{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T22:30:09Z","timestamp":1768084209226,"version":"3.49.0"},"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T00:00:00Z","timestamp":1381881600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0076516","type":"journal-article","created":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T17:26:19Z","timestamp":1381944379000},"page":"e76516","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["Hemorrhage-Adjusted Iron Requirements, Hematinics and Hepcidin Define Hereditary Hemorrhagic Telangiectasia as a Model of Hemorrhagic Iron Deficiency"],"prefix":"10.1371","volume":"8","author":[{"given":"Helen","family":"Finnamore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Le Couteur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Hickson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Busbridge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Whelan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire L.","family":"Shovlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,10,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1017\/S1368980008002401","article-title":"Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993\u20132005","volume":"12","author":"E McLean","year":"2009","journal-title":"Public Health Nutr"},{"key":"ref2","unstructured":"Center for Disease Control (2002) Iron Deficiency United States, 1999\u20132000. MMWR Weekly 51: 897\u2013899. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/mm5140a1.htm#tab1\" xlink:type=\"simple\">http:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/mm5140a1.htm#tab1<\/ext-link>. Accessed 2013 Sep 9."},{"key":"ref3","unstructured":"World Health Organization (2002) The World Health Report 2002: Reducing Risks, Promoting Healthy Life. Geneva 2002. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/whr\/2002\/en\/whr02_en.pdf\" xlink:type=\"simple\">http:\/\/www.who.int\/whr\/2002\/en\/whr02_en.pdf<\/ext-link>. Accessed 2013 Sep 9."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1182\/blood-2011-01-258467","article-title":"Hepcidin and iron regulation, 10 years later","volume":"117","author":"T Ganz","year":"2011","journal-title":"Blood"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0010-7824(72)90015-7","article-title":"Quantitation of menstrual blood loss-further evaluation of the alkaline hematin method","volume":"5","author":"STJ Shaw","year":"1972","journal-title":"Contraception"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.0954-6820.1966.tb02880.x","article-title":"Menstrual blood loss and iron deficiency","volume":"180","author":"L Hallberg","year":"1966","journal-title":"Acta Medica Scandinavica"},{"key":"ref7","unstructured":"Nelson M, Erens B, Bates B, Church S, Boshier T, editors (2007) Low income diet and nutrition survey \u2013 Food Standards Agency. London: The Stationary Office."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1079\/PHN2002455","article-title":"Risk factors for low iron intake and poor iron status in a national sample of British young people aged 4\u201318 years","volume":"6","author":"C Thane","year":"2003","journal-title":"Public Health Nutr"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1136\/gut.2010.228874","article-title":"Guidelines for the management of iron deficiency anaemia","volume":"60","author":"AF Goddard","year":"2011","journal-title":"Gut"},{"key":"ref10","unstructured":"United Nations Children\u2019s Fund, United Nations University and World Health Organization (2001) Iron deficiency anaemia: assessment, prevention, and control. A guide for programme managers. WHO\/NHD\/01.3 Geneva."},{"key":"ref11","first-page":"1e36","article-title":"Recommendations to prevent and control iron deficiency in the United States","volume":"47","year":"1998","journal-title":"MMWR Recomm Rep"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/0735-1097(95)00007-Q","article-title":"Endothelium-derived relaxing factor is important in mediating the high output state in chronic severe anemia","volume":"25","author":"IS Anand","year":"1995","journal-title":"J Am Coll Cardiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"5999","DOI":"10.1113\/jphysiol.2008.160960","article-title":"The increase in pulmonary arterial pressure caused by hypoxia depends on iron status","volume":"586","author":"TG Smith","year":"2008","journal-title":"J Physiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1136\/thoraxjnl-2011-201076","article-title":"Low serum iron levels are associated with elevated plasma levels of coagulation factor VIII and pulmonary emboli\/deep venous thromboses in replicate cohorts of patients with hereditary hemorrhagic telangiectasia","volume":"67","author":"JA