{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T07:26:06Z","timestamp":1768721166556,"version":"3.49.0"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T00:00:00Z","timestamp":1383091200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0078279","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T00:21:27Z","timestamp":1383178887000},"page":"e78279","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Ectopic Activation of Wnt\/\u03b2-Catenin Signaling in Lens Fiber Cells Results in Cataract Formation and Aberrant Fiber Cell Differentiation"],"prefix":"10.1371","volume":"8","author":[{"given":"Barbora","family":"Antosova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Smolikova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romana","family":"Borkovcova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hynek","family":"Strnad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jitka","family":"Lachova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ondrej","family":"Machon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zbynek","family":"Kozmik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,10,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/eye.1999.117","article-title":"Lens development","volume":"3b)","author":"JW McAvoy","year":"1999","journal-title":"Eye (Lond) 13 (Pt"},{"key":"ref2","first-page":"271","article-title":"Cell division, cell elongation and the co-ordination of crystallin gene expression during lens morphogenesis in the rat","volume":"45","author":"JW McAvoy","year":"1978","journal-title":"J Embryol Exp Morphol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1242\/dev.121.5.1433","article-title":"The role of Pax-6 in eye and nasal development","volume":"121","author":"JC Grindley","year":"1995","journal-title":"Development"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/6844","article-title":"Prox1 function is crucial for mouse lens-fibre elongation","volume":"21","author":"JT Wigle","year":"1999","journal-title":"Nat Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1101\/gad.12.6.776","article-title":"Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice","volume":"12","author":"S Nishiguchi","year":"1998","journal-title":"Genes Dev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1101\/gad.184000","article-title":"Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye","volume":"14","author":"R Ashery-Padan","year":"2000","journal-title":"Genes Dev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1073\/pnas.96.7.3781","article-title":"Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development","volume":"96","author":"JI Kim","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1242\/dev.127.2.307","article-title":"Regulation of mouse lens fiber cell development and differentiation by the Maf gene","volume":"127","author":"BZ Ring","year":"2000","journal-title":"Development"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"43259","DOI":"10.1074\/jbc.M111.264580","article-title":"The orchestration of mammalian tissue morphogenesis through a series of coherent feed-forward loops","volume":"286","author":"Q Xie","year":"2011","journal-title":"J Biol Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1242\/dev.032888","article-title":"Pax6 is essential for lens fiber cell differentiation","volume":"136","author":"O Shaham","year":"2009","journal-title":"Development"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1101\/gad.12.20.3162","article-title":"Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development","volume":"12","author":"P Zhang","year":"1998","journal-title":"Genes Dev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/aja.1001940202","article-title":"Coincident loss of mitochondria and nuclei during lens fiber cell differentiation","volume":"194","author":"S Bassnett","year":"1992","journal-title":"Dev Dyn"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2005.01.020","article-title":"Growth factor regulation of lens development","volume":"280","author":"FJ Lovicu","year":"2005","journal-title":"Dev Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ydbio.2008.03.028","article-title":"Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation","volume":"318","author":"H Zhao","year":"2008","journal-title":"Dev Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1242\/dev.128.22.4425","article-title":"Fgf receptor signaling plays a role in lens induction","volume":"128","author":"SC Faber","year":"2001","journal-title":"Development"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ydbio.2008.09.003","article-title":"Essential role of BMPs in FGF-induced secondary lens fiber differentiation","volume":"324","author":"BA Boswell","year":"2008","journal-title":"Dev Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1242\/dev.129.15.3727","article-title":"Bmp signaling is required for development of primary lens fiber cells","volume":"129","author":"SC Faber","year":"2002","journal-title":"Development"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1242\/dev.128.20.3995","article-title":"Requirement