{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:22:08Z","timestamp":1790839328673,"version":"4.1.0"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T00:00:00Z","timestamp":1383091200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0077509","type":"journal-article","created":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T20:27:06Z","timestamp":1383164826000},"page":"e77509","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Olfaction in Three Genetic and Two MPTP-Induced Parkinson\u2019s Disease Mouse Models"],"prefix":"10.1371","volume":"8","author":[{"given":"Stefan","family":"Kurtenbach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Wewering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanns","family":"Hatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva M.","family":"Neuhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"L\u00fcbbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,10,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.neuro.22.1.123","article-title":"Etiology and pathogenesis of Parkinson\u2019s disease","volume":"22","author":"CW Olanow","year":"1999","journal-title":"Annual review of neuroscience"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.1007\/s00415-008-5005-2","article-title":"Genes associated with Parkinson syndrome","volume":"255","author":"S Biskup","year":"2008","journal-title":"Journal of neurology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1365-2990.2008.00952.x","article-title":"Review: Familial Parkinson\u2019s disease\u2013genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease","volume":"34","author":"C Schiesling","year":"2008","journal-title":"Neuropathology and applied neurobiology"},{"key":"ref4","first-page":"9848","article-title":"Neuroprotective role of the Reaper-related serine protease HtrA2\/Omi revealed by targeted deletion in mice","volume":"24","author":"L Martins","year":"2004","journal-title":"\u2026 and cellular biology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1212\/WNL.66.10_suppl_4.S10","article-title":"Etiology of Parkinson\u2019s disease","volume":"66","author":"V Schapira AH","year":"2006","journal-title":"Neurology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1111\/j.1471-4159.2005.03442.x","article-title":"Proteomic analysis of parkin knockout mice: alterations in energy metabolism, protein handling and synaptic function","volume":"95","author":"M Periquet","year":"2005","journal-title":"Journal of neurochemistry"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease","volume":"24","author":"H Braak","year":"2003","journal-title":"Neurobiology of aging"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neurobiolaging.2003.04.001","article-title":"Poor and protracted myelination as a contributory factor to neurodegenerative disorders","volume":"25","author":"H Braak","year":"2004","journal-title":"Neurobiology of aging"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.1365-2990.2011.01194.x","article-title":"Unmyelinated axons are more vulnerable to degeneration than myelinated axons of the cardiac nerve in Parkinson\u2019s disease","volume":"37","author":"S Orimo","year":"2011","journal-title":"Neuropathology and applied neurobiology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s007020200013","article-title":"Olfactory function in idiopathic Parkinson\u2019s disease (IPD): results from cross-sectional studies in IPD patients and long-term follow-up of de-novo IPD patients","volume":"109","author":"A M\u00fcller","year":"2002","journal-title":"Journal of neural transmission"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1212\/WNL.33.7.943","article-title":"Olfactory impairment in Parkinson\u2019s disease","volume":"33","author":"CD Ward","year":"1983","journal-title":"Neurology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0021-9681(75)90058-2","article-title":"Olfactory function in patients with Parkinson\u2019s disease","volume":"28","author":"KA Ansari","year":"1975","journal-title":"Journal of chronic diseases"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/mds.21413","article-title":"Olfactory loss may be a first sign of idiopathic Parkinson\u2019s disease","volume":"22","author":"A Haehner","year":"2007","journal-title":"Movement disorders"},{"key":"ref14","first-page":"436","article-title":"Olfactory dysfunction in Parkinson\u2019s disease","volume":"62","author":"C Hawkes","year":"1997","journal-title":"Journal of Neurology, \u2026"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/qjmed\/92.8.473","article-title":"Is Parkinson\u2019s disease a primary olfactory disorder?","volume":"92","author":"CH Hawkes","year":"1999","journal-title":"QJM?: monthly journal of the Association of Physicians"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1001\/archneur.55.1.84","article-title":"Olfaction in neurodegenerative disease: a meta-analysis of olfactory