{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:43:29Z","timestamp":1791265409888,"version":"4.1.0"},"reference-count":61,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T00:00:00Z","timestamp":1385942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0078191","type":"journal-article","created":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T16:14:07Z","timestamp":1386000847000},"page":"e78191","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":65,"title":["Helicobacter pylori Cholesteryl \u03b1-Glucosides Contribute to Its Pathogenicity and Immune Response by Natural Killer T Cells"],"prefix":"10.1371","volume":"8","author":[{"given":"Yuki","family":"Ito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Luis","family":"Vela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Matsumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitomi","family":"Hoshino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Tyznik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heeseob","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Girardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk M.","family":"Zajonc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Liddington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiro","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingfeng","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanna","family":"Bugaytsova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bor\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongsheng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinong","family":"Zong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Seeberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Kronenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,12,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0140-6736(84)91816-6","article-title":"Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration","volume":"1","author":"BJ Marshall","year":"1984","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/nrc703","article-title":"Helicobacter pylori and gastrointestinal tract adenocarcinomas","volume":"2","author":"RM Peek Jr","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"17807","DOI":"10.1073\/pnas.0407503101","article-title":"Induction of peripheral lymph node addressin in human gastric mucosa infected by Helicobacter pylori","volume":"101","author":"M Kobayashi","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3109\/00365529309098333","article-title":"Role of Helicobacter pylori in the pathogenesis of gastritis, peptic ulcer and gastric cancer","volume":"Suppl 196","author":"P Sipponen","year":"1993","journal-title":"Scand J Gastroenterol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1136\/gut.49.4.474","article-title":"Helicobacter pylori and two ultrastructurally distinct layers of gastric mucous cell mucins in the surface mucous gel layer","volume":"49","author":"E Hidaka","year":"2001","journal-title":"Gut"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"8991","DOI":"10.1073\/pnas.96.16.8991","article-title":"Expression cloning of a human alpha1, 4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1\u21924Galbeta\u2192R, a glycan specifically expressed in the gastric gland mucous cell-type mucin","volume":"96","author":"J Nakayama","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1111\/j.1462-5822.2007.00921.x","article-title":"Helicobacter pylori is invasive and it may be a facultative intracellular organism","volume":"9","author":"A Dubois","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/BF01886504","article-title":"A dual staining method for identifying mucins of different gastric epithelial mucous cells","volume":"23","author":"H Ota","year":"1991","journal-title":"Histochem J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1042\/bj3640191","article-title":"Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution","volume":"364","author":"H Nordman","year":"2002","journal-title":"Biochem J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1172\/JCI59087","article-title":"Essential role of gastric gland mucin in preventing gastric cancer in mice","volume":"122","author":"F Karasawa","year":"2012","journal-title":"J Clin Invest"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2174\/138920009787048428","article-title":"Carbohydrate-dependent defense mechanisms against Helicobacter pylori infection","volume":"10","author":"M Kobayashi","year":"2009","journal-title":"Curr Drug Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1126\/science.1099250","article-title":"Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection","volume":"305","author":"M Kawakubo","year":"2004","journal-title":"Science"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"5327","DOI":"10.1128\/jb.177.18.5327-5333.1995","article-title":"Unique cholesteryl glucosides in Helicobacter pylori: composition and structural analysis","volume":"177","author":"Y Hirai","year":"1995","journal-title":"J Bacteriol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/nm1480","article-title":"Cholesterol glucosylation promotes immune evasion by Helicobacter pylori","volume":"12","author":"C Wunder","year":"2006","journal-title":"Nat Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1369\/jhc.2010.957092","article-title":"Membrane-associated activation of cholesterol alpha-glucosyltransferase, an enzyme responsible for biosynthesis of cholesteryl-alpha-D-glucopyranoside in Helicobacter pylori critical for its survival","volume":"59","author":"H Hoshino","year":"2011","journal-title":"J Histochem Cytochem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.bbrc.2006.08.145","article-title":"Expression cloning of