{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:56:15Z","timestamp":1754488575335},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T00:00:00Z","timestamp":1380067200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0076329","type":"journal-article","created":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T18:37:11Z","timestamp":1380134231000},"page":"e76329","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Stem Cell-Like Dog Placenta Cells Afford Neuroprotection against Ischemic Stroke Model via Heat Shock Protein Upregulation"],"prefix":"10.1371","volume":"8","author":[{"given":"SeongJin","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Tajiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Franzese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Franzblau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EunKyung","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Platt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar V.","family":"Borlongan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,9,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.tvjl.2012.10.018","article-title":"Survival and clinical outcome of dogs with ischaemic stroke","volume":"196","author":"H Gredal","year":"2013","journal-title":"Vet J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"821","DOI":"10.2174\/1566524011313050013","article-title":"The multiple aspects of stroke and stem cell therapy","volume":"13","author":"B Onteniente","year":"2013","journal-title":"Curr Mol Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1179\/1743132813Y.0000000210","article-title":"Therapeutic applications of bone marrow-derived stem cells in ischemic stroke","volume":"35","author":"L Wang","year":"2013","journal-title":"Neurol Res"},{"key":"ref4","first-page":"S139","article-title":"Stem cell therapy in stroke: a review literature","volume":"4","author":"R Meamar","year":"2013","journal-title":"Int J Prev Med"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Rosado-de-Castro PH, Pimentel-Coelho PM, Barbosa da Fonseca LM, de Freitas GR, Mendez-Otero R (2013) The Rise of Cell Therapy Trials for Stroke: Review of Published and Registered Studies. Stem Cells Dev.","DOI":"10.1089\/scd.2013.0089"},{"key":"ref6","first-page":"291","article-title":"Collection, isolation and characterization of the stem cells of umbilical cord blood","volume":"54","author":"T Revencu","year":"2013","journal-title":"Rom J Morphol Embryol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e64752","DOI":"10.1371\/journal.pone.0064752","article-title":"Awakened by cellular stress: isolation and characterization of a novel population of pluripotent stem cells derived from human adipose tissue","volume":"8","author":"S Heneidi","year":"2013","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.cellbio.19.111301.143037","article-title":"Adult stem cell plasticity: fact or artifact?","volume":"19","author":"M Raff","year":"2003","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1177\/1933719108327621","article-title":"A new role for the human placenta as a hematopoietic site throughout gestation","volume":"16","author":"A Barcena","year":"2009","journal-title":"Reprod Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.placenta.2008.09.009","article-title":"Human fetal membranes: a source of stem cells for tissue regeneration and repair?","volume":"30","author":"S Ilancheran","year":"2009","journal-title":"Placenta"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1089\/scd.2007.0154","article-title":"Comparison of human placenta- and bone marrow-derived multipotent mesenchymal stem cells","volume":"17","author":"S Barlow","year":"2008","journal-title":"Stem Cells Dev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1634\/stemcells.2007-0439","article-title":"Wharton&apos;s jelly-derived cells are a primitive stromal cell population","volume":"26","author":"DL Troyer","year":"2008","journal-title":"Stem Cells"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1097\/01.TP.0000144606.84234.49","article-title":"Engraftment potential of human amnion and chorion cells derived from term placenta","volume":"78","author":"M Bailo","year":"2004","journal-title":"Transplantation"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1634\/stemcells.2007-0594","article-title":"Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells","volume":"26","author":"O Parolini","year":"2008","journal-title":"Stem Cells"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1634\/stemcells.2004-0098","article-title":"Isolation of multipotent cells from human term placenta","volume":"23","author":"BL Yen","year":"2005","journal-title":"Stem Cells"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1634\/stemcells.2004-0357","article-title":"Stem cell characteristics of amniotic epithelial cells","volume":"23","author":"T Miki","year":"2005","journal-title":"Stem Cells"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1182\/blood-2003-04-1291","article-title":"Amniotic fluid as a novel source of mesenchymal stem cells for therapeutic transplantation","volume":"102","author":"PS In 't Anker","year":"2003","journal-title":"Blood"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1634\/stemcells.21-1-105","article-title":"Searching for alternative sources of postnatal human mesenchymal stem cells: candidate MSC-like cells from umbilical cord","volume":"21","author":"YA Romanov","year":"2003","journal-title":"Stem