Livesey","year":"2012","journal-title":"Thorax"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1056\/NEJM199510053331407","article-title":"Hereditary hemorrhagic telangiectasia","volume":"333","author":"AE Guttmacher","year":"1995","journal-title":"New Engl J Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1136\/jmg.2009.069013","article-title":"International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia","volume":"48","author":"ME Faughnan","year":"2011","journal-title":"J Med Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.blre.2010.07.001","article-title":"Hereditary hemorrhagic telangiectasia: pathophysiology, diagnosis and treatment","volume":"24","author":"CL Shovlin","year":"2010","journal-title":"Blood Rev"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1007\/s10620-011-1585-2","article-title":"Natural history and outcome of hepatic vascular malformations in a large cohort of patients with hereditary hemorrhagic telangiectasia","volume":"56","author":"E Buscarini","year":"2011","journal-title":"Dig Dis Sci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1152\/jappl.1993.75.1.321","article-title":"Cardiopulmonary response to exercise in patients with intrapulmonary vascular shunts","volume":"75","author":"MK Whyte","year":"1993","journal-title":"J Appl Physiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1161\/01.CIR.0000052623.16194.80","article-title":"Hemodilution is common in patients with advanced heart failure","volume":"107","author":"AS Androne","year":"2003","journal-title":"Circulation"},{"key":"ref21","first-page":"16","article-title":"Anemia as a risk factor for ischemic heart disease","volume":"6","author":"A Zeidman","year":"2004","journal-title":"Isr Med Assoc J"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.amjmed.2008.07.012","article-title":"Individualized treatment for iron-deficiency anemia in adults","volume":"121","author":"M Alleyne","year":"2008","journal-title":"Am J Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejca.2011.09.011","article-title":"Diagnosis and management of anemia and iron deficiency in patients with hematological malignancies or solid tumours in France in 2009\u20132010: the AnemOnHe study","volume":"48","author":"M Spielmann","year":"2012","journal-title":"Eur J Cancer"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/bja\/aeq361","article-title":"Detection, evaluation, and management of preoperative anaemia in the elective orthopaedic surgical patient: NATA guidelines","volume":"106","author":"LT Goodnough","year":"2011","journal-title":"Br J Anaesth"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00277-011-1381-2","article-title":"Postpartum anemia II: prevention and treatment","volume":"91","author":"N Milman","year":"2012","journal-title":"Ann Hematol"},{"key":"ref26","unstructured":"Royal Pharmaceutical Society of Great Britain and British Medical Association (2012) British National Formulary 63: BMJ Publishing Group, London."},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Hallberg L, Ryttinger L, Solvell L (1966) Side-effects of oral iron therapy. A double-blind study of different iron compounds in tablet form. Acta Med Scand Suppl 459: 3\u201310.","DOI":"10.1111\/j.0954-6820.1966.tb19403.x"},{"key":"ref28","unstructured":"Centers for Disease Control and Prevention (2011). Nutrition for everyone: Basics: Iron and iron deficiency. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cdc.gov\/nutrition\/everyone\/basics\/vitamins\/iron.html\" xlink:type=\"simple\">http:\/\/www.cdc.gov\/nutrition\/everyone\/basics\/vitamins\/iron.html<\/ext-link>. Accessed 2013 Sep 9."},{"key":"ref29","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/PAT.0b013e32834e8291","article-title":"Should we screen for iron deficiency anaemia? A review of the evidence and recent recommendations","volume":"44(2)","author":"SR Pasricha","year":"2012","journal-title":"Pathology"},{"key":"ref30","first-page":"1240","article-title":"Plasma ferritin concentrations: their clinical significance and relevance to patient care","volume":"122","author":"LS Valberg","year":"1980","journal-title":"Can Med Assoc J"},{"key":"ref31","unstructured":"NICE Clinical Knowledge Summaries: Interpreting ferritin levels. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/cks.nhs.uk\/anaemia_iron_deficiency\/management\/scenario_diagnosis\/investigations\/interpreting_ferritin_levels#\" xlink:type=\"simple\">http:\/\/cks.nhs.uk\/anaemia_iron_deficiency\/management\/scenario_diagnosis\/investigations\/interpreting_ferritin_levels#<\/ext-link>. Accessed 2013 Sep 9."