{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:42:51Z","timestamp":1790617371428,"version":"4.1.0"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2013,10,4]],"date-time":"2013-10-04T00:00:00Z","timestamp":1380844800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0076333","type":"journal-article","created":{"date-parts":[[2013,10,4]],"date-time":"2013-10-04T17:05:42Z","timestamp":1380906342000},"page":"e76333","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":37,"title":["Alterations of Tear Mediators in Patients with Keratoconus after Corneal Crosslinking Associate with Corneal Changes"],"prefix":"10.1371","volume":"8","author":[{"given":"Bence Lajos","family":"Kolozsv\u00e1ri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Berta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Petrovski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kata","family":"Mih\u00e1ltz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Gogol\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9va","family":"Rajnav\u00f6lgyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Sz\u00e9les","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariann","family":"Fodor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,10,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0039-6257(97)00119-7","article-title":"Keratoconus","volume":"42","author":"YS Rabinowitz","year":"1998","journal-title":"Surv Ophthalmol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0039-6257(84)90094-8","article-title":"Keratoconus and related non-inflammatory corneal thinning disorders","volume":"28","author":"JH Krachmer","year":"1984","journal-title":"Surv Ophthalmol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0002-9394(02)02220-1","article-title":"Riboflavin\/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus","volume":"135","author":"G Wollensak","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.jcrs.2007.12.039","article-title":"Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results","volume":"34","author":"F Raiskup-Wolf","year":"2008","journal-title":"J Cataract Refract Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1001\/archophthalmol.2009.205","article-title":"Intraoperative and postoperative effects of corneal collagen cross-linking on progressive keratoconus","volume":"127","author":"P Vinciguerra","year":"2009","journal-title":"Arch Ophthalmol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jcrs.2011.08.041","article-title":"Higher-order aberrations after corneal collagen crosslinking for keratoconus and corneal ectasia","volume":"38","author":"SA Greenstein","year":"2012","journal-title":"J Cataract Refract Surg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1016\/j.jcrs.2011.08.026","article-title":"Corneal collagen crosslinking in progressive keratoconus: multicenter results from the French National Reference Center for Keratoconus","volume":"37","author":"D Asri","year":"2011","journal-title":"J Cataract Refract Surg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.jcrs.2011.01.029","article-title":"Corneal topography indices after corneal collagen crosslinking for keratoconus and corneal ectasia: one-year results","volume":"37","author":"SA Greenstein","year":"2011","journal-title":"J Cataract Refract Surg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jcrs.2010.07.030","article-title":"Corneal collagen crosslinking for keratoconus and corneal ectasia: One-year results","volume":"37","author":"PS Hersh","year":"2011","journal-title":"J Cataract Refract Surg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3928\/1081597X-20120823-01","article-title":"Corneal changes in progressive keratoconus after cross-linking assessed by Scheimpflug camera","volume":"28","author":"K Kr\u00e1nitz","year":"2012","journal-title":"J Refract Surg"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.jcrs.2011.11.029","article-title":"Patient subjective visual function after corneal collagen crosslinking for keratoconus and corneal ectasia","volume":"38","author":"NO Brooks","year":"2012","journal-title":"J Cataract Refract Surg"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1046\/j.1442-9071.2001.d01-17.x","article-title":"Is the corneal degradation in keratoconus caused by matrix-metalloproteinases?","volume":"29","author":"SA Collier","year":"2001","journal-title":"Clin Exp Ophthalmol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1097\/ICO.0b013e31816a3591","article-title":"Inflammatory response to contact lenses in patients with keratoconus compared with myopic subjects","volume":"27","author":"I Lema","year":"2008","journal-title":"Cornea"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1136\/bjo.2008.144253","article-title":"Subclinical keratoconus and inflammatory molecules from tears","volume":"93","author":"I Lema","year":"2009","journal-title":"Br J Ophthalmol"},{"key":"ref15","first-page":"1949","article-title":"Tear proteomics in keratoconus","volume":"16","author":"C Pannebaker","year":"2010","journal-title":"Mol Vis"},{"key":"ref16","first-page":"e16437","article-title":"Subnormal cytokine profile in the tear fluid of keratoconus patients","volume":"6","author":"AS Jun","year":"2011"},{"key":"ref17","first-page":"e303","article-title":"Proteases, proteolysis and inflammatory molecules in the tears of people with keratoconus","volume":"90","author":"SA Balasubramanian","year":"2012"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/exer.2001.1028","article-title":"Altered Expression of Growth Factors and Cytokines in Keratoconus, Bullous Keratopathy and Diabetic Corneas","volume":"73","author":"M Saghizadeh","year":"2001","journal-title":"Exp