{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:30:13Z","timestamp":1782880213539,"version":"3.54.5"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T00:00:00Z","timestamp":1381190400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0076792","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T21:27:49Z","timestamp":1381267669000},"page":"e76792","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Grb2 Is Regulated by Foxd3 and Has Roles in Preventing Accumulation and Aggregation of Mutant Huntingtin"],"prefix":"10.1371","volume":"8","author":[{"given":"Shounak","family":"Baksi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihar R.","family":"Jana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitai Pada","family":"Bhattacharyya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debashis","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,10,8]]},"reference":[{"key":"ref1","author":"PS Harper","year":"1996"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1093\/hmg\/ddm217","article-title":"Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity","volume":"16","author":"RS Atwal","year":"2007","journal-title":"Hum Mol Genet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1093\/hmg\/9.19.2799","article-title":"Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells","volume":"9","author":"F Trettel","year":"2000","journal-title":"Hum Mol Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/hmg\/9.4.503","article-title":"Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice","volume":"9","author":"VC Wheeler","year":"2000","journal-title":"Hum Mol Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"8121","DOI":"10.1074\/jbc.272.13.8121","article-title":"SH3 domain-dependent association of huntingtin with epidermal growth factor receptor signaling complexes","volume":"272","author":"YF Liu","year":"1997","journal-title":"J Biol Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1053\/sonc.2001.28555","article-title":"GRB2: a pivotal protein in signal transduction","volume":"28","author":"AM Tari","year":"2001","journal-title":"Semin Oncol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"50996","DOI":"10.1074\/jbc.M204869200","article-title":"Endocytosis of epidermal growth factor receptor regulated by Grb2-mediated recruitment of the Rab5 GTPase-activating protein RN-tre","volume":"277","author":"L Martinu","year":"2002","journal-title":"J Biol Chem"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1091\/mbc.E04-09-0832","article-title":"Growth factor receptor binding protein 2-mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocytosis","volume":"16","author":"F Huang","year":"2005","journal-title":"Mol Biol Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1146\/annurev.neuro.24.1.1217","article-title":"Nerve growth factor signaling, neuroprotection, and neural repair","volume":"24","author":"MV Sofroniew","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0968-0004(03)00168-3","article-title":"The hunt for huntingtin function: interaction partners tell many different stories","volume":"28","author":"P Harjes","year":"2003","journal-title":"Trends Biochem Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/0092-8674(90)90439-L","article-title":"The fork head domain: a novel DNA binding motif of eukaryotic transcription factors?","volume":"63","author":"D Weigel","year":"1990","journal-title":"Cell"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/hmg\/ddl013","article-title":"Regional and cellular gene expression changes in human Huntington\u2019s disease brain","volume":"15","author":"A Hodges","year":"2006","journal-title":"Hum Mol Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e135","DOI":"10.1371\/journal.pgen.0030135","article-title":"Unbiased gene expression analysis implicates the huntingtin polyglutamine tract in extra-mitochondrial energy metabolism","volume":"3","author":"JM Lee","year":"2007","journal-title":"PLOS Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"L Mangiarini","year":"1996","journal-title":"Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"29949","DOI":"10.1074\/jbc.M112.371724","article-title":"Dysfunction of the ubiquitin ligase Ube3a may be associated with synaptic pathophysiology in a mouse model of Huntington disease","volume":"287","author":"M Maheshwari","year":"2012","journal-title":"J Biol Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"50514","DOI":"10.1074\/jbc.M309348200","article-title":"Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington\u2019s disease knock-in striatal cells","volume":"278","author":"S Gines","year":"2003","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/hmg\/ddg046","article-title":"Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington\u2019s disease knock-in mice","volume":"12","author":"S Gines","year":"2003","journal-title":"Hum