for TGFbeta receptor signaling during terminal lens fiber differentiation","volume":"128","author":"RU de Iongh","year":"2001","journal-title":"Development"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1242\/dev.129.16.3795","article-title":"Bone morphogenetic protein signaling and the initiation of lens fiber cell differentiation","volume":"129","author":"TL Belecky-Adams","year":"2002","journal-title":"Development"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrc2389","article-title":"Wnt signalling and its impact on development and cancer","volume":"8","author":"A Klaus","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.ydbio.2008.07.002","article-title":"Differential requirement for beta-catenin in epithelial and fiber cells during lens development","volume":"321","author":"S Cain","year":"2008","journal-title":"Dev Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/dvg.20277","article-title":"Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function","volume":"45","author":"J Kreslova","year":"2007","journal-title":"Genesis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/dvg.20583","article-title":"Lens morphogenesis is dependent on Pax6-mediated inhibition of the canonical Wnt\/beta-catenin signaling in the lens surface ectoderm","volume":"48","author":"O Machon","year":"2010","journal-title":"Genesis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1471-213X-6-14","article-title":"Optic cup and facial patterning defects in ocular ectoderm beta-catenin gain-of-function mice","volume":"6","author":"LA Miller","year":"2006","journal-title":"BMC Dev Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ydbio.2005.07.019","article-title":"The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm","volume":"285","author":"AN Smith","year":"2005","journal-title":"Dev Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0012-1606(03)00179-9","article-title":"A role for Wnt\/beta-catenin signaling in lens epithelial differentiation","volume":"259","author":"RJ Stump","year":"2003","journal-title":"Dev Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4794","DOI":"10.1167\/iovs.09-3567","article-title":"Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation","volume":"50","author":"G Martinez","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.cell.2006.10.018","article-title":"Wnt\/beta-catenin signaling in development and disease","volume":"127","author":"H Clevers","year":"2006","journal-title":"Cell"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"8668","DOI":"10.1073\/pnas.151258098","article-title":"Rescue of a Wnt mutation by an activated form of LEF-1: regulation of maintenance but not initiation of Brachyury expression","volume":"98","author":"J Galceran","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"17667","DOI":"10.1074\/jbc.M311678200","article-title":"Inhibition of lens fiber cell morphogenesis by expression of a mutant SV40 large T antigen that binds CREB-binding protein\/p300 but not pRb","volume":"279","author":"Q Chen","year":"2004","journal-title":"J Biol Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1167\/iovs.02-1311","article-title":"Genetic background influences cataractogenesis, but not lens growth deficiency, in Cx50-knockout mice","volume":"44","author":"DA Gerido","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0092-8674(00)81631-1","article-title":"De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin","volume":"95","author":"U Gat","year":"1998","journal-title":"Cell"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ydbio.2007.08.038","article-title":"A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus","volume":"311","author":"O Machon","year":"2007","journal-title":"Dev Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"7815","DOI":"10.1073\/pnas.82.23.7815","article-title":"Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice","volume":"82","author":"PA Overbeek","year":"1985","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.exer.2008.10.011","article-title":"Genetics of crystallins: cataract and beyond","volume":"88","author":"J Graw","year":"2009","journal-title":"Exp Eye Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1091\/mbc.E02-10-0637","article-title":"Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)","volume":"14","author":"PA Nielsen","year":"2003","journal-title":"Mol Biol Cell"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1006\/exer.2002.1175","article-title":"Systematic analysis of E-, N- and P-cadherin expression in mouse eye development","volume":"74","author":"L Xu","year":"2002","journal-title":"Exp Eye Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"19254","DOI":"10.1074\/jbc.274.27.19254","article-title":"Regulation of lens fiber cell differentiation by transcription factor c-Maf","volume":"274","author":"S Kawauchi","year":"1999","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1167\/iovs.04-0151","article-title":"Ectopic Pax6 expression disturbs lens fiber cell differentiation","volume":"45","author":"MK