{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:21:25Z","timestamp":1791397285105,"version":"4.3.3"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T00:00:00Z","timestamp":1383696000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0078257","type":"journal-article","created":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T22:13:45Z","timestamp":1383776025000},"page":"e78257","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":230,"title":["Diversified Microbiota of Meconium Is Affected by Maternal Diabetes Status"],"prefix":"10.1371","volume":"8","author":[{"given":"Jianzhong","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Bashir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heriberto","family":"Fernandez-Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Itzkowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiheng","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Loudon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Peter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,11,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"588S","DOI":"10.1080\/07315724.2004.10719428","article-title":"The developmental origins of adult disease","volume":"23","author":"DJ Barker","year":"2004","journal-title":"J Am Coll Nutr"},{"key":"ref2","unstructured":"Buchanan TA (1995) Pregnancy in preexisting diabetes. National Diabetes Data Group: Diabetes in America. pp. 719\u2013733."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1046\/j.1464-5491.2003.01017.x","article-title":"Pregnancy in women with Type 2 diabetes: 12 years outcome data 1990\u20132002","volume":"20","author":"F Dunne","year":"2003","journal-title":"Diabet Med"},{"key":"ref4","article-title":"Peri-conception hyperglycaemia and nephropathy are associated with risk of congenital anomaly in women with pre-existing diabetes: a population-based cohort study","author":"R Bell","year":"2012","journal-title":"Diabetologia"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"963735","DOI":"10.1155\/2012\/963735","article-title":"Associations of existing diabetes, gestational diabetes, and glycosuria with offspring IQ and educational attainment: the Avon Longitudinal Study of Parents and Children","volume":"2012","author":"A Fraser","year":"2012","journal-title":"Exp Diabetes Res"},{"key":"ref6","first-page":"104","article-title":"Growth and neurodevelopmental outcome of children born to mothers with pregestational and gestational diabetes","volume":"3","author":"A Ornoy","year":"2005","journal-title":"Pediatr Endocrinol Rev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e221","DOI":"10.1542\/peds.111.3.e221","article-title":"Maternal gestational diabetes, birth weight, and adolescent obesity","volume":"111","author":"MW Gillman","year":"2003","journal-title":"Pediatrics"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/sj.ijo.0803760","article-title":"Maternal smoking during pregnancy and child overweight: systematic review and meta-analysis","volume":"32","author":"E Oken","year":"2008","journal-title":"Int J Obes (Lond)"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"11971","DOI":"10.1073\/pnas.1002601107","article-title":"Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns","volume":"107","author":"MG Dominguez-Bello","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1542\/peds.2011-2736","article-title":"The human microbiome and its potential importance to pediatrics","volume":"129","author":"CL Johnson","year":"2012","journal-title":"Pediatrics"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e177","DOI":"10.1371\/journal.pbio.0050177","article-title":"Development of the human infant intestinal microbiota","volume":"5","author":"C Palmer","year":"2007","journal-title":"PLoS Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e3056","DOI":"10.1371\/journal.pone.0003056","article-title":"Microbial prevalence, diversity and abundance in amniotic fluid during preterm labor: a molecular and culture-based investigation","volume":"3","author":"DB DiGiulio","year":"2008","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/gbe\/evp057","article-title":"Comparative metagenomics and population dynamics of the gut microbiota in mother and infant","volume":"2","author":"PA Vaishampayan","year":"2010","journal-title":"Genome Biol Evol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e9964","DOI":"10.1371\/journal.pone.0009964","article-title":"Comparative Analysis of Fecal Microbiota in Infants with and without Eczema","volume":"5","author":"PY Hong","year":"2010","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e23031","DOI":"10.1371\/journal.pone.0023031","article-title":"Early Colonization with a Group of Lactobacilli Decreases the Risk for Allergy at Five Years of Age Despite Allergic Heredity","volume":"6","author":"MA Johansson","year":"2011","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"6718","DOI":"10.1128\/AEM.05212-11","article-title":"Low Relative Abundances of the Mucolytic Bacterium Akkermansia muciniphila and Bifidobacterium spp. in Feces of Children with Autism","volume":"77","author":"L Wang","year":"2011","journal-title":"Applied and Environmental Microbiology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/1471-2180-11-193","article-title":"Evaluation of stool microbiota signatures in two cohorts of Asian (Singapore and Indonesia) newborns at risk of atopy","volume":"11","author":"GC Yap","year":"2011","journal-title":"Bmc Microbiology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1111\/j.1365-2222.2009.03326.x","article-title":"Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responses","volume":"39","author":"YM Sjogren","year":"2009","journal-title":"Clinical and Experimental Allergy"},{"issue":"Suppl 1","key":"ref19","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3109\/14767058.2012.663231","article-title":"Composition and roles of intestinal microbiota in children","volume":"25","author":"A Guarino","year":"2012","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"Suppl 1","key":"ref20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.earlhumdev.2010.01.004","article-title":"Mode of delivery affects the bacterial community in the newborn gut","volume":"86","author":"G Biasucci","year":"2010","journal-title":"Early Hum Dev"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1086\/513669","article-title":"Broad-spectrum bacterial rDNA polymerase chain reaction assay for detecting amniotic fluid infection among women in premature labor","volume":"24","author":"J Hitti","year":"1997","journal-title":"Clin Infect Dis"},{"key":"ref22","first-page":"261","article-title":"Detection of ureaplasmas by the polymerase chain reaction in the amniotic fluid of patients with cervical insufficiency","volume":"38","author":"KJ Oh","year":"2010","journal-title":"J