functioning in Alzheimer\u2019s and Parkinson's diseases","volume":"55","author":"RI Mesholam","year":"1998","journal-title":"Archives of neurology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/ana.20160","article-title":"Idiopathic hyposmia as a preclinical sign of Parkinson\u2019s disease","volume":"56","author":"MM Ponsen","year":"2004","journal-title":"Annals of neurology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"S309","DOI":"10.1016\/S1353-8020(08)70022-1","article-title":"Gene-environment interactions in Parkinson\u2019s disease","volume":"13","author":"CA Ross","year":"2007","journal-title":"Parkinsonism & related disorders"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s007020100004","article-title":"Neurochemical findings in the MPTP model of Parkinson\u2019s disease","volume":"108","author":"N Schmidt","year":"2001","journal-title":"Journal of neural transmission"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1460-9568.2003.02408.x","article-title":"The mouse MPTP model: gene expression changes in dopaminergic neurons","volume":"17","author":"K Kuhn","year":"2003","journal-title":"European Journal of Neuroscience"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e8762","DOI":"10.1371\/journal.pone.0008762","article-title":"Progression of Parkinson\u2019s disease pathology is reproduced by intragastric administration of rotenone in mice","volume":"5","author":"F Pan-Montojo","year":"2010","journal-title":"PloS one"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.expneurol.2006.07.001","article-title":"The risk is in the air: Intranasal administration of MPTP to rats reproducing clinical features of Parkinson\u2019s disease","volume":"202","author":"RDS Prediger","year":"2006","journal-title":"Experimental neurology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s12640-009-9087-0","article-title":"Single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL\/6 mice models early preclinical phase of Parkinson\u2019s disease","volume":"17","author":"RDS Prediger","year":"2010","journal-title":"Neurotoxicity research"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.neuron.2010.04.034","article-title":"Genetic animal models of Parkinson\u2019s disease","volume":"66","author":"TM Dawson","year":"2010","journal-title":"Neuron"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000085064","article-title":"Influence of different promoters on the expression pattern of mutated human alpha-synuclein in transgenic mice","volume":"1","author":"L Maskri","year":"2004","journal-title":"Neuro-degenerative diseases"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1093\/hmg\/ddm083","article-title":"Mono- and double-mutant mouse models of Parkinson\u2019s disease display severe mitochondrial damage","volume":"16","author":"CC Stichel","year":"2007","journal-title":"Human molecular genetics"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1093\/hmg\/ddq564","article-title":"Genetic mouse models for Parkinson\u2019s disease display severe pathology in glial cell mitochondria","volume":"20","author":"S Schmidt","year":"2011","journal-title":"Human molecular genetics"},{"key":"ref28","first-page":"375462","article-title":"Spinal cord pathology in alpha-synuclein transgenic mice","volume":"2010","author":"S Mendritzki","year":"2010","journal-title":"Parkinson\u2019s disease"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/0031-9384(95)02163-9","article-title":"Odor sensitivity is impaired in HIV-positive cognitively impaired patients","volume":"59","author":"J Razani","year":"1996","journal-title":"Physiology & behavior"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0197-4580(01)00263-9","article-title":"Olfactory impairment increases as a function of age in persons with Down syndrome","volume":"23","author":"RK Nijjar","year":"2002","journal-title":"Neurobiology of aging"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1017\/S1355617700000278","article-title":"Sensory- and memory-mediated olfactory dysfunction in Huntington\u2019s disease","volume":"1","author":"S Nordin","year":"1995","journal-title":"Journal of the International Neuropsychological Society?: JINS"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1093\/schbul\/sbp111","article-title":"Scents and nonsense: olfactory dysfunction in schizophrenia","volume":"35","author":"BI Turetsky","year":"2009","journal-title":"Schizophrenia bulletin"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1113\/jphysiol.2007.129601","article-title":"Mechanisms of neuronal chloride accumulation in intact mouse olfactory epithelium","volume":"583","author":"WT Nickell","year":"2007","journal-title":"The Journal of physiology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1152\/jn.00962.2005","article-title":"Neuronal chloride accumulation in olfactory epithelium of mice lacking NKCC1","volume":"95","author":"WT