{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T22:54:26Z","timestamp":1758840866779},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T00:00:00Z","timestamp":1381449600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0077562","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T23:12:50Z","timestamp":1381533170000},"page":"e77562","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Sex-Specific Effects of NLRP6\/AVR and ADM Loci on Susceptibility to Essential Hypertension in a Sardinian Population"],"prefix":"10.1371","volume":"8","author":[{"given":"Nicola","family":"Glorioso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria L.","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Didishvili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria F.","family":"Ortu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Zaninello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Fresu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiseppe","family":"Argiolas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Troffa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson","family":"Ruiz-Opazo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,10,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0140-6736(07)61299-9","article-title":"Essential hypertension","volume":"370","author":"FH Messerli","year":"2007","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/j.amjmed.2008.05.019","article-title":"Management of hypertension and cerebrovascular disease in the elderly","volume":"121","author":"L Pedelty","year":"2008","journal-title":"Am J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/jhh.2008.67","article-title":"The pressure of finding human hypertension genes: new tools, old dilemmas","volume":"22","author":"F Charchar","year":"2008","journal-title":"J Hum Hypertens"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1038\/ejhg.2008.102","article-title":"Replication of the Wellcome Trust genome-wide association study of essential hypertension: the Family Blood Pressure Program","volume":"16","author":"GB Ehret","year":"2008","journal-title":"Eur J Hum Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1042\/CS20050208","article-title":"Molecular genetics of human hypertension","volume":"110","author":"M Gong","year":"2006","journal-title":"Clin Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/ng.384","article-title":"Genome-wide association study of blood pressure and hypertension","volume":"41","author":"D Levy","year":"2009","journal-title":"Nat Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/ng.361","article-title":"Genome-wide association study identifies eight loci associated with blood pressure","volume":"41","author":"C Newton-Cheh","year":"2009","journal-title":"Nat Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature10405","article-title":"Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk","volume":"478","year":"2011","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature05911","article-title":"Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls","volume":"447","year":"2007","journal-title":"Nature"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1126\/science.1975705","article-title":"Alteration of alpha 1 Na+,K(+)-ATPase 86Rb+ influx by a single amino acid substitution","volume":"249","author":"VL Herrera","year":"1990","journal-title":"Science"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1172\/JCI3868","article-title":"The \u03b11 Na,K-ATPase gene is a susceptibility hypertension gene in the Dahl salt-sensitive<sup>HSD<\/sup> rat","volume":"102","author":"VL Herrera","year":"1998","journal-title":"J Clin Invest"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1152\/physiolgenomics.00285.2005","article-title":"Sex-specific QTLs and interacting loci underlie salt-sensitive hypertension and target organ complications in Dahl S\/jrHS hypertensive rats","volume":"26","author":"VL Herrera","year":"2006","journal-title":"Physiol Genomics"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1152\/physiolgenomics.00108.2004","article-title":"Sex-specific effects of dual ET-1\/ANG II receptor (Dear) variants in Dahl salt-sensitive\/resistant hypertension rat model","volume":"20","author":"Y Kaneko","year":"2005","journal-title":"Physiol Genomics"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1161\/01.HYP.38.2.204","article-title":"Interaction of \u03b11Na,K-ATPase and Na.K: 2Cl-cotransporter genes in human essential hypertension","volume":"38","author":"N Glorioso","year":"2001","journal-title":"Hypertension"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1161\/01.RES.0000267716.96196.60","article-title":"Association of ATP1A1 and dear single-nucleotide polymorphism haplotypes with essential hypertension: sex-specific and haplotype-specific effects","volume":"100","author":"N Glorioso","year":"2007","journal-title":"Circ Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1152\/physiolgenomics.00012.2011","article-title":"<italic>DEspR<\/italic> T\/CATAAAA-box