{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:30:25Z","timestamp":1790447425032,"version":"4.1.0"},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T00:00:00Z","timestamp":1382400000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0077258","type":"journal-article","created":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T22:00:47Z","timestamp":1382479247000},"page":"e77258","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Thiopental Inhibits Global Protein Synthesis by Repression of Eukaryotic Elongation Factor 2 and Protects from Hypoxic Neuronal Cell Death"],"prefix":"10.1371","volume":"8","author":[{"given":"Christian I.","family":"Schwer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius","family":"Lehane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Guelzow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Zenker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl M.","family":"Strosing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sashko","family":"Spassov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Erxleben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Heimrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmut","family":"Buerkle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matjaz","family":"Humar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,10,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.2174\/1381612013397311","article-title":"Current aspects of pathophysiology and cell dysfunction after severe head injury","volume":"7","author":"J Sahuquillo","year":"2001","journal-title":"Curr Pharm Des"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3171\/jns.1992.77.2.0169","article-title":"Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology","volume":"77","author":"BK Siesjo","year":"1992","journal-title":"J Neurosurg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-510X(00)00386-5","article-title":"Brain ischemia and reperfusion: molecular mechanisms of neuronal injury","volume":"179","author":"BC White","year":"2000","journal-title":"J Neurol Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0005-2728(99)00030-4","article-title":"Roles of nitric oxide in brain hypoxia-ischemia","volume":"1411","author":"JP Bolanos","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.2174\/138161208784480216","article-title":"Cyclooxygenase inhibition in ischemic brain injury","volume":"14","author":"E Candelario-Jalil","year":"2008","journal-title":"Curr Pharm Des"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/glia.20169","article-title":"Multiple roles for MMPs and TIMPs in cerebral ischemia","volume":"50","author":"LA Cunningham","year":"2005","journal-title":"Glia"},{"key":"ref7","first-page":"67","article-title":"Cellular and molecular pathways of ischemic neuronal death","volume":"35","author":"SJ Won","year":"2002","journal-title":"J Biochem Mol Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1146\/annurev.ph.58.030196.002543","article-title":"Downregulation of cellular metabolism during environmental stress: mechanisms and implications","volume":"58","author":"SC Hand","year":"1996","journal-title":"Annu Rev Physiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/S0002-9440(10)63747-9","article-title":"Physiological and pathological responses to hypoxia","volume":"164","author":"C Michiels","year":"2004","journal-title":"Am J Pathol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S1095-6433(00)00234-8","article-title":"Surviving hypoxia without really dying","volume":"126","author":"RG Boutilier","year":"2000","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.2741\/2267","article-title":"Intranasal administration with NAD+ profoundly decreases brain injury in a rat model of transient focal ischemia","volume":"12","author":"W Ying","year":"2007","journal-title":"Front Biosci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1042\/BJ20070024","article-title":"Signalling to translation: how signal transduction pathways control the protein synthetic machinery","volume":"403","author":"CG Proud","year":"2007","journal-title":"Biochem J"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"5360","DOI":"10.1046\/j.1432-1033.2002.03290.x","article-title":"Regulation of peptide-chain elongation in mammalian cells","volume":"269","author":"GJ Browne","year":"2002","journal-title":"Eur J Biochem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1432-1033.1990.tb19169.x","article-title":"Functional properties of phosphorylated elongation factor 2","volume":"191","author":"U Carlberg","year":"1990","journal-title":"Eur J Biochem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/334170a0","article-title":"Phosphorylation of elongation factor 2 by EF-2 kinase affects rate of translation","volume":"334","author":"AG Ryazanov","year":"1988","journal-title":"Nature"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1128\/MCB.01270-12","article-title":"Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase","volume":"33","author":"AA Hizli","year":"2013","journal-title":"Mol Cell Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0014-5793(87)80081-9","article-title":"Ca2+\/calmodulin-dependent phosphorylation of elongation factor 2","volume":"214","author":"AG Ryazanov","year":"1987","journal-title":"FEBS Lett"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/bj3530621","article-title":"Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+\/calmodulin-independent activity","volume":"353","author":"TA Diggle","year":"2001","journal-title":"Biochem J"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"12220","DOI":"10.1074\/jbc.M309773200","article-title":"Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398","volume":"279","author":"GJ Browne","year":"2004","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"393","DOI":"10.4161\/auto.5.3.7762","article-title":"A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses","volume":"5","author":"BF Py","year":"2009","journal-title":"Autophagy"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"9554","DOI":"10.1128\/MCB.25.21.9554-9575.2005","article-title":"AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress","volume":"25","author":"K Terai","year":"2005","journal-title":"Mol Cell Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1158\/0008-5472.CAN-05-1554","article-title":"Elongation factor-2 kinase