},{"key":"ref32","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1164\/ajrccm.183.6.828","article-title":"Pulmonary thromboemboli modifying the natural history of pulmonary arteriovenous malformations","volume":"183","author":"F Roked","year":"2011","journal-title":"Am J Resp Crit Care Med"},{"key":"ref33","unstructured":"Santhirapala V, Howard LSGE, Murphy K, Mukherjee B, Busbridge M, <etal>et al<\/etal>. (2013) Oxygen delivery and consumption is preserved in hypoxaemic patients with pulmonary arteriovenous malformations and hereditary haemorrhagic telangiectasia. Hematology Reports 5 (s1) 33\u201334."},{"key":"ref34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-3148.2007.00818.x","article-title":"Evidence-based criteria for the care and selection of blood donors, with some comments on the relationship to blood supply, and emphasis on the management of donation-induced iron depletion","volume":"18","author":"F Boulton","year":"2008","journal-title":"Transfus Med"},{"key":"ref35","first-page":"167","article-title":"The effect of repeated blood donations on the iron status of male Saudi blood donors","volume":"9","author":"SM Abdullah","year":"2011","journal-title":"Blood Transfus"},{"key":"ref36","first-page":"150","article-title":"New tools in studies on iron nutrition. Principles, applications and consequences","volume":"44","author":"L Hallberg","year":"2000","journal-title":"Scand J Nutr"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Silva BM, Hosman AE, Devlin HL, Shovlin CL (2013) A questionnaire-based study suggests lifestyle and dietary factors influencing nosebleed severity in hereditary hemorrhagic telangiectasia (HHT). Laryngoscope, 2013 <comment>doi: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1002\/lary.23893\" xlink:type=\"simple\">10.1002\/lary.23893<\/ext-link><\/comment>","DOI":"10.1002\/lary.23893"},{"key":"ref38","first-page":"309","article-title":"Epistaxis: an update on current management. Postgrad Med J","volume":"81","author":"LER Pope","year":"2005"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1177\/000348949810700808","article-title":"Aspirin, nonsteroidal anti-inflammatory drugs, and epistaxis. A regional record linkage case control study","volume":"107","author":"HL Tay","year":"1998","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"ref40","first-page":"429","article-title":"Nasal Arterial Vasculature Arch Facial Plast Surg","volume":"14","author":"Y Saban","year":"2012"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"300e9","DOI":"10.1016\/j.jacc.2011.02.057","article-title":"Iron deficiency and raised hepcidin in idiopathic pulmonary arterial hypertension: clinical prevalence, outcomes, and mechanistic insights","volume":"58","author":"CJ Rhodes","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1164\/rccm.200908-1284OC","article-title":"Clinical outcomes of pulmonary arterial hypertension in patients carrying an ACVRL1 (ALK1) mutation","volume":"181","author":"B Girerd","year":"2010","journal-title":"Am J Respir Crit Care Med 2010"},{"key":"ref43","first-page":"561","article-title":"Side effects of iron supplements in blood donors: superior tolerance of heme iron","volume":"123","author":"E Frykman","year":"1994","journal-title":"J Lab Clin Med"},{"key":"ref44","unstructured":"Royal Pharmaceutical Society of Great Britain and British Medical Association (2012) British National Formulary 63: BMJ Publishing Group, London."},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.amjmed.2005.01.065","article-title":"Are we giving too much iron? Low-dose iron therapy is effective in octogenarians","volume":"118","author":"E Rimon","year":"2005","journal-title":"Am J Med"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.nutr.21.1.1","article-title":"Perspectives on nutritional iron deficiency","volume":"21","author":"L Hallberg","year":"2001","journal-title":"Ann Rev Nutrition"},{"key":"ref47","first-page":"263","article-title":"A comparative trial of a controlled-release iron tablet preparation (\u2018Ferrocontin\u2019 Continus) and ferrous fumarate tablets","volume":"3","author":"A Aronstam","year":"1982","journal-title":"Pharmatherapeutica"},{"key":"ref48","unstructured":"National Institute for Health and Clinical Excellence (NICE) (2011) Colorectal cancer. Costing report. Implementing NICE Guidance. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/guidance.nice.org.uk\/CG131\/CostingReport\/pdf\/English\" xlink:type=\"simple\">http:\/\/guidance.nice.org.uk\/CG131\/CostingReport\/pdf\/English<\/ext-link>. Accessed 2013 Sep 9."},{"key":"ref49","unstructured":"Curtis L (2011). Unit costs of health and social care 2011. PSSRU, Canterbury. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.pssru.ac.uk\/uc\/uc2011contents.htm\" xlink:type=\"simple\">http:\/\/www.pssru.ac.uk\/uc\/uc2011contents.htm<\/ext-link>. Accessed 2013 September 9."