cholesterol alpha-glucosyltransferase, a unique enzyme that can be inhibited by natural antibiotic gastric mucin O-glycans, from Helicobacter pylori","volume":"349","author":"H Lee","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/glycob\/cwn037","article-title":"Alpha1,4GlcNAc-capped mucin-type O-glycan inhibits cholesterol alpha-glucosyltransferase from Helicobacter pylori and suppresses H. pylori growth","volume":"18","author":"H Lee","year":"2008","journal-title":"Glycobiology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev.immunol.21.120601.141057","article-title":"The regulatory role of Valpha14 NKT cells in innate and acquired immune response","volume":"21","author":"M Taniguchi","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nrmicro1657","article-title":"The unique role of natural killer T cells in the response to microorganisms","volume":"5","author":"E Tupin","year":"2007","journal-title":"Nat Rev Microbiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1146\/annurev.cellbio.042308.113238","article-title":"Rolling cell adhesion","volume":"26","author":"RP McEver","year":"2010","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev.immunol.21.090501.080131","article-title":"Ligands for L-selectin: homing, inflammation, and beyond","volume":"22","author":"SD Rosen","year":"2004","journal-title":"Annu Rev Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0065-2776(08)01002-X","article-title":"Natural killer cell tolerance licensing and other mechanisms","volume":"101","author":"AH Jonsson","year":"2009","journal-title":"Adv Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/ni.1953","article-title":"Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses","volume":"11","author":"S Paust","year":"2010","journal-title":"Nat Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1084\/jem.20051473","article-title":"Suppression of tumor formation in lymph nodes by L-selectin-mediated natural killer cell recruitment","volume":"202","author":"S Chen","year":"2005","journal-title":"J Exp Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/ni1380","article-title":"Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria","volume":"7","author":"Y Kinjo","year":"2006","journal-title":"Nat Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.4049\/jimmunol.165.9.4797","article-title":"Cutting edge: CD1d deficiency impairs murine host defense against the spirochete, Borrelia burgdorferi","volume":"165","author":"H Kumar","year":"2000","journal-title":"J Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/nature03407","article-title":"Recognition of bacterial glycosphingolipids by natural killer T cells","volume":"434","author":"Y Kinjo","year":"2005","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/ni.2096","article-title":"Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria","volume":"12","author":"Y Kinjo","year":"2011","journal-title":"Nat Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/41483","article-title":"The complete genome sequence of the gastric pathogen Helicobacter pylori","volume":"388","author":"JF Tomb","year":"1997","journal-title":"Nature"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.1128\/AEM.69.8.4866-4874.2003","article-title":"Directed evolution of Thermus maltogenic amylase toward enhanced thermal resistance","volume":"69","author":"YW Kim","year":"2003","journal-title":"Appl Environ Microbiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1084\/jem.191.1.115","article-title":"Virulent strains of Helicobacter pylori demonstrate delayed phagocytosis and stimulate homotypic phagosome fusion in macrophages","volume":"191","author":"LA Allen","year":"2000","journal-title":"J Exp Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1126\/science.1086871","article-title":"Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation","volume":"301","author":"B Gebert","year":"2003","journal-title":"Science"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1126\/science.1067147","article-title":"SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein","volume":"295","author":"H Higashi","year":"2002","journal-title":"Science"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"W284","DOI":"10.1093\/nar\/gki418","article-title":"FFAS03: a server for profile\u2013profile sequence alignments","volume":"33","author":"L Jaroszewski","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"20705","DOI":"10.1074\/jbc.M702087200","article-title":"Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria","volume":"282","author":"ME Guerin","year":"2007","journal-title":"J Biol Chem"},{"key":"ref36","unstructured":"Andersen LP, Wadstrom T (2001) Helicobacter pylori: Physiology and Genetics. In: Mobley HLT, Mendz GL, Hazell SL, editors. Basic bacteriology and culture. Washington, D.C.: ASM Press."},{"key":"ref37","first-page":"407","article-title":"Alteration in the composition of cholesteryl glucosides and other lipids in Helicobacter pylori undergoing morphological change from spiral to coccoid form","volume":"237","author":"H Shimomura","year":"2004","journal-title":"FEMS Microbiol Lett"},{"key":"ref38","first-page":"1161","article-title":"Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994","volume":"20","author":"MF Dixon","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nrc1141","article-title":"Control of gut differentiation and intestinal-type gastric carcinogenesis","volume":"3","author":"Y Yuasa","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"27765","DOI":"10.1074\/jbc.M603345200","article-title":"Cloning of a cholesterol-alpha-glucosyltransferase from Helicobacter pylori","volume":"281","author":"AH Lebrun","year":"2006","journal-title":"J Biol