{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:41:42Z","timestamp":1776469302257,"version":"3.51.2"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T00:00:00Z","timestamp":1381449600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0076986","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T03:19:31Z","timestamp":1381547971000},"page":"e76986","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effect of Nadir CD4+ T Cell Count on Clinical Measures of Periodontal Disease in HIV+ Adults before and during Immune Reconstitution on HAART"],"prefix":"10.1371","volume":"8","author":[{"given":"Lance T.","family":"Vernon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine A.","family":"Demko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise C.","family":"Babineau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuelei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Toossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Weinberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benigno","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,10,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1034\/j.1601-0825.8.s2.5.x","article-title":"Periodontal diseases and HIV infection","volume":"8","author":"PG Robinson","year":"2002","journal-title":"Oral Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1600-0757.2005.00136.x","article-title":"Environmental and other modifying factors of the periodontal diseases","volume":"40","author":"DF Kinane","year":"2006","journal-title":"Periodontol 2000"},{"key":"ref3","first-page":"20","article-title":"Periodontal disease. A potential intraoral expression of AIDS may be rapidly progressive periodontitis","volume":"15","author":"J Winkler","year":"1987","journal-title":"J Claif Dent Assoc"},{"key":"ref4","article-title":"Diagnosis and management of HIV-associated periodontal lesions","author":"JR Winkler","year":"1989","journal-title":"J Am Dent Assoc Suppl"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1600-0528.2009.00485.x","article-title":"Characterizing traditionally defined periodontal disease in HIV+ adults","volume":"37","author":"LT Vernon","year":"2009","journal-title":"Community Dent Oral Epidemiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1752-7325.1998.tb03012.x","article-title":"Prevalence of HIV-associated periodontitis and chronic periodontitis in a southeastern US study group","volume":"58","author":"RG McKaig","year":"1998","journal-title":"J Public Health Dent"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1001\/jama.300.5.520","article-title":"Estimation of HIV incidence in the United States","volume":"300","author":"HI Hall","year":"2008","journal-title":"JAMA"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1089\/aid.2010.0320","article-title":"A prospective cohort study of periodontal disease measures and cardiovascular disease markers in HIV-infected adults","volume":"27","author":"LT Vernon","year":"2011","journal-title":"AIDS Res Hum Retroviruses"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/sj.bdj.4810352","article-title":"Antibiotic prophylaxis for patients with joint prostheses - still a dilemma for dental practitioners","volume":"194","author":"RA Seymour","year":"2003","journal-title":"Br Dent J"},{"key":"ref10","doi-asserted-by":"crossref","DOI":"10.14219\/jada.archive.2007.0262","article-title":"Prevention of infective endocarditis: guidelines from the American Heart Association","author":"W Wilson","year":"2007"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1902\/annals.2002.7.1.79","article-title":"Relationships among clinical measures of periodontal disease and their associations with systemic markers","volume":"7","author":"JD Beck","year":"2002","journal-title":"Ann Periodontol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/CIRCULATIONAHA.104.511998","article-title":"Periodontal disease and coronary heart disease: a reappraisal of the exposure","volume":"112","author":"JD Beck","year":"2005","journal-title":"Circulation"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1600-0528.1987.tb00525.x","article-title":"Representativeness of the "Ramfjord teeth" for epidemiologic studies of gingivitis and periodontitis","volume":"15","author":"JL Fleiss","year":"1987","journal-title":"Community Dent Oral Epidemiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1365-2249.2005.02913.x","article-title":"Inhibition of human immunodeficiency virus-1 (HIV-1) by beta-chemokine analogues in mononuclear cells from HIV-1-infected patients with active tuberculosis","volume":"142","author":"Z Toossi","year":"2005","journal-title":"Clin Exp Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/j.1600-051x.2004.00608.x","article-title":"Quantitative real-time polymerase chain reaction based on single copy gene sequence for detection of periodontal pathogens","volume":"31","author":"JM Morillo","year":"2004","journal-title":"J Clin Periodontol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1601-0825.1996.tb00202.x","article-title":"The periodontal health of homosexual men with HIV infection: a controlled study","volume":"2","author":"PG Robinson","year":"1996","journal-title":"Oral Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1902\/jop.2006.P04039","article-title":"Longitudinal evaluation of loss of attachment in HIV-infected women compared to HIV-uninfected women","volume":"77","author":"M Alves","year":"2006","journal-title":"J Periodontol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1600-0528.1991.tb00168.x","article-title":"Periodontal