},{"key":"ref50","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1002\/lary.20818","article-title":"An epistaxis severity score for hereditary hemorrhagic telangiectasia","volume":"120","author":"J Hoag","year":"2010","journal-title":"Laryngoscope"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"200","DOI":"10.12968\/hmed.2006.67.Sup4.20879","article-title":"Blood transfusion: a practical guide","volume":"67","author":"E Burdett","year":"2006","journal-title":"Br J Hosp Med (Lond)"},{"key":"ref52","unstructured":"Royal College of Obstetricians and Gynaecologists (2009) Prevention and management of postpartum hemorrhage. Green-top Guideline no 52. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.rcog.org.uk\/womens-health\/clinical-guidance\/prevention-and-management-postpartum-haemorrhage-green-top-52\" xlink:type=\"simple\">http:\/\/www.rcog.org.uk\/womens-health\/clinical-guidance\/prevention-and-management-postpartum-haemorrhage-green-top-52<\/ext-link>. Accessed 2013 Sep 9."},{"key":"ref53","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0020-1383(99)00191-6","article-title":"Transfusion requirements in femoral neck fracture","volume":"31","author":"DG Swain","year":"2000","journal-title":"Injury"},{"key":"ref54","first-page":"66","article-title":"Diagnostic criteria for hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome). Am J Med Genet","volume":"91","author":"CL Shovlin","year":"2000"},{"key":"ref55","unstructured":"International Agency for Research on Cancer and World Health Organisation (2010) European Prospective Investigation into Cancer and Nutrition. British Medical Association. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/epic.iarc.fr\/about.php\" xlink:type=\"simple\">http:\/\/epic.iarc.fr\/about.php<\/ext-link>. Accessed 2013 September 9."},{"key":"ref56","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1365-277X.2005.00593.x","article-title":"The CAFE computer program for nutritional analysis of the EPIC-Norfolk food frequency questionnaire and identification of extreme nutrient values","volume":"18","author":"AA Welch","year":"2005","journal-title":"J Hum Nutr Dietet"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1079\/PHN2000102","article-title":"Nutritional methods in the European Prospective Investigation of Cancer in Norfolk","volume":"4","author":"SA Bingham","year":"2001","journal-title":"Public Health Nutr"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1080\/09674845.2009.11730263","article-title":"Development of a novel immunoassay for the iron regulatory peptide hepcidin","volume":"66","author":"M Busbridge","year":"2009","journal-title":"Br J Biomed Sci"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1056\/NEJMc1213554","article-title":"Antiplatelet and anticoagulant agents in hereditary hemorrhagic telangiectasia","volume":"368","author":"HL Devlin","year":"2013","journal-title":"N Engl J Med"},{"key":"ref60","unstructured":"(2004) The National Diet &amp; Nutrition Survey: Adults aged 19 to 64 years. Nutritional status (anthropometry and blood analytes), blood pressure and physical activity. HMSO, Norwich. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.food.gov.uk\/multimedia\/pdfs\/ndnsfour.pdf\" xlink:type=\"simple\">http:\/\/www.food.gov.uk\/multimedia\/pdfs\/ndnsfour.pdf<\/ext-link>. Page 63, table 4.1. Accessed 2013 Sep 9."},{"key":"ref61","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0009-8981(00)00273-4","article-title":"Low frequency of elevated serum transferrin saturation in elderly subjects","volume":"298","author":"CBA Franzini","year":"2000","journal-title":"Clin Chim Acta"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1111\/j.1478-3231.2012.02828.x","article-title":"The serum hepcidin:ferritin ratio is a potential biomarker for cirrhosis","volume":"32","author":"TC Tan","year":"2012","journal-title":"Liver Int"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1182\/blood-2007-06-096503","article-title":"Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis","volume":"110","author":"A Piperno","year":"2007","journal-title":"Blood"},{"key":"ref64","unstructured":"Department of Health (1991) Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. HMSO, London."},{"key":"ref65","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0140-6736(58)91282-0","article-title":"Gastrointestinal intolerance to oral iron preparations","volume":"2","author":"DN Kerr","year":"1958","journal-title":"Lancet"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0076516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T18:30:30Z","timestamp":1564511430000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0076516"}},"subtitle":[],"editor":[{"given":"Dermot","family":"Cox","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,10,16]]},"references-count":65,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0076516","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,16]]}}}