{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:59:21Z","timestamp":1789480761064,"version":"build-2803163510"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T00:00:00Z","timestamp":1383004800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0077948","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T22:29:01Z","timestamp":1383085741000},"page":"e77948","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["EBUS-TBNA Provides Highest RNA Yield for Multiple Biomarker Testing from Routinely Obtained Small Biopsies in Non-Small Cell Lung Cancer Patients - A Comparative Study of Three Different Minimal Invasive Sampling Methods"],"prefix":"10.1371","volume":"8","author":[{"given":"Gerald","family":"Schmid-Bindert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Henzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lothar R.","family":"Pilz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengxiang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caicun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,10,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"A Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"ref2","first-page":"735","article-title":"Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study.Lancet","volume":"Oncol12(8)","author":"C Zhou","year":"2011"},{"key":"ref3","first-page":"410","article-title":"Wakelee HA, Dahlberg SE, Brahmer JR, Schiller JH, Perry MC, et al. (2012)","volume":"Cancer76(3)","journal-title":"Differential effect of age on survival in advanced NSCLC in women versus men: analysis of recent Eastern Cooperative Oncology Group (ECOG) studies, with and without bevacizumab.Lung"},{"key":"ref4","first-page":"222","article-title":"Comparison of pemetrexed plus cisplatin with other first-line doublets in advanced non-small cell lung cancer (NSCLC): a combined analysis of three phase 3 trials.Lung","volume":"Cancer76(2)","author":"J Treat","year":"2012"},{"key":"ref5","first-page":"226","article-title":"Individualized Chemotherapy in Advanced NSCLC Patients Based on mRNA Levels of BRCA1 and RRM1.Chin J Cancer","volume":"Res24(3)","author":"SX Ren","year":"2012"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1365-2559.2011.03854.x","article-title":"Personalized medicine for lung cancer: new challenges for pathology","volume":"60","author":"KM Kerr","year":"2012","journal-title":"Histopathology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1097\/JTO.0b013e3181ddbbe9","article-title":"Tissue banking of diagnostic lung cancer biopsies for extraction of high quality RNA","volume":"5","author":"MH Lawson","year":"2010","journal-title":"J Thorac Oncol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1183\/09031936.01.00275301","article-title":"The new World Health Organization classification of lung tumours","volume":"18","author":"E Brambilla","year":"2001","journal-title":"Eur Respir J"},{"key":"ref9","first-page":"1078","article-title":"High-level mRNA of excision repair cross-complementation group 1 gene is associated with poor outcome of platinum-based doublet chemotherapy of advanced nonsmall cell lung cancer patients.Cancer","volume":"Invest28(10)","author":"S Ren","year":"2010"},{"key":"ref10","first-page":"1411","article-title":"ERCC1, RRM1 and BRCA1 mRNA expression levels and clinical outcome of advanced non-small cell lung cancer","volume":"Oncol28(4)","author":"C Su","year":"2011","journal-title":"Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/00130404-200601000-00007","article-title":"Rapid detection of epidermal growth factor receptor mutations in non-small cell lung cancer using real-time polymerase chain reaction with TaqMan-MGB probes","volume":"12(1)","author":"C Zhou","year":"2006","journal-title":"Cancer J"},{"key":"ref12","first-page":"67","article-title":"EGFR mutations are detected comparably in cytologic and surgical pathology specimens of nonsmall cell lung cancer","volume":"117","author":"JH Smouse","year":"2009","journal-title":"Cancer"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/s10147-008-0772-4","article-title":"Accuracy of epidermal growth factor receptor gene mutation analysis by direct sequencing method based on small biopsy specimens from patients with non-small cell lung cancer: analysis of results in 19 patients","volume":"13","author":"K Masago","year":"2008","journal-title":"Int J Clin Oncol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/dc.22905","article-title":"Epidermal growth factor receptor and Kras gene expression: Reliability of mutational analysis on cytological samples","volume":"41(7)","author":"C Bozzetti","year":"2013","journal-title":"Diagn Cytopathol Diagn Cytopathol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.lungcan.2013.01.007","article-title":"Reliability of EGFR and KRAS mutation analysis on fine-needle aspiration washing in non-small cell lung cancer","volume":"Cancer80(1)","author":"C Bozzetti","year":"2013","journal-title":"Lung"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/cncy.20151","article-title":"EGFR and KRAS mutations in lung carcinoma: molecular testing by using cytology specimens","volume":"119(2)","author":"S Billah","year":"2011","journal-title":"Cancer Cytopathol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1007\/s00432-010-0853-4","article-title":"Dose effect of cigarette smoking on frequency and spectrum of epidermal growth factor receptor gene mutations in Korean patients with non-small cell lung cancer","volume":"136","author":"YJ Lee","year":"2010","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref18","first-page":"e40109","article-title":"Identification of enriched driver gene alterations in subgroups of non-small cell lung cancer patients based on histology and smoking status.PLoS ONE","volume":"7(6)","author":"SJ An","year":"2012"},{"key":"ref19","first-page":"430","article-title":"Epidermal growth factor receptor mutations and their correlation with gefitinib therapy in patients with non-small cell lung cancer: a meta-analysis based on updated individual patient data from six medical centers in mainland China.J Thorac","volume":"Oncol2(5)","author":"YL Wu","year":"2007"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1097\/JTO.0b013e3181fd418d","article-title":"Association of epidermal growth factor receptor activating mutations with low ERCC1 gene expression in non-small cell lung cancer","volume":"5","author":"DR Gandara","year":"2010","journal-title":"J Thorac Oncol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1002\/cncr.27603","article-title":"Association of EGFR mutation or ALK rearrangement with expression of DNA repair and synthesis genes in never-smoker women with pulmonary adenocarcinoma","volume":"118(22)","author":"S Ren","year":"2012","journal-title":"Cancer"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1183\/09031936.00097908","article-title":"Effectiveness and safety of endobronchial ultrasound-transbronchial needle aspiration: a systematic review","volume":"J33","author":"L Varela-Lema","year":"2009","journal-title":"Eur Respir"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1111\/j.1440-1843.2012.02223.x","article-title":"Predicting malignancy in mediastinal lymph nodes by endobronchial ultrasound: a new ultrasound scoring system. Respirology","volume":"17(8)","author":"G Schmid-Bindert","year":"2012","journal-title":"Respirology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0077948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T04:38:38Z","timestamp":1540269518000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0077948"}},"subtitle":[],"editor":[{"given":"John D.","family":"Minna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,10,29]]},"references-count":23,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0077948","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,29]]}}}