{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:32:44Z","timestamp":1790166764332,"version":"4.1.0"},"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T00:00:00Z","timestamp":1381968000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0076961","type":"journal-article","created":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T21:08:48Z","timestamp":1382044128000},"page":"e76961","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":48,"title":["Effects of Taurine Supplementation on Hepatic Markers of Inflammation and Lipid Metabolism in Mothers and Offspring in the Setting of Maternal Obesity"],"prefix":"10.1371","volume":"8","author":[{"given":"Minglan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare M.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah M.","family":"Sloboda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clint","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Vickers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,10,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1089\/jwh.2010.2397","article-title":"Transition to overweight or obesity among women of reproductive age","volume":"20","author":"MM Hillemeier","year":"2011","journal-title":"J Womens Health (Larchmt)"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/NMC.0b013e3182430296","article-title":"Maternal obesity: improving pregnancy outcomes","volume":"37","author":"PM Nodine","year":"2012","journal-title":"MCN Am J Matern Child Nurs"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.2337\/diacare.16.12.1598","article-title":"Prepregnancy weight and antepartum insulin secretion predict glucose tolerance five years after gestational diabetes mellitus","volume":"16","author":"BE Metzger","year":"1993","journal-title":"Diabetes Care"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S0026-0495(99)90225-1","article-title":"Evidence of a state of increased insulin resistance in preeclampsia","volume":"48","author":"R Kaaja","year":"1999","journal-title":"Metabolism"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1530\/REP-10-0088","article-title":"Obesity, insulin resistance, and pregnancy outcome","volume":"140","author":"PM Catalano","year":"2010","journal-title":"Reproduction"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/oby.2002.118","article-title":"Liver-fat accumulation and insulin resistance in obese women with previous gestational diabetes","volume":"10","author":"M Tiikkainen","year":"2002","journal-title":"Obes Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1203\/PDR.0b013e3182055ede","article-title":"Obesity in pregnancy: implications for the mother and lifelong health of the child. A consensus statement","volume":"69","author":"L Poston","year":"2011","journal-title":"Pediatr Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ajhb.20590","article-title":"Early life events and their consequences for later disease: a life history and evolutionary perspective","volume":"19","author":"PD Gluckman","year":"2007","journal-title":"Am J Hum Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1136\/bmj.310.6977.428","article-title":"Fetal and infant growth and cardiovascular risk factors in women","volume":"310","author":"CH Fall","year":"1995","journal-title":"BMJ"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1161\/01.CIR.94.6.1310","article-title":"Birth weight and adult hypertension and obesity in women","volume":"94","author":"GC Curhan","year":"1996","journal-title":"Circulation"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1161\/HYPERTENSIONAHA.107.101477","article-title":"Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming","volume":"51","author":"AM Samuelsson","year":"2008","journal-title":"Hypertension"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1113\/jphysiol.2008.163477","article-title":"Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet","volume":"587","author":"GJ Howie","year":"2009","journal-title":"J Physiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1139\/y99-060","article-title":"Taurine attenuates hypertension and improves insulin sensitivity in the fructose-fed rat, an animal model of insulin resistance","volume":"77","author":"CV Anuradha","year":"1999","journal-title":"Can J Physiol Pharmacol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"E744","DOI":"10.1152\/ajpendo.00355.2002","article-title":"N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress","volume":"285","author":"CA Haber","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s00726-011-0883-5","article-title":"The potential usefulness of taurine on diabetes mellitus and its complications","volume":"42","author":"T Ito","year":"2012","journal-title":"Amino Acids"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0305-0491(85)90232-9","article-title":"A comparison by species, age and sex of cysteinesulfinate decarboxylase activity and taurine concentration in liver and brain of animals","volume":"82","author":"JA Worden","year":"1985","journal-title":"Comp Biochem Physiol B"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1023\/B:NERE.0000010443.05899.2f","article-title":"Is taurine beneficial in reducing risk factors for diabetes mellitus?","volume":"29","author":"F Franconi","year":"2004","journal-title":"Neurochem Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.jnutbio.2008.05.008","article-title":"Taurine supplementation modulates glucose homeostasis and islet function","volume":"20","author":"EM Carneiro","year":"2009","journal-title":"J Nutr Biochem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S1262-3636(07)70202-1","article-title":"Taurine modifies insulin signaling enzymes in the fructose-fed insulin resistant rats","volume":"31","author":"AT Nandhini","year":"2005","journal-title":"Diabetes Metab"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1677\/joe.0.1590341","article-title":"Effects of taurine on the insulin secretion of rat fetal islets from dams fed a low-protein diet","volume":"159","author":"H Cherif","year":"1998","journal-title":"J Endocrinol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1007\/s00125-002-0833-6","article-title":"Taurine supplementation to a low protein diet during foetal and early postnatal life restores a normal proliferation and apoptosis of rat pancreatic