{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:46:38Z","timestamp":1777517198467,"version":"3.51.4"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T00:00:00Z","timestamp":1381795200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0078244","type":"journal-article","created":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T03:13:33Z","timestamp":1381893213000},"page":"e78244","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Experimental Glomerular Endothelial Injury In Vivo"],"prefix":"10.1371","volume":"8","author":[{"given":"George","family":"Haddad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin Fu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Rayner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan G.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,10,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1056\/NEJMoa1106483","article-title":"Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany","volume":"365","author":"C Frank","year":"2011","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1093\/brain\/aws090","article-title":"The neurological syndrome in adults during the 2011 northern German E. coli serotype O104:H4 outbreak","volume":"135","author":"T Magnus","year":"2012","journal-title":"Brain"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s00467-008-0799-9","article-title":"Duration of oliguria and anuria as predictors of chronic renal-related sequelae in post-diarrheal hemolytic uremic syndrome","volume":"23","author":"RS Oakes","year":"2008","journal-title":"Pediatr Nephrol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1542\/peds.94.1.35","article-title":"A 20-year population-based study of postdiarrheal hemolytic uremic syndrome in Utah","volume":"94","author":"RL Siegler","year":"1994","journal-title":"Pediatrics"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"554","DOI":"10.2215\/CJN.04760512","article-title":"Genetics and outcome of atypical hemolytic uremic syndrome: a nationwide French series comparing children and adults","volume":"8","author":"V Fremeaux-Bacchi","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref6","article-title":"Antibody-mediated renal allograft rejection: diagnosis and pathogenesis","author":"RB Colvin","year":"2007","journal-title":"Review"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1182\/blood-2011-02-321315","article-title":"Small vessels, big trouble in the kidneys and beyond: hematopoietic stem cell transplantation-associated thrombotic microangiopathy","volume":"118","author":"BL Laskin","year":"2011","journal-title":"Blood"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1182\/blood.V60.4.1030.1030","article-title":"Pathologic effects of plasma from patients with thrombotic thrombocytopenic purpura on platelets and cultured vascular endothelial cells","volume":"60","author":"ER Burns","year":"1982","journal-title":"Blood"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1681\/ASN.V124767","article-title":"Verocytotoxin-induced apoptosis of human microvascular endothelial cells","volume":"12","author":"AH Pijpers","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"40567","DOI":"10.1074\/jbc.M206351200","article-title":"Shiga-like toxin inhibition of FLICE-like inhibitory protein expression sensitizes endothelial cells to bacterial lipopolysaccharide-induced apoptosis","volume":"277","author":"RD Erwert","year":"2002","journal-title":"J Biol Chem"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1096\/fj.01-0521com","article-title":"Damage to nuclear DNA induced by Shiga toxin 1 and ricin in human endothelial cells","volume":"16","author":"M Brigotti","year":"2002","journal-title":"FASEB J"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1128\/IAI.01581-07","article-title":"Shiga toxin 2 causes apoptosis in human brain microvascular endothelial cells via C\/EBP homologous protein","volume":"76","author":"J Fujii","year":"2008","journal-title":"Infect Immun"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1182\/blood-2002-10-3301","article-title":"Molecular and functional analysis of Shiga toxin-induced response patterns in human vascular endothelial cells","volume":"102","author":"A Matussek","year":"2003","journal-title":"Blood"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1172\/JCI57313","article-title":"The CXCR4\/CXCR7\/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice","volume":"122","author":"TN Petruzziello-Pellegrini","year":"2012","journal-title":"J Clin Invest"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1056\/NEJMoa011033","article-title":"Prothrombotic coagulation abnormalities preceding the hemolytic-uremic syndrome","volume":"346","author":"WL Chandler","year":"2002","journal-title":"N Engl J Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1128\/IAI.00679-08","article-title":"Shiga toxin 2 targets the murine renal collecting duct epithelium","volume":"77","author":"MA Psotka","year":"2009","journal-title":"Infect Immun"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1365-2249.2008.03826.x","article-title":"Shiga toxin-2 results in renal tubular injury but not thrombotic microangiopathy in heterozygous factor H-deficient mice","volume":"155","author":"D Paix\u00e3o-Cavalcante","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1600-6143.2008.02159.x","article-title":"Banff 07 classification of renal allograft pathology: updates and future directions","volume":"8","author":"K Solez","year":"2008","journal-title":"Am J Transplant"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0140-6736(66)92829-7","article-title":"Hyperacute rejection of kidney allografts, associated with pre-existing humoral antibodies against donor cellls","volume":"288","author":"F Kissmeyer-Nielsen","year":"1966","journal-title":"Lancet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1097\/00007890-199606150-00007","article-title":"Pathologic features of acute renal allograft rejection associated with donor-specific antibody","volume":"61","author":"K Trpkov","year":"1996","journal-title":"Transplant"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1681\/ASN.V133779","article-title":"Acute humoral rejection in kidney transplantation: II. Morphology, immunopathology, and pathologic classification","volume":"13","author":"S Mauiyyedi","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/019131290924108","article-title":"Ultrastructure as a diagnostic adjunct in the evaluation of lung allograft biopsies","volume":"29","author":"CM Magro","year":"2005","journal-title":"Ultrastruct Pathol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1111\/j.1600-6143.2005.01102.x","article-title":"Peritubular capillary damage in acute humoral rejection: an ultrastructural study on human renal allografts","volume":"5","author":"P Lipt\u00e1k","year":"2005","journal-title":"Am J Transplant"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2353\/ajpath.2008.070391","article-title":"An experimental model of acute humoral rejection of renal allografts associated with concomitant cellular rejection","volume":"173","author":"A Bickerstaff","year":"2008","journal-title":"Am