Cells"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s10517-012-1890-6","article-title":"Intravenous xenotransplantation of human placental mesenchymal stem cells to rats: comparative analysis of homing in rat brain in two models of experimental ischemic stroke","volume":"154","author":"IV Kholodenko","year":"2012","journal-title":"Bull Exp Biol Med"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Chen J, Shehadah A, Pal A, Zacharek A, Cui X, <etal>et al<\/etal>.. (2012) Neuroprotective Effect of Human Placenta-derived Cell Treatment of Stroke in Rats. Cell Transplant.","DOI":"10.3727\/096368911X637380"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1007\/s10517-010-0837-z","article-title":"Mechanisms of positive effects of transplantation of human placental mesenchymal stem cells on recovery of rats after experimental ischemic stroke","volume":"148","author":"KN Yarygin","year":"2009","journal-title":"Bull Exp Biol Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"S146","DOI":"10.1161\/STROKEAHA.108.533091","article-title":"Cell therapy for stroke: remaining issues to address before embarking on clinical trials","volume":"40","author":"CV Borlongan","year":"2009","journal-title":"Stroke"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3171\/jns.2005.103.1.0038","article-title":"Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trial","volume":"103","author":"D Kondziolka","year":"2005","journal-title":"J Neurosurg"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.nbd.2009.10.003","article-title":"Optimizing the success of cell transplantation therapy for stroke","volume":"37","author":"TM Bliss","year":"2010","journal-title":"Neurobiol Dis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1161\/STROKEAHA.108.526863","article-title":"Stem Cell Therapies as an Emerging Paradigm in Stroke (STEPS): bridging basic and clinical science for cellular and neurogenic factor therapy in treating stroke","volume":"40","year":"2009","journal-title":"Stroke"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/02656730500069955","article-title":"The role of heat shock proteins Hsp70 and Hsp27 in cellular protection of the central nervous system","volume":"21","author":"TB Franklin","year":"2005","journal-title":"Int J Hyperthermia"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1080\/14734220310016114","article-title":"A review of heat shock protein induction following cerebellar injury","volume":"2","author":"LP Reynolds","year":"2003","journal-title":"Cerebellum"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/1096-9861(20001218)428:3<495::AID-CNE7>3.0.CO;2-4","article-title":"Hyperthermic induction of the 27-kDa heat shock protein (Hsp27) in neuroglia and neurons of the rat central nervous system","volume":"428","author":"AM Krueger-Naug","year":"2000","journal-title":"J Comp Neurol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s004010050832","article-title":"Sequential analysis of subacute and chronic neuronal, astrocytic and microglial alterations after transient global ischemia in rats","volume":"95","author":"B Lin","year":"1998","journal-title":"Acta Neuropathol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1096\/fj.14.10.1307","article-title":"Glial cell survival is enhanced during melatonin-induced neuroprotection against cerebral ischemia","volume":"14","author":"CV Borlongan","year":"2000","journal-title":"FASEB J"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1749-6632.2001.tb03612.x","article-title":"Modulation of cyclooxygenase-2 and brain reactive astrogliosis by purinergic P2 receptors","volume":"939","author":"R Brambilla","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/00004647-199601000-00020","article-title":"Acute focal ischemia-induced alterations in MAP2 immunostaining: description of temporal changes and utilization as a marker for volumetric assessment of acute brain injury","volume":"16","author":"DA Dawson","year":"1996","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1248\/bpb.30.313","article-title":"Tacrolimus (FK506) limits accumulation of granulocytes and platelets and protects against brain damage after transient focal cerebral ischemia in rat","volume":"30","author":"T Noto","year":"2007","journal-title":"Biol Pharm Bull"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e4764","DOI":"10.1371\/journal.pone.0004764","article-title":"Identification of ischemic regions in a rat model of stroke","volume":"4","author":"A Popp","year":"2009","journal-title":"PLoS One"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"9768","DOI":"10.1523\/JNEUROSCI.19-22-09768.1999","article-title":"Differential expression of small heat shock proteins in reactive astrocytes after focal ischemia: possible role of beta-adrenergic receptor","volume":"19","author":"T Imura","year":"1999","journal-title":"J Neurosci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(95)00198-Y","article-title":"Immunohistochemical localization of the low molecular weight stress protein HSP27 following focal cerebral ischemia in the rat","volume":"679","author":"H Kato","year":"1995","journal-title":"Brain Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1523\/JNEUROSCI.5169-11.2012","article-title":"Phosphorylation of HSP27 by protein kinase D is essential for mediating neuroprotection against ischemic neuronal injury","volume":"32","author":"RA Stetler","year":"2012","journal-title":"J