{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:03:41Z","timestamp":1791036221139,"version":"4.1.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2013,9,23]],"date-time":"2013-09-23T00:00:00Z","timestamp":1379894400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0076406","type":"journal-article","created":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T01:28:31Z","timestamp":1379986111000},"page":"e76406","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Short-Term Nutritional Interventions on Right Ventricular Function in Healthy Men"],"prefix":"10.1371","volume":"8","author":[{"given":"Ralph L.","family":"Widya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiaan","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u00ebtte R.","family":"Boon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutger W.","family":"van der Meer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes W. A.","family":"Smit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"de Roos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick C. N.","family":"Rensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hildo J.","family":"Lamb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,9,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/MCO.0b013e32830a98e3","article-title":"Metabolic MRI of myocardial and hepatic triglyceride content in response to nutritional interventions","volume":"11","author":"HJ Lamb","year":"2008","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.2337\/db07-0768","article-title":"Short-term caloric restriction induces accumulation of myocardial triglycerides and decreases left ventricular diastolic function in healthy subjects","volume":"56","author":"RW van der Meer","year":"2007","journal-title":"Diabetes"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1210\/jc.2007-2524","article-title":"Effects of short-term high-fat, high-energy diet on hepatic and myocardial triglyceride content in healthy men","volume":"93","author":"RW van der Meer","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1210\/jc.2007-2015","article-title":"Progressive caloric restriction induces dose-dependent changes in myocardial triglyceride content and diastolic function in healthy men","volume":"93","author":"S Hammer","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0735-1097(00)01102-5","article-title":"Independent and additive prognostic value of right ventricular systolic function and pulmonary artery pressure in patients with chronic heart failure","volume":"37","author":"S Ghio","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S1525-2167(02)00171-3","article-title":"Prognostic importance of the right ventricular function assessed by Doppler tissue imaging","volume":"4","author":"J Meluz\u00edn","year":"2003","journal-title":"Eur J Echocardiogr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.cardfail.2010.05.004","article-title":"Right ventricular dysfunction is a strong predictor of developing atrial fibrillation in acutely decompensated heart failure patients, ACAP-HF data analysis","volume":"16","author":"EF Aziz","year":"2010","journal-title":"J Card Fail"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nrcardio.2010.118","article-title":"Imaging the right ventricle--current state of the art","volume":"7","author":"LL Mertens","year":"2010","journal-title":"Nat. Rev Cardiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/j.jacc.2009.06.048","article-title":"Adult congenital heart disease importance of the right ventricle","volume":"54","author":"CA Warnes","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1475-2840-9-25","article-title":"Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle","volume":"9","author":"CE van den Brom","year":"2010","journal-title":"Cardiovasc Diabetol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2337\/dc12-0474","article-title":"Right ventricular involvement in diabetic cardiomyopathy","volume":"36","author":"RL Widya","year":"2013","journal-title":"Diabetes Care"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1172\/JCI105052","article-title":"Serial studies on the metabolism of human adipose tissue I. Lipogenesis and free fatty acid uptake and release in small aspirated samples of subcutaneous fat","volume":"43","author":"J Hirsch","year":"1964","journal-title":"J Clin Invest"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00041433-200306000-00008","article-title":"Lipotoxicity: when tissues overeat","volume":"14","author":"JE Schaffer","year":"2003","journal-title":"Curr Opin Lipidol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1146\/annurev.med.53.082901.104057","article-title":"Lipotoxic diseases","volume":"53","author":"RH Unger","year":"2002","journal-title":"Annu Rev Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1210\/en.2003-0242","article-title":"Cardiac lipid accumulation associated with diastolic dysfunction in obese mice","volume":"144","author":"C Christoffersen","year":"2003","journal-title":"Endocrinology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/s00125-005-1755-x","article-title":"Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats","volume":"48","author":"DM Ouwens","year":"2005","journal-title":"Diabetologia"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1073\/pnas.97.4.1784","article-title":"Lipotoxic heart disease in obese rats: implications for human obesity","volume":"97","author":"YT Zhou","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1006\/jmcc.1996.9997","article-title":"1H NMR measurement of triacylglycerol accumulation in the post-ischemic canine heart after transient increase of plasma lipids","volume":"29","author":"JA Balschi","year":"1997","journal-title":"J Mol Cell Cardiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S1388-1981(02)00342-6","article-title":"Lipoapoptosis: its mechanism and its diseases","volume":"1585","author":"RH Unger","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/hep.21983","article-title":"Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver","volume":"47","author":"G Perseghin","year":"2008","journal-title":"Hepatology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jacc.2010.02.049","article-title":"Effects