Chem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1126\/science.278.5343.1626","article-title":"CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides","volume":"278","author":"T Kawano","year":"1997","journal-title":"Science"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1574-695X.2007.00338.x","article-title":"Host response to Helicobacter pylori infection before initiation of the adaptive immune response","volume":"51","author":"HM Algood","year":"2007","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.4049\/jimmunol.173.2.1249","article-title":"Human dendritic cells respond to Helicobacter pylori, promoting NK cell and Th1-effector responses in vitro","volume":"173","author":"N Hafsi","year":"2004","journal-title":"J Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/ni.1894","article-title":"Programming dendritic cells to induce T(H)2 and tolerogenic responses","volume":"11","author":"B Pulendran","year":"2010","journal-title":"Nat Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.4049\/jimmunol.0901115","article-title":"Helicobacter pylori-induced Th17 responses modulate Th1 cell responses, benefit bacterial growth, and contribute to pathology in mice","volume":"184","author":"Y Shi","year":"2010","journal-title":"J Immunol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nature09447","article-title":"Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling","volume":"467","author":"K Ghoreschi","year":"2010","journal-title":"Nature"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nri2785","article-title":"FOXP3+ regulatory T cells in the human immune system","volume":"10","author":"S Sakaguchi","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/path.2851","article-title":"Prominent expression of sialyl Lewis X-capped core 2-branched O-glycans on high endothelial venule-like vessels in gastric MALT lymphoma","volume":"224","author":"M Kobayashi","year":"2011","journal-title":"J Pathol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrmicro1658","article-title":"Helicobacter pylori evolution and phenotypic diversification in a changing host","volume":"5","author":"S Suerbaum","year":"2007","journal-title":"Nat Rev Microbiol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1053\/j.gastro.2005.03.037","article-title":"Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers","volume":"128","author":"J Houghton","year":"2005","journal-title":"Gastroenterology"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1369\/jhc.5A6836.2006","article-title":"Terminal alpha1,4-linked N-acetylglucosamine in Helicobacter pylori-associated intestinal metaplasia of the human stomach and gastric carcinoma cell lines","volume":"54","author":"B Ferreira","year":"2006","journal-title":"J Histochem Cytochem"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/ni1225","article-title":"The crystal structure of human CD1d with and without alpha-galactosylceramide","volume":"6","author":"M Koch","year":"2005","journal-title":"Nat Immunol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1074-7613(02)00453-3","article-title":"Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells","volume":"17","author":"F Heller","year":"2002","journal-title":"Immunity"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1523-5378.2008.00559.x","article-title":"Conventional, regulatory, and unconventional T cells in the immunologic response to Helicobacter pylori","volume":"13","author":"J O'Keeffe","year":"2008","journal-title":"Helicobacter"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1172\/JCI44845","article-title":"Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity","volume":"121","author":"YJ Chang","year":"2011","journal-title":"J Clin Invest"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, inflammation, and cancer","volume":"140","author":"SI Grivennikov","year":"2010","journal-title":"Cell"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.cell.2006.08.019","article-title":"Glycosylation in cellular mechanisms of health and disease","volume":"126","author":"K Ohtsubo","year":"2006","journal-title":"Cell"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1126\/science.1098801","article-title":"Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin","volume":"305","author":"M Aspholm-Hurtig","year":"2004","journal-title":"Science"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"34651","DOI":"10.1074\/jbc.M604574200","article-title":"Cag pathogenicity island-independent up-regulation of matrix metalloproteinases-9 and -2 secretion and expression in mice by Helicobacter pylori infection","volume":"281","author":"P Kundu","year":"2006","journal-title":"J Biol Chem"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0076-6879(06)17014-7","article-title":"Activation of natural killer T cells by glycolipids","volume":"417","author":"E Tupin","year":"2006","journal-title":"Methods Enzymol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jconrel.2008.09.078","article-title":"Liposomal glycosphingolipids activate natural killer T cell-mediated immune responses through the endosomal pathway","volume":"133","author":"J Inoue","year":"2009","journal-title":"J Control Release"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0078191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:05:03Z","timestamp":1540253103000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0078191"}},"subtitle":[],"editor":[{"given":"Roger","family":"Chammas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,2]]},"references-count":61,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0078191","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718198857.793490179","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,2]]}}}