J Pathol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1111\/j.1600-6143.2009.02786.x","article-title":"CCR5 is required for regulation of alloreactive T-cell responses to single class II MHC-mismatched murine cardiac grafts","volume":"9","author":"T Nozaki","year":"2009","journal-title":"Am J Transplant"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1161\/ATVBAHA.107.159434","article-title":"Suppressing PTEN activity by tobacco smoke plus interleukin-1beta modulates dissociation of VE-cadherin\/beta-catenin complexes in endothelium","volume":"28","author":"SS Barbieri","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref27","first-page":"725","article-title":"The kidneys of mice with autoimmune disease acquire a hypofibrinolytic\/procoagulant state that correlates with the development of glomerulonephritis and tissue microthrombosis","volume":"151","author":"K Yamamoto","year":"1997","journal-title":"Am J Pathol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1097\/01.ASN.0000128047.13396.48","article-title":"Hypoperfusion of peritubular capillaries induces chronic hypoxia before progression of tubulointerstitial injury in a progressive model of rat glomerulonephritis","volume":"15","author":"M Matsumoto","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.yexmp.2004.04.003","article-title":"Marasmius oreades lectin induces renal thrombotic microangiopathic lesions","volume":"77","author":"RL Warner","year":"2004","journal-title":"Exp Mol Pathol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1111\/j.1600-6143.2007.01895.x","article-title":"Transplant glomerulopathy: subclinical incidence and association with alloantibody","volume":"7","author":"JM Gloor","year":"2007","journal-title":"Am J Transplant"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/TP.0b013e3181e065de","article-title":"Evidence for antibody-mediated injury as a major determinant of late kidney allograft failure","volume":"90","author":"RS Gaston","year":"2010","journal-title":"Transplantation"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1600-6143.2010.03415.x","article-title":"Inflammation lesions in kidney transplant biopsies: association with survival is due to the underlying diseases","volume":"11","author":"J Sellar\u00e9s","year":"2011","journal-title":"Am J Transplant"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1600-6143.2010.03383.x","article-title":"De novo donor HLA-specific antibodies after heart transplantation are an independent predictor of poor patient survival","volume":"11","author":"JD Smith","year":"2011","journal-title":"Am J Transplant"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0344-0338(82)80087-3","article-title":"The glomerular lesions in endotheliotropic hemolytic nephroangiopathy (hemolytic uremic syndrome, malignant nephrosclerosis, post partum renal insufficiency)","volume":"173","author":"HD John","year":"1982","journal-title":"Pathol Res Pract"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/(SICI)1096-8652(199812)59:4<279::AID-AJH3>3.0.CO;2-J","article-title":"Role of caspases 1 and 3 and Bcl-2-related molecules in endothelial cell apoptosis associated with thrombotic microangiopathies","volume":"59","author":"D Mitra","year":"1998","journal-title":"Am J Hematol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3109\/01913129709021919","article-title":"Antibody-mediated rejection of human renal allografts: an electron microscopic study of peritubular capillaries","volume":"21","author":"G Lajoie","year":"1997","journal-title":"Ultrastruct Pathol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1523-1755.2005.00085.x","article-title":"Injury and progressive loss of peritubular capillaries in the development of chronic allograft nephropathy","volume":"67","author":"Y Ishii","year":"2005","journal-title":"Kidney Int"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1084\/jem.20070301","article-title":"Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains","volume":"204","author":"MC Pickering","year":"2007","journal-title":"J Exp Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1056\/NEJMoa0707330","article-title":"VEGF inhibition and renal thrombotic microangiopathy","volume":"358","author":"V Eremina","year":"2008","journal-title":"N Engl J Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1681\/ASN.2006050419","article-title":"A murine model of HUS: Shiga toxin with lipopolysaccharide mimics the renal damage and physiologic response of human disease","volume":"17","author":"TR Keepers","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/jcp.1041360303","article-title":"Differential expression of cell surface glycoproteins on various organ-derived microvascular endothelia and endothelial cell cultures","volume":"136","author":"PN Belloni","year":"1988","journal-title":"J Cell Physiol"},{"key":"ref42","first-page":"H2547","article-title":"Permeability-related changes revealed at endothelial cell borders in inflamed venules by lectin binding","volume":"271","author":"G Thurston","year":"1996","journal-title":"Am J Physiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1093\/ndt\/gfm774","article-title":"A murine model of site-specific renal microvascular endothelial injury and thrombotic microangiopathy","volume":"23","author":"B Hohenstein","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1097\/00007890-199711150-00014","article-title":"Species differences in the expression of major histocompatibility complex class II antigens on coronary artery endothelium: implications for cell-mediated xenoreactivity","volume":"64","author":"JK Choo","year":"1997","journal-title":"Transplantation"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1093\/nar\/25.3.518","article-title":"Polynucleotide:adenosine glycosidase activity of ribosome-inactivating proteins: effect on DNA, RNA and poly(A)","volume":"25","author":"L Barbieri","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1182\/blood-2009-12-259267","article-title":"Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice","volume":"116","author":"R Pawlinski","year":"2010","journal-title":"Blood"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1182\/blood-2003-02-0635","article-title":"A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation","volume":"104","author":"S Daniel","year":"2004","journal-title":"Blood"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.2353\/ajpath.2009.090113","article-title":"Lipopolysaccharide can trigger a cathepsin B-dependent programmed death response in human endothelial cells","volume":"175","author":"JH Li","year":"2009","journal-title":"Am J Pathol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0078244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T05:35:59Z","timestamp":1646804159000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0078244"}},"subtitle":[],"editor":[{"given":"David","family":"Long","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,10,15]]},"references-count":48,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0078244","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,15]]}}}