{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:13:31Z","timestamp":1767179611956,"version":"build-2238731810"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T00:00:00Z","timestamp":1382313600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0077695","type":"journal-article","created":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T17:14:44Z","timestamp":1382375684000},"page":"e77695","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["SMAD3 rs17228212 Gene Polymorphism Is Associated with Reduced Risk to Cerebrovascular Accidents and Subclinical Atherosclerosis in Anti-CCP Negative Spanish Rheumatoid Arthritis Patients"],"prefix":"10.1371","volume":"8","author":[{"given":"Mercedes","family":"Garc\u00eda-Berm\u00fadez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"L\u00f3pez-Mej\u00edas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Genre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santos","family":"Casta\u00f1eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Gonz\u00e1lez-Juanatey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Llorca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Corrales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.","family":"Miranda-Filloy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Rueda-Gotor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"G\u00f3mez-Vaquero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Rodr\u00edguez-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjam\u00edn","family":"Fern\u00e1ndez-Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dora","family":"Pascual-Salcedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Balsa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"L\u00f3pez-Longo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Carreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isidoro","family":"Gonz\u00e1lez-\u00c1lvaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Gonz\u00e1lez-Gay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,10,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.semarthrit.2005.03.004","article-title":"Rheumatoid arthritis: a disease associated with accelerated atherogenesis","volume":"35","author":"MA Gonzalez-Gay","year":"2005","journal-title":"Semin Arthritis Rheum"},{"key":"ref2","first-page":"943","article-title":"Influence of nonclassical cardiovascular risk factors on the accuracy of predicting subclinical atherosclerosis in rheumatoid arthritis","volume":"34","author":"PH Dessein","year":"2007","journal-title":"J Rheumatol"},{"key":"ref3","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/574817","article-title":"Genetic markers of cardiovascular disease in rheumatoid arthritis","volume":"2012","author":"L Rodr\u00edguez-Rodr\u00edguez","year":"2012","journal-title":"Mediat Inflamm"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e49214","DOI":"10.1371\/journal.pone.0049214","article-title":"Study of association of CD40-CD154 gene polymorphisms with disease susceptibility and cardiovascular risk in Spanish rheumatoid arthritis patients","volume":"7","author":"M Garc\u00eda-Berm\u00fadez","year":"2012","journal-title":"PLOS ONE"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.atherosclerosis.2012.06.008","article-title":"NFKB1-94ATTG ins\/del polymorphism (rs28362491) is associated with cardiovascular disease in patients with rheumatoid arthritis","volume":"224","author":"R L\u00f3pez-Mej\u00edas","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1056\/NEJMoa072366","article-title":"Genomewide association analysis of coronary artery disease","volume":"357","author":"NJ Samani","year":"2007","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/jcb.21255","article-title":"A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling","volume":"101","author":"KA Brown","year":"2007","journal-title":"J Cell Biochem"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/ni1549","article-title":"Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer","volume":"9","author":"Y Tone","year":"2008","journal-title":"Nat Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.clim.2008.01.009","article-title":"The Th17\/Treg imbalance in patients with acute coronary syndrome","volume":"127","author":"X Cheng","year":"2008","journal-title":"Clin Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1161\/CIRCGENETICS.110.940858","article-title":"Transforming growth factor-beta signaling pathway in patients with Kawasaki disease","volume":"4","author":"C Shimizu","year":"2011","journal-title":"Circ Cardiovasc Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1136\/gut.2009.199679","article-title":"New IBD genetics: common pathways with other diseases","volume":"60","author":"CW Lees","year":"2011","journal-title":"Gut"},{"key":"ref12","author":"FC Arnett"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"62","author":"D Aletaha","year":"2010","journal-title":"Arthritis Rheum"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.semarthrit.2008.01.012","article-title":"Carotid intima-media thickness predicts the development of cardiovascular events in patients with rheumatoid arthritis","volume":"38","author":"C Gonzalez-Juanatey","year":"2009","journal-title":"Semin Arthritis