of hepatic triglyceride content on myocardial metabolism in type 2 diabetes","volume":"56","author":"LJ Rijzewijk","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.bcp.2012.06.020","article-title":"Niacin reduces plasma CETP levels by diminishing liver macrophage content in CETP transgenic mice","volume":"84","author":"Z Li","year":"2012","journal-title":"Biochem Pharmacol"},{"key":"ref23","first-page":"H253","article-title":"Activated macrophages decrease rat cardiac myocyte contractility: importance of ICAM-1-dependent adhesion","volume":"277","author":"MG Simms","year":"1999","journal-title":"Am J Physiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1148\/radiol.2451061904","article-title":"Metabolic imaging of myocardial triglyceride content: reproducibility of 1H MR spectroscopy with respiratory navigator gating in volunteers","volume":"245","author":"RW van der Meer","year":"2007","journal-title":"Radiology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF02668096","article-title":"Java-based graphical user interface for the MRUI quantitation package","volume":"12","author":"A Naressi","year":"2001","journal-title":"Magma"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/0002-8703(93)90544-J","article-title":"Magnetic resonance measurement of velocity and flow: technique, validation, and cardiovascular applications","volume":"126","author":"SA Rebergen","year":"1993","journal-title":"Am Heart J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0730-725X(94)00076-F","article-title":"Reproducibility of MRI-derived measurements of right ventricular volumes and myocardial mass","volume":"13","author":"PM Pattynama","year":"1995","journal-title":"Magn Reson Imaging"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ahj.2003.10.005","article-title":"Interstudy reproducibility of right ventricular volumes, function, and mass with cardiovascular magnetic resonance","volume":"147","author":"F Grothues","year":"2004","journal-title":"Am Heart J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1056\/NEJM198710223171717","article-title":"Simplified calculation of body-surface area","volume":"317","author":"RD Mosteller","year":"1987","journal-title":"N Engl J Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/0002-9149(84)90035-3","article-title":"Augmentation of atrial contribution to left ventricular inflow with aging as assessed by intracardiac Doppler flowmetry","volume":"53","author":"K Miyatake","year":"1984","journal-title":"Am J Cardiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"15584","DOI":"10.1021\/bi048307o","article-title":"Caloric restriction results in phospholipid depletion, membrane remodeling, and triacylglycerol accumulation in murine myocardium","volume":"43","author":"X Han","year":"2004","journal-title":"Biochemistry"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"6452","DOI":"10.1073\/pnas.89.14.6452","article-title":"Long-chain fatty acids activate calcium channels in ventricular myocytes","volume":"89","author":"JM Huang","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1161\/hc1202.105290","article-title":"New concepts in diastolic dysfunction and diastolic heart failure: Part II: causal mechanisms and treatment","volume":"105","author":"MR Zile","year":"2002","journal-title":"Circulation"},{"key":"ref34","first-page":"E308","article-title":"Metabolic and hemodynamic effects of insulin on human hearts","volume":"264","author":"E Ferrannini","year":"1993","journal-title":"Am J Physiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"H1345","DOI":"10.1152\/ajpheart.2000.278.4.H1345","article-title":"Myocardial substrate metabolism influences left ventricular energetics in vivo","volume":"278","author":"C Korvald","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.2337\/dc11-0685","article-title":"Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases plasma CETP and increases apolipoprotein AI levels without improving the cholesterol efflux properties of HDL","volume":"34","author":"Y Wang","year":"2011","journal-title":"Diabetes Care"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1016\/S0021-9258(18)61650-3","article-title":"Purification and characterization of a human plasma cholesteryl ester transfer protein","volume":"262","author":"CB Hesler","year":"1987","journal-title":"J Biol Chem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"740","DOI":"10.5812\/kowsar.1735143X.404","article-title":"Comparison of portal vein doppler indices and hepatic vein doppler waveform in patients with nonalcoholic fatty liver disease with healthy control","volume":"11","author":"E Solhjoo","year":"2011","journal-title":"Hepat Mon"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ejrad.2004.05.011","article-title":"Hepatic vein Doppler waveform in patients with diffuse fatty infiltration of the liver","volume":"54","author":"L Oguzkurt","year":"2005","journal-title":"Eur J Radiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1479-5876-9-28","article-title":"Increase of plasma IL-9 and decrease of plasma IL-5, IL-7, and IFN-\u03b3 in patients with chronic heart failure","volume":"9","author":"C Cappuzzello","year":"2011","journal-title":"J Transl Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"H1366","DOI":"10.1152\/ajpheart.00111.2012","article-title":"Macrophages modulate cardiac function in lipotoxic cardiomyopathy","volume":"303","author":"JD Schilling","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.2337\/db11-1275","article-title":"Short-term hyperinsulinemia and hyperglycemia increase myocardial lipid content in normal subjects","volume":"61","author":"Y Winhofer","year":"2012","journal-title":"Diabetes"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0076406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T19:53:20Z","timestamp":1646596400000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0076406"}},"subtitle":[],"editor":[{"given":"Matthias","family":"Stuber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,9,23]]},"references-count":42,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,9,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0076406","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,23]]}}}