AF9 fusion gene in acute leukemia","volume":"20","author":"HG Super","year":"1997","journal-title":"Genes Chromosomes Cancer"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1073\/pnas.042702899","article-title":"Genomic DNA breakpoints in AML1\/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia","volume":"99","author":"Y Zhang","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nrg2041","article-title":"Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions","volume":"8","author":"C Lanct\u00f4t","year":"2007","journal-title":"Nat Rev Genet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1101\/SQB.1993.058.01.085","article-title":"Role of chromosome territories in the functional compartmentalization of the cell nucleus","volume":"58","author":"T Cremer","year":"1993","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/35066075","article-title":"Chromosome territories, nuclear architecture and gene regulation in mammalian cells","volume":"2","author":"T Cremer","year":"2001","journal-title":"Nat Rev Genet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1083\/jcb.200111071","article-title":"Spatial organization of active and inactive genes and noncoding DNA within chromosome territories","volume":"157","author":"NL Mahy","year":"2002","journal-title":"J Cell Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e192","DOI":"10.1371\/journal.pbio.0050192","article-title":"Myc dynamically and preferentially relocates to a transcription factory occupied by Igh","volume":"5","author":"CS Osborne","year":"2007","journal-title":"PLOS Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"8989","DOI":"10.1073\/pnas.1204406109","article-title":"Model for MLL translocations in therapy-related leukemia involving topoisomerase IIbeta-mediated DNA strand breaks and gene proximity","volume":"109","author":"IG Cowell","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1242\/jcs.089847","article-title":"Chromatin mobility is increased at sites of DNA double-strand breaks","volume":"125","author":"PM Krawczyk","year":"2012","journal-title":"J Cell Sci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/jcb.21656","article-title":"Repositioning of ETO gene in cells treated with VP-16, an inhibitor of DNA-Topoisomerase II","volume":"104","author":"MA Rubtsov","year":"2008","journal-title":"J Cell Biochem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"398","DOI":"10.7124\/bc.00012D","article-title":"Treatment of lymphoid cells with the topoisomerase II poison etoposide leads to an increased juxtaposition of AML1 and ETO genes on the surface of nucleoli","volume":"27","author":"MA Rubtsov","year":"2011","journal-title":"Biopolymers Cell"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1126\/science.290.5489.62","article-title":"Cancer. Proximity matters","volume":"290","author":"JR Savage","year":"2000","journal-title":"Science"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1126\/science.290.5489.138","article-title":"Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells","volume":"290","author":"MN Nikiforova","year":"2000","journal-title":"Science"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1126\/science.1088845","article-title":"Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains","volume":"303","author":"JA Aten","year":"2004","journal-title":"Science"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1126\/science.280.5363.590","article-title":"In situ visualization of DNA double-strand break repair in human fibroblasts","volume":"280","author":"BE Nelms","year":"1998","journal-title":"Science"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/ncb1591","article-title":"Positional stability of single double-strand breaks in mammalian cells","volume":"9","author":"E Soutoglou","year":"2007","journal-title":"Nat Cell Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1083\/jcb.200510015","article-title":"Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks","volume":"172","author":"MJ Kruhlak","year":"2006","journal-title":"J Cell Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1073\/pnas.0810987106","article-title":"Live cell microscopy analysis of radiation-induced DNA double-strand break motion","volume":"106","author":"B Jakob","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1093\/bioinformatics\/btq013","article-title":"NEMO: a tool for analyzing gene and chromosome territory distributions from 3D-FISH experiments","volume":"26","author":"E Iannuccelli","year":"2010","journal-title":"Bioinformatics"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0075871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T21:36:03Z","timestamp":1596576963000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0075871"}},"subtitle":[],"editor":[{"given":"Svetlana","family":"Pack","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,9,25]]},"references-count":44,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,9,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0075871","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,25]]}}}