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R package version 3.1\u201389 ed."},{"key":"ref22","unstructured":"Sarkar D (2009) lattice: Lattice Graphics. R package version 0.17\u201322 ed."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1651-2227.1979.tb05025.x","article-title":"Human colostral and breast milk cells. 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Australia: The University of Western Australia."},{"key":"ref30","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1093\/carcin\/21.4.799","article-title":"DNA damage in human breast milk cells and its induction by \u2018early\u2019 and \u2018late\u2019 milk extracts","volume":"21","author":"FL Martin","year":"2000","journal-title":"Carcinogenesis"},{"key":"ref31","unstructured":"Buescher ES, Pickering LK (1986) Polymorphonuclear leukocytes in human colostrum and milk. In: Howell RR, Morriss FH, Pickering LK, Human Milk in Infant Nutrition and Health. USA: Charles C. 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