Neurosci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2174\/156720210792231822","article-title":"Intravenous implanted neural stem cells migrate to injury site, reduce infarct volume, and improve behavior after cerebral ischemia","volume":"7","author":"CC Shen","year":"2010","journal-title":"Curr Neurovasc Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.3727\/096368910X507204","article-title":"Nonsenescent Hsp27-upregulated MSCs implantation promotes neuroplasticity in stroke model","volume":"19","author":"SP Liu","year":"2010","journal-title":"Cell Transplant"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1006\/exnr.1997.6730","article-title":"Transplantation of cryopreserved human embryonal carcinoma-derived neurons (NT2N cells) promotes functional recovery in ischemic rats","volume":"149","author":"CV Borlongan","year":"1998","journal-title":"Exp Neurol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1161\/01.STR.17.3.472","article-title":"Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination","volume":"17","author":"JB Bederson","year":"1986","journal-title":"Stroke"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/nm1097-1129","article-title":"Testis-derived Sertoli cells have a trophic effect on dopamine neurons and alleviate hemiparkinsonism in rats","volume":"3","author":"PR Sanberg","year":"1997","journal-title":"Nat Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"13038","DOI":"10.1523\/JNEUROSCI.4407-08.2008","article-title":"Hsp27 protects against ischemic brain injury via attenuation of a novel stress-response cascade upstream of mitochondrial cell death signaling","volume":"28","author":"RA Stetler","year":"2008","journal-title":"J Neurosci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e66001","DOI":"10.1371\/journal.pone.0066001","article-title":"Human-derived physiological heat shock protein 27 complex protects brain after focal cerebral ischemia in mice","volume":"8","author":"S Teramoto","year":"2013","journal-title":"PLoS One"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1111\/j.1742-4658.2008.06291.x","article-title":"Transduced human PEP-1-heat shock protein 27 efficiently protects against brain ischemic insult","volume":"275","author":"JJ An","year":"2008","journal-title":"FEBS J"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1002\/art.11365","article-title":"Stem cell therapy in a caprine model of osteoarthritis","volume":"48","author":"JM Murphy","year":"2003","journal-title":"Arthritis Rheum"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/01.bor.0000130284.64686.63","article-title":"Mesenchymal stem cells in osteoarthritis","volume":"16","author":"FP Luyten","year":"2004","journal-title":"Curr Opin Rheumatol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1089\/ten.1999.5.267","article-title":"Autologous mesenchymal stem cell-mediated repair of tendon","volume":"5","author":"HA Awad","year":"1999","journal-title":"Tissue Eng"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1089\/scd.2004.13.463","article-title":"Mesenchymal stem cells in autoimmune disease","volume":"13","author":"NS El-Badri","year":"2004","journal-title":"Stem Cells Dev"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jns.2005.03.026","article-title":"The therapeutic use of stem cells for myelin repair in autoimmune demyelinating disorders","volume":"233","author":"S Pluchino","year":"2005","journal-title":"J Neurol Sci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1517\/14712598.6.1.17","article-title":"Stem cells in inflammatory demyelinating disorders: a dual role for immunosuppression and neuroprotection","volume":"6","author":"A Uccelli","year":"2006","journal-title":"Expert Opin Biol Ther"},{"key":"ref52","first-page":"272","article-title":"Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial","volume":"8","author":"LL Black","year":"2007","journal-title":"Vet Ther"},{"key":"ref53","first-page":"192","article-title":"Effect of intraarticular injection of autologous adipose-derived mesenchymal stem and regenerative cells on clinical signs of chronic osteoarthritis of the elbow joint in dogs","volume":"9","author":"LL Black","year":"2008","journal-title":"Vet Ther"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.brainres.2009.12.001","article-title":"Transplantation of placenta-derived mesenchymal stromal cells upon experimental stroke in rats","volume":"1315","author":"A Kranz","year":"2010","journal-title":"Brain Res"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1517\/14712598.2013.763925","article-title":"Manufacturing and banking of mesenchymal stem cells","volume":"13","author":"S Thirumala","year":"2013","journal-title":"Expert Opin Biol Ther"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1002\/bit.24425","article-title":"Closed system isolation and scalable expansion of human placental mesenchymal stem cells","volume":"109","author":"NE Timmins","year":"2012","journal-title":"Biotechnol Bioeng"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0076329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T13:30:11Z","timestamp":1564061411000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0076329"}},"subtitle":[],"editor":[{"given":"Vladimir N.","family":"Uversky","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,9,25]]},"references-count":56,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,9,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0076329","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,25]]}}}