Perinat Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s00284-005-0020-3","article-title":"Isolation of commensal bacteria from umbilical cord blood of healthy neonates born by cesarean section","volume":"51","author":"E Jimenez","year":"2005","journal-title":"Current Microbiology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/cea.12063","article-title":"Meconium microbiota types dominated by lactic acid or enteric bacteria are differentially associated with maternal eczema and respiratory problems in infants","volume":"43","author":"MJ Gosalbes","year":"2013","journal-title":"Clin Exp Allergy"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.resmic.2007.12.007","article-title":"Is meconium from healthy newborns actually sterile?","volume":"159","author":"E Jimenez","year":"2008","journal-title":"Res Microbiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1472-765X.2008.02475.x","article-title":"Bifidobacterium and Lactobacillus DNA in the human placenta","volume":"48","author":"R Satokari","year":"2009","journal-title":"Lett Appl Microbiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1203\/01.PDR.0000153869.96337.90","article-title":"Bacteria and inflammatory cells in fetal membranes do not always cause preterm labor","volume":"57","author":"JH Steel","year":"2005","journal-title":"Pediatr Res"},{"issue":"Suppl 4","key":"ref28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1469-0691.2012.03876.x","article-title":"Metagenomics and development of the gut microbiota in infants","volume":"18","author":"Y Valles","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00284-010-9582-9","article-title":"Molecular characterisation of the faecal microbiota in patients with type II diabetes","volume":"61","author":"X Wu","year":"2010","journal-title":"Curr Microbiol"},{"key":"ref30","article-title":"Gut microbial colonisation in premature neonates predicts neonatal sepsis","author":"JC Madan","year":"2012","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jpeds.2009.06.063","article-title":"Intestinal Microbial Ecology in Premature Infants Assessed with Non-Culture-Based Techniques","volume":"156","author":"M Mshvildadze","year":"2010","journal-title":"Journal of Pediatrics"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e66986","DOI":"10.1371\/journal.pone.0066986","article-title":"Bacterial Diversity in Meconium of Preterm Neonates and Evolution of Their Fecal Microbiota during the First Month of Life","volume":"8","author":"L Moles","year":"2013","journal-title":"PLoS One"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S0002-9378(87)80045-5","article-title":"The significance of one abnormal glucose tolerance test value on adverse outcome in pregnancy","volume":"157","author":"O Langer","year":"1987","journal-title":"Am J Obstet Gynecol"},{"key":"ref34","first-page":"103","article-title":"The relationship of one abnormal glucose tolerance test value and pregnancy complications","volume":"73","author":"MK Lindsay","year":"1989","journal-title":"Obstet Gynecol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e22788","DOI":"10.1371\/journal.pone.0022788","article-title":"Oral microbiome profiles: 16S rRNA pyrosequencing and microarray assay comparison","volume":"6","author":"J Ahn","year":"2011","journal-title":"PLoS One"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"JG Caporaso","year":"2010","journal-title":"Nature Methods"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate - a Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Y Benjamini","year":"1995","journal-title":"Journal of the Royal Statistical Society Series B-Methodological"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e8422","DOI":"10.1371\/journal.pone.0008422","article-title":"The effects of circumcision on the penis microbiome","volume":"5","author":"LB Price","year":"2010","journal-title":"PLoS One"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1093\/bioinformatics\/bts342","article-title":"Associating microbiome composition with environmental covariates using generalized UniFrac distances","volume":"28","author":"J Chen","year":"2012","journal-title":"Bioinformatics"},{"key":"ref40","unstructured":"Oksanen J (2007) Multivariate analysis of ecological communities in R: vegan tutorial. R package version 2-0."},{"key":"ref41","doi-asserted-by":"crossref","first-page":"e33387","DOI":"10.1371\/journal.pone.0033387","article-title":"Proof of concept of microbiome-metabolome analysis and delayed gluten exposure on celiac disease autoimmunity in genetically at-risk infants","volume":"7","author":"M Sellitto","year":"2012","journal-title":"PLoS One"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature11450","article-title":"A metagenome-wide association study of gut microbiota in type 2 diabetes","volume":"490","author":"J Qin","year":"2012","journal-title":"Nature"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3920\/BM2011.0038","article-title":"Molecular monitoring of the development of intestinal microbiota in Japanese infants","volume":"3","author":"H Tsuji","year":"2012","journal-title":"Benef Microbes"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"520","DOI":"10.2337\/dc11-1043","article-title":"Helicobacter pylori infection is associated with an increased rate of diabetes","volume":"35","author":"CY Jeon","year":"2012","journal-title":"Diabetes Care"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e9085","DOI":"10.1371\/journal.pone.0009085","article-title":"Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults","volume":"5","author":"N Larsen","year":"2010","journal-title":"PLoS One"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"6812","DOI":"10.1128\/AEM.00933-09","article-title":"The complete genome of Comamonas testosteroni reveals its genetic adaptations to changing environments","volume":"75","author":"YF Ma","year":"2009","journal-title":"Appl Environ Microbiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"e1000344","DOI":"10.1371\/journal.pgen.1000344","article-title":"Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths","volume":"5","author":"M Touchon","year":"2009","journal-title":"PLoS Genet"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cell.2012.07.008","article-title":"Host remodeling of the gut microbiome and metabolic changes during pregnancy","volume":"150","author":"O Koren","year":"2012","journal-title":"Cell"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0078257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T07:40:42Z","timestamp":1716104442000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0078257"}},"subtitle":[],"editor":[{"given":"Herman","family":"Tse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,6]]},"references-count":48,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0078257","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,6]]}}}