{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:34:06Z","timestamp":1790278446644,"version":"4.1.0"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T00:00:00Z","timestamp":1381795200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0077633","type":"journal-article","created":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T03:13:53Z","timestamp":1381893233000},"page":"e77633","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["Accelerated Activation of SOCE Current in Myotubes from Two Mouse Models of Anesthetic- and Heat-Induced Sudden Death"],"prefix":"10.1371","volume":"8","author":[{"given":"Viktor","family":"Yarotskyy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feliciano","family":"Protasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T.","family":"Dirksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,10,15]]},"reference":[{"key":"ref1","article-title":"Malignant hyperthermia susceptibility","author":"H Rosenberg","year":"2010","journal-title":"GeneReviews at GeneTests: Medical Genetics Information Resource [database online]"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/ALN.0b013e318167aee2","article-title":"Cardiac arrests and deaths associated with malignant hyperthermia in north america from 1987 to 2006: a report from the north american malignant hyperthermia registry of the malignant hyperthermia association of the United States","volume":"108","author":"MG Larach","year":"2008","journal-title":"Anesthesiology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/0140-6736(91)92304-K","article-title":"Evidence for related myopathies in exertional heat stroke and malignant hyperthermia","volume":"338","author":"PM Hopkins","year":"1991","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1001\/jama.286.2.168","article-title":"Malignant hyperthermia and apparent heat stroke","volume":"286","author":"JR Tobin","year":"2001","journal-title":"JAMA"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00000542-200101000-00019","article-title":"Evidence for susceptibility to malignant hyperthermia in patients with exercise-induced rhabdomyolysis","volume":"94","author":"F Wappler","year":"2001","journal-title":"Anesthesiology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1093\/bja\/88.4.508","article-title":"Malignant hyperthermia associated with exercise-induced rhabdomyolysis or congenital abnormalities and a novel RYR1 mutation in New Zealand and Australian pedigrees","volume":"88","author":"M Davis","year":"2002","journal-title":"Br J Anaesth"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1213\/ane.0b013e3181a9d8d9","article-title":"The relationship between exertional heat illness, exertional rhabdomyolysis, and malignant hyperthermia","volume":"109","author":"JF Capacchione","year":"2009","journal-title":"Anesth Analg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.legalmed.2008.12.004","article-title":"Identification of malignant hyperthermia-susceptible ryanodine receptor type 1 gene (RYR1) mutations in a child who died in a car after exposure to a high environmental temperature","volume":"11","author":"H Nishio","year":"2009","journal-title":"Leg Med (Tokyo)"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1097\/ALN.0b013e3182320068","article-title":"Identical de novo mutation in the type 1 ryanodine receptor gene associated with fatal, stress-induced malignant hyperthermia in two unrelated families","volume":"115","author":"L Groom","year":"2011","journal-title":"Anesthesiology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1096\/fj.05-4497fje","article-title":"Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse","volume":"20","author":"MG Chelu","year":"2006","journal-title":"FASEB J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1097\/00000542-200612000-00016","article-title":"Pharmacologic and functional characterization of malignant hyperthermia in the R163C RyR1 knock-in mouse","volume":"105","author":"T Yang","year":"2006","journal-title":"Anesthesiology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1096\/fj.08-121335","article-title":"Anesthetic- and heat-induced sudden death in calsequestrin-1-knockout mice","volume":"23","author":"M Dainese","year":"2009","journal-title":"FASEB J"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1113\/jphysiol.2009.171967","article-title":"Calsequestrin-1: a new candidate gene for malignant hyperthermia and exertional\/environmental heat stroke","volume":"587","author":"F Protasi","year":"2009","journal-title":"J Physiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1073\/pnas.0812661106","article-title":"A retrograde signal from RyR1 alters DHP receptor inactivation and limits window Ca2+ release in muscle fibers of Y522S RyR1 knock-in mice","volume":"106","author":"Z Andronache","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"22326","DOI":"10.1073\/pnas.1009168108","article-title":"Massive