{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T18:43:43Z","timestamp":1773427423499,"version":"3.50.1"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T00:00:00Z","timestamp":1380758400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0076715","type":"journal-article","created":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T21:01:08Z","timestamp":1380834068000},"page":"e76715","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Alterations of Red Cell Membrane Properties in Nneuroacanthocytosis"],"prefix":"10.1371","volume":"8","author":[{"given":"Claudia","family":"Siegl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Hamminger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Jank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Ahting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Bader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Danek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Gregory","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Hartig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Hayflick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Prokisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther M.","family":"Sammler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuhal","family":"Yapici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Prohaska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Salzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,10,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.nbd.2012.03.006","article-title":"Brain, blood, and iron: perspectives on the roles of erythrocytes and iron in neurodegeneration","volume":"46","author":"R Prohaska","year":"2012","journal-title":"Neurobiol Dis"},{"key":"ref2","first-page":"92","article-title":"Neurologic phenotypes associated with acanthocytosis","volume":"68","author":"RH Walker","year":"2007"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/88825","article-title":"The gene encoding a newly discovered protein, chorein, is mutated in chorea-acanthocytosis","volume":"28","author":"S Ueno","year":"2001","journal-title":"Nat Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/88821","article-title":"A conserved sorting-associated protein is mutant in chorea-acanthocytosis","volume":"28","author":"L Rampoldi","year":"2001","journal-title":"Nat Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/0092-8674(94)90136-8","article-title":"Isolation of the gene for McLeod syndrome that encodes a novel membrane transport protein","volume":"77","author":"M Ho","year":"1994","journal-title":"Cell"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1212\/01.WNL.0000085866.68470.6D","article-title":"Huntington\u2019s disease--like 2 can present as chorea-acanthocytosis","volume":"61","author":"RH Walker","year":"2003","journal-title":"Neurology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1056\/NEJMoa020817","article-title":"Genetic, clinical, and radiographic delineation of Hallervorden-Spatz syndrome","volume":"348","author":"SJ Hayflick","year":"2003","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.ajhg.2011.09.007","article-title":"Absence of an orphan mitochondrial protein, c19orf12, causes a distinct clinical subtype of neurodegeneration with brain iron accumulation","volume":"89","author":"MB Hartig","year":"2011","journal-title":"Am J Hum Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1212\/WNL.0b013e31827e07be","article-title":"New NBIA subtype: genetic, clinical, pathologic, and radiographic features of MPAN","volume":"80","author":"P Hogarth","year":"2013","journal-title":"Neurology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1016\/j.bpj.2011.09.050","article-title":"Native ultrastructure of the red cell cytoskeleton by cryo-electron tomography","volume":"101","author":"A Nans","year":"2011","journal-title":"Biophys J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1182\/blood-2009-02-203216","article-title":"Adducin forms a bridge between the erythrocyte membrane and its cytoskeleton and regulates membrane cohesion","volume":"114","author":"WA Anong","year":"2009","journal-title":"Blood"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/09687689509072424","article-title":"Do band 3 protein conformational changes mediate shape changes of human erythrocytes?","volume":"12","author":"J Gimsa","year":"1995","journal-title":"Mol Membr Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S0006-3495(98)77546-0","article-title":"A possible molecular mechanism governing human erythrocyte shape","volume":"75","author":"J Gimsa","year":"1998","journal-title":"Biophys J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1006\/jtbi.1998.0845","article-title":"A basis of echinocytosis and stomatocytosis in the disc-sphere transformations of the erythrocyte","volume":"196","author":"P Wong","year":"1999","journal-title":"J Theor Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1042\/BJ20121008","article-title":"Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology","volume":"448","author":"A Wieschhaus","year":"2012","journal-title":"Biochem J"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1073\/pnas.71.11.4457","article-title":"Biological membranes as bilayer couples. A molecular mechanism of drug-erythrocyte interactions","volume":"71","author":"MP Sheetz","year":"1974","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF01925863","article-title":"Mechanism of red blood cell acanthocytosis and echinocytosis in vivo","volume":"77","author":"Y Lange","year":"1984","journal-title":"J Membr Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/BF01871936","article-title":"Shape determinants of McLeod acanthocytes","volume":"107","author":"JK Khodadad","year":"1989","journal-title":"J Membr Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1212\/WNL.41.7.1000","article-title":"Diagnostic tests for choreoacanthocytosis","volume":"41","author":"TE Feinberg","year":"1991","journal-title":"Neurology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1182\/blood.V95.7.2420","article-title":"Lysophosphatidic acid opens a Ca(++) channel in human erythrocytes","volume":"95","author":"L Yang","year":"2000","journal-title":"Blood"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1172\/JCI111129","article-title":"Alteration of membrane phospholipid bilayer organization in human erythrocytes during drug-induced endocytosis","volume":"72","author":"SL Schrier","year":"1983","journal-title":"J Clin Invest"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1161\/01.ATV.0000252898.48084.6a","article-title":"Lysophosphatidic acid induces thrombogenic activity through phosphatidylserine exposure and procoagulant microvesicle generation in human erythrocytes","volume":"27","author":"SM Chung","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1159\/000335798","article-title":"Regulation of phosphatidylserine exposure in red blood cells","volume":"28","author":"DB