Mol Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"10720","DOI":"10.1523\/JNEUROSCI.2126-08.2008","article-title":"Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner","volume":"28","author":"CL Benn","year":"2008","journal-title":"J Neurosci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1111\/j.1471-4159.2008.05252.x","article-title":"Calcineurin is involved in the early activation of NMDA-mediated cell death in mutant huntingtin knock-in striatal cells","volume":"105","author":"X Xifr\u00f3","year":"2008","journal-title":"J Neurochem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"25628","DOI":"10.1074\/jbc.M804291200","article-title":"Rosiglitazone treatment prevents mitochondrial dysfunction in mutant huntingtin-expressing cells: possible role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in the pathogenesis of Huntington disease","volume":"283","author":"RA Quintanilla","year":"2008","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1126\/science.1172871","article-title":"Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity","volume":"324","author":"S Subramaniam","year":"2009","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3233\/JAD-2010-1371","article-title":"Grb2-mediated alteration in the trafficking of AbetaPP: insights from Grb2-AICD interaction","volume":"20","author":"M Raychaudhuri","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e51415","DOI":"10.1371\/journal.pone.0051415","article-title":"Identification of HYPK-Interacting Proteins Reveals Involvement of HYPK in Regulating Cell Growth, Cell Cycle, Unfolded Protein Response and Cell Death","volume":"7","author":"KR Choudhury","year":"2012","journal-title":"PLOS ONE"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s10571-007-9220-7","article-title":"Increased caspase-2, calpain activations and decreased mitochondrial complex II activity in cells expressing exogenous huntingtin exon 1 containing CAG repeat in the pathogenic range","volume":"27","author":"P Majumder","year":"2007","journal-title":"Cell Mol Neurobiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e23837","DOI":"10.1371\/journal.pone.0023837","article-title":"Regulation of miR-146a by RelA\/NFkB and p53 in STHdh(Q111)\/Hdh(Q111) cells, a cell model of Huntington\u2019s disease","volume":"6","author":"J Ghose","year":"2011","journal-title":"PLOS ONE"},{"key":"ref26","first-page":"Q111","article-title":"Altered microRNAs in STHdh","author":"M Sinha","year":"2010"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/hmg\/ddm301","article-title":"HYPK, a Huntingtin interacting protein, reduces aggregates and apoptosis induced by N-terminal Huntingtin with 40 glutamines in Neuro2a cells and exhibits chaperone-like activity","volume":"17","author":"S Raychaudhuri","year":"2008","journal-title":"Hum Mol Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1093\/nar\/gkp1011","article-title":"Transcription regulation of caspase-1 by R393 of HIPPI and its molecular partner HIP-1","volume":"38","author":"M Banerjee","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"33759","DOI":"10.1074\/jbc.M111.265173","article-title":"Regulation of RE1 protein silencing transcription factor (REST) expression by HIP1 protein interactor (HIPPI)","volume":"286","author":"M Datta","year":"2011","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.4161\/rna.8.6.16035","article-title":"Micro RNA -214,-150,-146a and-125b target Huntingtin gene","volume":"8","author":"M Sinha","year":"2011","journal-title":"RNA Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"55080","DOI":"10.1074\/jbc.M406418200","article-title":"Chaperone activity and prodan binding at the self-associating domain of erythroid spectrin","volume":"279","author":"M Bhattacharyya","year":"2004","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.4161\/auto.6.8.13617","article-title":"Early alterations of autophagy in Huntington disease-like mice","volume":"6","author":"MY Heng","year":"2010","journal-title":"Autophagy"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1158\/1541-7786.MCR-10-0454","article-title":"FOXD3 regulates migration properties and Rnd3 expression in melanoma cells","volume":"9","author":"P Katiyar","year":"2011","journal-title":"Mol Cancer Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1091\/mbc.E02-08-0532","article-title":"Grb2 regulates internalization of EGF receptors through clathrin-coated pits","volume":"14","author":"X Jiang","year":"2003","journal-title":"Mol Biol Cell"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0076792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T14:44:34Z","timestamp":1564497874000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0076792"}},"subtitle":[],"editor":[{"given":"Kah-Leong","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,10,8]]},"references-count":34,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0076792","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,8]]}}}