islets","volume":"45","author":"S Boujendar","year":"2002","journal-title":"Diabetologia"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00125-004-1357-z","article-title":"Effect of maternal low-protein diet and taurine on the vulnerability of adult Wistar rat islets to cytokines","volume":"47","author":"S Merezak","year":"2004","journal-title":"Diabetologia"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1530\/REP-12-0388","article-title":"Maternal taurine supplementation in rats partially prevents the adverse effects of early-life protein deprivation on beta-cell function and insulin sensitivity","volume":"145","author":"C Tang","year":"2013","journal-title":"Reproduction"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Lin S, Hirai S, Yamaguchi Y, Goto T, Takahashi N, <etal>et al<\/etal>.. (2013) Taurine improves obesity-induced inflammatory responses and modulates the unbalanced phenotype of adipose tissue macrophages. Mol Nutr Food Res.","DOI":"10.1002\/mnfr.201300150"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/ijo.2010.149","article-title":"A systematic review on animal models of maternal high fat feeding and offspring glycaemic control","volume":"35","author":"H Ainge","year":"2011","journal-title":"Int J Obes (Lond)"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"DR Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"DE Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"27029","DOI":"10.1074\/jbc.M202638200","article-title":"The role of SREBP-1c in nutritional regulation of lipogenic enzyme gene expression","volume":"277","author":"AK Stoeckman","year":"2002","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"12027","DOI":"10.1073\/pnas.1534923100","article-title":"Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes","volume":"100","author":"JD Horton","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1128\/MCB.19.5.3760","article-title":"ADD1\/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose","volume":"19","author":"M Foretz","year":"1999","journal-title":"Mol Cell Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1172\/JCI34275","article-title":"Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice","volume":"118","author":"C Postic","year":"2008","journal-title":"J Clin Invest"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0005-2760(96)00066-5","article-title":"The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation","volume":"1302","author":"K Schoonjans","year":"1996","journal-title":"Biochim Biophys Acta"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/j.1432-1033.1994.0967b.x","article-title":"Dexamethasone and insulin demonstrate marked and opposite regulation of the steady-state mRNA level of the peroxisomal proliferator-activated receptor (PPAR) in hepatic cells. Hormonal modulation of fatty-acid-induced transcription","volume":"225","author":"HH Steineger","year":"1994","journal-title":"Eur J Biochem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1006\/bbrc.2000.3966","article-title":"PPARalpha agonists reduce 11beta-hydroxysteroid dehydrogenase type 1 in the liver","volume":"279","author":"A Hermanowski-Vosatka","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"7522","DOI":"10.1073\/pnas.121164498","article-title":"Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance","volume":"98","author":"JK Kim","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref37","doi-asserted-by":"crossref","DOI":"10.1194\/jlr.R800085-JLR200","article-title":"Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways","volume":"50","author":"IJ Goldberg","year":"2009","journal-title":"J Lipid Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1753-4887.2005.tb00132.x","article-title":"Dietary fructose: implications for dysregulation of energy homeostasis and lipid\/carbohydrate metabolism","volume":"63","author":"PJ Havel","year":"2005","journal-title":"Nutr Rev"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.jhep.2008.02.011","article-title":"Fructose consumption as a risk factor for non-alcoholic fatty liver disease","volume":"48","author":"X Ouyang","year":"2008","journal-title":"J Hepatol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1007\/s10620-006-9359-y","article-title":"The restorative effect of taurine on experimental nonalcoholic steatohepatitis","volume":"51","author":"SW Chen","year":"2006","journal-title":"Dig Dis Sci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1021\/jf103167u","article-title":"Preventive effects of taurine on development of hepatic steatosis induced by a high-fat\/cholesterol dietary habit","volume":"59","author":"YY Chang","year":"2011","journal-title":"J Agric Food Chem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"R1710","DOI":"10.1152\/ajpregu.00677.2010","article-title":"Experimental evidence for therapeutic potential of taurine in the treatment of nonalcoholic fatty liver disease","volume":"301","author":"CL Gentile","year":"2011","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"R Bataller","year":"2005","journal-title":"J Clin Invest"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1053\/jhep.2001.29628","article-title":"Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients","volume":"34","author":"J Crespo","year":"2001","journal-title":"Hepatology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1309\/6VJ4DWGYDU0XYJ8Q","article-title":"Correlation of serum TNF-alpha levels and histologic liver injury scores in pediatric nonalcoholic fatty liver disease","volume":"127","author":"M Manco","year":"2007","journal-title":"Am J Clin Pathol"},{"key":"ref46","unstructured":"Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, <etal>et al<\/etal>.. (2010) Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology 139: 323\u2013334 e327."