Rheum"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/art.22482","article-title":"HLA-DRB1 and persistent chronic inflammation contribute to cardiovascular events and cardiovascular mortality in patients with rheumatoid arthritis","volume":"57","author":"MA Gonzalez-Gay","year":"2007","journal-title":"Arthritis Rheum"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"6A","DOI":"10.1016\/0735-1097(93)90455-A","article-title":"The epidemiology of heart failure: the Framingham Study","volume":"22","author":"KK Ho","year":"1993","journal-title":"J Am Coll Cardiol"},{"key":"ref17","doi-asserted-by":"crossref","DOI":"10.1136\/annrheumdis-2013-eular.1779","article-title":"Carotid ultrasound is useful for the cardiovascular risk stratification of patients with rheumatoid arthritis: results of a population-based study","author":"A Corrales","year":"2013"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/art.21707","article-title":"Effect of anti-tumor necrosis factor alpha therapy on the progression of subclinical atherosclerosis in severe rheumatoid arthritis","volume":"55","author":"C Gonzalez-Juanatey","year":"2006","journal-title":"Arthritis Rheum"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1093\/rheumatology\/ker206","article-title":"Multi-examiner reliability of automated radio frequency-based ultrasound measurements of common carotid intima-media thickness in rheumatoid arthritis","volume":"50","author":"E Naredo","year":"2011","journal-title":"Rheumatology (Oxf)"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3899\/jrheum.120621","article-title":"Carotid plaque characteristics and disease activity in rheumatoid arthritis","volume":"40","author":"AG Semb","year":"2013","journal-title":"J Rheumatol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1056\/NEJM199901073400103","article-title":"Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group","volume":"340","author":"DH O'Leary","year":"1999","journal-title":"N Engl J Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1161\/01.STR.0000048214.56981.6F","article-title":"Genetic and environmental contributions to atherosclerosis phenotypes in men and women: heritability of carotid intima-media thickness in the Framingham Heart Study","volume":"34","author":"CS Fox","year":"2003","journal-title":"Stroke"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1161\/01.STR.0000142132.20442.d8","article-title":"Genetic and environmental contributions to carotid intima-media thickness and obesity phenotypes in the Northern Manhattan Family Study","volume":"35","author":"SH Juo","year":"2004","journal-title":"Stroke"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nrrheum.2012.16","article-title":"Validated methods for assessment of subclinical atherosclerosis in rheumatology","volume":"8","author":"G Kerekes","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S0140-6736(10)60826-4","article-title":"Rheumatoid arthritis","volume":"376","author":"DL Scott","year":"2010","journal-title":"Lancet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMra043430","article-title":"Inflammation, atherosclerosis, and coronary artery disease","volume":"352","author":"GK Hansson","year":"2005","journal-title":"N Engl J Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/art.24390","article-title":"Association between anti-cyclic citrullinated peptide antibodies and ischemic heart disease in patients with rheumatoid arthritis","volume":"61","author":"FJ L\u00f3pez-Longo","year":"2009","journal-title":"Arthritis Rheum"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nrrheum.2011.204","article-title":"The influence of ACPA status and characteristics on the course of RA","volume":"8","author":"A Willemze","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.1002\/art.21385","article-title":"Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins","volume":"52","author":"TW Huizinga","year":"2005","journal-title":"Arthritis Rheum"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1136\/annrheumdis-2011-201225","article-title":"Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients","volume":"71","author":"S Viatte","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nrrheum.2011.28","article-title":"Rheumatoid arthritis: Are ACPA-positive and ACPA-negative RA the same disease?","volume":"7","author":"NA Daha","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrrheum.2012.237","article-title":"Genetics and epigenetics of rheumatoid arthritis","volume":"9","author":"S Viatte","year":"2013","journal-title":"Nat Rev Rheumatol"}],"updated-by":[{"DOI":"10.1371\/annotation\/3fc037c1-2585-4d2b-a781-e04ab7b3bfeb","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,11,7]],"date-time":"2013-11-07T00:00:00Z","timestamp":1383782400000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0077695","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T03:16:25Z","timestamp":1540005385000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0077695"}},"subtitle":[],"editor":[{"given":"Amr\u00a0H","family":"Sawalha","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,10,21]]},"references-count":32,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0077695","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,21]]}}}