Duncan","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1101\/gad.14.2.245","article-title":"A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle","volume":"14","author":"A Blixt","year":"2000","journal-title":"Genes Dev"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/1526-968X(200006)27:2<81::AID-GENE50>3.0.CO;2-N","article-title":"Forkhead Foxe3 maps to the dysgenetic lens locus and is critical in lens development and differentiation","volume":"27","author":"I Brownell","year":"2000","journal-title":"Genesis"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1038\/emboj.2012.124","article-title":"Mitotic and mitogenic Wnt signalling","volume":"31","author":"C Niehrs","year":"2012","journal-title":"EMBO J"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.semcdb.2006.10.004","article-title":"Cell cycle regulation in the developing lens","volume":"17","author":"AE Griep","year":"2006","journal-title":"Semin Cell Dev Biol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"5931","DOI":"10.1093\/emboj\/18.21.5931","article-title":"Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene","volume":"18","author":"N Harada","year":"1999","journal-title":"EMBO J"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1242\/dev.125.17.3365","article-title":"Overlapping effects of different members of the FGF family on lens fiber differentiation in transgenic mice","volume":"125","author":"FJ Lovicu","year":"1998","journal-title":"Development"},{"key":"ref46","first-page":"4223","article-title":"Induction of cell cycle entry and cell death in postmitotic lens fiber cells by overexpression of E2F1 or E2F2","volume":"41","author":"Q Chen","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1242\/jcs.113.18.3173","article-title":"Overexpression of PAX6(5a) in lens fiber cells results in cataract and upregulation of (alpha)5(beta)1 integrin expression","volume":"18)","author":"MK Duncan","year":"2000","journal-title":"J Cell Sci 113 (Pt"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jmb.2005.05.072","article-title":"Tissue-specific regulation of the mouse alphaA-crystallin gene in lens via recruitment of Pax6 and c-Maf to its promoter","volume":"351","author":"Y Yang","year":"2005","journal-title":"J Mol Biol"},{"key":"ref49","first-page":"1","article-title":"Intracellular ions, protein metabolism, and cataract formation","volume":"3","author":"J Piatigorsky","year":"1980","journal-title":"Curr Top Eye Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1387\/ijdb.041854jg","article-title":"Congenital hereditary cataracts","volume":"48","author":"J Graw","year":"2004","journal-title":"Int J Dev Biol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.preteyeres.2007.07.002","article-title":"Genetic and epigenetic mechanisms of gene regulation during lens development","volume":"26","author":"A Cvekl","year":"2007","journal-title":"Prog Retin Eye Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0378-1119(02)00425-0","article-title":"Complex regulatory element within the gammaE- and gammaF-crystallin enhancers mediates Pax6 regulation and is required for induction by retinoic acid","volume":"286","author":"J Kralova","year":"2002","journal-title":"Gene"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jmb.2004.07.102","article-title":"Transcriptional regulation of mouse alphaB- and gammaF-crystallin genes in lens: opposite promoter-specific interactions between Pax6 and large Maf transcription factors","volume":"344","author":"Y Yang","year":"2004","journal-title":"J Mol Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nrc3090","article-title":"Cyclin D as a therapeutic target in cancer","volume":"11","author":"EA Musgrove","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1073\/pnas.96.10.5522","article-title":"The cyclin D1 gene is a target of the beta-catenin\/LEF-1 pathway","volume":"96","author":"M Shtutman","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/18884","article-title":"Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells","volume":"398","author":"O Tetsu","year":"1999","journal-title":"Nature"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00795-008-0395-x","article-title":"A study of the proliferating activity in lens epithelium and the identification of tissue-type stem cells","volume":"41","author":"N Yamamoto","year":"2008","journal-title":"Med Mol Morphol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1242\/dev.084111","article-title":"Visualization of cell cycle in mouse embryos with Fucci2 reporter directed by Rosa26 promoter","volume":"140","author":"T Abe","year":"2012","journal-title":"Development"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0078279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T04:04:40Z","timestamp":1716091480000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0078279"}},"subtitle":[],"editor":[{"given":"Anand","family":"Swaroop","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,10,30]]},"references-count":58,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0078279","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,30]]}}}