{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T09:05:28Z","timestamp":1775293528013,"version":"3.50.1"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T00:00:00Z","timestamp":1381881600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0078050","type":"journal-article","created":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T21:15:05Z","timestamp":1381958105000},"page":"e78050","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Salicylate Prevents Virus-Induced Type 1 Diabetes in the BBDR Rat"],"prefix":"10.1371","volume":"8","author":[{"given":"Chaoxing","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Jurczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"diIorio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Norowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Brehm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian W.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis L.","family":"Guberski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale L.","family":"Greiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Bortell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,10,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1146\/annurev.iy.08.040190.003243","article-title":"Type-I diabetes: a chronic autoimmune disease of human, mouse, and rat","volume":"8","author":"L Casta\u00f1o","year":"1990","journal-title":"Annu Rev Immunol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s001250051626","article-title":"Heterogeneity of type I diabetes: analysis of monozygotic twins in Great Britain and the United States","volume":"44","author":"MJ Redondo","year":"2001","journal-title":"Diabetologia"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1046\/j.1464-5491.1999.00098.x","article-title":"Enterovirus variants in the serum of children at the onset of Type 1 diabetes mellitus","volume":"16","author":"C Nairn","year":"1999","journal-title":"Diabet Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"d35","DOI":"10.1136\/bmj.d35","article-title":"Enterovirus infection and type 1 diabetes mellitus: systematic review and meta-analysis of observational molecular studies","volume":"342","author":"WC Yeung","year":"2011","journal-title":"BMJ"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-1-62703-068-7_3","article-title":"The BB rat as a model of human type 1 diabetes","volume":"933","author":"R Bortell","year":"2012","journal-title":"Methods Mol Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1093\/ilar.45.3.278","article-title":"Rat models of type 1 diabetes: genetics, environment, and autoimmunity","volume":"45","author":"JP Mordes","year":"2004","journal-title":"Ilar J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.4049\/jimmunol.170.7.3592","article-title":"Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations","volume":"170","author":"D Zipris","year":"2003","journal-title":"J Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5873","DOI":"10.1128\/JVI.67.10.5873-5878.1993","article-title":"Infection of peripancreatic lymph nodes but not islets precedes Kilham rat virus-induced diabetes in BB\/Wor rats","volume":"67","author":"DW Brown","year":"1993","journal-title":"J Virol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.clim.2009.02.007","article-title":"DNA microarray analysis for the identification of innate immune pathways implicated in virus-induced autoimmune diabetes","volume":"132","author":"TR Wolter","year":"2009","journal-title":"Clin Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s001250051162","article-title":"Plasma concentration of C-reactive protein is increased in type I diabetic patients without clinical macroangiopathy and correlates with markers of endothelial dysfunction: evidence for chronic inflammation","volume":"42","author":"CG Schalkwijk","year":"1999","journal-title":"Diabetologia"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1210\/jc.2007-2185","article-title":"Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state","volume":"93","author":"S Devaraj","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1007\/s00109-010-0666-6","article-title":"Altered Toll-like receptor signaling pathways in human type 1 diabetes","volume":"88","author":"AJ Meyers","year":"2010","journal-title":"J Mol Med (Berl)"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1345\/aph.1M483","article-title":"Potential role of salicylates in type 2 diabetes","volume":"44","author":"MM Rumore","year":"2010","journal-title":"Ann Pharmacother"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nri2925","article-title":"Type 2 diabetes as an inflammatory disease","volume":"11","author":"MY Donath","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1752-8062.2008.00026.x","article-title":"Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes. Clin","volume":"1","author":"AB Goldfine","year":"2008","journal-title":"Transl Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"346","DOI":"10.7326\/0003-4819-152-6-201003160-00004","article-title":"The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial","volume":"152","author":"AB Goldfine","year":"2010","journal-title":"Ann Intern Med"},{"key":"ref17","first-page":"346","article-title":"The adipocyte IKK\/NFkappaB pathway: a therapeutic target for insulin resistance","volume":"10","author":"H Ruan","year":"2009","journal-title":"Curr Opin Investig Drugs"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1258\/ebm.2010.010150","article-title":"Haptoglobin as an early serum biomarker of virus-induced autoimmune type 1 diabetes in biobreeding diabetes resistant and LEW1.WR1 rats","volume":"235","author":"AJ Kruger","year":"2010","journal-title":"Exp Biol Med (Maywood)"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1126\/science.1658938","article-title":"Induction of type I diabetes by Kilham's rat virus in diabetes-resistant BB\/Wor rats","volume":"254","author":"DL Guberski","year":"1991","journal-title":"Science"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.2337\/db10-0372","article-title":"Identification of a serum-induced transcriptional signature associated with type 1 diabetes in the BioBreeding rat","volume":"59","author":"M Kaldunski","year":"2010","journal-title":"Diabetes"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/nature09386","article-title":"A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk","volume":"467","author":"M Heinig","year":"2010","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/hmg\/ddn342","article-title":"IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells","volume":"18","author":"S Liu","year":"2009","journal-title":"Hum Mol Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.4049\/jimmunol.180.3.1929","article-title":"Identification of a molecular signature in human type 1 diabetes mellitus using serum and functional genomics","volume":"180","author":"X Wang","year":"2008","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.2337\/db11-0264","article-title":"Children with islet autoimmunity and enterovirus infection demonstrate a distinct cytokine profile","volume":"61","author":"WC Yeung","year":"2012","journal-title":"Diabetes"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0078050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T10:52:52Z","timestamp":1688554372000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0078050"}},"subtitle":[],"editor":[{"given":"Dong-Yan","family":"Jin","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,10,16]]},"references-count":24,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0078050","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,16]]}}}