alterations of sarcoplasmic reticulum free calcium in skeletal muscle fibers lacking calsequestrin revealed by a genetically encoded probe","volume":"107","author":"M Canato","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","first-page":"301","article-title":"Porcine malignant hyperthermia: effects of temperature and extracellular calcium concentration on halothane-induced contracture of susceptible skeletal muscle","volume":"42","author":"TE Nelson","year":"1975","journal-title":"Anesthesiology"},{"key":"ref17","first-page":"107","article-title":"Calcium content and contracture in isolated muscle of malignant hyperthermia in pigs","volume":"219","author":"TE Nelson","year":"1981","journal-title":"J Pharmacol Exp Ther"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/BF03006495","article-title":"The importance of calcium ions for in vitro malignant hyperthermia testing","volume":"37","author":"JE Fletcher","year":"1990","journal-title":"Can J Anaesth"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/00000542-199109000-00006","article-title":"Effects of calcium-free solution, calcium antagonists, and the calcium agonist BAY K 8644 on mechanical responses of skeletal muscle from patients susceptible to malignant hyperthermia","volume":"75","author":"PJ Adnet","year":"1991","journal-title":"Anesthesiology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"25645","DOI":"10.1074\/jbc.M110.104976","article-title":"Store-operated Ca2+ entry in malignant hyperthermia-susceptible human skeletal muscle","volume":"285","author":"AM Duke","year":"2010","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1074\/jbc.M209045200","article-title":"A retrograde signal from calsequestrin for the regulation of store-operated Ca2+ entry in skeletal muscle","volume":"278","author":"DW Shin","year":"2003","journal-title":"J Biol Chem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.bpj.2010.06.050","article-title":"Increased store-operated Ca2+ entry in skeletal muscle with reduced calsequestrin-1 expression","volume":"99","author":"X Zhao","year":"2010","journal-title":"Biophys J"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"33477","DOI":"10.1074\/jbc.M602306200","article-title":"Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor","volume":"281","author":"X Zhao","year":"2006","journal-title":"J Biol Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.bpj.2012.06.001","article-title":"Temperature and RyR1 Regulate the Activation Rate of Store-Operated Ca(2+) Entry Current in Myotubes","volume":"103","author":"V Yarotskyy","year":"2012","journal-title":"Biophys J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1085\/jgp.115.4.467","article-title":"Functional impact of the ryanodine receptor on the skeletal muscle L-type Ca(2+) channel","volume":"115","author":"G Avila","year":"2000","journal-title":"J Gen Physiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"15572","DOI":"10.1074\/jbc.M600090200","article-title":"Knocking down type 2 but not type 1 calsequestrin reduces calcium sequestration and release in C2C12 skeletal muscle myotubes","volume":"281","author":"Y Wang","year":"2006","journal-title":"J Biol Chem"},{"key":"ref27","article-title":"Differential effect of calsequestrin ablation on structure and function of fast and slow twitch skeletal fibers","author":"C Paolini","year":"2011","journal-title":"J Biomed Biotechnol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1085\/jgp.201010454","article-title":"Paradoxical buffering of calcium by calsequestrin demonstrated for the calcium store of skeletal muscle","volume":"136","author":"L Royer","year":"2010","journal-title":"J Gen Physiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cell.2008.02.042","article-title":"RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice","volume":"133","author":"WJ Durham","year":"2008","journal-title":"Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1085\/jgp.201010592","article-title":"Measurement of RyR permeability reveals a role of calsequestrin in termination of SR Ca(2+) release in skeletal muscle","volume":"138","author":"M Sztretye","year":"2011","journal-title":"J Gen Physiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nchembio.558","article-title":"Temperature-dependent STIM1 activation induces Ca(2)+ influx and modulates gene expression","volume":"7","author":"B Xiao","year":"2011","journal-title":"Nat Chem Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1113\/jphysiol.2007.135046","article-title":"Store-operated Ca2+ entry during intracellular Ca2+ release in mammalian skeletal muscle","volume":"583","author":"BS Launikonis","year":"2007","journal-title":"J Physiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.ceca.2010.04.001","article-title":"Ultra-rapid activation and