{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:40:12Z","timestamp":1772638812165,"version":"3.50.1"},"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T00:00:00Z","timestamp":1384387200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0078239","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T22:52:43Z","timestamp":1384469563000},"page":"e78239","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["Antinociceptive Effects of Analgesic-Antitumor Peptide (AGAP), a Neurotoxin from the Scorpion Buthus martensii Karsch, on Formalin-Induced Inflammatory Pain through a Mitogen-Activated Protein Kinases\u2013Dependent Mechanism in Mice"],"prefix":"10.1371","volume":"8","author":[{"given":"Qinghong","family":"Mao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaping","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueting","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wuguang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junli","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,11,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1042\/bj2570509","article-title":"Purification and N-terminal partial sequence of anti-epilepsy peptide from venom of the scorpion Buthus martensii Karsch","volume":"257","author":"XH Zhou","year":"1989","journal-title":"Biochem J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1046\/j.1432-1327.1999.00625.x","article-title":"Scorpion toxins specific for Na+-channels","volume":"264","author":"LD Possani","year":"1999","journal-title":"Eur J Biochem"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1081\/PB-120015456","article-title":"Isolation, purification, and N-terminal partial sequence of an antitumor peptide from the venom of the Chinese scorpion Buthus martensii Karsch","volume":"32","author":"YF Liu","year":"2002","journal-title":"Prep Biochem Biotechnol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1046-5928(02)00609-5","article-title":"Expression of an antitumor-analgesic peptide from the venom of Chinese scorpion Buthus martensii karsch in Escherichia coli","volume":"27","author":"YF Liu","year":"2003","journal-title":"Protein Expr Purif"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1002\/btpr.433","article-title":"Expression and purification of an antitumor-analgesic peptide from the venom of Mesobuthus martensii Karsch by small ubiquitin-related modifier fusion in Escherichia coli","volume":"26","author":"P Cao","year":"2010","journal-title":"Biotechnol Prog"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jep.2008.02.003","article-title":"Anti-nociceptive effects induced by intrathecal injection of BmK AS, a polypeptide from the venom of Chinese-scorpion Buthus martensi Karsch, in rat formalin test","volume":"117","author":"T Liu","year":"2008","journal-title":"J Ethnopharmacol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/16040","article-title":"Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity","volume":"2","author":"RR Ji","year":"1999","journal-title":"Nat Neurosci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1523\/JNEUROSCI.23-10-04017.2003","article-title":"p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain","volume":"23","author":"SX Jin","year":"2003","journal-title":"J Neurosci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"8310","DOI":"10.1523\/JNEUROSCI.2396-04.2004","article-title":"Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization","volume":"24","author":"Y Kawasaki","year":"2004","journal-title":"J Neurosci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1016\/j.lfs.2004.01.007","article-title":"MAPK activation in nociceptive neurons and pain hypersensitivity","volume":"74","author":"K Obata","year":"2004","journal-title":"Life Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/j.1745-7254.2005.00123.x","article-title":"Activation of ERK\/CREB pathway in spinal cord contributes to chronic constrictive injury-induced neuropathic pain in rats","volume":"26","author":"XS Song","year":"2005","journal-title":"Acta Pharmacol Sin"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.brainresrev.2008.12.011","article-title":"MAP kinase and pain","volume":"60","author":"RR Ji","year":"2009","journal-title":"Brain Res Rev"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1002\/jcb.23166","article-title":"Analgesic-antitumor peptide inhibits proliferation and migration of SHG-44 human malignant glioma cells","volume":"112","author":"Y Zhao","year":"2011","journal-title":"J Cell Biochem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0304-3959(87)90088-1","article-title":"The formalin test in mice: dissociation between inflammatory and non-inflammatory pain","volume":"30","author":"S Hunskaar","year":"1987","journal-title":"Pain"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0304-3959(89)90222-4","article-title":"Modified formalin test: characteristic biphasic pain response","volume":"38","author":"M Shibata","year":"1989","journal-title":"Pain"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0304-3959(92)90003-T","article-title":"The formalin test: an evaluation of the method","volume":"51","author":"A Tjolsen","year":"1992","journal-title":"Pain"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"7575","DOI":"10.1523\/JNEUROSCI.15-11-07575.1995","article-title":"Persistent cardiovascular and behavioral nociceptive responses to subcutaneous formalin require peripheral nerve input","volume":"15","author":"BK Taylor","year":"1995","journal-title":"J Neurosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.bbrc.2010.02.179","article-title":"Location of the analgesic domain in Scorpion toxin BmK AGAP by mutagenesis of disulfide bridges","volume":"394","author":"R Ma","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neuron.2007.07.016","article-title":"Nociceptors\u2013noxious stimulus detectors","volume":"55","author":"CJ Woolf","year":"2007","journal-title":"Neuron"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.neuropharm.2006.05.024","article-title":"Inhibition of tetanically sciatic stimulation-induced LTP of spinal neurons and Fos expression by disrupting glutamate transporter GLT-1","volume":"51","author":"ZY Wang","year":"2006","journal-title":"Neuropharmacology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1097\/ALN.0b013e3181d3e0df","article-title":"EphrinBs\/EphBs signaling is involved in modulation of spinal nociceptive processing through a mitogen-activated protein kinases-dependent mechanism","volume":"112","author":"JP Ruan","year":"2010","journal-title":"Anesthesiology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0078239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T22:43:48Z","timestamp":1564699428000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0078239"}},"subtitle":[],"editor":[{"given":"Michel R.","family":"Popoff","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,14]]},"references-count":21,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0078239","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,14]]}}}