promoter variant decreases DEspR transcription and is associated with increased BP in Sardinian males","volume":"43","author":"N Glorioso","year":"2011","journal-title":"Physiol Genomics"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/BF03402000","article-title":"The dual AngII\/AVP receptor gene N119S\/C163R variant exhibits sodium-induced dysfunction and cosegregates with salt-sensitive hypertension in the Dahl Salt sensitive hypertensive rat model","volume":"8","author":"N Ruiz-Opazo","year":"2002","journal-title":"Mol Medicine"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.2174\/092986707780830943","article-title":"Adrenomedullin in the kidney-renal physiological and pathophysiological roles","volume":"14","author":"T Nishikimi","year":"2007","journal-title":"Curr Med Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1080\/10641960802443068","article-title":"A pilot study on level of blood vasoactive factors in prehypertensive and hypertensive patients","volume":"30","author":"Z Wang","year":"2008","journal-title":"Clin Exp Hypertens"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1126\/science.8511584","article-title":"Who are the Europeans?","volume":"260","author":"A Piazza","year":"1993","journal-title":"Science"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1469-1809.1996.tb01183.x","article-title":"Genetic analysis of Sardinia: I. data on 12 polymorphisms in 21 linguistic domains","volume":"60","author":"N Cappello","year":"1996","journal-title":"Ann Hum Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1471-2156-6-S1-S4","article-title":"Genome scan linkage analysis comparing microsatellites and single-nucleotide polymorphisms markers for two measures of alcoholism in chromosomes 1, 4, and 7","volume":"6","author":"G Chen","year":"2005","journal-title":"BMC Genetics"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1186\/1471-2156-6-S1-S84","article-title":"The efficacy of short tandem repeat polymorphisms versus single-nucleotide polymorphisms for resolving population structure","volume":"6","author":"JS Kauwe","year":"2005","journal-title":"BMC Genet"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1161\/01.HYP.0000088560.10830.37","article-title":"Chronic salt loading upregulates expression of adrenomedullin and its receptors in adrenal glands and kidneys of the rat","volume":"42","author":"YN Cao","year":"2003","journal-title":"Hypertension"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1358\/dnp.2002.15.8.840072","article-title":"The role of adrenomedullin in cardiovascular and renal function","volume":"15","author":"J Chao","year":"2002","journal-title":"Drug News Perspect"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1161\/hc4101.097111","article-title":"Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene","volume":"104","author":"T Shindo","year":"2001","journal-title":"Circulation"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1291\/hypres.28.229","article-title":"Haplotype-based case-control study revealing an association between the adrenomedullin gene and proteinuria in subjects with essential hypertension","volume":"28","author":"Y Kobayashi","year":"2005","journal-title":"Hypertens Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/hr.2012.132","article-title":"Association of adrenomedullin gene polymorphisms and blood pressure in a Chinese population","volume":"36","author":"S Chen","year":"2013","journal-title":"Hypertens Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1161\/CIRCULATIONAHA.106.652842","article-title":"Associations of plasma natriuretic peptide, adrenomedullin, and homocysteine levels with alterations in arterial stiffness: the Framingham Heart Study","volume":"115","author":"D Levy","year":"2007","journal-title":"Circulation"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1152\/physiolgenomics.00199.2007","article-title":"Overlapping genes in Nalp6\/PYPAF5 locus encode two V2-type vasopressin isoreceptors: angiotensin-vasopressin receptor (AVR) and non-AVR","volume":"34","author":"VL Herrera","year":"2008","journal-title":"Physiol Genomics"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1152\/physiolgenomics.00154.2010","article-title":"AVR\/NAVR deficiency lowers blood pressure and differentially affects urinary concentrating ability, cognition, and anxiety-like behavior in male and female mice","volume":"43","author":"VL Herrera","year":"2011","journal-title":"Physiol Genomics"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0077562","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T15:02:53Z","timestamp":1564498973000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0077562"}},"subtitle":[],"editor":[{"given":"Ana Paula","family":"Arez","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,10,11]]},"references-count":31,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0077562","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,11]]}}}