{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:37:02Z","timestamp":1789205822635,"version":"build-2803163510"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0076627","type":"journal-article","created":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T22:53:54Z","timestamp":1380668034000},"page":"e76627","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Mitochondrial Sequence Variation in African-American Primary Open-Angle Glaucoma Patients"],"prefix":"10.1371","volume":"8","author":[{"given":"David W.","family":"Collins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harini V.","family":"Gudiseva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin T.","family":"Trachtman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Jerrehian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomasine","family":"Gorry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Merritt III","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison L.","family":"Rhodes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prithvi S.","family":"Sankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"Regina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eydie","family":"Miller-Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan M.","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,10,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(04)16257-0","article-title":"Primary open-angle glaucoma","volume":"363","author":"RN Weinreb","year":"2004","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4254","DOI":"10.1167\/iovs.06-0299","article-title":"Variations in primary open-angle glaucoma prevalence by age, gender, and race: a Bayesian meta-analysis","volume":"47","author":"AR Rudnicka","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/jama.1991.03470030069026","article-title":"Racial variations in the prevalence of primary open-angle glaucoma. The Baltimore Eye Survey","volume":"266","author":"JM Tielsch","year":"1991","journal-title":"JAMA"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.bbagen.2011.08.008","article-title":"A mitochondrial etiology of Alzheimer and Parkinson disease","volume":"1820","author":"P Coskun","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1056\/NEJM198905183202002","article-title":"A mitochondrial DNA mutation as a cause of Leber\u2019s hereditary optic neuropathy","volume":"320","author":"G Singh","year":"1989","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/molbev\/msl209","article-title":"Whole-mtDNA genome sequence analysis of ancient African lineages","volume":"24","author":"MK Gonder","year":"2007","journal-title":"Mol Biol Evol"},{"key":"ref7","first-page":"1468","article-title":"Mitochondrial DNA lineages of African origin confer susceptibility to primary open-angle glaucoma in Saudi patients","volume":"17","author":"KK Abu-Amero","year":"2011","journal-title":"Mol Vis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.mito.2011.11.004","article-title":"Mitochondrial dysfunction in glaucoma: understanding genetic influences","volume":"12","author":"G Lascaratos","year":"2012","journal-title":"Mitochondrion"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1076\/opep.9.5.333.10335","article-title":"Bias in self-reported family history and relationship to glaucoma: the Blue Mountains Eye Study","volume":"9","author":"P Mitchell","year":"2002","journal-title":"Ophthalmic Epidemiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1167\/iovs.07-1361","article-title":"Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants","volume":"49","author":"Y He","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1167\/iovs.05-1639","article-title":"Mitochondrial abnormalities in patients with primary open-angle glaucoma","volume":"47","author":"KK Abu-Amero","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1167\/iovs.12-9596","article-title":"Impaired complex-I-linked respiration and ATP synthesis in primary open-angle glaucoma patient lymphoblasts","volume":"53","author":"S Lee","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1167\/iovs.12-9815","article-title":"Mitochondrial dysfunction in glaucoma: closing the loop","volume":"53","author":"P Yu-Wai-Man","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s10384-005-0290-0","article-title":"Mitochondrial DNA mutations with Leber\u2019s hereditary optic neuropathy in Japanese patients with open-angle glaucoma","volume":"50","author":"Y Inagaki","year":"2006","journal-title":"Jpn J Ophthalmol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1136\/bjo.2005.084335","article-title":"The role of mitochondrial haplogroups in primary open angle glaucoma","volume":"90","author":"R Andrews","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"ref16","first-page":"1955","article-title":"Mitochondrial genetic background in Ghanaian patients with primary open-angle glaucoma","volume":"18","author":"KK Abu-Amero","year":"2012","journal-title":"Mol Vis"},{"key":"ref17","first-page":"e62","article-title":"Carnitine reduces the lipoperoxidative damage of the membrane and apoptosis after induction of cell stress in experimental glaucoma. Cell Death","volume":"1","author":"N Calandrella","year":"2010","journal-title":"Drosophila Inf Serv"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.ophtha.2004.02.001","article-title":"The Los Angeles Latino Eye Study: design, methods, and baseline data","volume":"111","author":"R Varma","year":"2004","journal-title":"Ophthalmology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1006\/bmme.1996.0040","article-title":"Detection and analysis of mitochondrial DNA deletions by whole genome PCR","volume":"58","author":"CH Tengan","year":"1996","journal-title":"Biochem Mol Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1002\/elps.200800601","article-title":"Human mitochondrial DNA complete amplification and sequencing: a new validated primer set that prevents nuclear DNA sequences of mitochondrial origin co-amplification","volume":"30","author":"A Ramos","year":"2009","journal-title":"Electrophoresis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"JT Robinson","year":"2011","journal-title":"Nat Biotechnol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"D823","DOI":"10.1093\/nar\/gkl927","article-title":"An enhanced MITOMAP with a global mtDNA mutational phylogeny","volume":"35","author":"E Ruiz-Pesini","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/humu.20801","article-title":"MITOMASTER: a bioinformatics tool for the analysis of mitochondrial DNA sequences","volume":"30","author":"MC Brandon","year":"2009","journal-title":"Hum Mutat"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"D749","DOI":"10.1093\/nar\/gkj010","article-title":"mtDB: Human Mitochondrial Genome Database, a resource for population genetics and medical sciences","volume":"34","author":"M Ingman","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"IA Adzhubei","year":"2010","journal-title":"Nat Methods"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1101\/gr.229102","article-title":"The human genome browser at UCSC","volume":"12","author":"WJ Kent","year":"2002","journal-title":"Genome Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1101\/gr.1933104","article-title":"Aligning multiple genomic sequences with the threaded blockset aligner","volume":"14","author":"M Blanchette","year":"2004","journal-title":"Genome Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"E386","DOI":"10.1002\/humu.20921","article-title":"Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation","volume":"30","author":"M van Oven","year":"2009","journal-title":"Hum Mutat"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.gene.2005.05.019","article-title":"An investigation of the variation in the transition bias among various animal mitochondrial DNA","volume":"355","author":"EM Belle","year":"2005","journal-title":"Gene"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e1003031","DOI":"10.1371\/journal.pcbi.1003031","article-title":"Shining a light on dark sequencing: characterising errors in Ion Torrent PGM data","volume":"9","author":"LM Bragg","year":"2013","journal-title":"PLOS Comput Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/humu.20846","article-title":"Exaggerated status of &quot;novel&quot; and &quot;pathogenic&quot; mtDNA sequence variants due to inadequate database searches","volume":"30","author":"HJ Bandelt","year":"2009","journal-title":"Hum Mutat"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"7391","DOI":"10.1073\/pnas.1202484109","article-title":"Mitochondrial DNA variant associated with Leber hereditary optic neuropathy and high-altitude Tibetans","volume":"109","author":"F Ji","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e7922","DOI":"10.1371\/journal.pone.0007922","article-title":"The background of mitochondrial DNA haplogroup J increases the sensitivity of Leber&apos;s hereditary optic neuropathy cells to 2,5-hexanedione toxicity","volume":"4","author":"A Ghelli","year":"2009","journal-title":"PLOS One"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.ajhg.2012.03.002","article-title":"A &quot;Copernican&quot; reassessment of the human mitochondrial DNA tree from its root","volume":"90","author":"DM Behar","year":"2012","journal-title":"Am J Hum Genet"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0076627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T18:59:41Z","timestamp":1588964381000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0076627"}},"subtitle":[],"editor":[{"given":"Hemachandra","family":"Reddy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,10,1]]},"references-count":34,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0076627","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,1]]}}}