deactivation of store-operated Ca(2+) entry in skeletal muscle","volume":"47","author":"JN Edwards","year":"2010","journal-title":"Cell Calcium"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1113\/jphysiol.2009.172148","article-title":"Checking your SOCCs and feet: the molecular mechanisms of Ca2+ entry in skeletal muscle","volume":"587","author":"RT Dirksen","year":"2009","journal-title":"J Physiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/ncb788","article-title":"Dysfunction of store-operated calcium channel in muscle cells lacking mg29","volume":"4","author":"Z Pan","year":"2002","journal-title":"Nat Cell Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1113\/jphysiol.2008.160481","article-title":"Differential dependence of store-operated and excitation-coupled Ca2+ entry in skeletal muscle on STIM1 and Orai1","volume":"586","author":"AD Lyfenko","year":"2008","journal-title":"J Physiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1073\/pnas.0536227100","article-title":"Identification of the coupling between skeletal muscle store-operated Ca2+ entry and the inositol trisphosphate receptor","volume":"100","author":"BS Launikonis","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1073\/pnas.0511252103","article-title":"Depletion &quot;skraps&quot; and dynamic buffering inside the cellular calcium store","volume":"103","author":"BS Launikonis","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1113\/jphysiol.2007.138024","article-title":"Reorganized stores and impaired calcium handling in skeletal muscle of mice lacking calsequestrin-1","volume":"583","author":"C Paolini","year":"2007","journal-title":"J Physiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1093\/bja\/47.1.62","article-title":"Control of the malignant hyperpyrexic syndrome in MHS swine by dantrolene sodium","volume":"47","author":"GG Harrison","year":"1975","journal-title":"Br J Anaesth"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/ACO.0b013e328337ffe0","article-title":"Anesthesia for patients with a history of malignant hyperthermia","volume":"23","author":"F Wappler","year":"2010","journal-title":"Curr Opin Anaesthesiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1042\/bj3260847","article-title":"Pharmacological distinction between dantrolene and ryanodine binding sites: evidence from normal and malignant hyperthermia-susceptible porcine skeletal muscle","volume":"326","author":"SS Palnitkar","year":"1997","journal-title":"Biochem J"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"18465","DOI":"10.1074\/jbc.270.31.18465","article-title":"Identification of dantrolene binding sites in porcine skeletal muscle sarcoplasmic reticulum","volume":"270","author":"J Parness","year":"1995","journal-title":"J Biol Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1124\/jpet.105.084046","article-title":"Effects of azumolene on Ca2+ sparks in skeletal muscle fibers","volume":"314","author":"Y Zhang","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"6580","DOI":"10.1074\/jbc.M408375200","article-title":"Dantrolene stabilizes domain interactions within the ryanodine receptor","volume":"280","author":"S Kobayashi","year":"2005","journal-title":"J Biol Chem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1124\/mol.107.043299","article-title":"Enhanced excitation-coupled calcium entry in myotubes expressing malignant hyperthermia mutation R163C is attenuated by dantrolene","volume":"73","author":"G Cherednichenko","year":"2008","journal-title":"Mol Pharmacol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"26965","DOI":"10.1074\/jbc.272.43.26965","article-title":"Dantrolene inhibition of sarcoplasmic reticulum Ca2+ release by direct and specific action at skeletal muscle ryanodine receptors","volume":"272","author":"BR Fruen","year":"1997","journal-title":"J Biol Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1085\/jgp.118.4.355","article-title":"Effects of dantrolene on steps of excitation-contraction coupling in mammalian skeletal muscle fibers","volume":"118","author":"P Szentesi","year":"2001","journal-title":"J Gen Physiol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1085\/jgp.200810105","article-title":"The skeletal L-type Ca(2+) current is a major contributor to excitation-coupled Ca(2+) entry","volume":"133","author":"RA Bannister","year":"2009","journal-title":"J Gen Physiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0077633","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T12:30:57Z","timestamp":1589027457000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0077633"}},"subtitle":[],"editor":[{"given":"Mohamed","family":"Trebak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,10,15]]},"references-count":49,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0077633","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,15]]}}}