regulates autophagy in human glioblastoma cells","volume":"66","author":"H Wu","year":"2006","journal-title":"Cancer Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.1242\/jcs.01540","article-title":"The AMP-activated protein kinase pathway\u2013new players upstream and downstream","volume":"117","author":"DG Hardie","year":"2004","journal-title":"J Cell Sci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s11064-010-0186-3","article-title":"A pharmacological activator of AMP-activated protein kinase protects hypoxic neurons in a concentration-dependent manner","volume":"35","author":"X Zhang","year":"2010","journal-title":"Neurochem Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1042\/CS20080066","article-title":"AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease","volume":"116","author":"AK Wong","year":"2009","journal-title":"Clin Sci (Lond)"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00109-011-0748-0","article-title":"AMP-activated protein kinase inhibits NF-kappaB signaling and inflammation: impact on healthspan and lifespan","volume":"89","author":"A Salminen","year":"2011","journal-title":"J Mol Med (Berl)"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"32771","DOI":"10.1074\/jbc.M403528200","article-title":"Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte","volume":"279","author":"AY Chan","year":"2004","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1471-4159.2011.07331.x","article-title":"AMP-activated protein kinase: a potential player in Alzheimer\u2019s disease","volume":"118","author":"A Salminen","year":"2011","journal-title":"J Neurochem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bbrc.2009.01.041","article-title":"Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells","volume":"380","author":"SJ Greco","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.bbrc.2008.01.099","article-title":"Inhibitory crosstalk between ERK and AMPK in the growth and proliferation of cardiac fibroblasts","volume":"368","author":"J Du","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/jcbfm.2009.255","article-title":"Effects of AMP-activated protein kinase in cerebral ischemia","volume":"30","author":"J Li","year":"2010","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1161\/CIRCRESAHA.108.187567","article-title":"AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633","volume":"104","author":"Z Chen","year":"2009","journal-title":"Circ Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1161\/01.STR.25.2.429","article-title":"L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat","volume":"25","author":"E Morikawa","year":"1994","journal-title":"Stroke"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ceca.2004.02.011","article-title":"Role of nitric oxide after brain ischaemia","volume":"36","author":"MA Moro","year":"2004","journal-title":"Cell Calcium"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1089\/neu.2007.9985","article-title":"Guidelines for the management of severe traumatic brain injury. XI. Anesthetics, analgesics, and sedatives","volume":"24","author":"SL Bratton","year":"2007","journal-title":"J Neurotrauma"},{"key":"ref36","unstructured":"Roberts I (2000) Barbiturates for acute traumatic brain injury. Cochrane Database Syst Rev CD000033."},{"key":"ref37","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1124\/mol.108.052183","article-title":"Heterocyclic Thioureylenes Protect from Calcium-Dependent Neuronal Cell Death","volume":"75","author":"M Humar","year":"2009","journal-title":"Molecular Pharmacology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/00000542-199808000-00023","article-title":"Thiopental inhibits increases in [Ca2+](i) induced by membrane depolarization, NMDA receptor activation, and ischemia in rat hippocampal and cortical slices","volume":"89","author":"RZ Zhan","year":"1998","journal-title":"Anesthesiology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1093\/bja\/81.6.932","article-title":"Differential inhibitory effects of thiopental, thiamylal and phenobarbital on both voltage-gated calcium channels and NMDA receptors in rat hippocampal slices","volume":"81","author":"RZ Zhan","year":"1998","journal-title":"British Journal of Anaesthesia"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1097\/00000542-200003000-00020","article-title":"Effect of barbiturates on hydroxyl radicals, lipid peroxidation, and hypoxic cell death in human NT2-N neurons","volume":"92","author":"R Almaas","year":"2000","journal-title":"Anesthesiology"},{"key":"ref41","unstructured":"Smith DS, Rehncrona S, Siesjo BK (1980) Barbiturates as protective agents in brain ischemia and as free radical scavengers in vitro. Acta Physiol Scand Suppl 492: 129\u2013134."},{"key":"ref42","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/00008506-200201000-00014","article-title":"Free radicals, antioxidants, and neurologic injury: possible relationship to cerebral protection by anesthetics","volume":"14","author":"JX Wilson","year":"2002","journal-title":"J Neurosurg Anesthesiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1124\/jpet.107.133108","article-title":"Thiopental protects human T lymphocytes from apoptosis in vitro via the expression of heat shock protein 70","volume":"325","author":"M Roesslein","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1097\/00130478-200307001-00014","article-title":"Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 13. The use of barbiturates in the control of intracranial hypertension in severe pediatric traumatic brain injury","volume":"4","author":"PD Adelson","year":"2003","journal-title":"Pediatr Crit Care Med"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00000542-198009000-00001","article-title":"Mechanisms of barbiturate protection","volume":"53","author":"PA Steen","year":"1980","journal-title":"Anesthesiology"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Lin CC, Wu YJ, Heimrich B, Schwemmle M (2013) Absence of a robust innate immune response in rat neurons facilitates persistent infection of Borna disease virus in neuronal tissue. Cell Mol Life Sci [Epub ahead of print].","DOI":"10.1007\/s00018-013-1402-5"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1097\/00000542-197612000-00013","article-title":"Gas chromatographic assay for free and total plasma levels of thiopental","volume":"45","author":"KE Becker