Nguyen","year":"2011","journal-title":"Cell Physiol Biochem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"12562","DOI":"10.1021\/bi025882o","article-title":"Protein kinase C activation induces phosphatidylserine exposure on red blood cells","volume":"41","author":"K de Jong","year":"2002","journal-title":"Biochemistry"},{"key":"ref25","first-page":"739","article-title":"[Studies on the erythrocyte membrane skeleton in a patient with chorea-acanthocytosis--theoretical speculation on the mechanism of neurological involvement]","volume":"44","author":"T Hosokawa","year":"1992","journal-title":"No Shinkei"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000040917","article-title":"Ultrastructural changes of erythrocyte membrane skeletons in chorea-acanthocytosis and McLeod syndrome revealed by the quick-freezing and deep-etching method","volume":"101","author":"N Terada","year":"1999","journal-title":"Acta Haematol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/S0006-3495(96)79649-2","article-title":"Remodeling the shape of the skeleton in the intact red cell","volume":"70","author":"JK Khodadad","year":"1996","journal-title":"Biophys J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1182\/blood.V99.7.2569","article-title":"Ca(++)-dependent vesicle release from erythrocytes involves stomatin-specific lipid rafts, synexin (annexin VII), and sorcin","volume":"99","author":"U Salzer","year":"2002","journal-title":"Blood"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S1554-4516(07)06003-6","article-title":"Insights in the organization and dynamics of erythrocyte lipid rafts","volume":"6","author":"U Salzer","year":"2007","journal-title":"Advances Planar Lipids Bilayers Liposomes"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1096\/fj.11-198317","article-title":"Chorein-sensitive polymerization of cortical actin and suicidal cell death in chorea-acanthocytosis","volume":"26","author":"M F\u00f6ller","year":"2012","journal-title":"FASEB J"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"5652","DOI":"10.1182\/blood-2011-05-355339","article-title":"Erythrocyte membrane changes of chorea-acanthocytosis are the result of altered Lyn kinase activity","volume":"118","author":"L De Franceschi","year":"2011","journal-title":"Blood"},{"key":"ref32","first-page":"648","article-title":"Increased membrane protein phosphorylation and anion transport activity in chorea-acanthocytosis","volume":"82","author":"O Olivieri","year":"1997","journal-title":"Haematologica"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"8026","DOI":"10.1073\/pnas.0803225105","article-title":"Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane","volume":"105","author":"M Salomao","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"12996","DOI":"10.1016\/S0021-9258(18)31485-6","article-title":"A tightly membrane-associated subpopulation of spectrin is 3H-palmitoylated","volume":"268","author":"M Mariani","year":"1993","journal-title":"J Biol Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1021\/bi035653h","article-title":"Phosphatidylserine binding sites in erythroid spectrin: location and implications for membrane stability","volume":"43","author":"X An","year":"2004","journal-title":"Biochemistry"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"35778","DOI":"10.1074\/jbc.M101364200","article-title":"Structural and functional characterization of protein 4.1R-phosphatidylserine interaction: potential role in 4.1R sorting within cells","volume":"276","author":"XL An","year":"2001","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.3324\/haematol.2009.006585","article-title":"4.1R-deficient human red blood cells have altered phosphatidylserine exposure pathways and are deficient in CD44 and CD47 glycoproteins","volume":"94","author":"KP Jeremy","year":"2009","journal-title":"Haematologica"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1523\/JNEUROSCI.4265-04.2005","article-title":"Altered neuronal mitochondrial coenzyme A synthesis in neurodegeneration with brain iron accumulation caused by abnormal processing, stability, and catalytic activity of mutant pantothenate kinase 2","volume":"25","author":"PT Kotzbauer","year":"2005","journal-title":"J Neurosci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e31015","DOI":"10.1371\/journal.pone.0031015","article-title":"Computational identification of phospho-tyrosine sub-networks related to acanthocyte generation in neuroacanthocytosis","volume":"7","author":"L De Franceschi","year":"2012","journal-title":"PLOS ONE"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S1388-1981(02)00149-X","article-title":"Regulation of neuronal cytoskeleton by lysophosphatidic acid: role of GSK-3","volume":"1582","author":"CL Sayas","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1083\/jcb.201012028","article-title":"High-resolution mapping reveals topologically distinct cellular pools of phosphatidylserine","volume":"194","author":"GD Fairn","year":"2011","journal-title":"J Cell Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.bbalip.2011.12.007","article-title":"Phospholipid flippases: building asymmetric membranes and transport vesicles","volume":"1821","author":"TT Sebastian","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1523\/JNEUROSCI.3654-12.2013","article-title":"Phospholipid scramblase-1-induced lipid reorganization regulates compensatory endocytosis in neuroendocrine cells","volume":"33","author":"S Ory","year":"2013","journal-title":"J Neurosci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/mds.22863","article-title":"Tongue protrusion and feeding dystonia: a hallmark of chorea-acanthocytosis","volume":"25","author":"B Bader","year":"2010","journal-title":"Mov Disord"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/ana.20200","article-title":"Chorein detection for the diagnosis of chorea-acanthocytosis","volume":"56","author":"C Dobson-Stone","year":"2004","journal-title":"Ann Neurol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1212\/WNL.0b013e3181bd80d4","article-title":"Development of mesial temporal lobe epilepsy in chorea-acanthocytosis","volume":"73","author":"R Scheid","year":"2009","journal-title":"Neurology"}],"updated-by":[{"DOI":"10.1371\/annotation\/9cae31b8-e1d9-4ba8-93e6-1f7276591746","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T00:00:00Z","timestamp":1382572800000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0076715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T21:21:36Z","timestamp":1646688096000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0076715"}},"subtitle":[],"editor":[{"given":"Athar\u00a0H","family":"Chishti","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,10,3]]},"references-count":46,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0076715","relation":{"correction":[{"id-type":"doi","id":"10.1371\/annotation\/9cae31b8-e1d9-4ba8-93e6-1f7276591746","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,3]]}}}