Eye Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.ophtha.2004.11.050","article-title":"Inflammatory molecules in the tears of patients with keratoconus","volume":"112","author":"I Lema","year":"2005","journal-title":"Ophthalmology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/ICL.0b013e3181b3e87f","article-title":"Elevated nerve growth factor in dry eye associated with established contact lens wear","volume":"35","author":"Q Liu","year":"2009","journal-title":"Eye Contact Lens"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3928\/1081-597X-19950901-14","article-title":"Videokeratographic indices to aid in screening for keratoconus","volume":"11","author":"YS Rabinowitz","year":"1995","journal-title":"J Refract Surg"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jcrs.2008.10.060","article-title":"Collagen crosslinking with ultraviolet-A and hypoosmolar riboflavin solution in thin corneas","volume":"35","author":"F Hafezi","year":"2009","journal-title":"J Cataract Refract Surg"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1089\/jir.2008.0116","article-title":"Long-term kinetics of cytokine responses in human tears after penetrating keratoplasty","volume":"29","author":"M Fodor","year":"2009","journal-title":"J Interferon Cytokine Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1097\/ICO.0b013e3181915943","article-title":"Scheimpflug imaging of corneas after collagen cross-linking","volume":"28","author":"T Koller","year":"2009","journal-title":"Cornea"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1755-3768.2010.01890.x","article-title":"Morphological and functional correlations in riboflavin UV A corneal collagen cross-linking for keratoconus","volume":"90","author":"C Mazzotta","year":"2012","journal-title":"Acta Ophthalmol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1097\/ICO.0b013e318041f073","article-title":"Wound healing in the rabbit cornea after corneal collagen cross-linking with riboflavin and UVA","volume":"26","author":"G Wollensak","year":"2007","journal-title":"Cornea"},{"key":"ref27","article-title":"Corneal healing after riboflavin <underline>ultraviolet-A<\/underline> <underline>collagen<\/underline> <underline>cross-linking<\/underline> <underline>determined<\/underline> <underline>by<\/underline> <underline>confocal<\/underline> <underline>laser<\/underline> <underline>scanning<\/underline> <underline>microscopy<\/underline> <underline>in<\/underline> <underline>vivo:<\/underline> <underline>early<\/underline> <underline>and<\/underline> <underline>late<\/underline> <underline>modifications.<\/underline> <underline>Am<\/underline> <underline>J<\/underline> <underline>Ophthalmol<\/underline> <underline>146:<\/underline> <underline>527-533<\/underline>","author":"C Mazzotta","year":"2008"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"8549","DOI":"10.1167\/iovs.11-7956","article-title":"Role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing","volume":"52","author":"N Ebihara","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/ICL.0b013e31814fb64b","article-title":"Abnormal rubbing and keratectasia","volume":"33","author":"CW McMonnies","year":"2007","journal-title":"Eye Contact Lens"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1080\/08830180802430974","article-title":"Regulatory effect of extracellular signal-regulated kinases (ERK) on type I collagen synthesis in human dermal fibroblasts stimulated by IL-4 and IL-13","volume":"27","author":"RK Bhogal","year":"2008","journal-title":"Int Rev Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.imbio.2009.06.007","article-title":"Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes","volume":"214","author":"Z Qiu","year":"2009","journal-title":"Immunobiology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1167\/iovs.04-0549","article-title":"Increased levels of catalase and catepsin V\/L<sup>2<\/sup> but decreased TIMP-1 in keratoconus corneas: Evidence that oxidative stress plays a role in this disorder","volume":"46","author":"MC Kenney","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.exer.2007.02.013","article-title":"Changes in the ballance of matrix metalloproteinases (TIMPs)-1 and -3 may promote keratocyte apoptosis in keratoconus","volume":"84","author":"FJ Matthews","year":"2007","journal-title":"Exp Eye Res"},{"key":"ref34","first-page":"1117","article-title":"Expression of degradative enzymes and protease inhibitors in corneas with keratoconus","volume":"39","author":"L Zhou","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/00003226-200007000-00014","article-title":"Levels of collagen degradation products (telopeptides) in the tear film of patients with keratoconus","volume":"19","author":"JH Abalain","year":"2000","journal-title":"Cornea"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/ICU.0b013e3283543b61","article-title":"Nerve growth factor therapy for corneal disease","volume":"23","author":"A Lambiase","year":"2012","journal-title":"Curr Opin Ophthalmol"},{"key":"ref37","first-page":"2185","article-title":"Lacrimal gland HGF, KGF, and EGF mRNA levels increase after corneal epithelial wounding","volume":"40","author":"SE Wilson","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0076333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T05:15:06Z","timestamp":1596604506000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0076333"}},"subtitle":[],"editor":[{"given":"Alexander\u00a0V.","family":"Ljubimov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,10,4]]},"references-count":37,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0076333","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,4]]}}}