Nickell","year":"2006","journal-title":"Journal of neurophysiology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/ana.410320116","article-title":"Lack of major olfactory dysfunction in MPTP-induced parkinsonism","volume":"32","author":"RL Doty","year":"1992","journal-title":"Annals of neurology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1023\/B:JOBB.0000041771.66775.d5","article-title":"MPTP as a mitochondrial neurotoxic model of Parkinson\u2019s disease","volume":"36","author":"S Przedborski","year":"2004","journal-title":"Journal of bioenergetics and biomembranes"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/cne.10804","article-title":"Developmental expression pattern of monoamine oxidases in sensory organs and neural crest derivatives","volume":"464","author":"T Vitalis","year":"2003","journal-title":"The Journal of comparative neurology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0014-2999(86)90444-9","article-title":"The influence of dose and dosing interval on MPTP-induced dopaminergic neurotoxicity in mice","volume":"129","author":"PK Sonsalla","year":"1986","journal-title":"European journal of pharmacology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S1568-1637(02)00066-1","article-title":"Age-related trends in gene expression in the chemosensory-nasal mucosae of senescence-accelerated mice","volume":"2","author":"TV Getchell","year":"2003","journal-title":"Ageing research reviews"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/WNR.0b013e32832aa95b","article-title":"Strain-specific sensitivity to MPTP of C57BL\/6 and BALB\/c mice is age dependent","volume":"20","author":"NM Filipov","year":"2009","journal-title":"Neuroreport"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1111\/j.1460-9568.2006.05060.x","article-title":"Persistent penetration of MPTP through the nasal route induces Parkinson\u2019s disease in mice","volume":"24","author":"AI Rojo","year":"2006","journal-title":"The European journal of neuroscience"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0378-4274(90)90192-O","article-title":"Tissue concentrations of MPTP and MPP+ after administration of lethal and sublethal doses of MPTP to mice","volume":"54","author":"R Fuller","year":"1990","journal-title":"Toxicology letters"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.neuroscience.2010.10.072","article-title":"Inducible dopaminergic glutathione depletion in an \u03b1-synuclein transgenic mouse model results in age-related olfactory dysfunction","volume":"172","author":"YH Kim","year":"2011","journal-title":"Neuroscience"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"8103","DOI":"10.1523\/JNEUROSCI.1495-09.2009","article-title":"Nonmotor symptoms of Parkinson\u2019s disease revealed in an animal model with reduced monoamine storage capacity","volume":"29","author":"TN Taylor","year":"2009","journal-title":"The Journal of neuroscience?: the official journal of the Society for Neuroscience"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00429-011-0347-4","article-title":"\u03b1-Synuclein in the olfactory system of a mouse model of Parkinson\u2019s disease: correlation with olfactory projections","volume":"217","author":"I Ubeda-Ba\u00f1on","year":"2012","journal-title":"Brain structure & function"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1460-9568.2008.06346.x","article-title":"Olfactory deficits in mice overexpressing human wildtype alpha-synuclein","volume":"28","author":"SM Fleming","year":"2008","journal-title":"The European journal of neuroscience"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"26946","DOI":"10.1074\/jbc.274.38.26946","article-title":"Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf","volume":"274","author":"M Flagella","year":"1999","journal-title":"The Journal of biological chemistry"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/BF00228798","article-title":"Ultrastructure of PkC(II\/III)-immunopositive structures in rat primary visual cortex","volume":"82","author":"CC Stichel","year":"1990","journal-title":"Experimental brain research"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"7426","DOI":"10.1523\/JNEUROSCI.19-17-07426.1999","article-title":"Specificity and sensitivity of a human olfactory receptor functionally expressed in human embryonic kidney 293 cells and Xenopus Laevis oocytes","volume":"19","author":"CH Wetzel","year":"1999","journal-title":"The Journal of neuroscience"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0077509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T14:47:09Z","timestamp":1564584429000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0077509"}},"subtitle":[],"editor":[{"given":"Alexander J.","family":"Whitworth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,10,30]]},"references-count":49,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0077509","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,30]]}}}