{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:48:48Z","timestamp":1790185728481,"version":"4.1.0"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T00:00:00Z","timestamp":1381968000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0076779","type":"journal-article","created":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T17:04:21Z","timestamp":1382029461000},"page":"e76779","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":117,"title":["Increased Pro-Inflammatory Cytokines, C-Reactive Protein and Nerve Growth Factor Expressions in Serum of Patients with Interstitial Cystitis\/Bladder Pain Syndrome"],"prefix":"10.1371","volume":"8","author":[{"given":"Yuan-Hong","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Hsin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Tzu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hann-Chorng","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,10,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.urology.2003.10.034","article-title":"Treatment of interstitial cystitis","volume":"63(3","author":"MB Chancellor","year":"2004","journal-title":"Urology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0022-5347(05)65931-9","article-title":"Histological and neurotrophic changes triggered by varying models of bladder inflammation","volume":"166","author":"MC Dupont","year":"2001","journal-title":"J Urol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/00042307-200307000-00007","article-title":"Recent developments in the management of interstitial cystitis","volume":"13","author":"K Bouchelouche","year":"2003","journal-title":"Curr Opin Urol"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Hanno PM, Sant GR (2001) Clinical highlights of the National Institute of Diabetes and Digestive and Kidney Diseases\/Interstitial Cystitis Association scientific conference on interstitial cystitis. Urology (Suppl 6A): 2\u20136.","DOI":"10.1016\/S0090-4295(01)01112-8"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1046\/j.1464-410X.1997.00097.x","article-title":"Increased nerve growth factor levels in the urinary bladder of women with idiopathic sensory urgency and interstitial cystitis","volume":"79","author":"EM Lowe","year":"1997","journal-title":"Br J Urol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1111\/j.1464-410X.2009.08675.x","article-title":"Urinary nerve growth factor level is increased in patients with interstitial cystitis\/bladder pain syndrome and decreased in responders to treatment","volume":"104","author":"HT Liu","year":"2009","journal-title":"BJU Int"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/nau.20938","article-title":"Elevation of serum C-reactive protein in patients with OAB and IC\/BPS implies chronic inflammation in the urinary bladder","volume":"30","author":"SD Chung","year":"2011","journal-title":"Neurourol Urodyn"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.urology.2006.08.1109","article-title":"The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis","volume":"69","author":"GR Sant","year":"2007","journal-title":"Urology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s11255-009-9647-5","article-title":"Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study","volume":"42","author":"P Tyagi","year":"2010","journal-title":"Int Urol Nephrol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s11934-006-0013-1","article-title":"Urinary and serologic markers for interstitial cystitis: an update","volume":"7","author":"DR Wilkinson","year":"2006","journal-title":"Curr Urol Rep"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0022-5347(01)64317-9","article-title":"Inflammatory cell types and clinical features of interstitial cystitis","volume":"158","author":"DR Erickson","year":"1997","journal-title":"J Urol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/01.ju.0000146466.71311.ab","article-title":"Do the National Institute of Diabetes and Digestive and Kidney Diseases cystoscopic criteria associate with other clinical and objective features of interstitial cystitis?","volume":"173","author":"DR Erickson","year":"2005","journal-title":"J Urol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.urology.2006.04.033","article-title":"Interleukin-6, histamine, and methylhistamine as diagnostic markers for interstitial cystitis","volume":"68","author":"LM Lamale","year":"2006","journal-title":"Urology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"F816","DOI":"10.1152\/ajprenal.90733.2008","article-title":"Interleukin-8 is essential for normal urothelial cell survival","volume":"297","author":"S Tseng-Rogenski","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1159\/000331969","article-title":"Cytologic examination of urine from patients with interstitial cystitis","volume":"42","author":"LG Dodd","year":"1998","journal-title":"Acta Cytol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1046\/j.1464-410x.2000.00646.x","article-title":"Interstitial cystitis: a review of immunological aspects of the aetiology and pathogenesis, with a hypothesis","volume":"85","author":"JP Van De Merwe","year":"2000","journal-title":"BJU Int"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1016\/S0022-5347(05)65518-8","article-title":"Increased urinary leukotriene E4 and eosinophil protein X excretion in patients with interstitial cystitis","volume":"166","author":"K Bouchelouche","year":"2001","journal-title":"J Urol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e44687","DOI":"10.1371\/journal.pone.0044687","article-title":"Increased urine and serum nerve growth factor levels in interstitial cystitis suggest chronic inflammation is involved in the pathogenesis of disease","volume":"7","author":"HT Liu","year":"2012","journal-title":"PLos One"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.urology.2008.07.031","article-title":"Multiplex analysis of urinary cytokine levels in rat model of cyclophosphamide-induced cystitis","volume":"73","author":"MC Smaldone","year":"2009","journal-title":"Urology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1016\/j.juro.2008.01.047","article-title":"Urine markers do not predict biopsy findings or presence of bladder ulcers in interstitial cystitis\/painful bladder syndrome","volume":"179","author":"DR Erickson","year":"2008","journal-title":"J Urol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1744-8069-3-38","article-title":"Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors","volume":"3","author":"S Bhangoo","year":"2007","journal-title":"Mol Pain"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1016\/j.juro.2012.01.034","article-title":"Urinary chemokines as noninvasive predictors of ulcerative interstitial cystitis","volume":"187","author":"P Tyagi","year":"2012","journal-title":"J Urol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/315641a0","article-title":"Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs","volume":"315","author":"CJ March","year":"1985","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S0022-5347(17)35212-6","article-title":"Interleukin-1B: a clinically relevant urinary marker","volume":"151","author":"SM Martins","year":"1994","journal-title":"J Urol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nrurol.2010.101","article-title":"Host-pathogen interactions in urinary tract infection","volume":"7","author":"GR Nielubowicz","year":"2010","journal-title":"Nat Rev Urol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/jid.2010.317","article-title":"Nerve growth factor partially recovers inflamed skin from stress-induced worsening in allergic inflammation","volume":"131","author":"EM Peters","year":"2011","journal-title":"J Invest Dermatol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.juro.2010.06.005","article-title":"Interstitial cystitis\/painful bladder syndrome and associated medical conditions with an emphasis on irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome","volume":"184","author":"JC Nickel","year":"2010","journal-title":"J Urol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0076779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T19:29:59Z","timestamp":1564514999000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0076779"}},"subtitle":[],"editor":[{"given":"Juliet","family":"Spencer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,10,17]]},"references-count":27,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0076779","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,17]]}}}