status of individuals in early stages of human immunodeficiency virus infection","volume":"19","author":"CR Drinkard","year":"1991","journal-title":"Community Dent Oral Epidemiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1902\/jop.1991.62.10.623","article-title":"Periodontal status of HIV-seropositive and AIDS patients","volume":"62","author":"RB Friedman","year":"1991","journal-title":"J Periodontol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.1600-051X.1997.tb00232.x","article-title":"Is there an association between periodontal condition and HIV infection?","volume":"24","author":"F Scheutz","year":"1997","journal-title":"J Clin Periodontol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1902\/jop.2007.060264","article-title":"Case definitions for use in population-based surveillance of periodontitis","volume":"78","author":"RC Page","year":"2007","journal-title":"J Periodontol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1177\/0022034510377793","article-title":"Accuracy of NHANES periodontal examination protocols","volume":"89","author":"PI Eke","year":"2010","journal-title":"J Dent Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1177\/0022034512457373","article-title":"Prevalence of periodontitis in adults in the United States: 2009 and 2010","volume":"91","author":"PI Eke","year":"2012","journal-title":"J Dent Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.0301-5661.2004.00128.x","article-title":"Baseline characteristics of participants in the oral health component of the Women's Interagency HIV Study","volume":"32","author":"R Mulligan","year":"2004","journal-title":"Community Dent Oral Epidemiol"},{"key":"ref25","article-title":"Increased atherosclerotic progression in patients with HIV: The role of traditional and immunologic risk factors","author":"P Hsue","year":"2003"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1097\/QAD.0b013e32811ebf79","article-title":"Progression of carotid artery intima-media thickening in HIV-infected and uninfected adults","volume":"21","author":"JS Currier","year":"2007","journal-title":"AIDS"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1097\/QAD.0b013e32832b514b","article-title":"Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosis","volume":"23","author":"PY Hsue","year":"2009","journal-title":"AIDS"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1042\/CS20070353","article-title":"HIV-positive patients treated with protease inhibitors have vascular changes resembling those observed in atherosclerotic cardiovascular disease","volume":"115","author":"J Lekakis","year":"2008","journal-title":"Clin Sci (Lond)"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1086\/516616","article-title":"Metabolic syndrome and subclinical atherosclerosis in patients infected with HIV","volume":"44","author":"A Mangili","year":"2007","journal-title":"Clin Infect Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/00333549121270S201","article-title":"Oral health care for people living with HIV\/AIDS","volume":"127","author":"RM Benjamin","year":"2012","journal-title":"Public Health Rep"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1177\/00333549121270S204","article-title":"Correlates of Unmet Dental Care Need Among HIV-Positive People Since Being Diagnosed with HIV","volume":"127","author":"Y Jeanty","year":"2012","journal-title":"Public Health Rep"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1902\/jop.1997.68.9.827","article-title":"Periodontal status of HIV-1 and HIV-2 seropositive and HIV seronegative female commercial sex workers in Senegal","volume":"68","author":"CF Ndiaye","year":"1997","journal-title":"J Periodontol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1177\/00333549121270S206","article-title":"Dental anxiety and the use of oral health services among people attending two HIV primary care clinics in Miami","volume":"127","author":"R Singer","year":"2012","journal-title":"Public Health Rep"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1177\/00333549121270S207","article-title":"Retention of people living with HIV\/AIDS in oral health care","volume":"127","author":"CR Tobias","year":"2012","journal-title":"Public Health Rep"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1177\/00333549121270S210","article-title":"Patient perspectives on improving oral health-care practices among people living with HIV\/AIDS","volume":"127","author":"S Rajabiun","year":"2012","journal-title":"Public Health Rep"},{"key":"ref36","first-page":"346","article-title":"Elevated phagocytosis, oxidative burst, and F-actin formation in PMNs from individuals with intraoral manifestations of HIV infection","volume":"1","author":"MI Ryder","year":"1988","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4599","DOI":"10.1182\/blood-2012-05-433946","article-title":"Shared monocyte subset phenotypes in HIV-1 infection and in uninfected subjects with acute coronary syndrome","volume":"120","author":"NT Funderburg","year":"2012","journal-title":"Blood"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0076986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T19:03:34Z","timestamp":1564513414000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0076986"}},"subtitle":[],"editor":[{"given":"Derya","family":"Unutmaz","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,10,11]]},"references-count":37,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0076986","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,11]]}}}