},{"key":"ref47","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.2337\/diabetes.54.12.3458","article-title":"Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver","volume":"54","author":"G Boden","year":"2005","journal-title":"Diabetes"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/S0022-2275(20)33379-4","article-title":"Cellular uptake and intracellular trafficking of long chain fatty acids","volume":"40","author":"MJ McArthur","year":"1999","journal-title":"J Lipid Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0378-1097(03)00611-6","article-title":"Taurine: new implications for an old amino acid","volume":"226","author":"GB Schuller-Levis","year":"2003","journal-title":"FEMS Microbiol Lett"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S1043-2760(00)00301-5","article-title":"Adipose tissue as an endocrine organ","volume":"11","author":"RS Ahima","year":"2000","journal-title":"Trends Endocrinol Metab"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1161\/hc0702.104279","article-title":"Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year","volume":"105","author":"P Ziccardi","year":"2002","journal-title":"Circulation"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.metabol.2012.10.005","article-title":"Effect of taurine and N-acetylcysteine on methionine restriction-mediated adiposity resistance","volume":"62","author":"AK Elshorbagy","year":"2013","journal-title":"Metabolism"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"H114","DOI":"10.1111\/j.1750-3841.2012.02687.x","article-title":"Dietary combination of fish oil and taurine decreases fat accumulation and ameliorates blood glucose levels in type 2 diabetic\/obese KK-A(y) mice","volume":"77","author":"N Mikami","year":"2012","journal-title":"J Food Sci"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"E396","DOI":"10.1152\/ajpendo.00343.2011","article-title":"High-fat diets induce changes in hippocampal glutamate metabolism and neurotransmission","volume":"302","author":"I Valladolid-Acebes","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/227609b0","article-title":"Brain damage in infant mice following oral intake of glutamate, aspartate or cysteine","volume":"227","author":"JW Olney","year":"1970","journal-title":"Nature"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0197-0186(00)00112-1","article-title":"Retinal glutamate in diabetes and effect of antioxidants","volume":"38","author":"RA Kowluru","year":"2001","journal-title":"Neurochem Int"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00592-011-0364-z","article-title":"The potential role of glutamate in the current diabetes epidemic","volume":"49","author":"AM Davalli","year":"2012","journal-title":"Acta Diabetol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/sj.ejcn.1602263","article-title":"Obesity, voracity, and short stature: the impact of glutamate on the regulation of appetite","volume":"60","author":"M Hermanussen","year":"2006","journal-title":"Eur J Clin Nutr"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0006-8993(96)01181-X","article-title":"Effects of maternal oral administration of monosodium glutamate at a late stage of pregnancy on developing mouse fetal brain","volume":"747","author":"T Yu","year":"1997","journal-title":"Brain Res"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1016\/S0021-9258(17)35926-4","article-title":"Exchange of cystine and glutamate across plasma membrane of human fibroblasts","volume":"261","author":"S Bannai","year":"1986","journal-title":"J Biol Chem"},{"key":"ref61","first-page":"183","article-title":"Excess of taurine supplementation in rat: effects on GABA-related amino acids in developing nervous tissues","volume":"41","author":"R Ientile","year":"1992","journal-title":"Ital J Biochem"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s11064-007-9465-z","article-title":"Dietary taurine supplementation ameliorates diabetic retinopathy via anti-excitotoxicity of glutamate in streptozotocin-induced Sprague-Dawley rats","volume":"33","author":"X Yu","year":"2008","journal-title":"Neurochem Res"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1210\/en.2010-1093","article-title":"Maternal fructose intake during pregnancy and lactation alters placental growth and leads to sex-specific changes in fetal and neonatal endocrine function","volume":"152","author":"MH Vickers","year":"2011","journal-title":"Endocrinology"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/labinvest.3700374","article-title":"Exploration of global gene expression in human liver steatosis by high-density oligonucleotide microarray","volume":"86","author":"F Chiappini","year":"2006","journal-title":"Lab Invest"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.jhep.2011.01.048","article-title":"Lack of interleukin-1alpha or interleukin-1beta inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice","volume":"55","author":"Y Kamari","year":"2011","journal-title":"J Hepatol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1172\/JCI60777","article-title":"IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice","volume":"122","author":"J Petrasek","year":"2012","journal-title":"J Clin Invest"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.rbmo.2012.01.016","article-title":"Taurine attenuates maternal and embryonic oxidative stress in a streptozotocin-diabetic rat model","volume":"24","author":"MM Shivananjappa","year":"2012","journal-title":"Reprod Biomed Online"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1210\/en.2005-0581","article-title":"Neonatal leptin treatment reverses developmental programming","volume":"146","author":"MH Vickers","year":"2005","journal-title":"Endocrinology"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1210\/en.2007-0981","article-title":"The effect of neonatal leptin treatment on postnatal weight gain in male rats is dependent on maternal nutritional status during pregnancy","volume":"149","author":"MH Vickers","year":"2008","journal-title":"Endocrinology"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"e53505","DOI":"10.1371\/journal.pone.0053505","article-title":"Pre-weaning growth hormone treatment reverses hypertension and endothelial dysfunction in adult male offspring of mothers undernourished during pregnancy","volume":"8","author":"C Gray","year":"2013","journal-title":"PLoS One"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0076961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T14:17:54Z","timestamp":1646835474000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0076961"}},"subtitle":[],"editor":[{"given":"Zane","family":"Andrews","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,10,17]]},"references-count":70,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0076961","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,17]]}}}