Jr","year":"1976","journal-title":"Anesthesiology"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3171\/jns.1982.56.2.0254","article-title":"Barbiturate inhibition of lymphocyte function. Differing effects of various barbiturates used to induce coma","volume":"56","author":"EA Neuwelt","year":"1982","journal-title":"J Neurosurg"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF01642801","article-title":"Postmortem concentrations of thiopental in tissues: a sudden death case","volume":"105","author":"T Yasuda","year":"1993","journal-title":"Int J Legal Med"},{"key":"ref50","first-page":"9","article-title":"Thiamylal and thiopental attenuate beta-adrenergic signaling pathway by suppressing adenylyl cyclase in rat ventricular myocytes","volume":"58","author":"I Hidaka","year":"2009","journal-title":"Hiroshima J Med Sci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1042\/bj0760047","article-title":"Barbiturates and Oxidative Phosphorylation","volume":"76","author":"WN Aldridge","year":"1960","journal-title":"Biochemical Journal"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.tem.2011.12.006","article-title":"AMPK functions as an adenylate charge-regulated protein kinase","volume":"23","author":"JS Oakhill","year":"2012","journal-title":"Trends Endocrinol Metab"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"Doenicke A (1965) General pharmacology of barbiturates. Duration of action, metabolism, physicochemical factors. Acta Anaesthesiol Scand Suppl 17: 11\u201316.","DOI":"10.1111\/j.1399-6576.1965.tb00603.x"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF01406868","article-title":"The effect of high dose barbiturate decompression after severe head injury. A controlled clinical trial","volume":"72","author":"HK Nordby","year":"1984","journal-title":"Acta Neurochir (Wien )"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/01.WCB.0000066287.21705.21","article-title":"Effects of hypothermia on energy metabolism in Mammalian central nervous system","volume":"23","author":"M Erecinska","year":"2003","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3346\/jkms.2006.21.2.337","article-title":"Neuroprotective effect of cycloheximide on hypoxic-ischemic brain injury in neonatal rats","volume":"21","author":"WS Park","year":"2006","journal-title":"J Korean Med Sci"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"568","DOI":"10.3171\/jns.1988.69.4.0568","article-title":"Reduction of cellular energy requirements. Screening for agents that may protect against CNS ischemia","volume":"69","author":"EL Zager","year":"1988","journal-title":"J Neurosurg"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.cell.2013.04.055","article-title":"The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation","volume":"153","author":"G Leprivier","year":"2013","journal-title":"Cell"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1042\/bj3360525","article-title":"Regulation of protein-synthesis elongation-factor-2 kinase by cAMP in adipocytes","volume":"336","author":"TA Diggle","year":"1998","journal-title":"Biochemical Journal"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1046\/j.1460-9568.2002.02403.x","article-title":"Expression of functional NR1\/NR2B-type NMDA receptors in neuronally differentiated SK-N-SH human cell line","volume":"16","author":"M Pizzi","year":"2002","journal-title":"European Journal of Neuroscience"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"9203","DOI":"10.1523\/JNEUROSCI.22-21-09203.2002","article-title":"Barbiturates induce mitochondrial depolarization and potentiate excitotoxic neuronal death","volume":"22","author":"CM Anderson","year":"2002","journal-title":"Journal of Neuroscience"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1124\/mol.65.2.350","article-title":"Barbiturates directly inhibit the calmodulin\/calcineurin complex: a novel mechanism of inhibition of nuclear factor of activated T cells","volume":"65","author":"M Humar","year":"2004","journal-title":"Molecular Pharmacology"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/00000542-200308000-00017","article-title":"Thiopental inhibits tumor necrosis factor alpha-induced activation of nuclear factor kappa B through suppression of I kappa B kinase activity","volume":"99","author":"T Loop","year":"2003","journal-title":"Anesthesiology"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/BF03016699","article-title":"Thiopentone and methohexital, but not pentobarbitone, reduce early focal cerebral ischemic injury in rats","volume":"48","author":"DJ Cole","year":"2001","journal-title":"Canadian Journal of Anaesthesia-Journal Canadien D Anesthesie"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/sj.bjp.0701884","article-title":"Nitric oxide induced cytotoxicity attenuation by thiopentone sodium but not pentobarbitone sodium in primary brain cultures","volume":"124","author":"S Shibuta","year":"1998","journal-title":"British Journal of Pharmacology"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1084\/jem.185.8.1481","article-title":"Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis","volume":"185","author":"M Leist","year":"1997","journal-title":"J Exp Med"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0006-8993(92)90726-P","article-title":"Anisomycin and cycloheximide protect cerebellar neurons in culture from anoxia","volume":"581","author":"F Dessi","year":"1992","journal-title":"Brain Res"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0006-8993(90)90144-Z","article-title":"Effects of cycloheximide on delayed neuronal death in rat hippocampus","volume":"534","author":"K Goto","year":"1990","journal-title":"Brain Res"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0014-2999(02)01490-5","article-title":"Mitochondrial respiratory chain as a new target for anti-ischemic molecules","volume":"441","author":"N Bouaziz","year":"2002","journal-title":"Eur J Pharmacol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0077258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T03:32:25Z","timestamp":1564543945000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0077258"}},"subtitle":[],"editor":[{"given":"Ferenc","family":"Gallyas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,10,22]]},"references-count":69,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0077258","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,22]]}}}